TWI746588B - 以自成體幹細胞分離之擬胞外體奈米囊胞作為促進血管生成活性之組成物的用途及其製造方法 - Google Patents

以自成體幹細胞分離之擬胞外體奈米囊胞作為促進血管生成活性之組成物的用途及其製造方法 Download PDF

Info

Publication number
TWI746588B
TWI746588B TW106121539A TW106121539A TWI746588B TW I746588 B TWI746588 B TW I746588B TW 106121539 A TW106121539 A TW 106121539A TW 106121539 A TW106121539 A TW 106121539A TW I746588 B TWI746588 B TW I746588B
Authority
TW
Taiwan
Prior art keywords
stem cells
adult stem
nanocysts
exosome
derived
Prior art date
Application number
TW106121539A
Other languages
English (en)
Chinese (zh)
Other versions
TW201805010A (zh
Inventor
金成泰
曺恩敬
賓範浩
李泰龍
高用松
金賽綸
洪佳慧
Original Assignee
南韓商愛茉莉太平洋股份有限公司
浦項工科大學校産學協力團
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 南韓商愛茉莉太平洋股份有限公司, 浦項工科大學校産學協力團 filed Critical 南韓商愛茉莉太平洋股份有限公司
Publication of TW201805010A publication Critical patent/TW201805010A/zh
Application granted granted Critical
Publication of TWI746588B publication Critical patent/TWI746588B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW106121539A 2016-06-30 2017-06-28 以自成體幹細胞分離之擬胞外體奈米囊胞作為促進血管生成活性之組成物的用途及其製造方法 TWI746588B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
??10-2016-0082981 2016-06-30
KR1020160082981A KR102623437B1 (ko) 2016-06-30 2016-06-30 성체줄기세포 유래의 엑소좀-모사 나노베지클을 포함하는 혈관 신생 촉진용 조성물
KR10-2016-0082981 2016-06-30

Publications (2)

Publication Number Publication Date
TW201805010A TW201805010A (zh) 2018-02-16
TWI746588B true TWI746588B (zh) 2021-11-21

Family

ID=60786095

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106121539A TWI746588B (zh) 2016-06-30 2017-06-28 以自成體幹細胞分離之擬胞外體奈米囊胞作為促進血管生成活性之組成物的用途及其製造方法

Country Status (3)

Country Link
KR (1) KR102623437B1 (ko)
TW (1) TWI746588B (ko)
WO (1) WO2018004143A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220249570A1 (en) * 2018-01-31 2022-08-11 Seoul National University R&Db Foundation Nanovesicles from adult stem cells and its use for targeted therapy
KR102184722B1 (ko) * 2018-01-31 2020-12-01 서울대학교산학협력단 성체줄기세포 유래의 나노베시클 및 이의 표적 치료용 용도
KR102678464B1 (ko) * 2019-01-11 2024-06-27 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모발이식 성공률 증가용 조성물
KR102255685B1 (ko) * 2019-08-30 2021-05-25 주식회사 뉴메이스 혈류 변화 부위 타겟팅 나노베지클을 이용한 동맥경화의 진단 및 치료 방법
EP4026550A4 (en) * 2019-09-06 2023-10-04 MDimune Inc. COMPOSITION FOR PREVENTING OR TREATING SALIVARY GLAND DISEASE USING CELL-DERIVED VESICLES
KR102142479B1 (ko) * 2020-01-09 2020-08-07 주식회사 엠디뮨 세포 압출기 및 세포 압출방법
CN111235108A (zh) * 2020-02-19 2020-06-05 大连医科大学附属第一医院 一种细胞膜纳米囊泡及其制备方法
KR102236375B1 (ko) * 2020-05-22 2021-04-05 주식회사 엠디뮨 단백질 항상성 조절인자가 풍부한 세포 유래 베시클 및 이의 제조 방법
KR102506995B1 (ko) * 2021-02-02 2023-03-08 주식회사 엠디뮨 세포 내 흡수능이 증대된 세포 유래 베시클 및 이의 제조 방법
US20240215568A1 (en) * 2021-04-28 2024-07-04 S&E Bio Co., Ltd. Freeze-dry protective agent for extracellular vesicles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101158536B1 (ko) 2010-05-03 2012-06-21 한국과학기술원 뚝갈 추출물의 분획물을 유효성분으로 함유하는 신생혈관 촉진제

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Jang et al., "Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors", ACS Nano, 2013, 7(9), pp 7698-7710.
Jang et al., "Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors", ACS Nano, 2013, 7(9), pp 7698-7710.; *
Merino-Gonzalez et al., "Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application", Frontiers in Physiology, Feb 2016, 7, Article 24.
Merino-Gonzalez et al., "Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Angiogenesis: Potencial Clinical Application", Frontiers in Physiology, Feb 2016, 7, Article 24.; *
Takuma et al., "Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation", European Journal of Pharmaceutics and Biopharmaceutics, Jan 2016, 98: 1-8. *

Also Published As

Publication number Publication date
KR102623437B1 (ko) 2024-01-11
WO2018004143A1 (ko) 2018-01-04
TW201805010A (zh) 2018-02-16
KR20180003322A (ko) 2018-01-09

Similar Documents

Publication Publication Date Title
TWI746588B (zh) 以自成體幹細胞分離之擬胞外體奈米囊胞作為促進血管生成活性之組成物的用途及其製造方法
CA2612694C (en) Purified component of blue-green algae and method of use
KR102475129B1 (ko) 인삼 유래의 엑소좀 유사 베지클을 유효성분으로 포함하는 항노화용 조성물
RU2440820C2 (ru) Противораковая композиция, включающая линию клеток, полученную из камбия и прокамбия стебля тисса (taxus)
US10251824B2 (en) Method for inducing pluripotent stem cells and pluripotent stem cells prepared by said method
JP7246569B2 (ja) 幹細胞由来エクソソーム生成促進及び幹細胞能増強用組成物
JP6868307B2 (ja) 脂肪幹細胞由来のエキソソームを有効成分として含む肝線維症予防または治療用の組成物
CN110312515A (zh) 新的抗血管生成细胞外囊泡
KR102312937B1 (ko) 시신경 질환 예방 및 치료용 약학적 조성물
JP4629834B2 (ja) 神経細胞賦活剤およびその利用
RU2679741C2 (ru) Средства для поддержания недифференцированного состояния и стимуляции пролиферации стволовых клеток
ES2678023T3 (es) Factores extraídos de embriones de pez y uso de mezclas de los mismos en el control de la multiplicación y la diferenciación de células madre
KR20220099837A (ko) 스피룰리나를 이용한 중간엽줄기세포에서의 엑소좀 생산 방법
JP2022517983A (ja) クローナル幹細胞を含むアトピー皮膚炎の予防または治療用薬学的組成物
TW201717981A (zh) 苦瓜素之萃取方法、包含苦瓜素之醫藥組成物及其用途
KR20200112092A (ko) 지방줄기세포 유래 엑소좀을 유효성분으로 포함하는 전신경화증의 예방, 치료, 또는 개선용 조성물
KR20140065184A (ko) 와송의 에틸아세테이트 분획물을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물
US9289444B2 (en) Composition for promoting hematogenesis containing quercetin 3-O-β-(2″-galloyl)-rhamnopyranoside as active ingredient
US20150359827A1 (en) Blue-green algae extract mixtures and methods of use
KR20240159793A (ko) 우유 유래 엑소좀을 유효성분으로 포함하는 신장 기능 개선용 조성물
TW201828956A (zh) 體幹細胞用於增加血基質氧化酶位準的用途
TW201828957A (zh) 體幹細胞用於降低腦啡肽酶位準的用途
WO2019018256A1 (en) USE OF SOMATIC STEM CELLS TO INCREASE PRMT LEVEL
TW201828958A (zh) 體幹細胞用於增加過氧化物酶體增殖物活化受體γ之位準的用途
ITRM20080177A1 (it) Composizione per somministrazione umana o animale comprendente centella asiatica ed acido lipoico per il trattamento degli stati infiammatori