TWI827173B - Specimen separation device - Google Patents
Specimen separation device Download PDFInfo
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- TWI827173B TWI827173B TW111128616A TW111128616A TWI827173B TW I827173 B TWI827173 B TW I827173B TW 111128616 A TW111128616 A TW 111128616A TW 111128616 A TW111128616 A TW 111128616A TW I827173 B TWI827173 B TW I827173B
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- 238000000926 separation method Methods 0.000 title claims abstract description 60
- 239000012528 membrane Substances 0.000 claims abstract description 27
- 230000004308 accommodation Effects 0.000 claims abstract description 16
- 239000011148 porous material Substances 0.000 claims abstract description 8
- 238000000605 extraction Methods 0.000 claims description 16
- 238000007789 sealing Methods 0.000 claims description 15
- 238000001802 infusion Methods 0.000 claims description 9
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000002699 waste material Substances 0.000 claims description 5
- 229920002101 Chitin Polymers 0.000 claims description 4
- 239000000645 desinfectant Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000003929 acidic solution Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000521257 Hydrops Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Separation Using Semi-Permeable Membranes (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
一種檢體分離裝置,包含一外殼及多個分離單元。該外殼界定一容置空間及連通該容置空間且朝上的一檢體輸入口。該等分離單元層狀上下相間隔且可拆裝地設於該外殼,且每一分離單元具有位於該容置空間中的一過濾膜。該等分離單元的過濾膜的孔徑尺寸不同,且由上而下位於越下方的過濾膜的孔徑尺寸越小,用以使檢體自該檢體輸入口進入後由上而下依序通過該等分離單元的過濾膜而將檢體中不同尺寸的成分分離。A specimen separation device includes a shell and multiple separation units. The housing defines an accommodating space and a specimen input port connected to the accommodating space and facing upward. The separation units are spaced up and down in layers and are detachably provided on the housing, and each separation unit has a filter membrane located in the accommodation space. The filter membranes of the separation units have different pore sizes, and the filter membranes located lower from top to bottom have smaller pore sizes, so that the sample enters from the sample input port and passes through the sample input port sequentially from top to bottom. The components of different sizes in the sample are separated by the filter membrane of the separation unit.
Description
本發明是有關於一種檢體分離裝置,特別是指一種用以分離生物檢體中不同尺寸之成分的檢體分離裝置。The present invention relates to a specimen separation device, and in particular, to a specimen separation device used to separate components of different sizes in biological specimens.
一般生物檢體在採檢後需要先處理,以自檢體中分離出所欲進行分析的成分,而供後續的相關檢查。Generally, biological specimens need to be processed first after collection to separate the components to be analyzed from the specimen for subsequent related examinations.
如何使分離檢體的程序較為簡化,且能減少檢驗人員與檢體的接觸機會,以降低生物感染風險,為待解決的問題。How to simplify the procedure of separating specimens and reduce the contact opportunities between examiners and specimens to reduce the risk of biological infection is a problem to be solved.
因此,本發明之一目的,即在提供一種可以簡化分離檢體的程序的檢體分離裝置。Therefore, one object of the present invention is to provide a specimen separation device that can simplify the procedure of separating specimens.
於是,本發明檢體分離裝置在一些實施態樣中,包含:一外殼及多個分離單元。該外殼界定一容置空間及連通該容置空間且朝上的一檢體輸入口。該等分離單元層狀上下相間隔且可拆裝地設於該外殼,且每一分離單元具有位於該容置空間中的一過濾膜。該等分離單元的過濾膜的孔徑尺寸不同,且由上而下位於越下方的過濾膜的孔徑尺寸越小,用以使檢體自該檢體輸入口進入後由上而下依序通過該等分離單元的過濾膜而將檢體中不同尺寸的成分分離。Therefore, in some embodiments, the specimen separation device of the present invention includes: a housing and a plurality of separation units. The housing defines an accommodating space and a specimen input port connected to the accommodating space and facing upward. The separation units are spaced up and down in layers and are detachably provided on the housing, and each separation unit has a filter membrane located in the accommodation space. The filter membranes of the separation units have different pore sizes, and the filter membranes located lower from top to bottom have smaller pore sizes, so that the sample enters from the sample input port and passes through the sample input port sequentially from top to bottom. The components of different sizes in the sample are separated by the filter membrane of the separation unit.
在一些實施態樣中,該外殼還界定連通該容置空間且位於該等分離單元下方的一抽氣口,該檢體分離裝置還包含連接該抽氣口用以自該容置空間抽氣的一抽氣單元。In some implementations, the housing also defines an air extraction port connected to the accommodation space and located below the separation units, and the specimen separation device further includes an air extraction port connected to the air extraction port for extracting air from the accommodation space. Extraction unit.
在一些實施態樣中,該檢體分離裝置還包含一收集盒及一刺破單元,該收集盒可拆裝地與該外殼組合,且具有配合容置於該檢體輸入口的一圍繞壁、蓋合於該圍繞壁的一上蓋,及封閉該圍繞壁底部的一封膜,該封膜與該圍繞壁共同界定用以容置檢體的一暫存空間,該刺破單元設於該外殼且位於該檢體輸入口處,包括用以將該封膜刺破的一穿刺器。In some embodiments, the specimen separation device further includes a collection box and a puncture unit. The collection box is detachably combined with the housing and has a surrounding wall that is accommodated in the specimen input port. , an upper cover covering the surrounding wall, and a sealing film closing the bottom of the surrounding wall. The sealing film and the surrounding wall jointly define a temporary storage space for accommodating the specimen, and the puncture unit is located on the surrounding wall. The housing is located at the specimen input port and includes a puncture tool for puncturing the sealing film.
在一些實施態樣中,該刺破單元還包括一攪拌器,該攪拌器用以與該穿刺器相配合在該穿刺器刺破該封膜後攪拌檢體。In some embodiments, the puncture unit further includes a stirrer, which is used to cooperate with the puncture tool to stir the specimen after the puncture tool punctures the sealing film.
在一些實施態樣中,該外殼還界定連通該容置空間且位於該等分離單元上方的一輸液口,該檢體分離裝置還包含連接該輸液口用以注入消毒液的一消毒單元。In some embodiments, the housing also defines an infusion port connected to the accommodation space and located above the separation units, and the specimen separation device further includes a sterilization unit connected to the infusion port for injecting disinfectant.
在一些實施態樣中,該檢體分離裝置還包含可拆裝地設於該外殼且位於該等分離單元下方用以盛裝廢液的一盛盤單元。In some embodiments, the specimen separation device further includes a tray unit removably provided on the housing and located below the separation units for containing waste liquid.
在一些實施態樣中,該等分離單元的過濾膜主要由甲殼素製成。In some embodiments, the filter membranes of the separation units are mainly made of chitin.
本發明具有以下功效:藉由該等分離單元將檢體中不同尺寸的成分分離,能夠一次完成分離程序,使分離檢體的程序較為簡化,且能減少檢驗人員與檢體的接觸機會,以降低生物感染風險。檢體中不同尺寸的成分分離後,即可針對由不同過濾膜捕捉的不同尺寸成分進行進階分析。The present invention has the following effects: by using the separation units to separate components of different sizes in the specimen, the separation process can be completed at one time, simplifying the procedure of separating the specimen, and reducing the contact opportunities between the inspection personnel and the specimen, so as to Reduce the risk of biological infection. After the components of different sizes in the sample are separated, advanced analysis can be performed on the components of different sizes captured by different filter membranes.
參閱圖1與圖2,本發明檢體分離裝置之一實施例,包含一外殼1、一收集盒2、一刺破單元3、多個分離單元4、一盛盤單元5、一抽氣單元6及一消毒單元7。Referring to Figures 1 and 2, one embodiment of the specimen separation device of the present invention includes a
該外殼1界定一容置空間11、連通該容置空間11且朝上的一檢體輸入口12、連通該容置空間11且位於該等分離單元4下方的一抽氣口13、及連通該容置空間11且位於該等分離單元4上方的一輸液口14。The
該收集盒2可拆裝地與該外殼1組合,且具有配合容置於該檢體輸入口12的一圍繞壁21、蓋合於該圍繞壁21的一上蓋22,及封閉該圍繞壁21底部的一封膜23,該封膜23與該圍繞壁21共同界定用以容置檢體的一暫存空間24。The
該刺破單元3設於該外殼1且位於該檢體輸入口12處,包括用以將該封膜23刺破的一穿刺器31,及一攪拌器32。該攪拌器32用以與該穿刺器31相配合在該穿刺器31刺破該封膜23後攪拌檢體,均勻化檢體分布。在本實施例中,該攪拌器32是以可轉動的葉片來攪拌。在變化的實施例,亦可採用能產生氣流來攪拌的攪拌器。The
該等分離單元4層狀上下相間隔且可拆裝地設於該外殼1。每一分離單元4具有一框體41及位於該容置空間11中的一過濾膜42。在本實施例中,每一分離單元4以類似抽屜形式與該外殼1組裝,而方便安裝於該外殼1且容易取出。該等分離單元4的過濾膜42的孔徑尺寸不同,且由上而下位於越下方的過濾膜42的孔徑尺寸越小,用以使檢體自該檢體輸入口12進入後由上而下依序通過該等分離單元4的過濾膜42而將檢體中不同尺寸的成分分離。適用於本實施例的檢體可例如痰液、糞便、肋膜積水、腹水、尿液、支氣管沖洗液等,可視檢體需求在該收集盒2加入適用的保存液及分離液,再經由該等分離單元4過濾,藉此,可針對不同尺寸與特性的細胞或特定生物蛋白進行分離或保留在過濾膜42上,以供後續相關的檢體判讀。過濾膜42以能在特定溶液中溶解的材料製成較佳,在本實施例中,該等分離單元4的過濾膜42主要由甲殼素(chitin+chitosan)製成,在特定酸性溶液的分解下,可由固態轉為液態,並藉由酸性溶液做為消毒方式,改善收集檢體後的醫療廢棄物處理流程。The
該盛盤單元5可拆裝地設於該外殼1且位於該等分離單元4下方用以盛裝廢液。在本實施例中,該盛盤單元5同樣以類似抽屜形式與該外殼1組裝,方便將盛裝廢液的該盛盤單元5取出,以處理廢液。The
該抽氣單元6連接該抽氣口13,用以自該容置空間11抽氣以形成真空狀態。藉由該抽氣單元6自該等分離單元4下方抽氣,可以形成自上往下流動的氣流,可以加速檢體通過該等過濾膜42,而且可控制該容置空間11內的氣壓,同時加上過濾膜42不同尺寸的過濾特性,讓檢體中的細胞在合適壓力下停留在適當的過濾膜42上。The
該消毒單元7連接該輸液口14,用以注入消毒液,以對該等分離單元4消毒。The
在變化的實施例中,該收集盒2及該刺破單元3亦可不設置,而可採用一外蓋(未圖示)將該檢體輸入口12覆蓋封閉。檢體可用容器收集後倒入該檢體輸入口12,再經由該等過濾膜42過濾,亦可達到將檢體分離的目的。另一變化的實施例,該刺破單元3亦可不設置攪拌器32,僅設置穿刺器31即可。In a modified embodiment, the
綜上所述,藉由該等分離單元4將檢體中不同尺寸的成分分離,能夠一次完成分離程序,使分離檢體的程序較為簡化,且能減少檢驗人員與檢體的接觸機會,以降低生物感染風險。In summary, by using the
惟以上所述者,僅為本發明之實施例而已,當不能以此限定本發明實施之範圍,凡是依本發明申請專利範圍及專利說明書內容所作之簡單的等效變化與修飾,皆仍屬本發明專利涵蓋之範圍內。However, the above are only examples of the present invention, and should not be used to limit the scope of the present invention. All simple equivalent changes and modifications made based on the patent scope of the present invention and the content of the patent specification are still within the scope of the present invention. Within the scope covered by the patent of this invention.
1:外殼 11:容置空間 12:檢體輸入口 13:抽氣口 14:輸液口 2:收集盒 21:圍繞壁 22:上蓋 23:封膜 24:暫存空間 3:刺破單元 31:穿刺器 32:攪拌器 4:分離單元 41:框體 42:過濾膜 5:盛盤單元 6:抽氣單元 7:消毒單元 1: Shell 11: Accommodation space 12: Specimen input port 13:Exhaust port 14:Infusion port 2: Collection box 21: around the wall 22: Upper cover 23:Sealing film 24:Temporary storage space 3: Puncture unit 31:Puncture device 32: Blender 4:Separation unit 41:frame 42:Filter membrane 5: Serving unit 6: Air extraction unit 7: Disinfection unit
本發明之其他的特徵及功效,將於參照圖式的實施方式中清楚地呈現,其中: 圖1是本發明檢體分離裝置的一實施例的一示意圖;及 圖2是該實施例的一分離單元的一立體示意圖。 Other features and effects of the present invention will be clearly presented in the embodiments with reference to the drawings, in which: Figure 1 is a schematic diagram of an embodiment of the specimen separation device of the present invention; and Figure 2 is a perspective view of a separation unit in this embodiment.
1:外殼 1: Shell
11:容置空間 11: Accommodation space
12:檢體輸入口 12: Specimen input port
13:抽氣口 13:Exhaust port
14:輸液口 14:Infusion port
2:收集盒 2: Collection box
21:圍繞壁 21: around the wall
22:上蓋 22: Upper cover
23:封膜 23:Sealing film
24:暫存空間 24:Temporary storage space
3:刺破單元 3: Puncture unit
31:穿刺器 31:Puncture device
32:攪拌器 32: Blender
4:分離單元 4:Separation unit
5:盛盤單元 5: Serving unit
6:抽氣單元 6: Air extraction unit
7:消毒單元 7: Disinfection unit
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110115476A (en) * | 2010-04-15 | 2011-10-21 | 주식회사 싸이토젠 | Microfluidic apparatus and method for separating targets using the same |
CN106796166A (en) * | 2014-06-12 | 2017-05-31 | 瓦弗根公司 | The unicellular capture that film is carried out is captured with polymer |
CN106834121A (en) * | 2010-05-20 | 2017-06-13 | 里波热姆斯国际股份公司 | Apparatus and method for preparing tissue, particularly adipose tissue |
CN107126589A (en) * | 2017-04-26 | 2017-09-05 | 中国科学院理化技术研究所 | Portable wearable device capable of purifying blood and preparation method and application thereof |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20110115476A (en) * | 2010-04-15 | 2011-10-21 | 주식회사 싸이토젠 | Microfluidic apparatus and method for separating targets using the same |
CN106834121A (en) * | 2010-05-20 | 2017-06-13 | 里波热姆斯国际股份公司 | Apparatus and method for preparing tissue, particularly adipose tissue |
CN106796166A (en) * | 2014-06-12 | 2017-05-31 | 瓦弗根公司 | The unicellular capture that film is carried out is captured with polymer |
CN107126589A (en) * | 2017-04-26 | 2017-09-05 | 中国科学院理化技术研究所 | Portable wearable device capable of purifying blood and preparation method and application thereof |
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