TWI740823B - 疫苗組成物及其用途 - Google Patents

疫苗組成物及其用途 Download PDF

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Publication number
TWI740823B
TWI740823B TW105111976A TW105111976A TWI740823B TW I740823 B TWI740823 B TW I740823B TW 105111976 A TW105111976 A TW 105111976A TW 105111976 A TW105111976 A TW 105111976A TW I740823 B TWI740823 B TW I740823B
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TW
Taiwan
Prior art keywords
crm
neu
crm197
peptide
fusion
Prior art date
Application number
TW105111976A
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English (en)
Chinese (zh)
Other versions
TW201705978A (zh
Inventor
烏蘇拉 委得曼
Original Assignee
澳大利亞商保健樂科技昆士蘭有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from AU2015901375A external-priority patent/AU2015901375A0/en
Application filed by 澳大利亞商保健樂科技昆士蘭有限公司 filed Critical 澳大利亞商保健樂科技昆士蘭有限公司
Publication of TW201705978A publication Critical patent/TW201705978A/zh
Application granted granted Critical
Publication of TWI740823B publication Critical patent/TWI740823B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103Receptors for growth factors
    • A61K39/001106Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/64Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/812Breast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/828Stomach
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16141Use of virus, viral particle or viral elements as a vector
    • C12N2760/16142Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW105111976A 2015-04-17 2016-04-15 疫苗組成物及其用途 TWI740823B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2015901375A AU2015901375A0 (en) 2015-04-17 A vaccine composition and uses thereof
AU2015901375 2015-04-17

Publications (2)

Publication Number Publication Date
TW201705978A TW201705978A (zh) 2017-02-16
TWI740823B true TWI740823B (zh) 2021-10-01

Family

ID=57125491

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105111976A TWI740823B (zh) 2015-04-17 2016-04-15 疫苗組成物及其用途

Country Status (13)

Country Link
US (1) US10532090B2 (enExample)
EP (1) EP3283105B1 (enExample)
JP (1) JP6957448B2 (enExample)
KR (1) KR102372615B1 (enExample)
CN (1) CN108025061B (enExample)
AU (1) AU2016250289B2 (enExample)
ES (1) ES2908071T3 (enExample)
NZ (1) NZ736194A (enExample)
RS (1) RS63080B1 (enExample)
RU (1) RU2726411C2 (enExample)
SG (1) SG11201708247XA (enExample)
TW (1) TWI740823B (enExample)
WO (1) WO2016164980A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210346484A1 (en) * 2017-12-11 2021-11-11 Medizinische Universitaet Wien Method of producing a vaccine composition and uses thereof
CA3090552A1 (en) * 2018-02-07 2019-08-15 Imugene Limited A vaccine composition and uses thereof
WO2022133447A1 (en) * 2020-12-16 2022-06-23 Dynavax Technologies Corporation Method for quantifying cpg-containing oligonucleotides in formulations comprising alum

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855321B1 (en) * 1998-04-27 2005-02-15 Chiron S.R.L. Polyepitope carrier protein
WO2011020604A1 (en) * 2009-08-18 2011-02-24 Pevion Biotech Ag Multiepitope vaccine for her2/neu-associated cancers
WO2013164354A1 (en) * 2012-05-01 2013-11-07 Affiris Ag Composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0739984A1 (en) * 1995-04-26 1996-10-30 San Tumorforschungs-Gmbh Bivalent polypeptides containing at least two domains
JP4658423B2 (ja) * 1999-08-03 2011-03-23 ザ オハイオ ステイト ユニバーシティ Her−2タンパク質に対する免疫反応性を増強するためのポリペプチドおよびポリヌクレオチド
EP1236740B1 (de) 2001-02-28 2012-07-18 Bio Life Science Forschungs- und Entwicklungsges.m.b.H. Vakzine gegen Krebserkrankungen, die mit dem HER-2/neu Onkogen assoziiert sind
WO2005021710A2 (en) * 2003-06-02 2005-03-10 University Of Miami Chimeric molecules and methods of use
EP1844788B1 (en) 2006-04-13 2010-07-14 Bio Life Science Forschungs- und Entwicklungsges.m.b.H. HER-2/neu multi-peptide vaccine
ES2528109T3 (es) * 2012-05-31 2015-02-04 Innavirvax Compuestos inmunogénicos que comprenden péptido gp41 de VIH acoplado a proteína portadora CRM197
EP3166646A4 (en) * 2014-07-07 2018-03-07 Duke University Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855321B1 (en) * 1998-04-27 2005-02-15 Chiron S.R.L. Polyepitope carrier protein
WO2011020604A1 (en) * 2009-08-18 2011-02-24 Pevion Biotech Ag Multiepitope vaccine for her2/neu-associated cancers
WO2013164354A1 (en) * 2012-05-01 2013-11-07 Affiris Ag Composition

Also Published As

Publication number Publication date
US10532090B2 (en) 2020-01-14
EP3283105A1 (en) 2018-02-21
CN108025061A (zh) 2018-05-11
TW201705978A (zh) 2017-02-16
EP3283105A4 (en) 2018-12-19
JP2018511659A (ja) 2018-04-26
SG11201708247XA (en) 2017-11-29
JP6957448B2 (ja) 2021-11-02
KR20180003560A (ko) 2018-01-09
RU2017137502A3 (enExample) 2019-09-16
KR102372615B1 (ko) 2022-03-08
RS63080B1 (sr) 2022-04-29
CN108025061B (zh) 2022-02-15
AU2016250289B2 (en) 2017-03-02
US20170119867A1 (en) 2017-05-04
RU2726411C2 (ru) 2020-07-14
BR112017021981A2 (pt) 2018-07-10
HK1248536A1 (zh) 2018-10-19
NZ736194A (en) 2022-08-26
EP3283105B1 (en) 2022-01-26
ES2908071T3 (es) 2022-04-27
RU2017137502A (ru) 2019-05-17
AU2016250289A1 (en) 2017-01-05
WO2016164980A1 (en) 2016-10-20

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