JP7535791B2 - 肺炎球菌融合タンパク質ワクチン - Google Patents

肺炎球菌融合タンパク質ワクチン Download PDF

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Publication number
JP7535791B2
JP7535791B2 JP2021513863A JP2021513863A JP7535791B2 JP 7535791 B2 JP7535791 B2 JP 7535791B2 JP 2021513863 A JP2021513863 A JP 2021513863A JP 2021513863 A JP2021513863 A JP 2021513863A JP 7535791 B2 JP7535791 B2 JP 7535791B2
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seq
fusion protein
polypeptide
vaccine
linker
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JP2022500409A5 (enExample
JP2022500409A (ja
Inventor
リチャード マリー，
インジェ ルー，
ファン ジャン，
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Boston Children's Hospital
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Boston Children's Hospital
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2021513863A 2018-09-12 2019-09-12 肺炎球菌融合タンパク質ワクチン Active JP7535791B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024077967A JP2024096456A (ja) 2018-09-12 2024-05-13 肺炎球菌融合タンパク質ワクチン

Applications Claiming Priority (3)

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US201862730199P 2018-09-12 2018-09-12
US62/730,199 2018-09-12
PCT/US2019/050800 WO2020056127A1 (en) 2018-09-12 2019-09-12 Pneumococcal fusion protein vaccines

Related Child Applications (1)

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JP2024077967A Division JP2024096456A (ja) 2018-09-12 2024-05-13 肺炎球菌融合タンパク質ワクチン

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JP2022500409A JP2022500409A (ja) 2022-01-04
JP2022500409A5 JP2022500409A5 (enExample) 2022-09-21
JP7535791B2 true JP7535791B2 (ja) 2024-08-19

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JP2024077967A Pending JP2024096456A (ja) 2018-09-12 2024-05-13 肺炎球菌融合タンパク質ワクチン

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US (3) US20200087361A1 (enExample)
EP (1) EP3849599A4 (enExample)
JP (2) JP7535791B2 (enExample)
KR (1) KR102922338B1 (enExample)
CN (1) CN113164580B (enExample)
AU (1) AU2019338448B2 (enExample)
BR (1) BR112021004185A2 (enExample)
CA (1) CA3111436A1 (enExample)
IL (1) IL281203A (enExample)
MX (1) MX2021002909A (enExample)
SG (1) SG11202101973YA (enExample)
TW (1) TWI852943B (enExample)
WO (1) WO2020056127A1 (enExample)

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EP4272750A3 (en) 2013-02-07 2024-01-24 Children's Medical Center, Corp. Protein antigens that provide protection against pneumococcal colonization and/or disease
CN112969474A (zh) 2018-09-12 2021-06-15 艾芬尼维克斯公司 多价肺炎球菌疫苗
MX2024002779A (es) 2021-09-09 2024-06-11 Affinivax Inc Vacunas neumocócicas multivalentes.
WO2023236878A1 (zh) * 2022-06-07 2023-12-14 北京大学第一医院 包含IgA蛋白酶截短体的融合蛋白及其用途
US20260217851A1 (en) * 2022-12-22 2026-07-30 The Medical College Of Wisconsin, Inc. Compositions that Target CD138 and CD3 and Methods of Making and Using the Same
WO2025193903A1 (en) 2024-03-15 2025-09-18 Affinivax, Inc. Pneumococcal polysaccharide compositions and uses thereof

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Also Published As

Publication number Publication date
EP3849599A1 (en) 2021-07-21
MX2021002909A (es) 2021-09-08
KR102922338B1 (ko) 2026-02-05
TWI852943B (zh) 2024-08-21
BR112021004185A2 (pt) 2021-05-25
KR20210088535A (ko) 2021-07-14
IL281203A (en) 2021-04-29
CA3111436A1 (en) 2020-03-19
AU2019338448A1 (en) 2021-05-06
SG11202101973YA (en) 2021-03-30
EP3849599A4 (en) 2022-06-29
US20230089151A1 (en) 2023-03-23
US12129283B2 (en) 2024-10-29
US20200087361A1 (en) 2020-03-19
US20250019407A1 (en) 2025-01-16
AU2019338448B2 (en) 2026-02-26
WO2020056127A1 (en) 2020-03-19
JP2024096456A (ja) 2024-07-12
CN113164580A (zh) 2021-07-23
TW202035436A (zh) 2020-10-01
JP2022500409A (ja) 2022-01-04
CN113164580B (zh) 2025-06-10

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