TWI712686B - 用於微流體裝置之培養站 - Google Patents

用於微流體裝置之培養站 Download PDF

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TWI712686B
TWI712686B TW105112528A TW105112528A TWI712686B TW I712686 B TWI712686 B TW I712686B TW 105112528 A TW105112528 A TW 105112528A TW 105112528 A TW105112528 A TW 105112528A TW I712686 B TWI712686 B TW I712686B
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microfluidic device
microns
station
minutes
microfluidic
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TW105112528A
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Chinese (zh)
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TW201643240A (zh
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凱斯Ｊ 布林格
羅素Ａ 紐斯壯
Ｊ 坦納 尼維爾
傑森Ｍ 麥克艾文
大衛Ａ 威斯貝克
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美商柏克萊燈光有限公司
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • C—CHEMISTRY; METALLURGY
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
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    • C12M23/20—Material Coatings
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/34—Internal compartments or partitions
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
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    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/50—Means for positioning or orientating the apparatus
    • C—CHEMISTRY; METALLURGY
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    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
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    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/06—Means for regulation, monitoring, measurement or control, e.g. flow regulation of illumination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Microbiology (AREA)
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  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
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  • Computer Hardware Design (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW105112528A 2015-04-22 2016-04-21 用於微流體裝置之培養站 TWI712686B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562178960P 2015-04-22 2015-04-22
US62/178,960 2015-04-22

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TW201643240A TW201643240A (zh) 2016-12-16
TWI712686B true TWI712686B (zh) 2020-12-11

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US (1) US20160340632A1 (https=)
EP (1) EP3286298A1 (https=)
JP (3) JP6805166B2 (https=)
KR (2) KR102546378B1 (https=)
CN (1) CN107532119A (https=)
AU (2) AU2016250580B2 (https=)
CA (1) CA2982412C (https=)
HK (1) HK1248750A1 (https=)
IL (2) IL290119B2 (https=)
SG (2) SG10202011358PA (https=)
TW (1) TWI712686B (https=)
WO (1) WO2016172350A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI903592B (zh) * 2024-06-26 2025-11-01 國立成功大學 組織檢測方法

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3078634A1 (en) * 2016-10-07 2018-04-12 Xinyu Liu A microfluidic analytical platform for autonomous immunoassays
CN110268108B (zh) 2016-12-12 2022-09-06 埃克切拉生物科学公司 用于使用微毛细管阵列进行筛选的方法和系统
EP3562796B1 (en) 2016-12-30 2023-04-19 Xcella Biosciences, Inc. Multi-stage sample recovery system
KR20200026878A (ko) 2017-06-06 2020-03-11 지머젠 인코포레이티드 균류 균주를 개량하기 위한 htp 게놈 공학 플랫폼
US11926814B2 (en) * 2017-08-23 2024-03-12 Northwestern University Multi-chamber fluidic platform
CN111201434A (zh) * 2017-10-16 2020-05-26 瑞泽恩制药公司 用于控制细胞培养物中的过程变量的原位拉曼光谱系统和方法
TWI699494B (zh) * 2018-01-24 2020-07-21 美商伊路米納有限公司 流體緩衝
US10307783B1 (en) * 2018-05-15 2019-06-04 The Procter & Gamble Company Microfluidic cartridge and microfluidic delivery device comprising the same
BR112020024839A2 (pt) 2018-06-06 2021-05-18 Zymergen Inc. manipulação de genes envolvidos em transdução de sinal para controlar a morfologia fúngica durante a fermentação e produção
CN112703059A (zh) * 2018-07-12 2021-04-23 伯克利之光生命科技公司 针对抗病性状筛选植物原生质体
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
BR112021006773A2 (pt) * 2018-10-10 2021-07-13 Stamm Vegh Corporation microbiorreator de fluxo contínuo
CN109465040B (zh) * 2018-10-16 2021-05-04 浙江优众新材料科技有限公司 一种微流控芯片的密封装置
ES3039910T3 (en) 2018-12-06 2025-10-27 Xcella Biosciences Inc Lateral loading of microcapillary arrays
WO2020168258A1 (en) 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
JP7209079B2 (ja) * 2019-03-19 2023-01-19 富士フイルム株式会社 細胞培養システム及び細胞培養方法
WO2020189219A1 (ja) 2019-03-19 2020-09-24 富士フイルム株式会社 情報処理装置、細胞培養システム、情報処理方法、及び情報処理プログラム
WO2020223555A1 (en) 2019-04-30 2020-11-05 Berkeley Lights, Inc. Methods for encapsulating and assaying cells
US11566217B2 (en) * 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
EP3839037B1 (en) * 2019-12-20 2022-08-17 Astraveus Bioprocessing device
EP4450281A3 (en) 2020-02-03 2025-01-22 Stamm Vegh Corporation Platform, systems, and devices for 3d printing
DE102020107599B3 (de) * 2020-03-19 2021-07-22 Ibidi Gmbh Verfahren zur Kultivierung von Zellen
EP4180510A4 (en) * 2020-07-07 2024-08-21 Shimadzu Corporation CELL CULTURE SYSTEM
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
CN115885031A (zh) * 2020-08-26 2023-03-31 株式会社岛津制作所 细胞培养容器和细胞培养系统
KR102605221B1 (ko) * 2021-07-02 2023-11-24 고려대학교 산학협력단 세포 광자극 장치
US12252678B2 (en) 2021-12-01 2025-03-18 Microfluidx Ltd Systems and methods for bioprocessing
TWI833614B (zh) * 2023-03-23 2024-02-21 揚朋科技股份有限公司 細胞製備系統

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070048863A1 (en) * 2005-07-25 2007-03-01 Bioprocessors Corp. Computerized factorial experimental design and control of reaction sites and arrays thereof
US20070196237A1 (en) * 2006-02-17 2007-08-23 Agency For Science, Technology And Research Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same
US20080299539A1 (en) * 2005-10-07 2008-12-04 Harry Lee Parallel integrated bioreactor device and method
US20100068706A1 (en) * 1998-12-24 2010-03-18 Cepheid Method for separating an analyte from a sample
EP2397224A1 (en) * 2010-06-15 2011-12-21 arrayon biotechnology S.A. Apparatus and platform for multiplex analysis
TW201211242A (en) * 2010-06-17 2012-03-16 Geneasys Pty Ltd Microfluidic device for genetic and mitochondrial analysis of a biological sample
US20130048089A1 (en) * 2010-04-29 2013-02-28 Nils B. Adey Analytical System For Performing Laboratory Protocols and Associated Methods

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
US7507579B2 (en) * 2002-05-01 2009-03-24 Massachusetts Institute Of Technology Apparatus and methods for simultaneous operation of miniaturized reactors
US7745203B2 (en) * 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
CN1177033C (zh) * 2002-11-05 2004-11-24 中国科学院上海技术物理研究所 动态空间细胞培养系统
US7612355B2 (en) 2004-04-12 2009-11-03 The Regents Of The University Of California Optoelectronic tweezers for microparticle and cell manipulation
GB0505379D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Cellular entity maturation and transportation systems
JP2006308332A (ja) * 2005-04-26 2006-11-09 Moritex Corp 固定反応物質と液体反応物質との反応用フローセル及び反応装置並びに反応装置の運転方法
WO2008119066A1 (en) 2007-03-28 2008-10-02 The Regents Of The University Of California Single-sided lateral-field and phototransistor-based optoelectronic tweezers
US10078075B2 (en) * 2011-12-09 2018-09-18 Vanderbilt University Integrated organ-on-chip systems and applications of the same
WO2014081840A1 (en) * 2012-11-21 2014-05-30 Vanderbilt University Organ on chip integration and applications of the same
WO2013086329A1 (en) * 2011-12-08 2013-06-13 Research Triangle Institute Human emulated response with microfluidic enhanced systems
CN104284725B (zh) * 2012-02-27 2017-04-26 洛桑联邦理工学院 具有可拆卸载玻片的样品处理装置
US9403172B2 (en) 2012-11-08 2016-08-02 Berkeley Lights, Inc. Circuit based optoelectronic tweezers
CN103667054B (zh) * 2013-09-18 2015-09-30 中国航天员科研训练中心 一种集成化微流控细胞培养芯片及其制备方法
EP3060645B1 (en) * 2013-10-22 2019-01-02 Berkeley Lights, Inc. Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
CN104073426B (zh) * 2014-06-27 2016-03-30 江苏卓微生物科技有限公司 细胞检测芯片适配器安装座

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100068706A1 (en) * 1998-12-24 2010-03-18 Cepheid Method for separating an analyte from a sample
US20070048863A1 (en) * 2005-07-25 2007-03-01 Bioprocessors Corp. Computerized factorial experimental design and control of reaction sites and arrays thereof
US20080299539A1 (en) * 2005-10-07 2008-12-04 Harry Lee Parallel integrated bioreactor device and method
US20070196237A1 (en) * 2006-02-17 2007-08-23 Agency For Science, Technology And Research Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same
US20130048089A1 (en) * 2010-04-29 2013-02-28 Nils B. Adey Analytical System For Performing Laboratory Protocols and Associated Methods
EP2397224A1 (en) * 2010-06-15 2011-12-21 arrayon biotechnology S.A. Apparatus and platform for multiplex analysis
TW201211242A (en) * 2010-06-17 2012-03-16 Geneasys Pty Ltd Microfluidic device for genetic and mitochondrial analysis of a biological sample

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI903592B (zh) * 2024-06-26 2025-11-01 國立成功大學 組織檢測方法

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