TWI723131B - 6‐雜環基‐4‐嗎啉‐4‐芳基吡啶‐2‐酮化合物 - Google Patents

6‐雜環基‐4‐嗎啉‐4‐芳基吡啶‐2‐酮化合物 Download PDF

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TWI723131B
TWI723131B TW106105178A TW106105178A TWI723131B TW I723131 B TWI723131 B TW I723131B TW 106105178 A TW106105178 A TW 106105178A TW 106105178 A TW106105178 A TW 106105178A TW I723131 B TWI723131 B TW I723131B
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aryl
pyridin
1hydro
methylmorpholin
compound according
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TW106105178A
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Chinese (zh)
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TW201731843A (zh
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傑西卡 馬丁松
馬丁 安德森
約翰 林斯特龍
理查 佛斯伯龍
弗雷德里克 拉姆
托比亞斯 金曼
珍妮 維克倫
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瑞典商斯普林特生物科技公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Life Sciences & Earth Sciences (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW106105178A 2016-02-19 2017-02-17 6‐雜環基‐4‐嗎啉‐4‐芳基吡啶‐2‐酮化合物 TWI723131B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16156533.8 2016-02-19
EP16156533 2016-02-19

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TW201731843A TW201731843A (zh) 2017-09-16
TWI723131B true TWI723131B (zh) 2021-04-01

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US (2) US11179399B2 (https=)
EP (1) EP3416957B1 (https=)
JP (1) JP6858984B2 (https=)
CN (1) CN108884067B (https=)
AU (1) AU2017219847B2 (https=)
CY (1) CY1123349T1 (https=)
DK (1) DK3416957T3 (https=)
ES (1) ES2821400T3 (https=)
HR (1) HRP20201430T1 (https=)
HU (1) HUE051059T2 (https=)
LT (1) LT3416957T (https=)
PL (1) PL3416957T3 (https=)
PT (1) PT3416957T (https=)
RS (1) RS60900B1 (https=)
RU (1) RU2762968C2 (https=)
SI (1) SI3416957T1 (https=)
SM (1) SMT202000529T1 (https=)
TW (1) TWI723131B (https=)
WO (1) WO2017140843A1 (https=)

Families Citing this family (13)

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DK3416957T3 (da) * 2016-02-19 2020-09-21 Sprint Bioscience Ab 6-heterocyclyl-4-morpholin-4-ylpyridin-2-on-forbindelser anvendelige ved behandlingen af cancer og diabetes
US11560374B2 (en) * 2017-08-23 2023-01-24 Sprint Bioscience Ab Morpholinylpyridone compounds
CN111094271B (zh) 2017-08-23 2023-02-28 思普瑞特生物科学公司 吡啶胺-吡啶酮化合物和嘧啶胺-吡啶酮化合物
JP7199738B2 (ja) 2017-08-23 2023-01-06 スプリント バイオサイエンス アクティエボラーグ アザインドリルピリドンおよびジアザインドリルピリドン化合物
WO2019038387A1 (en) 2017-08-23 2019-02-28 Sprint Bioscience Ab PYRIDYLPYRIDONE COMPOUNDS
ES3032793T3 (en) 2018-04-10 2025-07-24 Neuropore Therapies Inc Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways
CN112533917B (zh) * 2018-04-10 2024-06-21 神经孔疗法股份有限公司 作为vps34的抑制剂的吗啉衍生物
WO2020008046A1 (en) 2018-07-06 2020-01-09 Sprint Bioscience Ab Biomarker
WO2021113506A1 (en) * 2019-12-04 2021-06-10 Chdi Foundation, Inc. Atm kinase inhibitors and compositions and methods of use thereof
EP4251165A1 (en) * 2020-11-25 2023-10-04 Deciphera Pharmaceuticals, LLC Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection
CA3199988A1 (en) 2020-11-25 2022-06-02 Daniel L. Flynn Pyridylpyridone derivatives as vsp34 inhibitors for use in the treatment of a viral infection
WO2022115562A1 (en) * 2020-11-25 2022-06-02 Deciphera Pharmaceuticals, Llc Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection
AU2022326573A1 (en) 2021-08-13 2024-02-15 Deciphera Pharmaceuticals, Llc Combination therapy of vps34 inhibitors and sting agonist for use in the treatment of cancer

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GB2465405A (en) 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
BRPI1015943A8 (pt) 2009-07-02 2018-01-09 Sanofi Sa derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica.
AU2011346567A1 (en) 2010-12-21 2013-07-25 Novartis Ag Bi-heteroaryl compounds as Vps34 inhibitors
DK2655375T3 (en) 2010-12-23 2015-03-09 Sanofi Sa PYRIMIDINON DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF
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DK3416957T3 (da) * 2016-02-19 2020-09-21 Sprint Bioscience Ab 6-heterocyclyl-4-morpholin-4-ylpyridin-2-on-forbindelser anvendelige ved behandlingen af cancer og diabetes

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JP2019505595A (ja) 2019-02-28
AU2017219847B2 (en) 2021-02-04
RU2018131766A (ru) 2020-03-20
JP6858984B2 (ja) 2021-04-14
CY1123349T1 (el) 2021-12-31
AU2017219847A1 (en) 2018-10-04
HRP20201430T1 (hr) 2020-11-27
HUE051059T2 (hu) 2021-03-01
PL3416957T3 (pl) 2021-02-08
US20210161906A1 (en) 2021-06-03
CA3015005A1 (en) 2017-08-24
RU2762968C2 (ru) 2021-12-24
TW201731843A (zh) 2017-09-16
DK3416957T3 (da) 2020-09-21
CN108884067B (zh) 2021-01-08
EP3416957A1 (en) 2018-12-26
US20220175788A1 (en) 2022-06-09
WO2017140843A1 (en) 2017-08-24
RU2018131766A3 (https=) 2020-03-24
PT3416957T (pt) 2020-09-25
CN108884067A (zh) 2018-11-23
US11963963B2 (en) 2024-04-23
LT3416957T (lt) 2020-11-25
ES2821400T3 (es) 2021-04-26
EP3416957B1 (en) 2020-07-01
US11179399B2 (en) 2021-11-23
SI3416957T1 (sl) 2020-11-30
RS60900B1 (sr) 2020-11-30
SMT202000529T1 (it) 2020-11-10

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