TWI711469B - Antimicrobial composition and preparation method thereof - Google Patents

Abstract

An antimicrobial composition is provided. The antimicrobial composition includes a cationic antimicrobial agent, a non-ionic surfactant, an acid-base regulator, and a colorant. A preparation method of antimicrobial composition is also provided. The preparation method includes the following steps: providing a non-ionic surfactant solution, mixing an acid-base regulator which is carboxyl group-containing organic acid and a non-ionic surfactant solution, and mixing a colorant, a cationic antimicrobial agent, and the pH adjusted non-ionic surfactant solution to obtain the antimicrobial composition.

Description

Antimicrobial composition and preparation method thereof

The present invention relates to an antimicrobial composition and a preparation method thereof, and particularly relates to an antimicrobial composition with a cationic antimicrobial agent and a preparation method thereof.

Many infectious diseases are spread by contact, such as skin-to-skin contact, or skin-to-environmental surfaces with pathogens. The high population density nowadays increases the chance of exposure to pathogens in public places due to the above two reasons. If the mouth and nose are not cleaned after contact with pathogens, there is a very high risk of infection.

As the first-line hospital to care for patients, it is also the main area where germs gather. In the hospital, medical staff, patients and their families have the opportunity to come into contact with pathogens, especially medical staff have a very high probability of becoming a medium for spreading germs. There have been studies conducted on the hands, work clothes, stethoscopes and workbenches of medical staff. They have cultivated resistant strains. If infection control is not done in the hospital, it will bring great threat to patients.

In order to reduce the aforementioned various infection risks, many antimicrobial compositions have been developed. Cationic antimicrobial agents are often used as the main active ingredients of commercially available antimicrobial compositions. However, the nature of cationic antimicrobial agents is relatively unstable and prone to precipitation, and the industrial process is quite difficult. Among them, chlorhexidine gluconate (Chlorhexidine Gluconate), a cationic antimicrobial agent, has many restrictions in the formulation, for example: (1) Because chlorhexidine gluconate is a cationic compound, it will be difficult to form when encountering anionic substances. Salts soluble in water cause precipitation and may lead to a decrease in antimicrobial ability; (2) Chlorhexidine gluconate when used with cationic surfactants or nonionic surfactants, high concentration of interfacial activity The agent will form micelles and reduce the antimicrobial ability of chlorhexidine gluconate; (3) When the concentration of chlorhexidine gluconate exceeds 0.05% (weight/volume percentage), it will encounter inorganic acids, some organic acids and Its salts (such as: benzoates, bicarbonates, borates, carbonates, chlorides, citrates, iodides) ), nitrates, phosphates and sulfates are prone to precipitation. If the concentration of chlorhexidine gluconate is less than 0.01% (w/v), precipitation will not occur; (4) ) general tap water contains chlorine ions (Cl ^-), carbonate ions (CO ₃ ^2-), sulfate ion (SO ₄ ^2-), phosphate ion (PO ₄ ^3-), calcium (Ca ^2+), Magnesium ion (Mg ²⁺ ) ion will combine with chlorhexidine gluconate to produce precipitation; and (5) chlorhexidine gluconate is incompatible with some thickening agents, such as acacia, alginic acid Sodium (sodium alginate), sodium carboxymethylcellulose (sodium carboxymethylcellulose), starch (starch) and tragacanth (tragacanth) will react with chlorhexidine gluconate to produce precipitation. Therefore, how to develop an antimicrobial composition with a stable process and a product that is not easy to precipitate, the existing technology needs to be improved.

The purpose of the present disclosure is to provide an antimicrobial composition, which contains a cationic antimicrobial agent but does not easily produce precipitation.

The present disclosure provides an antimicrobial composition comprising a cationic antimicrobial agent, a non-ionic surfactant, an acid-base regulator, and a coloring agent, wherein the acid-base regulator is an organic acid containing a carboxyl group.

In some embodiments, the cationic antimicrobial agent includes, but is not limited to, chlorhexidine, salts of chlorhexidine, polyhexamethylene biguanide, benzalkonium halides, or combinations thereof . The benzalkonium halides include, but are not limited to, benzalkonium chloride, benzalkonium bromide, or a combination thereof.

In some embodiments, the salts of chlorhexidine include, but are not limited to, chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, and chlorhexidine hydrochloride. Set (chlorhexidine hydrochloride) or a combination thereof.

In some embodiments, the non-ionic surfactant includes, but is not limited to, decyl glucoside, cocamide dea, polyoxyethylene alkyl ether, polysorbate Polysorbate 20 or a combination thereof.

In some embodiments, the acid-base regulator includes, but is not limited to, lactic acid, citric acid, or a combination thereof.

In some embodiments, the colorant includes, but is not limited to, tartrazine (FD & C Yellow No. 5, tartrazine), ponceau (ponceau 4R), brilliant blue (FCF), sunset yellow (sunset yellow), Quinoline yellow (D & C Yellow No. 10, quinoline yellow), acid red 33 (D & C Red No. 33), allura red (allura red) or a combination thereof.

In some embodiments, the total volume of the antimicrobial composition is 100%, the weight/volume percentage of the cationic antimicrobial agent is 0.5% to 4%, and the weight/volume percentage of the nonionic surfactant is 3.5% to 10.5%, the weight/volume percentage of the acid-base regulator is 0.13% to 0.18%, and the weight/volume percentage of the coloring agent is 0.00002% to 0.036%.

In some embodiments, the cationic antimicrobial agent is chlorhexidine gluconate and the weight/volume percentage is 1.6% to 2.4%.

In some embodiments, the colorant is tartrazine and the weight/volume percentage is 0.00002% to 0.00006%.

In some embodiments, the antimicrobial composition further includes a thickener.

In some embodiments, the thickener includes, but is not limited to, hydroxy ethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, or a combination thereof.

In some embodiments, the antimicrobial composition further includes a moisture retention agent.

In some embodiments, the humectant includes, but is not limited to, glycerol, propylene glycol, sorbitol, or a combination thereof.

In some embodiments, the antimicrobial composition further includes an antifoaming agent.

In some embodiments, the antifoaming agent includes, but is not limited to, isopropyl alcohol, ethanol, or a combination thereof.

In some embodiments, the antimicrobial composition further includes a thickening agent, a humectant and an antifoaming agent, wherein the total volume of the antimicrobial composition is 100%, and the weight/volume percentage of the cationic antimicrobial agent is 0.5% to 4%, the weight/volume percentage of non-ionic surfactant is 3.5% to 10.5%, the weight/volume percentage of acid-base regulator is 0.13% to 0.18%, and the weight/volume percentage of colorant is 0.00002% to 0.036% , The weight/volume percentage of the thickener is 0.27% to 0.35%, the weight/volume percentage of the humectant is 0.1% to 5.0%, and the weight/volume percentage of the defoamer is 1.0% to 4.0%.

In some embodiments, the antimicrobial composition is contained in a container, and the material of the container includes, but is not limited to, high-density polyethylene, low-density polyethylene, polyethylene terephthalate, or a combination thereof.

Another object of the present disclosure is to provide a method for preparing an antimicrobial composition, so as to achieve the effect of stabilizing the cationic antimicrobial agent without precipitation during the preparation process.

The present disclosure provides a method for preparing an antimicrobial composition, comprising: providing a non-ionic surfactant aqueous solution; mixing an acid-base regulator and a non-ionic surfactant aqueous solution, wherein the acid-base regulator is an organic acid containing a carboxyl group , And used to adjust the pH value of the nonionic surfactant aqueous solution; and mix the colorant, the cationic antimicrobial agent, and the adjusted pH value of the nonionic surfactant aqueous solution to obtain an antimicrobial composition.

In some embodiments, the non-ionic surfactant comprises decyl glucoside, coco diethanolamine, polyoxyethylene alkyl ether, polysorbate twenty or a combination thereof.

In some embodiments, in the step of mixing the acid-base regulator and the nonionic surfactant aqueous solution, the acid-base regulator is lactic acid, and the adjusted acid-base value is pH 5.5 to pH 6.5.

In some embodiments, the cationic antimicrobial agent is chlorhexidine gluconate, and the weight/volume percentage of chlorhexidine gluconate is 2%.

In some embodiments, the step of providing an aqueous solution of a nonionic surfactant includes: mixing a humectant, a thickener and water to obtain an aqueous solution with a humectant and a thickener; The aqueous solution is mixed with the nonionic surfactant to form an aqueous solution of the nonionic surfactant.

In some embodiments, the step of mixing the colorant, the cationic antimicrobial agent, and the pH-adjusted nonionic surfactant aqueous solution includes: mixing the colorant, the cationic antimicrobial agent, and the pH-adjusted nonionic surfactant solution. An aqueous solution of an ionic surfactant is mixed with a defoamer to obtain an antimicrobial composition.

In view of the above, due to the unstable chemical properties of the cationic antimicrobial agent, it is easy to react with other ingredients in the antimicrobial composition to produce precipitation. With the composition ratio and preparation method of the present disclosure, the cationic antimicrobial agent can be The antimicrobial composition is not easy to produce precipitation effect. In terms of composition ratio, the use of non-ionic surfactants instead of anionic surfactants and amphoteric surfactants, and the use of organic acids containing carboxyl groups as acid-base regulators are all helpful to avoid the formation of cationic antimicrobial agents. The salt is hardly soluble in water and precipitates. In some embodiments, lactic acid is particularly selected as the acid-base regulator, and specific coloring agents are selected, and the amount of coloring agent used can be controlled to further improve the stability of the cationic antimicrobial agent in the antimicrobial composition, and reduce The amount of precipitation, or the chance of precipitation. Even if coloring agents that are anionic substances are used, controlling the amount of colorant used can prevent precipitation of antimicrobial agents, and the non-ionic surfactants and polyols added to the ingredients can also be used as solvents to add cationic antimicrobial Compatibility with different colorants.

In terms of the preparation method, controlling the pH value during the preparation process can effectively prevent the cationic antimicrobial agent from precipitating during the preparation process or storage and transportation of the antimicrobial composition. Preventing the cationic antimicrobial agent from generating precipitation in the antimicrobial composition can ensure that the content of the cationic antimicrobial agent in the antimicrobial composition is stable, and can achieve the antimicrobial effect.

In order to make the description of the present disclosure more detailed and complete, the following describes the implementation and specific embodiments of the present invention in detail; but this is not the only way to implement or use the specific embodiments of the present disclosure. The embodiments disclosed below can be combined or substituted with each other under beneficial circumstances, and other embodiments can also be added to an embodiment without further description or description.

The words "include", "include", "have" and similar words used in this text indicate the recorded features, regions, integers, steps, operations, elements and/or components, but do not exclude other features and regions , Integers, steps, operations, elements, components, and/or groups thereof.

Herein, the term "container" is used in the text to include, but is not limited to, a fixed shape or a non-fixed shape, such as a bag, a can, a tube, or a bottle.

The antimicrobial composition of various embodiments of the present invention mainly includes a cationic antimicrobial agent, a nonionic surfactant, an acid-base regulator and a coloring agent. Others such as thickeners, humectants, defoamers, fragrances, etc. are added according to product requirements.

Cationic antimicrobial agents include, but are not limited to, chlorhexidine, chlorhexidine salts, polyhexamethylene biguanide, benzalkonium halides, or combinations thereof. Salts of chlorhexidine include, but are not limited to, chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine hydrochloride, or a combination thereof. The benzalkonium halides include, but are not limited to, benzalkonium chloride, benzalkonium bromide, or a combination thereof. The concentration of the cationic antimicrobial agent ranges from 0.5 weight/volume percentage (w/v%) to 4w/v%. In some embodiments, the concentration of chlorhexidine gluconate may be 0.5w/v%, 1w/v%, 1.5w/v%, 2w/v%, 2.5w/v%, 3w/v%, 3.5w /v% or 4w/v%. Cationic antimicrobial agent is the main active ingredient in the antimicrobial composition. It combines positively charged molecules with negatively charged parts on the microbial cell wall, destroying the microbial cell wall, causing leakage of cell contents, and cell death. To achieve anti-microbial effect.

Non-ionic surfactants include, but are not limited to, decyl glucoside, coconut oil diethanolamine, polyoxyethylene alkyl ether, polysorbate twenty or a combination thereof, and the concentration of non-ionic surfactant is 3.5 w/v % To 10.5w/v%. In some embodiments, the nonionic surfactant is a basic nonionic surfactant, for example, decyl glucoside, and the concentration of decyl glucoside is 3.5w/v%, 3.57w/v%, 4w /v%, 4.5w/v%, 5w/v%, 5.5w/v%, 6w/v%, 6.5w/v%, 7w/v%, 7.5w/v%, 8w/v%, 8.5w /v%, 9w/v%, 9.5w/v%, 10w/v% or 10.5w/v%. Non-ionic surfactants have no charge at the hydrophilic end and will not dissociate when dissolved in water, so they have high stability and are not easily affected by the presence of strong electrolytes, and are not easily affected by acids and bases. Therefore, the use of non-ionic surfactants hardly react with cationic antimicrobial agents to cause precipitation.

Acid-base regulators include, but are not limited to, organic acids containing carboxyl groups. The carboxyl-containing organic acid includes lactic acid, citric acid or a combination thereof, and the concentration of the acid-base regulator is 0.13 w/v% to 0.18 w/v%. In some embodiments, the acid-base regulator is lactic acid, and the concentration of lactic acid is 0.13w/v%, 0.14w/v%, 0.15w/v%, 0.16w/v%, 0.17w/v%, or 0.18 w/v%. The main advantage of choosing organic acids containing carboxyl groups as acid-base regulators is that they are not easy to react with cationic antimicrobial agents to produce precipitation. Generally speaking, the common acid-base regulators are inorganic acids, such as hydrochloric acid and sulfuric acid. However, these inorganic acids are strong electrolytes and can completely dissociate hydrogen ions and their conjugate alkali ions when dissolved in water, and their conjugate alkali ions can easily react with cationic antimicrobial agents to form water-insoluble salts. Organic acids, especially those containing carboxyl groups, are weak electrolytes and can only be partially dissociated when dissolved in water, and are less likely to react with cationic antimicrobial agents. Preferably, lactic acid can be selected as the acid-base regulator, which is cheaper and easily available compared to other acid-base regulators. For example, gluconolactone, the use of lactic acid to adjust the pH of the solution requires less amount, because the pH value of lactic acid (pH1.75, 10w/v% lactic acid aqueous solution) is higher than the pH value of gluconolactone (pH3. 6) It is low, and the solution can be adjusted to the target pH value quickly, for example, the pH value is adjusted to pH 7 or less.

Coloring agents of different colors can be added according to requirements, such as antimicrobial compositions used on the surface of human skin or antimicrobial compositions used for environmental cleaning, and coloring agents of different colors can be added as a partition. In addition, adding a little coloring agent to make the antimicrobial composition have a color, and the area to be applied can be directly identified with the naked eye during use, which is also the purpose of the coloring agent. The colorant includes, but is not limited to, tartrazine, carmine, brilliant blue, sunset yellow, quinoline yellow, acid red 33, allure red or a combination thereof, and the concentration of the colorant in the antimicrobial composition is 0.00002w/v% To 0.036w/v% to avoid precipitation of cationic antimicrobial agents. In some embodiments, the concentration of the colorant in the antimicrobial composition may be 0.00002w/v% to 0.006w/v%, preferably 0.00002w/v% to 0.00006w/v%. In some embodiments, the colorant is tartrazine, and the concentration of tartrazine is 0.00002w/v%, 0.00003w/v%, 0.00004w/v%, 0.00005w/v%, or 0.00006w/v%. The colorant is an anionic substance, which has a negative charge in its structure and can easily form a water-insoluble salt with the positive charge on the cationic antimicrobial agent to cause precipitation. However, controlling the amount of colorant used, such as controlling it below 0.036w/v%, can prevent cationic antimicrobial agents from reacting and causing precipitation. Secondly, solvents other than water in the antimicrobial composition, such as non-ionic surfactants and polyols, can also increase the compatibility of the colorant and the cationic antimicrobial agent.

The thickener includes but is not limited to hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose or a combination thereof, and the concentration is adjusted to 0.27w/v% to 0.35w/v% according to the required consistency, It can prevent the antimicrobial composition from flowing out without pressing when it is loaded in a container with the opening facing down, such as a wall-mounted press bottle. In some embodiments, the thickener is hydroxyethyl cellulose, and the concentration of hydroxyethyl cellulose is 0.27w/v%, 0.28w/v%, 0.29w/v%, 0.3w/v%, 0.31 w/v%, 0.32w/v%, 0.33w/v%, 0.34w/v% or 0.35w/v%.

The humectant includes but is not limited to glycerin, propylene glycol, sorbitol or a combination thereof, and the concentration of the humectant is 0.1 w/v% to 5.0 w/v%. In some embodiments, the humectant is glycerin, and the concentration of glycerin is 0.1w/v%, 1w/v%, 2w/v%, 3w/v%, 4w/v%, or 5w/v%. Since the non-ionic surfactant in the antimicrobial agent will cause the moisturizing substance in the stratum corneum of the skin to be lost and cause dryness, adding a moisturizer can reduce irritation and protect the skin. Secondly, the polyols added as a humectant can also increase the compatibility of the colorant and the cationic antimicrobial agent.

The defoamer includes, but is not limited to, isopropanol, ethanol or a combination thereof, and the concentration of the defoamer is 1.0 w/v% to 4.0 w/v%. In some embodiments, the antifoaming agent is isopropanol, and the concentration of isopropanol is 1w/v%, 2w/v%, 3w/v%, or 4w/v%. Because the microbial composition contains surfactants, the foam produced during the production process is not easy to eliminate. Although the foam will not affect the efficacy of the cationic antimicrobial agent, the large amount of foam produced during the process will affect the interpretation of the pH value and the filling difficult. Adding a defoamer can change the surface tension, so that the local surface tension of the foam is reduced and the foam is collapsed, achieving the effect of defoaming.

The antimicrobial composition can be selected to add fragrances with different odors according to requirements, and the type and amount of fragrances used are not limited in the present invention.

In a specific embodiment, the antimicrobial composition is prepared according to the ratio of ingredients listed in Table 1:

In a specific embodiment, the antimicrobial composition is contained in a container, and the material of the container is selected to avoid precipitation when reacting with chlorhexidine gluconate. The material of the container includes, but is not limited to, polyethylene, polyethylene terephthalate (PET), or a combination thereof. Polyethylene can be divided into high density polyethylene (HDPE) and low density polyethylene (LDPE). The outer shape of the container can be designed according to use requirements, for example, a bottle shape or a tube shape, and the present invention is not limited.

Another aspect of the present invention is to provide a method for preparing the antimicrobial composition. Although a series of operations or steps are used in the following to illustrate the method disclosed herein, the sequence of these operations or steps should not be construed as a limitation of the present invention. For example, certain operations or steps may be performed in a different order and/or simultaneously with other steps. In addition, not all operations, steps, and/or features must be performed to implement the embodiments of the present invention. Furthermore, each operation or step described herein may include several sub-steps or actions.

The preparation method of the antimicrobial composition of the embodiment of the present invention is prepared by the following steps: (1) Provide a nonionic surfactant aqueous solution; (2) Add acid-base regulator to the nonionic surfactant aqueous solution (3) After mixing the colorant and pure water, add it to the aqueous solution of non-ionic surfactant and stir until uniform; (4) Add the cationic antimicrobial agent to the aqueous solution of non-ionic surfactant and stir to Uniformity; (5) After adding pure water to the non-ionic surfactant aqueous solution containing non-ionic surfactant, acid-base regulator, coloring agent and cationic antimicrobial agent, the antimicrobial composition is obtained after quantitative.

In step (1), when the nonionic surfactant aqueous solution is provided, the nonionic surfactant can be added to pure water and stirred until uniform. In some embodiments, the humectant and the thickener can be mixed first until the dispersion is uniform and there is no agglomeration, then poured into pure water and stirred until dissolved, and then a non-ionic surfactant is added and stirred until uniform to obtain a non-ionic interface Active agent aqueous solution.

In step (2), the acid-base regulator is an organic acid containing a carboxyl group, which is used to adjust the pH value of the aqueous solution of the non-ionic surfactant from greater than pH 11 to less than pH 7, preferably about pH 5.5 to pH 6.5 In some embodiments, it is adjusted to pH 5.8 to pH 6.2. Since the pH value of the non-ionic surfactant is relatively high, adjusting the pH value in this step can avoid precipitation of the cationic antimicrobial agent added later due to the high pH value. The acid-base regulator is preferably lactic acid, the advantages of which have been described in detail above, and will not be repeated here.

In step (3), since the selection and addition ratio of the coloring agent will affect the possibility of precipitation of the cationic antimicrobial agent, refer to the selection and addition ratio of the aforementioned coloring agent. In addition to coloring agents, flavors can be added as required. After adding the coloring agent, add perfume directly to the non-ionic surfactant aqueous solution until it is evenly stirred.

Before adding the cationic antimicrobial agent in step (4), it is necessary to confirm that the pH value of the nonionic surfactant aqueous solution is between pH 5.5 and 6.5 to prevent the cationic antimicrobial agent from precipitating due to excessive pH.

In step (5), adding pure water quantitatively refers to adding pure water to the weight of the antimicrobial composition intended to be prepared. For example, if it is scheduled to prepare 1 liter of antimicrobial composition, pure water is added in step (5) until the final product is 1 liter. Finally, measure the pH of the aqueous solution to be 5.0 to 7.0, preferably 6.0 to 6.5, to obtain the antimicrobial composition. In some embodiments, prior to adding pure water, a defoamer can be added to the aqueous solution of nonionic surfactant and stirred until uniform, so as to eliminate foam on the surface of the aqueous solution of nonionic surfactant.

In a specific embodiment, the antimicrobial composition can be prepared by the aforementioned steps according to the composition ratio listed in Table 1.

In a specific embodiment, the antimicrobial composition mainly includes a cationic antimicrobial agent, a nonionic surfactant, an acid-base regulator, a coloring agent, and a solvent. In some embodiments, the solvent is water. Others such as thickeners, humectants, defoamers, fragrances, etc. are added according to product requirements. Because when the cationic antimicrobial agent is chlorhexidine gluconate, its properties are relatively unstable and easy to produce precipitation. In order to avoid the occurrence of precipitation and reduce the content of chlorhexidine gluconate, which in turn affects the antimicrobial effect, the selection of formula ingredients and the control of pH in the process are important.

Non-ionic surfactants such as ethoxylated nonylphenol have environmental hormone problems. In a specific embodiment, the nonionic surfactant decyl glucoside used has low ecotoxicity, easy biodegradation and high temperature resistance. Due to the high pH of decyl glucoside, precipitation will occur if chlorhexidine gluconate is directly added at this time. Therefore, in the process, lactic acid is used to adjust the pH value before adding chlorhexidine gluconate, which is different from the prior art that adjusts the pH value in the final step of the process.

Furthermore, in order to avoid precipitation caused by the anions dissociated from chlorhexidine gluconate and the acid-base regulator, an organic acid containing carboxyl groups in the organic acid can be selected, preferably lactic acid as the acid-base regulator.

In a specific embodiment, adding a humectant to the antimicrobial composition can shorten the process time. For example, hydroxyethyl cellulose is first dispersed in a polyol (such as glycerin, propylene glycol) and then added to pure water for stirring and dissolution. There will be no undissolved small lumps. Specifically, the traditional method is to directly stir and dissolve hydroxyethyl cellulose in pure water, which is time-consuming and requires separate pot stirring. The preparation method of the antimicrobial composition of this embodiment is based on the same content of hydroxyethyl cellulose. After mixing glycerin with vegetarian, pure water is added and stirred. It only takes 1/3 to 1/5 of the traditional method and does not need to be stirred in a pot to complete the process.

In a specific embodiment, in the preparation method of the antimicrobial composition, after adding chlorhexidine gluconate, an antifoaming agent such as alcohol is added in order to eliminate foam on the surface of the solution by changing the surface tension.

In view of the above, due to the unstable chemical properties of the cationic antimicrobial agent, it is easy to react with other ingredients in the antimicrobial composition to produce precipitation. With the composition ratio and preparation method of the present disclosure, the cationic antimicrobial agent can be The antimicrobial composition is not easy to produce precipitation effect. In terms of composition ratio, the use of non-ionic surfactants instead of anionic surfactants and amphoteric surfactants, and the use of organic acids containing carboxyl groups as acid-base regulators are all helpful to avoid the formation of cationic antimicrobial agents. The salt is hardly soluble in water and precipitates. In some embodiments, lactic acid is specially selected as the acid-base regulator, and the specific coloring agent is selected and the amount of the coloring agent is controlled, which can further improve the stability of the cationic antimicrobial agent in the antimicrobial composition and reduce the occurrence of precipitation. Or the chance of precipitation occurring. Even if coloring agents that are anionic substances are used, controlling the amount of colorant used can prevent precipitation of antimicrobial agents, and the non-ionic surfactants and polyols added to the ingredients can also be used as solvents to add cationic antimicrobial Compatibility with different colorants.

In terms of the preparation method, controlling the pH value during the preparation process can effectively prevent the cationic antimicrobial agent from precipitating during the preparation process or storage and transportation of the antimicrobial composition. Preventing the cationic antimicrobial agent from generating precipitation in the antimicrobial composition can ensure that the content of the cationic antimicrobial agent in the antimicrobial composition is stable, and can achieve the antimicrobial effect.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention. Anyone familiar with the art can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection of the present invention The scope shall be subject to those defined in the attached patent scope.

Claims (22)

An antimicrobial composition comprising a cationic antimicrobial agent; a nonionic surfactant; an acid-base regulator, the acid-base regulator is an organic acid containing a carboxyl group; and a coloring agent; wherein the antimicrobial composition The total volume is calculated as 100%, the weight/volume percentage of the cationic antimicrobial agent is 0.5% to 4%; the weight/volume percentage of the nonionic surfactant is 3.5% to 10.5%; the weight of the acid-base regulator /Volume percentage is 0.13% to 0.18%; and the weight/volume percentage of the colorant is 0.00002% to 0.036%. The antimicrobial composition according to claim 1, wherein the cationic antimicrobial agent comprises chlorhexidine, a salt of chlorhexidine, polyhexamethylene biguanide, benzalkonium halide or a combination thereof. The antimicrobial composition according to claim 2, wherein the salt of chlorhexidine comprises chlorhexidine gluconate, chlorhexidine digluconate, chlorhexidine diacetate, chlorhexidine hydrochloride or a combination thereof. The antimicrobial composition according to claim 1, wherein the non-ionic surfactant comprises decyl glucoside, coco diethanolamine, polyoxyethylene alkyl ether, polysorbate twentieth or a combination thereof. The antimicrobial composition according to claim 1, wherein the acid-base regulator comprises lactic acid, citric acid or a combination thereof. The antimicrobial composition according to claim 1, wherein the colorant comprises tartrazine, carmine, brilliant blue, sunset yellow, quinoline yellow, acid red 33, allure red or a combination thereof. The antimicrobial composition according to claim 1, wherein the cationic antimicrobial agent is chlorhexidine gluconate and the weight/volume percentage is 1.6% to 2.4%. The antimicrobial composition according to claim 1, wherein the colorant is tartrazine and the weight/volume percentage is 0.00002% to 0.00006%. The antimicrobial composition according to claim 1, further comprising a thickening agent. The antimicrobial composition according to claim 9, wherein the thickener comprises hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose or a combination thereof. The antimicrobial composition according to claim 1, further comprising a humectant. The antimicrobial composition according to claim 11, wherein the humectant comprises glycerin, propylene glycol, sorbitol or a combination thereof. The antimicrobial composition according to claim 1, further comprising an antifoaming agent. The antimicrobial composition according to claim 13, wherein the antifoaming agent comprises isopropanol, ethanol or a combination thereof. The antimicrobial composition according to claim 1, further comprising a thickening agent, a humectant and a defoaming agent, wherein the weight/volume percentage of the thickening agent is 0.27% to 0.35%; The weight/volume percentage is 0.1% to 5.0%; and the weight/volume percentage of the defoamer is 1.0% to 4.0%. The antimicrobial composition according to any one of claims 1 to 15, which is contained in a container, wherein the material of the container comprises high density polyethylene, low density polyethylene, polyethylene terephthalate or Its combination. A preparation method of an antimicrobial composition comprises: providing a nonionic surfactant aqueous solution; mixing an acid-base regulator and the nonionic surfactant aqueous solution, wherein the acid-base regulator is an organic acid containing a carboxyl group, and Used to adjust the pH value of the non-ionic surfactant aqueous solution; and A colorant, a cationic antimicrobial agent, and an aqueous solution of a non-ionic surfactant with adjusted pH value are mixed to obtain the antimicrobial composition. The preparation method according to claim 17, wherein the non-ionic surfactant comprises decyl glucoside, coco diethanolamine, polyoxyethylene alkyl ether, polysorbate twenty or a combination thereof. The preparation method according to claim 17, wherein in the step of mixing an acid-base regulator and the nonionic surfactant aqueous solution, the acid-base regulator is lactic acid, and the adjusted acid-base value is from pH 5.5 to pH6.5. The preparation method according to claim 17, wherein the cationic antimicrobial agent is chlorhexidine gluconate, and the weight/volume percentage of chlorhexidine gluconate is 2%. The preparation method according to claim 17, wherein the step of providing the nonionic surfactant aqueous solution comprises: mixing a humectant, a thickener and water to obtain an aqueous solution with the humectant and the thickener; and The aqueous solution containing the humectant and the thickener is mixed with a non-ionic surfactant to form the non-ionic surfactant aqueous solution. The preparation method according to claim 17 or 21, which The step of mixing the colorant, the cationic antimicrobial agent, and the pH-adjusted nonionic surfactant aqueous solution includes: mixing the colorant, the cationic antimicrobial agent, and the pH-adjusted nonionic interface The active agent aqueous solution is mixed with a defoamer to obtain the antimicrobial composition.