TWI818375B - 編碼vegf-a多肽的經修飾rna、配製物及關於它們之用途 - Google Patents

編碼vegf-a多肽的經修飾rna、配製物及關於它們之用途 Download PDF

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TWI818375B
TWI818375B TW110145699A TW110145699A TWI818375B TW I818375 B TWI818375 B TW I818375B TW 110145699 A TW110145699 A TW 110145699A TW 110145699 A TW110145699 A TW 110145699A TW I818375 B TWI818375 B TW I818375B
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vegf
modified rna
formulation
subject
injection
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TW110145699A
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TW202218670A (zh
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萊夫 Ｋ 帕林德
蕾吉娜 Ｄ 弗里切丹尼爾森
肯尼 Ｍ 漢森
黎明 甘
強納森 克拉克
安夏洛特 Ｅ 艾格尼爾
肯尼斯 Ｒ 簡
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美商瑪德那特克斯股份有限公司
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW110145699A 2016-06-07 2017-06-07 編碼vegf-a多肽的經修飾rna、配製物及關於它們之用途 TWI818375B (zh)

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US201662346979P 2016-06-07 2016-06-07
US62/346,979 2016-06-07
US201662411091P 2016-10-21 2016-10-21
US62/411,091 2016-10-21
US201662432005P 2016-12-09 2016-12-09
US62/432,005 2016-12-09

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TWI818375B true TWI818375B (zh) 2023-10-11

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TW106118838A TWI752036B (zh) 2016-06-07 2017-06-07 編碼vegf-a多肽的經修飾rna、配製物及關於它們之用途

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JP7345888B2 (ja) * 2021-06-17 2023-09-19 株式会社ニューギン 遊技機
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AU2017277277A1 (en) 2019-01-03
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HRP20211569T1 (hr) 2022-01-21
LT3464338T (lt) 2022-01-10
RU2756313C2 (ru) 2021-09-29
RS62556B1 (sr) 2021-12-31
MA45172A (fr) 2019-04-10
US11866475B2 (en) 2024-01-09
RU2018147229A (ru) 2020-07-10
JP2021100961A (ja) 2021-07-08
AU2017277277B2 (en) 2023-05-04
KR20220038819A (ko) 2022-03-29
WO2017214175A1 (en) 2017-12-14
CA3026500A1 (en) 2017-12-14
PL3464338T3 (pl) 2021-12-27
DK3464338T3 (da) 2021-10-18
KR20230107891A (ko) 2023-07-18
IL263370A (en) 2018-12-31
TWI752036B (zh) 2022-01-11
TW201808325A (zh) 2018-03-16
RU2018147229A3 (https=) 2020-09-23
MA45172B1 (fr) 2021-11-30
KR102376245B1 (ko) 2022-03-21
KR102494499B1 (ko) 2023-01-31
TW202218670A (zh) 2022-05-16
KR102552543B1 (ko) 2023-07-06
MX2018015110A (es) 2019-09-06
EP3464338A1 (en) 2019-04-10
AU2023208200A1 (en) 2023-08-17
KR20190039066A (ko) 2019-04-10
EP3971204A1 (en) 2022-03-23
CN109790207B (zh) 2023-06-20
JP6859369B2 (ja) 2021-04-14
CN116606861A (zh) 2023-08-18
SMT202100586T1 (it) 2021-11-12
SI3464338T1 (sl) 2022-02-28
JP2019521976A (ja) 2019-08-08
SG10202012175YA (en) 2021-01-28
HUE056055T2 (hu) 2022-01-28
CN109790207A (zh) 2019-05-21
PT3464338T (pt) 2021-10-19
KR20230019505A (ko) 2023-02-08
CY1124667T1 (el) 2022-07-22
ES2895421T3 (es) 2022-02-21
US20200407411A1 (en) 2020-12-31
EP3464338B1 (en) 2021-07-21

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