TWI788332B - 抗-par2抗體及其用途 - Google Patents

抗-par2抗體及其用途 Download PDF

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Publication number
TWI788332B
TWI788332B TW107109179A TW107109179A TWI788332B TW I788332 B TWI788332 B TW I788332B TW 107109179 A TW107109179 A TW 107109179A TW 107109179 A TW107109179 A TW 107109179A TW I788332 B TWI788332 B TW I788332B
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TW
Taiwan
Prior art keywords
antibody
antigen
seq
amino acid
homo sapiens
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TW107109179A
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English (en)
Chinese (zh)
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TW201843176A (zh
Inventor
克萊兒 道伯森 道伯森
理查 威廉斯 威廉斯
依安 葛瑞爾 葛瑞爾
沙德哈娜 帕迪切提
大衛 費爾曼
彼得 諾頓
菲力浦 牛頓
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英商梅迪繆思有限公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW107109179A 2017-03-16 2018-03-16 抗-par2抗體及其用途 TWI788332B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762472462P 2017-03-16 2017-03-16
US62/472,462 2017-03-16
US201862637766P 2018-03-02 2018-03-02
US62/637,766 2018-03-02

Publications (2)

Publication Number Publication Date
TW201843176A TW201843176A (zh) 2018-12-16
TWI788332B true TWI788332B (zh) 2023-01-01

Family

ID=61827709

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107109179A TWI788332B (zh) 2017-03-16 2018-03-16 抗-par2抗體及其用途

Country Status (19)

Country Link
US (3) US10836822B2 (fr)
EP (1) EP3596125A1 (fr)
JP (2) JP7222901B2 (fr)
CN (1) CN110446720B (fr)
AU (2) AU2018235031B2 (fr)
BR (1) BR112019018752A2 (fr)
CA (1) CA3055251A1 (fr)
CL (1) CL2019002626A1 (fr)
CO (1) CO2019010975A2 (fr)
CR (1) CR20190417A (fr)
IL (1) IL269134B2 (fr)
MA (1) MA49886A (fr)
MX (1) MX2019010802A (fr)
NZ (1) NZ757915A (fr)
PH (1) PH12019502087A1 (fr)
SG (1) SG11201908056QA (fr)
TW (1) TWI788332B (fr)
UA (1) UA125757C2 (fr)
WO (1) WO2018167322A1 (fr)

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LT2708559T (lt) 2008-04-11 2018-06-11 Chugai Seiyaku Kabushiki Kaisha Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių
EP2647706B1 (fr) 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Molécule de liaison à l'antigène, apte à se lier de façon répétée à une pluralité de molécules d'antigène
MX352889B (es) 2011-02-25 2017-12-13 Chugai Pharmaceutical Co Ltd Anticuerpo de fc especifico para fcyriib.
US20150050269A1 (en) 2011-09-30 2015-02-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
SG11201700841QA (en) 2014-12-19 2017-03-30 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
MY183415A (en) 2014-12-19 2021-02-18 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
KR102605798B1 (ko) 2015-02-05 2023-11-23 추가이 세이야쿠 가부시키가이샤 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
MX2019001448A (es) 2016-08-05 2019-09-13 Chugai Pharmaceutical Co Ltd Composicion para profilaxis o tratamiento de enfermedades relacionadas con interleucina 8 (il-8).
JP7191833B2 (ja) 2017-01-30 2022-12-19 中外製薬株式会社 抗スクレロスチン抗体およびその使用
TW202227489A (zh) 2020-08-18 2022-07-16 美商希佛隆公司 抗par-2抗體及其使用方法
GB202204159D0 (en) 2022-03-24 2022-05-11 Heptares Therapeutics Ltd Antibodies
WO2024156720A1 (fr) 2023-01-25 2024-08-02 Medimmune Limited Thérapie contre la migraine

Citations (1)

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TW201002345A (en) * 2008-03-19 2010-01-16 Regeneron Pharma Use of protease-activated receptor 2 antagonists

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ATE489395T1 (de) 2000-12-12 2010-12-15 Medimmune Llc Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung
EP1604207A2 (fr) * 2003-03-11 2005-12-14 Bayer HealthCare AG Agents diagnostiques et therapeutiques destines a des maladies associees au recepteur 2 active par la proteinase (par2) couple aux proteines g
WO2005103081A2 (fr) 2004-04-20 2005-11-03 Genmab A/S Anticorps monoclonaux humains diriges contre cd20
JP2008519039A (ja) * 2004-11-04 2008-06-05 ニュー イングランド メデカル センター ホスピタルズ インク Gタンパク質共役型受容体アゴニストおよびアンタゴニストならびに使用方法
US20100034194A1 (en) 2006-10-11 2010-02-11 Siemens Communications Inc. Eliminating unreachable subscribers in voice-over-ip networks
CL2008001887A1 (es) * 2007-06-29 2008-10-03 Amgen Inc Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende.
LT2708559T (lt) 2008-04-11 2018-06-11 Chugai Seiyaku Kabushiki Kaisha Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių
ES2487846T3 (es) 2008-05-01 2014-08-25 Amgen, Inc. Anticuerpos anti-hepcindina y métodos de uso
JP2011530515A (ja) * 2008-08-05 2011-12-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Par−2活性化のエフェクターおよび炎症の調節におけるその使用
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TW201002345A (en) * 2008-03-19 2010-01-16 Regeneron Pharma Use of protease-activated receptor 2 antagonists

Non-Patent Citations (1)

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Title
期刊 Igawa et. al., " Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization" nature biotechnology, volume 28, number 11, Nature Publishing Group, 2010, p: 1203–1207 *

Also Published As

Publication number Publication date
EP3596125A1 (fr) 2020-01-22
US20230242639A1 (en) 2023-08-03
AU2018235031B2 (en) 2021-08-12
IL269134B2 (en) 2024-07-01
MA49886A (fr) 2020-06-24
US20180305450A1 (en) 2018-10-25
US11591389B2 (en) 2023-02-28
IL269134A (en) 2019-11-28
MX2019010802A (es) 2019-10-30
TW201843176A (zh) 2018-12-16
SG11201908056QA (en) 2019-09-27
CN110446720A (zh) 2019-11-12
AU2018235031A1 (en) 2019-10-31
CN110446720B (zh) 2023-09-12
CL2019002626A1 (es) 2019-12-06
UA125757C2 (uk) 2022-06-01
WO2018167322A1 (fr) 2018-09-20
US20210061905A1 (en) 2021-03-04
US10836822B2 (en) 2020-11-17
IL269134B1 (en) 2024-03-01
NZ757915A (en) 2023-05-26
AU2021257983A1 (en) 2021-11-25
BR112019018752A2 (pt) 2020-05-05
JP2020509762A (ja) 2020-04-02
JP2023055895A (ja) 2023-04-18
CO2019010975A2 (es) 2019-10-21
CR20190417A (es) 2019-12-06
JP7222901B2 (ja) 2023-02-15
CA3055251A1 (fr) 2018-09-20
PH12019502087A1 (en) 2020-03-09
KR20190129925A (ko) 2019-11-20

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