TWI818910B - 吸入性肺炎、肺化膿症或肺膿瘍之治療劑 - Google Patents
吸入性肺炎、肺化膿症或肺膿瘍之治療劑 Download PDFInfo
- Publication number
- TWI818910B TWI818910B TW107120774A TW107120774A TWI818910B TW I818910 B TWI818910 B TW I818910B TW 107120774 A TW107120774 A TW 107120774A TW 107120774 A TW107120774 A TW 107120774A TW I818910 B TWI818910 B TW I818910B
- Authority
- TW
- Taiwan
- Prior art keywords
- genus
- bacteria belonging
- bacteria
- fluoro
- cyclopropylamino
- Prior art date
Links
- 206010035669 Pneumonia aspiration Diseases 0.000 title claims abstract description 49
- 201000009807 aspiration pneumonia Diseases 0.000 title claims abstract description 49
- 201000003453 lung abscess Diseases 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title abstract description 7
- 150000003839 salts Chemical class 0.000 claims abstract description 32
- 241000894006 Bacteria Species 0.000 claims description 130
- 125000006317 cyclopropyl amino group Chemical group 0.000 claims description 47
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 47
- 238000011282 treatment Methods 0.000 claims description 28
- 230000001225 therapeutic effect Effects 0.000 claims description 22
- 241000605861 Prevotella Species 0.000 claims description 19
- 241000122116 Parvimonas Species 0.000 claims description 13
- 241000606125 Bacteroides Species 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- 238000002347 injection Methods 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 241000193403 Clostridium Species 0.000 claims description 9
- 241000894007 species Species 0.000 claims description 8
- 241000186046 Actinomyces Species 0.000 claims description 7
- 230000000813 microbial effect Effects 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- ZRQIANXWARFGEJ-UHFFFAOYSA-N N1C=C(CC2=CC=CC=C12)C(=O)O.[O] Chemical compound N1C=C(CC2=CC=CC=C12)C(=O)O.[O] ZRQIANXWARFGEJ-UHFFFAOYSA-N 0.000 claims 1
- ZFIOCUITTUUVPV-MEDUHNTESA-N 7-[(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound C([C@@H]1[C@H](F)CN(C1)C1=C(C2=C(C(C(C(O)=O)=CN2CCF)=O)C=C1F)OC)NC1CC1 ZFIOCUITTUUVPV-MEDUHNTESA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 52
- 208000032376 Lung infection Diseases 0.000 description 39
- 229940124597 therapeutic agent Drugs 0.000 description 29
- 244000052616 bacterial pathogen Species 0.000 description 25
- 229940079593 drug Drugs 0.000 description 22
- 241000191992 Peptostreptococcus Species 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 238000011156 evaluation Methods 0.000 description 11
- -1 quinolinone carboxylic acid Chemical class 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 10
- 102100032752 C-reactive protein Human genes 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 8
- 206010057190 Respiratory tract infections Diseases 0.000 description 7
- 238000011976 chest X-ray Methods 0.000 description 7
- 125000005843 halogen group Chemical group 0.000 description 7
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 7
- 229930185107 quinolinone Natural products 0.000 description 7
- 230000000241 respiratory effect Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 6
- 241000606124 Bacteroides fragilis Species 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 206010035664 Pneumonia Diseases 0.000 description 5
- 239000000654 additive Substances 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 238000002591 computed tomography Methods 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 241000186361 Actinobacteria <class> Species 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- 241000351207 Peptoniphilus Species 0.000 description 4
- 241000911872 Streptococcus anginosus group Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229940124350 antibacterial drug Drugs 0.000 description 4
- 230000007012 clinical effect Effects 0.000 description 4
- 230000004064 dysfunction Effects 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 230000009747 swallowing Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108010074051 C-Reactive Protein Proteins 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 241001617393 Finegoldia Species 0.000 description 3
- 241000605909 Fusobacterium Species 0.000 description 3
- XAGMUUZPGZWTRP-ZETCQYMHSA-N LSM-5745 Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1C1(N)CC1 XAGMUUZPGZWTRP-ZETCQYMHSA-N 0.000 description 3
- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 241001135221 Prevotella intermedia Species 0.000 description 3
- 241001135223 Prevotella melaninogenica Species 0.000 description 3
- 241001135261 Prevotella oralis Species 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 241001291896 Streptococcus constellatus Species 0.000 description 3
- 208000033809 Suppuration Diseases 0.000 description 3
- 241000167878 Tissierella creatinini Species 0.000 description 3
- 125000003277 amino group Chemical group 0.000 description 3
- 229960003405 ciprofloxacin Drugs 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 229960003376 levofloxacin Drugs 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 229960003702 moxifloxacin Drugs 0.000 description 3
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 description 3
- 229960002625 pazufloxacin Drugs 0.000 description 3
- MPORYQCGWFQFLA-ONPDANIMSA-N 7-[(7s)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1r,2s)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid;trihydrate Chemical compound O.O.O.C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1.C([C@H]1N)N(C=2C(=C3C(C(C(C(O)=O)=CN3[C@H]3[C@H](C3)F)=O)=CC=2F)Cl)CC11CC1 MPORYQCGWFQFLA-ONPDANIMSA-N 0.000 description 2
- 241000186066 Actinomyces odontolyticus Species 0.000 description 2
- 241001135228 Bacteroides ovatus Species 0.000 description 2
- 241000223782 Ciliophora Species 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 241000192016 Finegoldia magna Species 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 241000605952 Fusobacterium necrophorum Species 0.000 description 2
- 241000605986 Fusobacterium nucleatum Species 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000123728 Leptotrichia buccalis Species 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241001464887 Parvimonas micra Species 0.000 description 2
- 241000192013 Peptoniphilus asaccharolyticus Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241001135213 Porphyromonas endodontalis Species 0.000 description 2
- 241000605862 Porphyromonas gingivalis Species 0.000 description 2
- 241001135215 Prevotella bivia Species 0.000 description 2
- 241001135217 Prevotella buccae Species 0.000 description 2
- 241001135209 Prevotella denticola Species 0.000 description 2
- 241000605951 Prevotella loescheii Species 0.000 description 2
- 241001135225 Prevotella nigrescens Species 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 241000192142 Proteobacteria Species 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 208000018875 hypoxemia Diseases 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical class [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 229960003177 sitafloxacin Drugs 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- BSIMZHVOQZIAOY-SCSAIBSYSA-N 1-carbapenem-3-carboxylic acid Chemical compound OC(=O)C1=CC[C@@H]2CC(=O)N12 BSIMZHVOQZIAOY-SCSAIBSYSA-N 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 1
- 241001156739 Actinobacteria <phylum> Species 0.000 description 1
- 241000456624 Actinobacteria bacterium Species 0.000 description 1
- 241000933025 Actinomyces europaeus Species 0.000 description 1
- 241000511656 Actinomyces georgiae Species 0.000 description 1
- 241000511654 Actinomyces gerencseriae Species 0.000 description 1
- 241000544634 Actinomyces graevenitzii Species 0.000 description 1
- 241000186041 Actinomyces israelii Species 0.000 description 1
- 241000511582 Actinomyces meyeri Species 0.000 description 1
- 241000186045 Actinomyces naeslundii Species 0.000 description 1
- 241001464988 Actinomyces neuii Species 0.000 description 1
- 241000163019 Actinomyces radicidentis Species 0.000 description 1
- 241000900280 Actinomyces radingae Species 0.000 description 1
- 241001147825 Actinomyces sp. Species 0.000 description 1
- 241000900275 Actinomyces turicensis Species 0.000 description 1
- 241001478947 Actinomyces urogenitalis Species 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 206010003504 Aspiration Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241001135322 Bacteroides eggerthii Species 0.000 description 1
- 241001195773 Bacteroides massiliensis Species 0.000 description 1
- 241001122266 Bacteroides nordii Species 0.000 description 1
- 241001122267 Bacteroides salyersiae Species 0.000 description 1
- 241000606123 Bacteroides thetaiotaomicron Species 0.000 description 1
- 241000606219 Bacteroides uniformis Species 0.000 description 1
- 241000606215 Bacteroides vulgatus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010011376 Crepitations Diseases 0.000 description 1
- 241000179197 Cyclospora Species 0.000 description 1
- 108010013198 Daptomycin Proteins 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000605956 Fusobacterium mortiferum Species 0.000 description 1
- 241000605975 Fusobacterium varium Species 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241001453171 Leptotrichia Species 0.000 description 1
- 241000029613 Leptotrichia goodfellowii Species 0.000 description 1
- 241000029588 Leptotrichia hofstadii Species 0.000 description 1
- 241000495747 Leptotrichia hongkongensis Species 0.000 description 1
- 241000029603 Leptotrichia shahii Species 0.000 description 1
- 241001558986 Leptotrichia trevisanii Species 0.000 description 1
- 241000029590 Leptotrichia wadei Species 0.000 description 1
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000530062 Peptoniphilus harei Species 0.000 description 1
- 241000530065 Peptoniphilus ivorii Species 0.000 description 1
- 241001464881 Peptoniphilus lacrimalis Species 0.000 description 1
- 241000192035 Peptostreptococcus anaerobius Species 0.000 description 1
- 241000684246 Peptostreptococcus stomatis Species 0.000 description 1
- 241000605894 Porphyromonas Species 0.000 description 1
- 241001135211 Porphyromonas asaccharolytica Species 0.000 description 1
- 241001135239 Porphyromonas levii Species 0.000 description 1
- 241000770209 Porphyromonas uenonis Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000987248 Prevotella bergensis Species 0.000 description 1
- 241001135206 Prevotella buccalis Species 0.000 description 1
- 241001135219 Prevotella disiens Species 0.000 description 1
- 241001135262 Prevotella oris Species 0.000 description 1
- 241000864367 Prevotella pallens Species 0.000 description 1
- 241000530934 Prevotella timonensis Species 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194008 Streptococcus anginosus Species 0.000 description 1
- 241000194046 Streptococcus intermedius Species 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 241000131405 Tissierella Species 0.000 description 1
- 241001327082 Tissierella creatinophila Species 0.000 description 1
- 241000167944 Tissierella praeacuta Species 0.000 description 1
- 241001148134 Veillonella Species 0.000 description 1
- 241001533207 Veillonella atypica Species 0.000 description 1
- 241001148135 Veillonella parvula Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 208000022506 anaerobic bacteria infectious disease Diseases 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000011203 antimicrobial therapy Methods 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 210000003123 bronchiole Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 229940047766 co-trimoxazole Drugs 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 description 1
- 229960005484 daptomycin Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003221 ear drop Substances 0.000 description 1
- 229940047652 ear drops Drugs 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 239000004503 fine granule Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
- 229960005287 lincomycin Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229910052751 metal Chemical class 0.000 description 1
- 239000002184 metal Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 230000002956 necrotizing effect Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- OGJPXUAPXNRGGI-UHFFFAOYSA-N norfloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 OGJPXUAPXNRGGI-UHFFFAOYSA-N 0.000 description 1
- 229960001180 norfloxacin Drugs 0.000 description 1
- 239000002997 ophthalmic solution Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762520961P | 2017-06-16 | 2017-06-16 | |
| US62/520,961 | 2017-06-16 | ||
| JP2018068159 | 2018-03-30 | ||
| JP2018-068159 | 2018-03-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201906607A TW201906607A (zh) | 2019-02-16 |
| TWI818910B true TWI818910B (zh) | 2023-10-21 |
Family
ID=66213244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW107120774A TWI818910B (zh) | 2017-06-16 | 2018-06-15 | 吸入性肺炎、肺化膿症或肺膿瘍之治療劑 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20210137913A1 (https=) |
| EP (1) | EP3639826A4 (https=) |
| JP (3) | JP6618660B2 (https=) |
| KR (1) | KR20200016960A (https=) |
| CN (1) | CN110891571A (https=) |
| AU (1) | AU2018283234A1 (https=) |
| BR (1) | BR112019025960A2 (https=) |
| CA (1) | CA3067188A1 (https=) |
| CL (1) | CL2019003630A1 (https=) |
| IL (1) | IL270831A (https=) |
| MX (1) | MX2019014931A (https=) |
| PH (1) | PH12019502835A1 (https=) |
| SG (1) | SG11201911826VA (https=) |
| TW (1) | TWI818910B (https=) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016148066A1 (ja) * | 2015-03-13 | 2016-09-22 | 杏林製薬株式会社 | 呼吸器感染症治療剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962470A1 (de) * | 1999-12-22 | 2001-07-12 | Schulz Hans Herrmann | Verwendung von Chemotherapeutika |
| CN100410249C (zh) | 2003-09-10 | 2008-08-13 | 杏林制药株式会社 | 7-(4-取代-3-环丙基氨基甲基-1-吡咯烷基)喹诺酮羧酸衍生物 |
| SA112330992B1 (ar) | 2011-11-10 | 2015-09-13 | كيورين فارماسوتيكال كو.، ليمتد | صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي |
| EP3305294A4 (en) * | 2015-06-02 | 2019-02-20 | Kyorin Pharmaceutical Co., Ltd. | AQUEOUS MEDICINE |
-
2018
- 2018-06-15 BR BR112019025960-0A patent/BR112019025960A2/pt not_active IP Right Cessation
- 2018-06-15 AU AU2018283234A patent/AU2018283234A1/en not_active Abandoned
- 2018-06-15 TW TW107120774A patent/TWI818910B/zh active
- 2018-06-15 JP JP2019525551A patent/JP6618660B2/ja active Active
- 2018-06-15 KR KR1020207000644A patent/KR20200016960A/ko not_active Ceased
- 2018-06-15 SG SG11201911826VA patent/SG11201911826VA/en unknown
- 2018-06-15 EP EP18818391.7A patent/EP3639826A4/en not_active Withdrawn
- 2018-06-15 CA CA3067188A patent/CA3067188A1/en not_active Abandoned
- 2018-06-15 MX MX2019014931A patent/MX2019014931A/es unknown
- 2018-06-15 CN CN201880039674.9A patent/CN110891571A/zh active Pending
- 2018-06-15 US US16/620,630 patent/US20210137913A1/en not_active Abandoned
-
2019
- 2019-11-01 JP JP2019200166A patent/JP6671532B2/ja active Active
- 2019-11-21 IL IL270831A patent/IL270831A/en unknown
- 2019-12-11 CL CL2019003630A patent/CL2019003630A1/es unknown
- 2019-12-16 PH PH12019502835A patent/PH12019502835A1/en unknown
-
2020
- 2020-03-03 JP JP2020036036A patent/JP7098671B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016148066A1 (ja) * | 2015-03-13 | 2016-09-22 | 杏林製薬株式会社 | 呼吸器感染症治療剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200016960A (ko) | 2020-02-17 |
| TW201906607A (zh) | 2019-02-16 |
| IL270831A (en) | 2020-01-30 |
| PH12019502835A1 (en) | 2020-10-05 |
| JP6671532B2 (ja) | 2020-03-25 |
| JP2020079330A (ja) | 2020-05-28 |
| AU2018283234A1 (en) | 2019-12-12 |
| MX2019014931A (es) | 2020-02-13 |
| US20210137913A1 (en) | 2021-05-13 |
| CL2019003630A1 (es) | 2020-07-10 |
| JP2020015769A (ja) | 2020-01-30 |
| EP3639826A4 (en) | 2021-03-03 |
| CN110891571A (zh) | 2020-03-17 |
| JPWO2018230686A1 (ja) | 2019-12-12 |
| JP6618660B2 (ja) | 2019-12-11 |
| EP3639826A1 (en) | 2020-04-22 |
| JP7098671B2 (ja) | 2022-07-11 |
| CA3067188A1 (en) | 2018-12-20 |
| SG11201911826VA (en) | 2020-01-30 |
| BR112019025960A2 (pt) | 2020-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2563809C2 (ru) | Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза | |
| Jácomo et al. | Effect of oral hygiene with 0.12% chlorhexidine gluconate on the incidence of nosocomial pneumonia in children undergoing cardiac surgery | |
| Michalopoulos et al. | Cure of multidrug-resistant Acinetobacter baumannii bacteraemia with continuous intravenous infusion of colistin | |
| Wise | Maximizing efficacy and reducing the emergence of resistance | |
| EP2956153A1 (en) | Treatment of evolving bacterial resistance diseases including klebsiella pneumoniae with liposomally formulated glutathione | |
| US20140377357A1 (en) | Poloxamer Based Inhalation Composition | |
| JP2015536949A5 (https=) | ||
| TWI818910B (zh) | 吸入性肺炎、肺化膿症或肺膿瘍之治療劑 | |
| Altinsoy et al. | The effects of topical chlorhexidine-benzydamine spray on laryngeal mask airway application | |
| TW202415375A (zh) | 吸入性肺炎、肺化膿症或肺膿瘍之治療劑 | |
| HK40098387A (zh) | 吸入性肺炎、肺化脓或肺脓肿的治疗剂 | |
| US20030073625A1 (en) | Methods of preventing ventilator associated pneumonia by oral administration of antimicrobial IB-367 peptides | |
| HK40026671A (en) | Therapeutic agent for aspiration pneumonia, lung suppuration, or lung abscess | |
| Charan et al. | Nosocomial Infections-An Overview of Prophylactic Approaches to Control VAP. | |
| KR20120083344A (ko) | 세프타롤린을 사용한 박테리아 감염 치료용 조성물 및 방법 | |
| CN106507666A9 (zh) | 1，3‑丙二磺酸或其药学上可接受的盐用于治疗肉样瘤病的用途 | |
| JP2017137289A (ja) | 嚢胞性線維症のためのフルオロキノロン製剤 | |
| CN118946357A (zh) | 呼吸系统疾病治疗剂 | |
| WO2014205157A1 (en) | Inhalation composition for treating respiratory tract infections | |
| US20140377355A1 (en) | Levofloxacin Inhalation Composition | |
| DEEP | International Journal of Modern Pharmaceutical Research | |
| Raschke | PMH, FH, SH | |
| Stirling et al. | Respiratory Intensive Care | |
| AU2002248434A1 (en) | Methods of preventing ventilator associated pneumonia by oral administration of antimicrobial IB-367 peptides | |
| UA111272U (uk) | Спосіб профілактики антибіотикоасоційованої діареї після операції на легенях і плеврі |