TWI845600B - Gpr35調節劑 - Google Patents

Gpr35調節劑 Download PDF

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Publication number
TWI845600B
TWI845600B TW109102674A TW109102674A TWI845600B TW I845600 B TWI845600 B TW I845600B TW 109102674 A TW109102674 A TW 109102674A TW 109102674 A TW109102674 A TW 109102674A TW I845600 B TWI845600 B TW I845600B
Authority
TW
Taiwan
Prior art keywords
alkyl
compound
pharmaceutically acceptable
solvent
acceptable salt
Prior art date
Application number
TW109102674A
Other languages
English (en)
Chinese (zh)
Other versions
TW202043234A (zh
Inventor
羅伯特 席古奇
Original Assignee
美商普羅米修斯生物科學股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商普羅米修斯生物科學股份有限公司 filed Critical 美商普羅米修斯生物科學股份有限公司
Publication of TW202043234A publication Critical patent/TW202043234A/zh
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Publication of TWI845600B publication Critical patent/TWI845600B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW109102674A 2019-01-24 2020-01-22 Gpr35調節劑 TWI845600B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962796459P 2019-01-24 2019-01-24
US62/796,459 2019-01-24
US201962873703P 2019-07-12 2019-07-12
US62/873,703 2019-07-12
US201962928223P 2019-10-30 2019-10-30
US62/928,223 2019-10-30

Publications (2)

Publication Number Publication Date
TW202043234A TW202043234A (zh) 2020-12-01
TWI845600B true TWI845600B (zh) 2024-06-21

Family

ID=71733100

Family Applications (1)

Application Number Title Priority Date Filing Date
TW109102674A TWI845600B (zh) 2019-01-24 2020-01-22 Gpr35調節劑

Country Status (13)

Country Link
US (2) US11053251B2 (enExample)
EP (1) EP3914256B1 (enExample)
JP (1) JP7588077B2 (enExample)
KR (1) KR102863894B1 (enExample)
CN (1) CN113631168B (enExample)
AU (1) AU2020210930B2 (enExample)
BR (1) BR112021014566A2 (enExample)
CA (1) CA3127786A1 (enExample)
IL (1) IL285074B2 (enExample)
MA (1) MA54825A (enExample)
MX (1) MX2021008941A (enExample)
TW (1) TWI845600B (enExample)
WO (1) WO2020154492A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI906328B (zh) * 2020-07-23 2025-12-01 美商普羅米修斯生物科學股份有限公司 靶向gpr35之治療劑

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI845600B (zh) 2019-01-24 2024-06-21 美商普羅米修斯生物科學股份有限公司 Gpr35調節劑
CN114375339A (zh) 2019-05-14 2022-04-19 普罗米修斯生物科学公司 Tl1a患者选择方法、系统和装置
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
GB202303387D0 (en) * 2023-03-08 2023-04-19 Thirtyfivebio Ltd Compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200611693A (en) * 2004-05-26 2006-04-16 Arena Pharm Inc GPR35 and modulators thereof for the treatment of metabolic-related disorders
TW201842191A (zh) * 2017-04-20 2018-12-01 美國錫安山醫學中心 預測患有發炎性腸病之個體對抗-tnf治療無反應的方法
TW202014217A (zh) * 2018-04-27 2020-04-16 美國錫安山醫學中心 標靶gpr35以治療發炎性腸病症的組合物及方法

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GB1338235A (en) * 1970-12-15 1973-11-21 May & Baker Ltd Azapurinones
GB1421970A (en) * 1973-06-12 1976-01-21 May & Baker Ltd 8-azapurin-6-one derivatives
US4052390A (en) * 1973-06-12 1977-10-04 May & Baker Limited Azapurinones
GB1561345A (en) 1976-10-22 1980-02-20 May & Baker Ltd 8 - azapuring - 6 - ones
US4923874A (en) * 1988-07-21 1990-05-08 G. D. Searle & Co. Use of 8-azapurin-6-one derivatives for control of hypertension
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
FR2845993B1 (fr) 2002-10-16 2005-02-11 Univ Pasteur Composes pharmaceutiques inhibiteurs specifiques de la pde5 du muscle lisse, compositions pharmaceutiques les contenant et utilisations therapeutiques
CA2558721A1 (en) * 2004-02-27 2005-09-15 Pfizer Inc. Screening method for emulators of neural activity and digestive system using gpr35
US20070287630A1 (en) 2006-06-12 2007-12-13 Driwater, Inc. Moisturizing agent with nutrients
WO2012167053A1 (en) * 2011-06-01 2012-12-06 Janus Biotherapeutics, Inc. Novel immune system modulators
TWI707038B (zh) 2013-08-05 2020-10-11 美商扭轉生物科技有限公司 重新合成之基因庫
US20150273088A1 (en) 2014-03-28 2015-10-01 Washington University Zaprinast analogues as glutaminase inhibitors and methods to predict response thereto
US10519373B2 (en) 2014-06-29 2019-12-31 Profile Products, L.L.C. Bark and wood fiber growing medium
TWI845600B (zh) 2019-01-24 2024-06-21 美商普羅米修斯生物科學股份有限公司 Gpr35調節劑
WO2020163713A1 (en) 2019-02-08 2020-08-13 Cedars-Sinai Medical Center Methods, systems, and kits for treating inflammatory disease targeting skap2
MA54903A (fr) 2019-02-08 2021-12-15 Cedars Sinai Medical Center Méthodes, compositions et kits pour traiter une maladie inflammatoire ciblant il18r1
CN114375339A (zh) 2019-05-14 2022-04-19 普罗米修斯生物科学公司 Tl1a患者选择方法、系统和装置
WO2021108694A1 (en) 2019-11-27 2021-06-03 Cedars-Sinai Medical Center Predicting extraintestinal manifestations of inflammatory bowel disease
WO2022020617A1 (en) 2020-07-23 2022-01-27 Prometheus Biosciences, Inc. Therapeutic agents targeting gpr35
JP2023551602A (ja) 2020-11-13 2023-12-08 プロメテウス バイオサイエンシーズ，インク． Ｔｌ１ａを標的とする炎症性疾患の治療のための方法、システム、およびキット
WO2022140283A1 (en) 2020-12-21 2022-06-30 Cedars-Sinai Medical Center Tl1a therapy compositions and methods of treatment therewith

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200611693A (en) * 2004-05-26 2006-04-16 Arena Pharm Inc GPR35 and modulators thereof for the treatment of metabolic-related disorders
TW201842191A (zh) * 2017-04-20 2018-12-01 美國錫安山醫學中心 預測患有發炎性腸病之個體對抗-tnf治療無反應的方法
TW202014217A (zh) * 2018-04-27 2020-04-16 美國錫安山醫學中心 標靶gpr35以治療發炎性腸病症的組合物及方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Laura Jenkins Antagonists of GPR35 Display High Species Ortholog Selectivity and Varying Modes of Action THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Vol. 343, No. 3 2012 683-695 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI906328B (zh) * 2020-07-23 2025-12-01 美商普羅米修斯生物科學股份有限公司 靶向gpr35之治療劑

Also Published As

Publication number Publication date
MA54825A (fr) 2021-12-01
CN113631168A (zh) 2021-11-09
JP7588077B2 (ja) 2024-11-21
AU2020210930B2 (en) 2025-08-14
KR102863894B1 (ko) 2025-09-23
TW202043234A (zh) 2020-12-01
EP3914256A4 (en) 2022-09-28
EP3914256B1 (en) 2024-05-29
IL285074B1 (en) 2024-08-01
EP3914256A1 (en) 2021-12-01
CN113631168B (zh) 2024-11-19
JP2022518523A (ja) 2022-03-15
US11053251B2 (en) 2021-07-06
US11773101B2 (en) 2023-10-03
CA3127786A1 (en) 2020-07-30
AU2020210930A1 (en) 2021-09-09
IL285074B2 (en) 2024-12-01
IL285074A (en) 2021-09-30
US20210380590A1 (en) 2021-12-09
KR20210119485A (ko) 2021-10-05
MX2021008941A (es) 2021-10-13
US20200239476A1 (en) 2020-07-30
WO2020154492A1 (en) 2020-07-30
BR112021014566A2 (pt) 2022-01-04

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