TWI803619B - 治療神經性病變疼痛之方法 - Google Patents

治療神經性病變疼痛之方法 Download PDF

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Publication number
TWI803619B
TWI803619B TW108113193A TW108113193A TWI803619B TW I803619 B TWI803619 B TW I803619B TW 108113193 A TW108113193 A TW 108113193A TW 108113193 A TW108113193 A TW 108113193A TW I803619 B TWI803619 B TW I803619B
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TW
Taiwan
Prior art keywords
phenyl
fluorophenyl
oxy
methyl
prolinamide
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TW108113193A
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English (en)
Chinese (zh)
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TW201946619A (zh
Inventor
趙媛
翰墨許 奈克
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美商百健Ｍａ公司
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Publication of TW201946619A publication Critical patent/TW201946619A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW108113193A 2018-04-16 2019-04-16 治療神經性病變疼痛之方法 TWI803619B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862658347P 2018-04-16 2018-04-16
US62/658,347 2018-04-16

Publications (2)

Publication Number Publication Date
TW201946619A TW201946619A (zh) 2019-12-16
TWI803619B true TWI803619B (zh) 2023-06-01

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ID=68239826

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TW108113193A TWI803619B (zh) 2018-04-16 2019-04-16 治療神經性病變疼痛之方法
TW111111744A TW202245750A (zh) 2018-04-16 2019-04-16 治療神經性病變疼痛之方法

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TW111111744A TW202245750A (zh) 2018-04-16 2019-04-16 治療神經性病變疼痛之方法

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US (1) US20210154170A1 (enExample)
EP (1) EP3781157A4 (enExample)
JP (1) JP2021521227A (enExample)
KR (1) KR20210002472A (enExample)
CN (1) CN112367990A (enExample)
AU (1) AU2019255519A1 (enExample)
BR (1) BR112020021101A2 (enExample)
CA (1) CA3093401A1 (enExample)
EA (1) EA202092482A1 (enExample)
IL (1) IL277962A (enExample)
MX (1) MX2020010929A (enExample)
SG (1) SG11202008681PA (enExample)
TW (2) TWI803619B (enExample)
WO (1) WO2019204136A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406716B2 (en) * 1996-08-23 2002-06-18 Endo Pharmaceuticals Inc. Anticonvulsant containing composition for treating neuropathic pain
US20080280969A1 (en) * 2005-10-10 2008-11-13 Glaxo Group Limited Novel Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201409851D0 (en) * 2014-06-03 2014-07-16 Convergence Pharmaceuticals Diagnostic method
GB201417497D0 (en) * 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
AU2017353841A1 (en) * 2016-11-02 2019-05-30 Biogen Ma Inc. Novel dosage regimen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406716B2 (en) * 1996-08-23 2002-06-18 Endo Pharmaceuticals Inc. Anticonvulsant containing composition for treating neuropathic pain
US20080280969A1 (en) * 2005-10-10 2008-11-13 Glaxo Group Limited Novel Compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 S Tate,et al. The Journal of Pain, 摘要386~387, Volume 16, Issue 4, Supplement, Page S72, May 2015. Abstracts Presented at the 34th Annual Scientific Meeting of the American Pain Society, *

Also Published As

Publication number Publication date
JP2021521227A (ja) 2021-08-26
WO2019204136A1 (en) 2019-10-24
EA202092482A1 (ru) 2021-03-30
SG11202008681PA (en) 2020-10-29
IL277962A (en) 2020-11-30
KR20210002472A (ko) 2021-01-08
US20210154170A1 (en) 2021-05-27
TW201946619A (zh) 2019-12-16
AU2019255519A1 (en) 2020-10-01
TW202245750A (zh) 2022-12-01
EP3781157A4 (en) 2022-01-26
CA3093401A1 (en) 2019-10-24
EP3781157A1 (en) 2021-02-24
MX2020010929A (es) 2020-11-06
BR112020021101A2 (pt) 2021-02-23
CN112367990A (zh) 2021-02-12

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