TWI814703B - 供癌症醫療的節拍式口服吉西他賓 - Google Patents
供癌症醫療的節拍式口服吉西他賓 Download PDFInfo
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- TWI814703B TWI814703B TW106118362A TW106118362A TWI814703B TW I814703 B TWI814703 B TW I814703B TW 106118362 A TW106118362 A TW 106118362A TW 106118362 A TW106118362 A TW 106118362A TW I814703 B TWI814703 B TW I814703B
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- gemcitabine
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- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000009094 second-line therapy Methods 0.000 description 1
- 238000011519 second-line treatment Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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US20200384007A1 (en) * | 2019-06-06 | 2020-12-10 | Board Of Regents, The University Of Texas System | Lipid nanoparticles containing pharmaceutical and/or nutraceutical agents and methods thereof |
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CN102427803B (zh) * | 2009-04-27 | 2015-06-10 | 因华生技制药股份有限公司 | 亲水性药物之自微乳化医药组合物及其制备 |
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HUE038768T2 (hu) | 2005-02-18 | 2018-11-28 | Abraxis Bioscience Llc | Terápiás szerek kombinációi, valamint beadásukra szolgáló módszerek, és kombinációs terápia |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
CA2736939C (en) | 2008-09-23 | 2021-09-14 | Nektar Therapeutics | Means of achieving sustained-therapeutic sn-38 concentrations in a subject |
WO2010039039A1 (en) * | 2008-10-03 | 2010-04-08 | Clavis Pharma Asa | Oral formulations of gemcitabine derivatives |
CN101926779A (zh) * | 2010-08-19 | 2010-12-29 | 苏州特瑞药业有限公司 | 一种吉西他滨固体脂质纳米粒及其制备方法与用途 |
JPWO2013058294A1 (ja) * | 2011-10-18 | 2015-04-02 | 味の素株式会社 | 膵臓癌及び/又は胆道癌治療薬 |
US20150283237A1 (en) | 2014-04-02 | 2015-10-08 | Mitchell S. Felder | Ctla-4 blockade with metronomic chemotherapy for the treatment of cancer |
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Non-Patent Citations (3)
Title |
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期刊 Clin Cancer Res 2008;14(11) June 1, 2008, 3477-3486; * |
期刊 秀傳醫學雜誌Show-Chwan Med J 2004; 5(3-4): 125-136 * |
網路文獻 2013-06-05發布之「抗腫瘤藥行業深度報告」; * |
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CN114224865A (zh) | 2022-03-25 |
TW201808309A (zh) | 2018-03-16 |
JP2019517490A (ja) | 2019-06-24 |
EP3463298A1 (en) | 2019-04-10 |
US20170348341A1 (en) | 2017-12-07 |
EP3463298B1 (en) | 2021-09-01 |
CN109310631A (zh) | 2019-02-05 |
AU2017273495A1 (en) | 2018-12-20 |
AU2017273495B2 (en) | 2023-01-12 |
ES2898024T3 (es) | 2022-03-03 |
JP2022088622A (ja) | 2022-06-14 |
CA3026144A1 (en) | 2017-12-07 |
WO2017206940A1 (en) | 2017-12-07 |
US10835548B2 (en) | 2020-11-17 |
EP3463298A4 (en) | 2020-01-01 |
KR102383824B1 (ko) | 2022-04-06 |
KR20190015420A (ko) | 2019-02-13 |
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