JP7222901B2 - 抗ｐａｒ２抗体及びその使用 - Google Patents

抗ｐａｒ２抗体及びその使用 Download PDF

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Publication number
JP7222901B2
JP7222901B2 JP2019549512A JP2019549512A JP7222901B2 JP 7222901 B2 JP7222901 B2 JP 7222901B2 JP 2019549512 A JP2019549512 A JP 2019549512A JP 2019549512 A JP2019549512 A JP 2019549512A JP 7222901 B2 JP7222901 B2 JP 7222901B2
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antibody
antigen
seq
amino acid
binding fragment
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JP2020509762A (ja
JP2020509762A5 (cg-RX-API-DMAC7.html
Inventor
クレア・ドブソン
リチャード・ウィリアムズ
イアン・グレル
サダナ・ポディチェッティ
デイビッド・フェアマン
ピーター・ソーントン
フィリップ・ニュートン
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MedImmune Ltd
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MedImmune Ltd
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Priority to JP2025043151A priority patent/JP2025102812A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2019549512A 2017-03-16 2018-03-16 抗ｐａｒ２抗体及びその使用 Active JP7222901B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023015469A JP2023055895A (ja) 2017-03-16 2023-02-03 抗ｐａｒ２抗体及びその使用
JP2025043151A JP2025102812A (ja) 2017-03-16 2025-03-18 抗ｐａｒ２抗体及びその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762472462P 2017-03-16 2017-03-16
US62/472,462 2017-03-16
US201862637766P 2018-03-02 2018-03-02
US62/637,766 2018-03-02
PCT/EP2018/056776 WO2018167322A1 (en) 2017-03-16 2018-03-16 Anti-par2 antibodies and uses thereof

Related Child Applications (1)

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JP2023015469A Division JP2023055895A (ja) 2017-03-16 2023-02-03 抗ｐａｒ２抗体及びその使用

Publications (3)

Publication Number Publication Date
JP2020509762A JP2020509762A (ja) 2020-04-02
JP2020509762A5 JP2020509762A5 (cg-RX-API-DMAC7.html) 2021-04-15
JP7222901B2 true JP7222901B2 (ja) 2023-02-15

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JP2019549512A Active JP7222901B2 (ja) 2017-03-16 2018-03-16 抗ｐａｒ２抗体及びその使用
JP2023015469A Pending JP2023055895A (ja) 2017-03-16 2023-02-03 抗ｐａｒ２抗体及びその使用
JP2025043151A Pending JP2025102812A (ja) 2017-03-16 2025-03-18 抗ｐａｒ２抗体及びその使用

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JP2025043151A Pending JP2025102812A (ja) 2017-03-16 2025-03-18 抗ｐａｒ２抗体及びその使用

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US (4) US10836822B2 (cg-RX-API-DMAC7.html)
EP (2) EP4681726A3 (cg-RX-API-DMAC7.html)
JP (3) JP7222901B2 (cg-RX-API-DMAC7.html)
KR (1) KR102711884B1 (cg-RX-API-DMAC7.html)
CN (1) CN110446720B (cg-RX-API-DMAC7.html)
AU (3) AU2018235031B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019018752A2 (cg-RX-API-DMAC7.html)
CA (1) CA3055251A1 (cg-RX-API-DMAC7.html)
CL (1) CL2019002626A1 (cg-RX-API-DMAC7.html)
CO (1) CO2019010975A2 (cg-RX-API-DMAC7.html)
CR (1) CR20190417A (cg-RX-API-DMAC7.html)
DK (1) DK3596125T3 (cg-RX-API-DMAC7.html)
ES (1) ES3056721T3 (cg-RX-API-DMAC7.html)
FI (1) FI3596125T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20251643T1 (cg-RX-API-DMAC7.html)
IL (1) IL269134B2 (cg-RX-API-DMAC7.html)
LT (1) LT3596125T (cg-RX-API-DMAC7.html)
MA (1) MA49886A (cg-RX-API-DMAC7.html)
MX (1) MX2019010802A (cg-RX-API-DMAC7.html)
NZ (1) NZ757915A (cg-RX-API-DMAC7.html)
PH (1) PH12019502087A1 (cg-RX-API-DMAC7.html)
PL (1) PL3596125T3 (cg-RX-API-DMAC7.html)
PT (1) PT3596125T (cg-RX-API-DMAC7.html)
RS (1) RS67581B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201908056QA (cg-RX-API-DMAC7.html)
SI (1) SI3596125T1 (cg-RX-API-DMAC7.html)
TW (1) TWI788332B (cg-RX-API-DMAC7.html)
UA (1) UA125757C2 (cg-RX-API-DMAC7.html)
WO (1) WO2018167322A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201906004B (cg-RX-API-DMAC7.html)

Cited By (1)

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JP2023055895A (ja) * 2017-03-16 2023-04-18 メドイミューン・リミテッド 抗ｐａｒ２抗体及びその使用

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TW201920257A (zh) 2008-04-11 2019-06-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗原結合分子
TWI654203B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
SG10201609665PA (en) 2011-02-25 2017-01-27 Chugai Pharmaceutical Co Ltd FcɣRIIb-SPECIFIC Fc ANTIBODY
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
MX2017005774A (es) 2014-12-19 2017-07-28 Chugai Pharmaceutical Co Ltd Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso.
EA201791366A1 (ru) 2014-12-19 2018-02-28 Чугаи Сейяку Кабусики Кайся Антитела к c5 и способы их применения
CN114773469B (zh) 2015-02-05 2025-12-19 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
EP3394098A4 (en) 2015-12-25 2019-11-13 Chugai Seiyaku Kabushiki Kaisha ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE
CN116271014A (zh) 2016-08-05 2023-06-23 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
WO2018139623A1 (en) 2017-01-30 2018-08-02 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use
US12214216B1 (en) 2019-10-16 2025-02-04 Helen Feng Photon enhanced bone growth system and method
AU2021328375A1 (en) * 2020-08-18 2023-04-13 Cephalon Llc Anti-PAR-2 antibodies and methods of use thereof
GB202204159D0 (en) 2022-03-24 2022-05-11 Heptares Therapeutics Ltd Antibodies
AU2024212070A1 (en) 2023-01-25 2025-07-31 Medimmune Limited Migraine therapy
WO2025172573A1 (en) 2024-02-16 2025-08-21 Domain Therapeutics Combinations of par2 inhibitors and immune checkpoint inhibitors for the treatment of cancer
WO2025191185A1 (en) 2024-03-15 2025-09-18 Domain Therapeutics Azine-based compounds as par-2 inhibitors and therapeutic uses thereof

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JP2011530515A (ja) 2008-08-05 2011-12-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐａｒ−２活性化のエフェクターおよび炎症の調節におけるその使用
JP2013504577A (ja) 2009-09-09 2013-02-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトプロテアーゼ活性化受容体−２に対する高親和性ヒト抗体

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JP2011530515A (ja) 2008-08-05 2011-12-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐａｒ−２活性化のエフェクターおよび炎症の調節におけるその使用
JP2013504577A (ja) 2009-09-09 2013-02-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトプロテアーゼ活性化受容体−２に対する高親和性ヒト抗体

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JP2023055895A (ja) * 2017-03-16 2023-04-18 メドイミューン・リミテッド 抗ｐａｒ２抗体及びその使用

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CL2019002626A1 (es) 2019-12-06
US20210061905A1 (en) 2021-03-04
US20260078180A1 (en) 2026-03-19
KR102711884B1 (ko) 2024-10-02
BR112019018752A2 (pt) 2020-05-05
JP2025102812A (ja) 2025-07-08
UA125757C2 (uk) 2022-06-01
ES3056721T3 (en) 2026-02-24
JP2020509762A (ja) 2020-04-02
CR20190417A (es) 2019-12-06
HRP20251643T1 (hr) 2026-02-13
SI3596125T1 (sl) 2026-01-30
IL269134B2 (en) 2024-07-01
ZA201906004B (en) 2025-10-29
CN110446720B (zh) 2023-09-12
TWI788332B (zh) 2023-01-01
JP2023055895A (ja) 2023-04-18
CO2019010975A2 (es) 2019-10-21
CN110446720A (zh) 2019-11-12
KR20190129925A (ko) 2019-11-20
MX2019010802A (es) 2019-10-30
CA3055251A1 (en) 2018-09-20
DK3596125T3 (da) 2025-12-22
WO2018167322A1 (en) 2018-09-20
PH12019502087A1 (en) 2020-03-09
EP4681726A2 (en) 2026-01-21
IL269134B1 (en) 2024-03-01
EP3596125B1 (en) 2025-11-19
AU2025203947A9 (en) 2026-03-19
AU2018235031B2 (en) 2021-08-12
LT3596125T (lt) 2026-01-26
FI3596125T3 (fi) 2025-12-29
EP3596125A1 (en) 2020-01-22
TW201843176A (zh) 2018-12-16
NZ757915A (en) 2023-05-26
PT3596125T (pt) 2025-11-27
IL269134A (en) 2019-11-28
AU2025203947A1 (en) 2025-06-19
US10836822B2 (en) 2020-11-17
EP4681726A3 (en) 2026-04-01
PL3596125T3 (pl) 2026-02-09
US11591389B2 (en) 2023-02-28
RS67581B1 (sr) 2026-01-30
AU2021257983A1 (en) 2021-11-25
SG11201908056QA (en) 2019-09-27
AU2021257983B2 (en) 2025-02-27
MA49886A (fr) 2020-06-24
AU2018235031A1 (en) 2019-10-31
US20230242639A1 (en) 2023-08-03
US20180305450A1 (en) 2018-10-25

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