RU2762968C2 - 6-гетероциклил-4-морфолин-4-илпиридин-2-оны, пригодные для лечения рака и диабета - Google Patents

6-гетероциклил-4-морфолин-4-илпиридин-2-оны, пригодные для лечения рака и диабета Download PDF

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RU2762968C2
RU2762968C2 RU2018131766A RU2018131766A RU2762968C2 RU 2762968 C2 RU2762968 C2 RU 2762968C2 RU 2018131766 A RU2018131766 A RU 2018131766A RU 2018131766 A RU2018131766 A RU 2018131766A RU 2762968 C2 RU2762968 C2 RU 2762968C2
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pyridin
methylmorpholin
methyl
pyrrolidin
mmol
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RU2018131766A
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Russian (ru)
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RU2018131766A (ru
RU2018131766A3 (https=
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Джессика МАРТИНССОН
Мартин АНДЕРССОН
Йохан Линдстрём
Рикард ФОРСБЛОМ
Фредрик РАМ
Тобиас ЙИНМАН
Йенни Виклунд
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Спринт Биосайенс Аб
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2018131766A 2016-02-19 2017-02-17 6-гетероциклил-4-морфолин-4-илпиридин-2-оны, пригодные для лечения рака и диабета RU2762968C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16156533.8 2016-02-19
EP16156533 2016-02-19
PCT/EP2017/053614 WO2017140843A1 (en) 2016-02-19 2017-02-17 6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes

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RU2018131766A RU2018131766A (ru) 2020-03-20
RU2018131766A3 RU2018131766A3 (https=) 2020-03-24
RU2762968C2 true RU2762968C2 (ru) 2021-12-24

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RU2018131766A RU2762968C2 (ru) 2016-02-19 2017-02-17 6-гетероциклил-4-морфолин-4-илпиридин-2-оны, пригодные для лечения рака и диабета

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US (2) US11179399B2 (https=)
EP (1) EP3416957B1 (https=)
JP (1) JP6858984B2 (https=)
CN (1) CN108884067B (https=)
AU (1) AU2017219847B2 (https=)
CY (1) CY1123349T1 (https=)
DK (1) DK3416957T3 (https=)
ES (1) ES2821400T3 (https=)
HR (1) HRP20201430T1 (https=)
HU (1) HUE051059T2 (https=)
LT (1) LT3416957T (https=)
PL (1) PL3416957T3 (https=)
PT (1) PT3416957T (https=)
RS (1) RS60900B1 (https=)
RU (1) RU2762968C2 (https=)
SI (1) SI3416957T1 (https=)
SM (1) SMT202000529T1 (https=)
TW (1) TWI723131B (https=)
WO (1) WO2017140843A1 (https=)

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DK3416957T3 (da) * 2016-02-19 2020-09-21 Sprint Bioscience Ab 6-heterocyclyl-4-morpholin-4-ylpyridin-2-on-forbindelser anvendelige ved behandlingen af cancer og diabetes
US11560374B2 (en) * 2017-08-23 2023-01-24 Sprint Bioscience Ab Morpholinylpyridone compounds
CN111094271B (zh) 2017-08-23 2023-02-28 思普瑞特生物科学公司 吡啶胺-吡啶酮化合物和嘧啶胺-吡啶酮化合物
JP7199738B2 (ja) 2017-08-23 2023-01-06 スプリント バイオサイエンス アクティエボラーグ アザインドリルピリドンおよびジアザインドリルピリドン化合物
WO2019038387A1 (en) 2017-08-23 2019-02-28 Sprint Bioscience Ab PYRIDYLPYRIDONE COMPOUNDS
ES3032793T3 (en) 2018-04-10 2025-07-24 Neuropore Therapies Inc Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways
CN112533917B (zh) * 2018-04-10 2024-06-21 神经孔疗法股份有限公司 作为vps34的抑制剂的吗啉衍生物
WO2020008046A1 (en) 2018-07-06 2020-01-09 Sprint Bioscience Ab Biomarker
WO2021113506A1 (en) * 2019-12-04 2021-06-10 Chdi Foundation, Inc. Atm kinase inhibitors and compositions and methods of use thereof
EP4251165A1 (en) * 2020-11-25 2023-10-04 Deciphera Pharmaceuticals, LLC Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection
CA3199988A1 (en) 2020-11-25 2022-06-02 Daniel L. Flynn Pyridylpyridone derivatives as vsp34 inhibitors for use in the treatment of a viral infection
WO2022115562A1 (en) * 2020-11-25 2022-06-02 Deciphera Pharmaceuticals, Llc Morpholino derivatives as vsp34 inhibitors for use in the treatment of a viral infection
AU2022326573A1 (en) 2021-08-13 2024-02-15 Deciphera Pharmaceuticals, Llc Combination therapy of vps34 inhibitors and sting agonist for use in the treatment of cancer

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JP2019505595A (ja) 2019-02-28
AU2017219847B2 (en) 2021-02-04
RU2018131766A (ru) 2020-03-20
JP6858984B2 (ja) 2021-04-14
CY1123349T1 (el) 2021-12-31
AU2017219847A1 (en) 2018-10-04
HRP20201430T1 (hr) 2020-11-27
HUE051059T2 (hu) 2021-03-01
PL3416957T3 (pl) 2021-02-08
US20210161906A1 (en) 2021-06-03
CA3015005A1 (en) 2017-08-24
TW201731843A (zh) 2017-09-16
DK3416957T3 (da) 2020-09-21
CN108884067B (zh) 2021-01-08
EP3416957A1 (en) 2018-12-26
US20220175788A1 (en) 2022-06-09
TWI723131B (zh) 2021-04-01
WO2017140843A1 (en) 2017-08-24
RU2018131766A3 (https=) 2020-03-24
PT3416957T (pt) 2020-09-25
CN108884067A (zh) 2018-11-23
US11963963B2 (en) 2024-04-23
LT3416957T (lt) 2020-11-25
ES2821400T3 (es) 2021-04-26
EP3416957B1 (en) 2020-07-01
US11179399B2 (en) 2021-11-23
SI3416957T1 (sl) 2020-11-30
RS60900B1 (sr) 2020-11-30
SMT202000529T1 (it) 2020-11-10

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