TWI852943B - 肺炎鏈球菌融合蛋白疫苗 - Google Patents

肺炎鏈球菌融合蛋白疫苗 Download PDF

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Publication number
TWI852943B
TWI852943B TW108133139A TW108133139A TWI852943B TW I852943 B TWI852943 B TW I852943B TW 108133139 A TW108133139 A TW 108133139A TW 108133139 A TW108133139 A TW 108133139A TW I852943 B TWI852943 B TW I852943B
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Taiwan
Prior art keywords
seq
fusion protein
polypeptide
vaccine
linker
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TW108133139A
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English (en)
Chinese (zh)
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TW202035436A (zh
Inventor
理查德 馬利
路英杰
帆 張
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美商兒童醫療中心公司
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Publication of TW202035436A publication Critical patent/TW202035436A/zh
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/62Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW108133139A 2018-09-12 2019-09-12 肺炎鏈球菌融合蛋白疫苗 TWI852943B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862730199P 2018-09-12 2018-09-12
US62/730,199 2018-09-12

Publications (2)

Publication Number Publication Date
TW202035436A TW202035436A (zh) 2020-10-01
TWI852943B true TWI852943B (zh) 2024-08-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW108133139A TWI852943B (zh) 2018-09-12 2019-09-12 肺炎鏈球菌融合蛋白疫苗

Country Status (13)

Country Link
US (3) US20200087361A1 (enExample)
EP (1) EP3849599A4 (enExample)
JP (2) JP7535791B2 (enExample)
KR (1) KR102922338B1 (enExample)
CN (1) CN113164580B (enExample)
AU (1) AU2019338448B2 (enExample)
BR (1) BR112021004185A2 (enExample)
CA (1) CA3111436A1 (enExample)
IL (1) IL281203A (enExample)
MX (1) MX2021002909A (enExample)
SG (1) SG11202101973YA (enExample)
TW (1) TWI852943B (enExample)
WO (1) WO2020056127A1 (enExample)

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US11576958B2 (en) 2013-02-07 2023-02-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
CN112969474A (zh) 2018-09-12 2021-06-15 艾芬尼维克斯公司 多价肺炎球菌疫苗
MX2024002779A (es) 2021-09-09 2024-06-11 Affinivax Inc Vacunas neumocócicas multivalentes.
EP4538370A1 (en) * 2022-06-07 2025-04-16 Peking University First Hospital Fusion protein containing truncated iga protease and use thereof
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WO2025193903A1 (en) 2024-03-15 2025-09-18 Affinivax, Inc. Pneumococcal polysaccharide compositions and uses thereof

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Also Published As

Publication number Publication date
CN113164580A (zh) 2021-07-23
JP7535791B2 (ja) 2024-08-19
EP3849599A1 (en) 2021-07-21
BR112021004185A2 (pt) 2021-05-25
AU2019338448A1 (en) 2021-05-06
CN113164580B (zh) 2025-06-10
TW202035436A (zh) 2020-10-01
EP3849599A4 (en) 2022-06-29
KR102922338B1 (ko) 2026-02-05
IL281203A (en) 2021-04-29
CA3111436A1 (en) 2020-03-19
US20250019407A1 (en) 2025-01-16
KR20210088535A (ko) 2021-07-14
JP2024096456A (ja) 2024-07-12
WO2020056127A1 (en) 2020-03-19
AU2019338448B2 (en) 2026-02-26
US20230089151A1 (en) 2023-03-23
JP2022500409A (ja) 2022-01-04
MX2021002909A (es) 2021-09-08
US20200087361A1 (en) 2020-03-19
US12129283B2 (en) 2024-10-29
SG11202101973YA (en) 2021-03-30

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