TWI733685B - 靶向il-23a與b細胞活化因子(baff)之化合物及其用途 - Google Patents
靶向il-23a與b細胞活化因子(baff)之化合物及其用途 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A—HUMAN NECESSITIES
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/53—Hinge
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- Immunology (AREA)
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- Genetics & Genomics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Microbiology (AREA)
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- Dermatology (AREA)
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- Epidemiology (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562196170P | 2015-07-23 | 2015-07-23 | |
| US62/196,170 | 2015-07-23 | ||
| US201562201067P | 2015-08-04 | 2015-08-04 | |
| US62/201,067 | 2015-08-04 | ||
| US201662355302P | 2016-06-27 | 2016-06-27 | |
| US62/355,302 | 2016-06-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201712030A TW201712030A (zh) | 2017-04-01 |
| TWI733685B true TWI733685B (zh) | 2021-07-21 |
Family
ID=57835236
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW105123026A TWI733685B (zh) | 2015-07-23 | 2016-07-21 | 靶向il-23a與b細胞活化因子(baff)之化合物及其用途 |
| TW110122529A TWI861413B (zh) | 2015-07-23 | 2016-07-21 | 靶向il-23a與b細胞活化因子(baff)之化合物及其用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110122529A TWI861413B (zh) | 2015-07-23 | 2016-07-21 | 靶向il-23a與b細胞活化因子(baff)之化合物及其用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10280231B2 (https=) |
| EP (1) | EP3322436A4 (https=) |
| JP (1) | JP6866345B2 (https=) |
| KR (1) | KR102644875B1 (https=) |
| CN (1) | CN108135976B (https=) |
| AU (1) | AU2016297575B2 (https=) |
| CL (1) | CL2018000182A1 (https=) |
| CO (1) | CO2018001264A2 (https=) |
| EA (1) | EA201890360A1 (https=) |
| IL (1) | IL256665B2 (https=) |
| MX (1) | MX2018000959A (https=) |
| MY (1) | MY191081A (https=) |
| PE (1) | PE20180774A1 (https=) |
| PH (2) | PH12021552628A1 (https=) |
| SA (1) | SA518390788B1 (https=) |
| SG (1) | SG10201912593VA (https=) |
| TW (2) | TWI733685B (https=) |
| UA (1) | UA125433C2 (https=) |
| WO (1) | WO2017015433A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI861413B (zh) * | 2015-07-23 | 2024-11-11 | 德商包林格因蓋爾漢國際股份有限公司 | 靶向il-23a與b細胞活化因子(baff)之化合物及其用途 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9963510B2 (en) | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| PE20141162A1 (es) | 2010-11-04 | 2014-09-18 | Boehringer Ingelheim Int | Anticuerpos anti-il-23 |
| EP4039275A1 (en) | 2012-05-03 | 2022-08-10 | Boehringer Ingelheim International GmbH | Anti-il-23p19 antibodies |
| EP3172339A1 (en) | 2014-07-24 | 2017-05-31 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| CN107206081A (zh) | 2015-02-04 | 2017-09-26 | 勃林格殷格翰国际有限公司 | 治疗炎性疾病的方法 |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US12577297B2 (en) | 2019-09-09 | 2026-03-17 | Boehringer Ingelheim International Gmbh | Anti-IL-23p19 antibody formulations |
| KR20240067099A (ko) * | 2021-09-30 | 2024-05-16 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항-il23 항체 융합 단백질 및 용도 |
| JP2026502957A (ja) * | 2022-12-28 | 2026-01-27 | スージョウ トランセンタ セラピューティクス カンパニー,リミテッド | 抗baff抗体を含む二重特異性結合タンパク質及びその使用 |
| WO2025007943A1 (zh) * | 2023-07-06 | 2025-01-09 | 荣昌生物制药(烟台)股份有限公司 | 用taci-fc融合蛋白治疗anca相关性血管炎的方法 |
| WO2025170982A2 (en) * | 2024-02-06 | 2025-08-14 | Paragon Therapeutics, Inc. | Il-23 antibody compositions and methods of use |
| WO2026008004A1 (zh) * | 2024-07-04 | 2026-01-08 | 荣昌生物制药(烟台)股份有限公司 | 用TACI-Fc融合蛋白治疗抗磷脂综合征的方法 |
| CN119638823A (zh) * | 2024-12-10 | 2025-03-18 | 中国医学科学院病原生物学研究所 | 检测a35r蛋白的单克隆抗体及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012018687A1 (en) * | 2010-08-02 | 2012-02-09 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| US20130280256A1 (en) * | 2012-04-20 | 2013-10-24 | Eli Lilly And Company | Anti-baff-anti-il-17 bispecific antibodies |
| WO2013177101A2 (en) * | 2012-05-22 | 2013-11-28 | Bristol-Myers Squibb Company | Bispecific antibodies and methods of using the same |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880635B1 (en) | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| JPH0825869B2 (ja) | 1987-02-09 | 1996-03-13 | 株式会社ビタミン研究所 | 抗腫瘍剤包埋リポソ−ム製剤 |
| US4917951A (en) | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| AU2001268427B2 (en) * | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| US9284375B2 (en) * | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| EP3479844B1 (en) | 2005-04-15 | 2023-11-22 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
| JP2010513245A (ja) | 2006-12-14 | 2010-04-30 | アクトジェニックス・エヌブイ | 免疫調節を誘起するための結合分子の送達 |
| EP3424951A1 (en) | 2007-06-21 | 2019-01-09 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
| BRPI0822099A2 (pt) | 2007-12-21 | 2017-05-23 | Medimmune Ltd | membro de ligação isolado, uso de um membro de ligação isolado, método parav tratar um distúrbio, molécula de ácido nucléico isolada, célula hospedeira, e, método para produzir um membro de ligação |
| MX2010012142A (es) * | 2008-05-09 | 2011-04-05 | Abbott Gmbh & Co Kg | Anticuerpos para receptor de productos finales de glucacion avanzada (rage) y usos de los mismos. |
| EP2376109B1 (en) | 2008-12-19 | 2019-01-23 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
| US20130129723A1 (en) * | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| GB201002238D0 (en) * | 2010-02-10 | 2010-03-31 | Affitech As | Antibodies |
| PL3053932T3 (pl) * | 2010-02-19 | 2021-03-08 | Xencor, Inc. | Nowe immunoadhezyny CTLA4-IG |
| EP4012714A1 (en) | 2010-03-23 | 2022-06-15 | Iogenetics, LLC. | Bioinformatic processes for determination of peptide binding |
| TWI426920B (zh) | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
| PE20141162A1 (es) * | 2010-11-04 | 2014-09-18 | Boehringer Ingelheim Int | Anticuerpos anti-il-23 |
| GB201020738D0 (en) | 2010-12-07 | 2011-01-19 | Affitech Res As | Antibodies |
| WO2012083370A1 (en) * | 2010-12-22 | 2012-06-28 | Cephalon Australia Pty Ltd | Modified antibody with improved half-life |
| EP2686345B1 (en) * | 2011-03-16 | 2018-04-25 | Amgen Inc. | Fc variants |
| TWI588156B (zh) | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| CA2860600C (en) | 2012-02-15 | 2022-07-26 | F. Hoffmann-La Roche Ag | Fc-receptor based affinity chromatography |
| GB201203071D0 (en) | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| KR102181776B1 (ko) * | 2012-06-05 | 2020-11-24 | 삼성전자주식회사 | 범용 디바이스에서의 파일 송/수신 장치 및 방법 |
| WO2014100490A1 (en) | 2012-12-19 | 2014-06-26 | Adimab, Llc | Multivalent antibody analogs, and methods of their preparation and use |
| JP2015088330A (ja) * | 2013-10-30 | 2015-05-07 | トヨタ自動車株式会社 | 硫黄含有全固体電池 |
| WO2015100246A1 (en) * | 2013-12-24 | 2015-07-02 | Ossianix, Inc. | Baff selective binding compounds and related methods |
| WO2016039801A1 (en) * | 2014-01-31 | 2016-03-17 | Boehringer Ingelheim International Gmbh | Novel anti-baff antibodies |
| IL256665B2 (en) * | 2015-07-23 | 2023-10-01 | Boehringer Ingelheim Int | IL-23A Targeting Compound and B-Cell Activating Factor Nucleic Acids Encoding Them and Use of Products Containing Them |
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012018687A1 (en) * | 2010-08-02 | 2012-02-09 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| US20130280256A1 (en) * | 2012-04-20 | 2013-10-24 | Eli Lilly And Company | Anti-baff-anti-il-17 bispecific antibodies |
| WO2013177101A2 (en) * | 2012-05-22 | 2013-11-28 | Bristol-Myers Squibb Company | Bispecific antibodies and methods of using the same |
Non-Patent Citations (3)
| Title |
|---|
| Lubberts, E. The IL-23–IL-17 axis in inflammatory arthritis. Nat Rev Rheumatol 11, 415–429 . Published:28 April 2015. |
| Su, Ding-Lei, et al. "Roles of pro-and anti-inflammatory cytokines in the pathogenesis of SLE." BioMed Research International 2012, p1-15 |
| Su, Ding-Lei, et al. "Roles of pro-and anti-inflammatory cytokines in the pathogenesis of SLE." BioMed Research International 2012, p1-15 Lubberts, E. The IL-23–IL-17 axis in inflammatory arthritis. Nat Rev Rheumatol 11, 415–429 . Published:28 April 2015. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI861413B (zh) * | 2015-07-23 | 2024-11-11 | 德商包林格因蓋爾漢國際股份有限公司 | 靶向il-23a與b細胞活化因子(baff)之化合物及其用途 |
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