JP6859369B2 - Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用 - Google Patents

Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用 Download PDF

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JP6859369B2
JP6859369B2 JP2018564389A JP2018564389A JP6859369B2 JP 6859369 B2 JP6859369 B2 JP 6859369B2 JP 2018564389 A JP2018564389 A JP 2018564389A JP 2018564389 A JP2018564389 A JP 2018564389A JP 6859369 B2 JP6859369 B2 JP 6859369B2
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vegf
modified rna
formulation
composition
citrate
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JP2019521976A5 (https=
JP2019521976A (ja
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パリンダー,ライフ・カールソン
フリッチェ・ダニエルソン,レジーナ・デジレ
ハンソン,ケニー・ミカエル
ガン,リー・ミーン
クラーク,ヨナタン
エグネル,アン−シャーロット・エヴァ
チエン,ケネス・ランドール
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ModernaTx Inc
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    • AHUMAN NECESSITIES
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    • C07K14/52Cytokines; Lymphokines; Interferons

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  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
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  • Urology & Nephrology (AREA)
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  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2018564389A 2016-06-07 2017-06-06 Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用 Active JP6859369B2 (ja)

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Application Number Priority Date Filing Date Title
JP2021049671A JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2022171389A JP2023011733A (ja) 2016-06-07 2022-10-26 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

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Application Number Priority Date Filing Date Title
US201662346979P 2016-06-07 2016-06-07
US62/346,979 2016-06-07
US201662411091P 2016-10-21 2016-10-21
US62/411,091 2016-10-21
US201662432005P 2016-12-09 2016-12-09
US62/432,005 2016-12-09
PCT/US2017/036188 WO2017214175A1 (en) 2016-06-07 2017-06-06 Modified rna encoding vegf-a polypeptides, formulations, and uses relating thereto

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JP2021049671A Division JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

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JP2019521976A JP2019521976A (ja) 2019-08-08
JP2019521976A5 JP2019521976A5 (https=) 2020-10-01
JP6859369B2 true JP6859369B2 (ja) 2021-04-14

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JP2018564389A Active JP6859369B2 (ja) 2016-06-07 2017-06-06 Vegf−aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2021049671A Active JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2022171389A Pending JP2023011733A (ja) 2016-06-07 2022-10-26 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

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JP2021049671A Active JP7167226B2 (ja) 2016-06-07 2021-03-24 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用
JP2022171389A Pending JP2023011733A (ja) 2016-06-07 2022-10-26 Vegf-aポリペプチドをコードする改変rna、製剤、およびそれに関連する使用

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116606861A (zh) 2016-06-07 2023-08-18 摩登纳特斯有限公司 编码vegf-a多肽的经修饰的rna、配制品和关于它们的用途
US11628227B2 (en) * 2017-07-05 2023-04-18 Wisconsin Alumni Research Foundation Mineral coated microparticles for gene delivery in chronic wound therapy
SI3703658T1 (sl) 2017-10-31 2022-09-30 Astrazeneca Ab Lipidni nanodelci za dostavljanje spremenjene RNA, ki kodira polipeptid VEGF-A
WO2020227690A1 (en) * 2019-05-08 2020-11-12 Modernatx, Inc. Methods of using lipid nanoparticles for delivering modified rna encoding a vegf-a polypeptide and pharmaceutical compositions comprising the same
JP7345888B2 (ja) * 2021-06-17 2023-09-19 株式会社ニューギン 遊技機
WO2023061985A2 (en) * 2021-10-12 2023-04-20 Modernatx, Inc. Compositions comprising modified rna encoding vegf-a and methods of use
WO2023084013A1 (en) * 2021-11-12 2023-05-19 Modernatx, Inc. Compositions comprising modified rna encoding vegf-a and methods of use

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004035227A1 (de) * 2004-07-21 2006-02-16 Curevac Gmbh mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen
AU2006211960A1 (en) 2005-02-08 2006-08-17 Board Of Regents, The University Of Texas System Compositions and methods involving MDA-7 for the treatment of cancer
RU2497532C2 (ru) * 2008-12-03 2013-11-10 Эморсайт, Инк. Композиции, улучшающие перфузию в области инфаркта и способы восстановления сосудистого повреждения
ES2600781T3 (es) 2008-12-04 2017-02-10 Curna, Inc. Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
WO2011069529A1 (en) * 2009-12-09 2011-06-16 Curevac Gmbh Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
EP2651445A2 (en) 2010-12-16 2013-10-23 SPRNA GmbH Pharmaceutical composition consisting of rna having alkali metal as counter ion and formulated with dications
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
EP3460064B8 (en) 2011-04-03 2024-03-20 The General Hospital Corporation d/b/a Massachusetts General Hospital Efficient protein expression in vivo using modified rna (mod-rna)
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
CN104968354A (zh) 2011-12-21 2015-10-07 现代治疗公司 增加器官或器官外植体的活力或寿命的方法
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
US10501513B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
US20140275229A1 (en) * 2012-04-02 2014-09-18 Moderna Therapeutics, Inc. Modified polynucleotides encoding udp glucuronosyltransferase 1 family, polypeptide a1
US9663564B2 (en) 2013-03-15 2017-05-30 The Regents Of The University Of California Vectors and methods to treat ischemia
WO2014152211A1 (en) * 2013-03-14 2014-09-25 Moderna Therapeutics, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
KR102354389B1 (ko) * 2013-08-21 2022-01-20 큐어백 아게 Rna―암호화된 단백질의 발현을 증가시키는 방법
RU2727639C2 (ru) 2014-01-15 2020-07-22 Ф.Хоффманн-Ля Рош Аг Варианты fc-области с модифицированной способностью связываться с fcrn и с сохраненной способностью связываться с белком а
EP3247398A4 (en) 2015-01-23 2018-09-26 Moderna Therapeutics, Inc. Lipid nanoparticle compositions
JP6948313B6 (ja) 2015-09-17 2022-01-14 モデルナティエックス インコーポレイテッド 治療剤の細胞内送達のための化合物および組成物
CN116606861A (zh) 2016-06-07 2023-08-18 摩登纳特斯有限公司 编码vegf-a多肽的经修饰的rna、配制品和关于它们的用途
WO2018104540A1 (en) 2016-12-08 2018-06-14 Curevac Ag Rnas for wound healing
MX389934B (es) 2016-12-09 2025-03-20 Desarrolladora Y Com De Tecnologias Biomedicas Decotecbio S A De C V Composición coadyuvante de un factor de crecimiento y un neuropéptido para acelerar la cicatrización de heridas y la repitelización de órganos.
SI3703658T1 (sl) 2017-10-31 2022-09-30 Astrazeneca Ab Lipidni nanodelci za dostavljanje spremenjene RNA, ki kodira polipeptid VEGF-A
JP2022532078A (ja) 2019-05-08 2022-07-13 アストラゼネカ アクチボラグ 皮膚及び創傷のための組成物並びにその使用の方法

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CN109790207A (zh) 2019-05-21
RU2756313C2 (ru) 2021-09-29
WO2017214175A1 (en) 2017-12-14
US11866475B2 (en) 2024-01-09
ES2895421T3 (es) 2022-02-21
SI3464338T1 (sl) 2022-02-28
JP7167226B2 (ja) 2022-11-08
RS62556B1 (sr) 2021-12-31
EP3464338A1 (en) 2019-04-10
US20200407411A1 (en) 2020-12-31
HUE056055T2 (hu) 2022-01-28
SG11201810816QA (en) 2018-12-28
RU2018147229A3 (https=) 2020-09-23
AU2017277277B2 (en) 2023-05-04
KR20230019505A (ko) 2023-02-08
CN116606861A (zh) 2023-08-18
EP3464338B1 (en) 2021-07-21
JP2023011733A (ja) 2023-01-24
TWI818375B (zh) 2023-10-11
KR20230107891A (ko) 2023-07-18
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