TWI788332B - 抗-par2抗體及其用途 - Google Patents

抗-par2抗體及其用途 Download PDF

Info

Publication number
TWI788332B
TWI788332B TW107109179A TW107109179A TWI788332B TW I788332 B TWI788332 B TW I788332B TW 107109179 A TW107109179 A TW 107109179A TW 107109179 A TW107109179 A TW 107109179A TW I788332 B TWI788332 B TW I788332B
Authority
TW
Taiwan
Prior art keywords
antibody
antigen
seq
amino acid
binding fragment
Prior art date
Application number
TW107109179A
Other languages
English (en)
Chinese (zh)
Other versions
TW201843176A (zh
Inventor
克萊兒 道伯森 道伯森
理查 威廉斯 威廉斯
依安 葛瑞爾 葛瑞爾
沙德哈娜 帕迪切提
大衛 費爾曼
彼得 諾頓
菲力浦 牛頓
Original Assignee
英商梅迪繆思有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 英商梅迪繆思有限公司 filed Critical 英商梅迪繆思有限公司
Publication of TW201843176A publication Critical patent/TW201843176A/zh
Application granted granted Critical
Publication of TWI788332B publication Critical patent/TWI788332B/zh

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
TW107109179A 2017-03-16 2018-03-16 抗-par2抗體及其用途 TWI788332B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762472462P 2017-03-16 2017-03-16
US62/472,462 2017-03-16
US201862637766P 2018-03-02 2018-03-02
US62/637,766 2018-03-02

Publications (2)

Publication Number Publication Date
TW201843176A TW201843176A (zh) 2018-12-16
TWI788332B true TWI788332B (zh) 2023-01-01

Family

ID=61827709

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107109179A TWI788332B (zh) 2017-03-16 2018-03-16 抗-par2抗體及其用途

Country Status (30)

Country Link
US (4) US10836822B2 (cg-RX-API-DMAC7.html)
EP (2) EP4681726A3 (cg-RX-API-DMAC7.html)
JP (3) JP7222901B2 (cg-RX-API-DMAC7.html)
KR (1) KR102711884B1 (cg-RX-API-DMAC7.html)
CN (1) CN110446720B (cg-RX-API-DMAC7.html)
AU (3) AU2018235031B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019018752A2 (cg-RX-API-DMAC7.html)
CA (1) CA3055251A1 (cg-RX-API-DMAC7.html)
CL (1) CL2019002626A1 (cg-RX-API-DMAC7.html)
CO (1) CO2019010975A2 (cg-RX-API-DMAC7.html)
CR (1) CR20190417A (cg-RX-API-DMAC7.html)
DK (1) DK3596125T3 (cg-RX-API-DMAC7.html)
ES (1) ES3056721T3 (cg-RX-API-DMAC7.html)
FI (1) FI3596125T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20251643T1 (cg-RX-API-DMAC7.html)
IL (1) IL269134B2 (cg-RX-API-DMAC7.html)
LT (1) LT3596125T (cg-RX-API-DMAC7.html)
MA (1) MA49886A (cg-RX-API-DMAC7.html)
MX (1) MX2019010802A (cg-RX-API-DMAC7.html)
NZ (1) NZ757915A (cg-RX-API-DMAC7.html)
PH (1) PH12019502087A1 (cg-RX-API-DMAC7.html)
PL (1) PL3596125T3 (cg-RX-API-DMAC7.html)
PT (1) PT3596125T (cg-RX-API-DMAC7.html)
RS (1) RS67581B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201908056QA (cg-RX-API-DMAC7.html)
SI (1) SI3596125T1 (cg-RX-API-DMAC7.html)
TW (1) TWI788332B (cg-RX-API-DMAC7.html)
UA (1) UA125757C2 (cg-RX-API-DMAC7.html)
WO (1) WO2018167322A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201906004B (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201920257A (zh) 2008-04-11 2019-06-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗原結合分子
TWI654203B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
SG10201609665PA (en) 2011-02-25 2017-01-27 Chugai Pharmaceutical Co Ltd FcɣRIIb-SPECIFIC Fc ANTIBODY
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
MX2017005774A (es) 2014-12-19 2017-07-28 Chugai Pharmaceutical Co Ltd Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso.
EA201791366A1 (ru) 2014-12-19 2018-02-28 Чугаи Сейяку Кабусики Кайся Антитела к c5 и способы их применения
CN114773469B (zh) 2015-02-05 2025-12-19 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE
CN116271014A (zh) 2016-08-05 2023-06-23 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
WO2018139623A1 (en) 2017-01-30 2018-08-02 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use
MA49886A (fr) * 2017-03-16 2020-06-24 Medimmune Ltd Anticorps anti-par2 et leurs utilisations
US12214216B1 (en) 2019-10-16 2025-02-04 Helen Feng Photon enhanced bone growth system and method
AU2021328375A1 (en) * 2020-08-18 2023-04-13 Cephalon Llc Anti-PAR-2 antibodies and methods of use thereof
GB202204159D0 (en) 2022-03-24 2022-05-11 Heptares Therapeutics Ltd Antibodies
AU2024212070A1 (en) 2023-01-25 2025-07-31 Medimmune Limited Migraine therapy
WO2025172573A1 (en) 2024-02-16 2025-08-21 Domain Therapeutics Combinations of par2 inhibitors and immune checkpoint inhibitors for the treatment of cancer
WO2025191185A1 (en) 2024-03-15 2025-09-18 Domain Therapeutics Azine-based compounds as par-2 inhibitors and therapeutic uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201002345A (en) * 2008-03-19 2010-01-16 Regeneron Pharma Use of protease-activated receptor 2 antagonists

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1355919B1 (en) 2000-12-12 2010-11-24 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
US20070053911A1 (en) * 2003-03-11 2007-03-08 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled proteinase activated receptor 2 (par2)
EP1740946B1 (en) 2004-04-20 2013-11-06 Genmab A/S Human monoclonal antibodies against cd20
US8440627B2 (en) * 2004-11-04 2013-05-14 Tufts Medical Center, Inc. G protein coupled receptor agonists and antagonists and methods of use
US20100034194A1 (en) 2006-10-11 2010-02-11 Siemens Communications Inc. Eliminating unreachable subscribers in voice-over-ip networks
CL2008001887A1 (es) * 2007-06-29 2008-10-03 Amgen Inc Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende.
TW201920257A (zh) 2008-04-11 2019-06-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗原結合分子
WO2009139822A1 (en) 2008-05-01 2009-11-19 Amgen Inc. Anti-hepcidin antibodies and methods of use
WO2010017086A1 (en) * 2008-08-05 2010-02-11 Boehringer Ingelheim International Gmbh Effectors of par-2 activation and their use in the modulation of inflammation
HUE051130T2 (hu) * 2008-08-07 2021-03-01 Idexx Lab Inc Eljárások szimmetrikus dimetilarginin kimutatására
JO3246B1 (ar) * 2009-09-09 2018-03-08 Regeneron Pharma اجسام مضادة بشرية ذات ألفة تفاعل عالية مع مستقبل 2 المفعل بالبروتين البشري
NZ602220A (en) 2010-03-11 2014-10-31 Rinat Neuroscience Corp Antibodies with ph dependent antigen binding
US20150203591A1 (en) 2012-08-02 2015-07-23 Regeneron Pharmaceuticals, Inc. Mutivalent antigen-binding proteins
NZ704771A (en) * 2012-08-13 2018-02-23 Regeneron Pharma Anti-pcsk9 antibodies with ph-dependent binding characteristics
EP3160996B1 (en) 2014-06-30 2022-06-08 Merck Patent GmbH Anti-tnfa antibodies with ph-dependent antigen binding
MA49886A (fr) * 2017-03-16 2020-06-24 Medimmune Ltd Anticorps anti-par2 et leurs utilisations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201002345A (en) * 2008-03-19 2010-01-16 Regeneron Pharma Use of protease-activated receptor 2 antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
期刊 Igawa et. al., " Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization" nature biotechnology, volume 28, number 11, Nature Publishing Group, 2010, p: 1203–1207 *

Also Published As

Publication number Publication date
CL2019002626A1 (es) 2019-12-06
US20210061905A1 (en) 2021-03-04
US20260078180A1 (en) 2026-03-19
KR102711884B1 (ko) 2024-10-02
BR112019018752A2 (pt) 2020-05-05
JP2025102812A (ja) 2025-07-08
UA125757C2 (uk) 2022-06-01
ES3056721T3 (en) 2026-02-24
JP2020509762A (ja) 2020-04-02
CR20190417A (es) 2019-12-06
HRP20251643T1 (hr) 2026-02-13
SI3596125T1 (sl) 2026-01-30
IL269134B2 (en) 2024-07-01
ZA201906004B (en) 2025-10-29
CN110446720B (zh) 2023-09-12
JP2023055895A (ja) 2023-04-18
CO2019010975A2 (es) 2019-10-21
CN110446720A (zh) 2019-11-12
KR20190129925A (ko) 2019-11-20
MX2019010802A (es) 2019-10-30
CA3055251A1 (en) 2018-09-20
DK3596125T3 (da) 2025-12-22
WO2018167322A1 (en) 2018-09-20
PH12019502087A1 (en) 2020-03-09
EP4681726A2 (en) 2026-01-21
IL269134B1 (en) 2024-03-01
EP3596125B1 (en) 2025-11-19
AU2025203947A9 (en) 2026-03-19
AU2018235031B2 (en) 2021-08-12
LT3596125T (lt) 2026-01-26
FI3596125T3 (fi) 2025-12-29
EP3596125A1 (en) 2020-01-22
TW201843176A (zh) 2018-12-16
NZ757915A (en) 2023-05-26
PT3596125T (pt) 2025-11-27
JP7222901B2 (ja) 2023-02-15
IL269134A (en) 2019-11-28
AU2025203947A1 (en) 2025-06-19
US10836822B2 (en) 2020-11-17
EP4681726A3 (en) 2026-04-01
PL3596125T3 (pl) 2026-02-09
US11591389B2 (en) 2023-02-28
RS67581B1 (sr) 2026-01-30
AU2021257983A1 (en) 2021-11-25
SG11201908056QA (en) 2019-09-27
AU2021257983B2 (en) 2025-02-27
MA49886A (fr) 2020-06-24
AU2018235031A1 (en) 2019-10-31
US20230242639A1 (en) 2023-08-03
US20180305450A1 (en) 2018-10-25

Similar Documents

Publication Publication Date Title
US20260078180A1 (en) Anti-par2 antibodies and uses thereof
JP6367233B2 (ja) 抗ｐｄｇｆｒ−ベータ抗体及びそれらの使用
TWI596115B (zh) 具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體
JP2021090461A (ja) レプチン受容体を活性化させる抗原結合タンパク質
TWI613218B (zh) ＧＦＲα３之人類抗體及其使用方法
TW202019966A (zh) 雙特異性抗－ＢＣＭＡｘ抗－ＣＤ３抗體及其用途
ES3040144T3 (en) Antigen-binding proteins that antagonize leptin receptor
MX2012013369A (es) Anticuerpos hacia gdf8 humano.
JP7402223B2 (ja) 抗ｆｃイプシロン－ｒ１アルファ（ｆｃｅｒ１ａ）抗体、ｆｃｅｒ１ａおよびｃｄ３に結合する二重特異性抗原結合分子、ならびにそれらの使用
TW202317643A (zh) 用於抗pacap抗體的組合物和方法
EA044850B1 (ru) Антитела к par2 и пути их применения
US20250043017A1 (en) BISPECIFIC PD-L1x4-1BB ANTIBODIES AND METHODS OF USE THEREOF
BR122025022029A2 (pt) Anticorpos anti-par2 ou seu fragmento de ligação ao antígeno, ácido nucleico, vetor, célula hospedeira, composição e seus usos
TW202519559A (zh) 雙特異性PD-L1xCD28抗體及其使用方法
HK1261378A1 (en) Human antibodies to gfr 3 and methods of use thereof