KR20210008251A - Ethanol free hand sanitizer with simultaneous moisturizing and disinfecting action and manufacturing method of the same - Google Patents

Abstract

The present invention relates to an ethanol-free hand sanitizer with both moisturizing and sterilizing action, which prevents skin irritation with no irritating alcohol such as ethanol, provides moisturizing power by including a natural moisturizer, minimizes foaming, stickiness and slippage while having excellent sterilization power, and is easily formulated in a form of a lotion without adding a separate anti-foaming agent or ethanol, and to a manufacturing method thereof.

Description

Ethanol-free hand sanitizer that has both moisturizing and sterilizing effects and its manufacturing method {ETHANOL FREE HAND SANITIZER WITH SIMULTANEOUS MOISTURIZING AND DISINFECTING ACTION AND MANUFACTURING METHOD OF THE SAME}

The present invention relates to an ethanol-free hand sanitizer having both a moisturizing and sterilizing action and a method for producing the same, and more particularly, it is possible to suppress skin irritation because there is no irritating alcohol such as ethanol, and to provide a moisturizing power including a natural moisturizer. , An ethanol-free hand sanitizer that has both moisturizing and sterilizing effects that can minimize foaming, stickiness, and slippage while having excellent sterilization, and can be easily formulated in a lotion form without adding a separate antifoam or ethanol. It relates to a manufacturing method.

In general, hand sanitizers are gel-type formulations containing alcohol as a main component, and most contain 60 to 95% of ethanol or 2-propanol as alcohol. These hand sanitizers are provided in hospitals or government offices and can be easily used, and in particular, nurses or medical workers who take care of patients in hospitals are often used. However, conventional hand sanitizers have strong skin irritation from ethanol, which is the main ingredient, and if used frequently, the skin may become dry or severe, the hands may crack or crack.

Accordingly, in recent years, glycerin, hyaluronic acid, butylene glycol and propylene glycol, which have a moisturizing and moisturizing effect, are added to hand sanitizers containing ethanol to improve moisturizing power, but if they are still used frequently, the skin moisturizing power due to the effect of ethanol. It is difficult to maintain properly.

In addition, glycerin, hyaluronic acid, butylene glycol and propylene glycol added to prevent the hand sanitizer from drying out will intensify stickiness and slipperiness when prescribed in excess, so the feeling of use is very poor when applied to the skin. .

Meanwhile, cationic surfactants occupy about 8% of the surfactant market. The cationic surfactant has a structure opposite to that of an anionic surfactant, so it is called reverse soap, and has a biological activity that stops or inhibits the growth of microorganisms, so it can perform excellent sterilization and disinfection.

In addition, the cationic surfactant has a property of suppressing the generation of static electricity, so it is widely used in cosmetics for hair such as rinses and hair treatments, and is used as a softener, waterproofing agent, and dye fixing agent in the textile industry, and many minerals and metals Since it has a negative charge, it is used for flotation, lubrication, and corrosion protection.

In order to improve the problem of the hand sanitizer containing ethanol described above, some hand sanitizers using a cationic surfactant having a sterilizing effect have been disclosed.

For example, a cationic surface active agent that can be used as a sterilizing and disinfecting purposes is a quaternary ammonium halide ^- and the like is, and these quaternary or benzalkonium chloride, cetyl pyridinium chloride, benzalkonium flutes in the ammonium (R4N + Cl). That is, the quaternary ammonium compound can be used as a cationic surfactant type sterilizing disinfectant commonly called Quat or Qac's.

However, the quaternary ammonium compound, which is such a cationic surfactant, has a disadvantage of low sterilizing power against Gram negative bacteria and bacteriophages and forming bubbles.

Accordingly, conventional products are manufactured and sold by a method that is ejected into a foam type and applied to the skin. However, since the foam type product occupies a larger volume than the actual amount, the added value of the product may be reduced.

As another method, there is a method of suppressing the generation of foam in the process of manufacturing a hand sanitizer with a cationic surfactant by adding an antifoaming agent, but there is still a problem due to foam, which is difficult to apply to production.

To improve this problem, it is necessary to include an excess of ethanol or to add an antifoaming agent. However, if ethanol is included to suppress the generation of bubbles, the problem of ethanol described above may reappear as it is.

In addition, the antifoaming agent is mainly used as a silicone-based dimethicone or a simethicone-based antifoaming agent. If the antifoaming agent is added in this way, the problem of increasing stickiness and slipperiness when applied to the skin may occur again.

Therefore, formulation of a hand sanitizer using benzalkonium chloride or cetylpyridinium chloride among quaternary ammonium salts among cationic surfactants having sterilizing power without using ethanol is a very difficult task.

Accordingly, the applicant uses quaternary ammonium salt of a cationic surfactant as a sterilizing component, but minimizes foaming, which is a disadvantage of formulating a sterilization disinfectant, and prevents skin irritation, a disadvantage of hand sanitizers containing ethanol as the main component. The product development of a formulation that can minimize stickiness and slippage when applied to the skin while simultaneously implementing excellent sterilizing action was reviewed.

Domestic Registration Publication No. 10-1758327

The present invention was conceived to solve the problems of conventional hand sanitizers, so that it can have excellent sterilizing power without using ethanol, and at the same time suppress skin irritation and provide skin moisturizing effect, and applied to the skin. It is an object to provide an ethanol-free hand sanitizer and a method of manufacturing the same, which can be easily formulated in a lotion form through a general emulsification manufacturing process while minimizing stickiness and slippage during the time of manufacture, and has both a moisturizing and sterilizing action.

One aspect of the present invention, purified water; 0.01 to 0.5% by weight of benzalkonium chloride or cetylpyridinium chloride; 0.1 to 20% by weight of at least one of cetanol, cetosteyl alcohol and stearyl alcohol; 0.1 to 6.0% by weight of polysorbate 80 or polysorbate 60 or polysorbate 20; Natural moisturizer; And thickeners; It includes, and is formed in an emulsified-type formulation, does not contain ethanol, and provides an ethanol-free hand sanitizer having both a moisturizing and sterilizing action.

According to a preferred feature of the present invention, 0.01 to 0.2% by weight of the benzalkonium chloride or cetylpyridinium chloride may be included.

According to a preferred feature of the present invention, the thickener may be 0.1 to 5% by weight of Carbomer (Acrylates/C10-30 Alkyl Acrylate Cross-polymer) or 0.1 to 10% by weight of HPC (Hydroxypropyl Cellulose) or 0.1 to 10% by weight of HEC (Hydroxyethyl Cellulose). It may contain to 10% by weight.

According to a preferred feature of the present invention, the natural moisturizing agent may contain 0.1 to 10% by weight of jojoba oil, 0.1 to 10% by weight of hyaluronic acid, and 0.1 to 10% by weight of olive oil.

According to a preferred feature of the present invention, 0.5 to 5% by weight of sorbitan monooleate; 0.5 to 5% by weight of isopropyl myristic acid; And 0.5 to 5% by weight of liquid paraffin; It may further include.

Another aspect of the present invention is to prepare an aqueous mixture by mixing and dissolving 0.01 to 0.5% by weight of benzalkonium chloride or cetylpyridinium chloride and a thickener in purified water, and at least one of cetanol, cetosteyl alcohol and stearyl alcohol A first step of preparing an oily mixture by mixing and dissolving 0.1 to 20% by weight and 0.1 to 6.0% by weight of polysorbate 80 or polysorbate 60 or polysorbate 20; A second step of preparing a first mixture by mixing the aqueous mixture and the oily mixture with each other and stirring at a temperature of 75 to 80° C. at a speed of 2500 RPM for 5 minutes; A third step of preparing a second mixture by stirring and cooling the first mixture at 100 RPM in a vacuum state to lower the temperature to 40° C.; In the second mixture, trolamine and a natural moisturizer are added, firstly stirred at 2500RPM for 5 minutes, and then vacuum degassed to lower the temperature to 25°C at 100RPM, stirred, and cooled to prepare a third mixture. step; And a fifth step of filtering and filling the third mixture. It includes, and is formed in an emulsified-type formulation, and provides a method for producing an ethanol-free hand sanitizer having both a moisturizing and sterilizing action to prevent ethanol from being contained.

According to an embodiment of the present invention, a certain amount of benzalkonium chloride or cetylpyridinium chloride, which is a quaternary ammonium salt among cationic surfactants, is included to provide excellent sterilization and disinfection, and, unlike conventional techniques, irritating alcohols such as ethanol are used. As it does not contain skin irritation, it can prevent the skin from drying out, cracking or cracking of the hands, and provides skin moisturizing effects including natural moisturizers, but when applied to the skin, it provides excellent moisturizing by minimizing stickiness and slipping. There is an effect that can have both action and sterilization action at the same time.

In addition, according to an embodiment of the present invention, it is possible to easily formulate a hand sanitizer in a lotion form without using ethanol or an antifoaming agent by suppressing the generation of bubbles, which is a problem in formulating a conventional cationic surfactant-based disinfectant disinfectant. It can have an effect.

1 is a photograph showing a test of sterilization power using a benzalkonium chloride content of 0.1% by weight of a hand sanitizer.
FIG. 2 is a photograph showing a test of sterilization power using a benzalkonium chloride content of 0.06% by weight of a hand sanitizer.

Hereinafter, a preferred embodiment of the present invention will be described. However, embodiments of the present invention may be modified in various forms, and the scope of the present invention is not limited to the embodiments described below.

In addition, "including" certain elements throughout the specification means that other elements may be further included rather than excluding other elements unless specifically stated to the contrary.

Hand sanitizer

The hand sanitizer according to the present embodiment is purified water, at least one of benzalkonium chloride or cetylpyridinium chloride, cetanol, cetostyl alcohol and stearyl alcohol, polysorbate 80 or polysorbate 60 or polysorbate 20 One of them, including natural moisturizers and thickeners, has both moisturizing and sterilizing effects. In addition, the hand sanitizer is a hand sanitizer that does not contain irritating alcohol components such as ethanol.

The cationic surfactant is a surfactant having sterilizing and disinfecting power and is a main component that acts as a sterilizing agent in the hand sanitizer of the present invention.

In addition, quaternary ammonium compounds, which are cationic surfactants, are less toxic, have no color, corrosiveness, and odor, and have excellent safety against heat, pH and organic matter.

Among the quaternary ammonium compounds, which are cationic surfactants, benzalkonium chloride or cetylpyridinium chloride increases in proportion to its sterilizing power as its content increases.

The cationic surfactant has a cationic charge, so that the hydrophilic group dissociates into a cation in water. In addition, depending on the pH of the solution, it can be either a cation or an anion.

Cationic surfactants that have both hydrophilic and hydrophobic groups in the molecule are dissolved in water and used. Therefore, it penetrates well into the target material and acts on the cell membrane of microorganisms to outflow the intracellular material, inhibit metabolic enzymes, and kill microorganisms.

However, as the content of the benzalkonium chloride or cetylpyridinium chloride increases, the skin irritation also becomes stronger.Therefore, in order to improve the skin irritation problem caused by the addition of benzalkonium chloride or cetylpyridinium chloride, it is necessary to adjust the pH of the hand sanitizer. There is. Since human skin is weakly acidic and has a pH of 5 to 7, when the pH exceeds 7, the skin is damaged, so the pH must be adjusted to 7 or less to prevent skin damage.

In this embodiment, the benzalkonium chloride or cetylpyridinium chloride may be contained in an amount of 0.01 to 0.5% by weight. If the content of the benzalkonium chloride or cetylpyridinium chloride is less than 0.01% by weight, the sterilizing power is too low, so the effect as a hand sanitizer is significantly reduced, and when the content of the benzalkonium chloride or cetylpyridinium chloride exceeds 0.5% by weight The pH of the hand sanitizer exceeds 7, and damage to the skin may occur when using the hand sanitizer.

In addition, the benzalkonium chloride or cetylpyridinium chloride may be contained in an amount of more preferably 0.01 to 0.2% by weight. If the content of the benzalkonium chloride or cetylpyridinium chloride is adjusted within this range, it is possible to maximize the sterilizing power of the hand sanitizer while maintaining a state with little damage to the skin.

The thickener may include one of Carbomer (Acrylates/C10-30 Alkyl Acrylate Cross-polymer), HPC (Hydroxypropyl Cellulose), and HEC (Hydroxyethyl Cellulose).

In this case, the thickener includes 0.1 to 5% by weight of Carbomer (Acrylates/C10-30 Alkyl Acrylate Cross-polymer) or 0.1 to 10% by weight of HPC (Hydroxypropyl Cellulose) or 0.1 to 10% by weight of HEC (Hydroxyethyl Cellulose) can do.

When the carbomer is less than 0.1% by weight, it may be difficult to control the viscosity of the hand sanitizer, and when the carbomer is more than 5% by weight, the viscosity is very high and production is difficult.

When the HEC is less than 0.1% by weight, the viscosity is very low, and a problem of flowing down when applying the skin may occur, and when the HPC is more than 10% by weight, the viscosity is very high and production is difficult.

When the HEC is less than 0.1% by weight, the viscosity is very low, and a problem of flowing down when applying the skin may occur, and when the HEC is more than 10% by weight, the viscosity is very high and production is difficult.

The natural moisturizer may be a natural oil, and may include, for example, at least one of jojoba oil, hyaluronic acid, and olive oil. In this embodiment, preferably, it may contain all of jojoba oil 0.1 to 10% by weight, hyaluronic acid 0.1 to 10% by weight, and olive oil 0.1 to 10% by weight. On the other hand, the natural moisturizer may contain synthetic oil.

When the content of each of the oils is less than 0.1% by weight, a problem may occur that the skin moisturizing power decreases, and when the content of each of the oils exceeds 10% by weight, slippage may occur, resulting in a very poor feeling of use. have.

In addition, the hand sanitizer of the present embodiment further includes a nonionic surfactant having less skin irritation in order to further increase sterilization and cleansing power and increase stability of emulsion formation. As the nonionic surfactant, one of polysorbate 80, polysorbate 60, and polysorbate 20 may be used.

In the case of conventional hand sanitizers using cationic surfactants, since silicone-based surfactants do not dissolve in water, an excessive amount of nonionic surfactants was used.Nonionic surfactants may also cause skin irritation, and excessive When used properly, stickiness or slippage occurs, and the feeling of use of the hand sanitizer is inferior compared to the hand sanitizer containing ethanol as the main component.

The hand sanitizer of the present embodiment may contain 0.1 to 6.0% by weight of one of polysorbate 80, polysorbate 60, and polysorbate 20.

When the polysorbate 80, polysorbate 60, and polysorbate 20 are less than 0.1% by weight, emulsification itself may not be formed, and the polysorbate 80, polysorbate 60 and polysorbate 20 may contain 6.0% by weight. Excessive use may cause skin irritation, and excessive use may cause stickiness or slippage, which may cause problems in the feeling of use and may cause the emulsion to break.

In the case of this embodiment, by controlling the content of at least one of benzylkonium chloride or cetylpyridinium chloride, and cetanol, cetosteyl alcohol, and statyl alcohol, the content of nonionic surfactants compared to conventional cationic surfactants is minimized. Yet, compared to the case of using only benzylkonium chloride or sekylipyridinium chloride, the sterilizing power can be further improved.

In addition, the hand sanitizer of the present embodiment may contain 0.1 to 20% by weight of at least one of cetanol, cetosteyl alcohol, and stearyl alcohol. Unlike ethanol, the cetanol, cetosteyl alcohol, and stearyl alcohol are less irritating even when they come into contact with the skin and do not increase the pH, and thus do not cause skin damage.

The cetanol, cetosteyl alcohol or stearyl alcohol acts to form an emulsion, and when added within the above range, it is easy to use as an emulsifying type formulation that maintains a hand sanitizer in the form of a lotion without using ethanol or a separate antifoam at all. Can be formed.

If the content of the cetanol, cetostearyl alcohol and stearyl alcohol is less than 0.1% by weight, there may be a problem of poor stability due to not being emulsified, and the content of cetanol, cetostearyl alcohol and stearyl alcohol is 20 When it exceeds the weight %, there may be a problem of solidification rather than formation of an emulsion.

In addition, the hand sanitizer of the present embodiment may further include sorbitan monooleate, isopropyl myristic acid, and liquid paraffin if necessary. At this time, sorbitan monooleate may further contain 0.5 to 5% by weight, isopropyl myristic acid may further contain 0.5 to 5% by weight, and liquid paraffin may further contain 0.5 to 5% by weight. The sorbitan monooleate, isopropyl myristic acid, and liquid paraffin may additionally serve as emulsifying agents.

When the sorbitan monooleate is less than 0.5% by weight, there may be a problem of not forming an emulsion or lowering the viscosity, and when the sorbitan monooleate is more than 5% by weight, a problem of solidification may occur.

In addition, when the isopropyl myristic acid is less than 0.5% by weight, it may exhibit an excessively stiff feeling of use, and a problem may occur that a homogeneous spreading phenomenon cannot be formed when the skin is applied, and the isopropyl myristic acid is 5% by weight. If it is exceeded, the emulsion phase may be broken or a slippery problem may occur during use.

In addition, when the liquid paraffin is less than 0.5% by weight, an excessively stiff feeling of use may occur, and when the liquid paraffin exceeds 5% by weight, the emulsion formation may be broken or a problem of slipping when used on the skin may occur.

Recently, as a method of simply disinfecting hands, conventionally, sterilizing and disinfecting agents in a gel formulation mainly containing ethanol have been mainly used. The sterilizing and disinfecting agent of the gel formulation containing ethanol as a main component has excellent sterilization power due to the characteristics of ethanol, but has a disadvantage of excessively strong skin irritation.

Recently, in order to improve this problem, benzalkonium chloride, cetylpyridinium chloride, and the like have been used among quaternary ammonium salts, which are cationic surfactants having bactericidal action.

However, in general, cationic surfactants have a disadvantage of forming bubbles, which causes problems due to bubbles in the manufacturing process, making it difficult to apply to production. That is, a conventional gel formulation containing benzalkonium chloride or cetylpyridinium chloride as a main component generates a lot of foam due to the nature of a surfactant, so that ethanol and an antifoaming agent must be included. Conventionally, only when the content of ethanol is 10 to 50%, bubbles do not occur, and a desired gel phase can be prepared using a thickener.

Due to the peculiar properties of benzalkonium chloride or cetylpyridinium chloride, it is very difficult to prepare a transparent gel. Thickeners mainly used to maintain the gel phase of hand sanitizers are Carbomer (Acrylates/C10-30 Alkyl Acrylate Cross-polymer), HPC (Hydroxypropyl Cellulose), HEC (Hydroxyethyl Cellulose), and the like.

However, it is very difficult to maintain a transparent gel phase due to the use of carbomer, and since a lot of bubbles are generated in the gel preparation process, ethanol or a separate antifoaming agent must be included.

In addition, HPC and HEC, which are thickeners, are not used as a hand sanitizer, especially for skin, due to difficulty in production due to foaming and stickiness when used.

The hand sanitizer of this embodiment uses benzalkonium chloride and cetylpyridinium chloride, but at least one of polysorbate 20 or 60 or 80, which is a nonionic surfactant, and cetanol and cetostearyl alcohol, which are base agents as emulsifiers. Due to the more than one emulsion-forming action, the sterilization power can be greatly improved without the use of ethanol at all, and it can prevent skin damage by minimizing skin irritation as it does not contain ethanol, and the wetting and moisturizing action of natural moisturizers. It is possible to provide excellent moisturizing power due to the action.

In this embodiment, cetanol, cetosteyl alcohol, or stearyl alcohol acts to form an emulsion, and when added within the range described above, the hand sanitizer is used to maintain a lotion form by suppressing foaming without using ethanol at all. It can be formed into an emulsion type formulation.

That is, the hand sanitizer of the present invention uses benzalkonium chloride or cetylpyridinium chloride, which are quaternary ammonium salts having no side effects and has sterilizing disinfecting power, as a main component, and to improve sterilization power without using ethanol to improve skin irritation. Nonionic surfactants are added in a small amount within the range that does not cause stickiness or slipping, and formulations including cetanol, cetostateyl alcohol and stearyl alcohol are easily possible, as well as the stickiness of existing moisturizers and antifoaming agents. It can provide a combination of excellent sterilizing power and skin moisturizing power while minimizing over-slip, so it can be expected to overcome several shortcomings of ethanol-based hand sanitizers on the market.

Experiment example

Hereinafter, characteristics of the conventional hand sanitizer and the hand sanitizer of the present invention will be compared and described. Numerical values listed in Tables 1 to 3 mean weight percent

First, Table 1 is for Comparative Example 1, Comparative Example 1 uses benzalkonium chloride as a disinfectant, glycerin and propylene glycol as a moisturizer, and polysorbate 80 or polysorbate 60 or polysorbate 20 of the present invention. Carbomer 940 was used as a thickening agent without including cetanol, cetostearyl alcohol and stearyl alcohol. At this time, the total amount of each sample of Comparative Example 1 is adjusted to 100 mL by filling purified water as necessary.

Table 2 is for Comparative Example 2, Comparative Example 2 uses benzalkonium chloride as a disinfectant, glycerin and propylene glycol as a moisturizing agent, and polysorbate 80 or polysorbate 60 or polysorbate 20 of the present invention It does not contain cetanol, cetosteyl alcohol, and stearyl alcohol, and uses HPC as a thickener. At this time, the total amount of each sample of Comparative Example 2 is adjusted to 100 mL by filling purified water as necessary.

Table 3 is for Comparative Example 3, Comparative Example 3 uses benzalkonium chloride as a disinfectant, and uses glycerin and propylene glycol as a moisturizer, and polysorbate 80 or polysorbate 60 or polysorbate 20 of the present invention It does not contain cetanol, cetosteyl alcohol, and stearyl alcohol, and uses HEC as a thickener. At this time, the total amount of each sample of Comparative Example 3 is adjusted to 100 mL by filling purified water as necessary.

ingredient #One #2 #3 #4 #5 Benzalkonium chloride 50% 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 glycerin 2 2 2 2 2 Propylene glycol 2 2 2 2 2 Trolamine 0.15 0.2 0.25 0.3 0.5 Carbomer940 0.15 0.2 0.25 0.3 0.5 Lemon scent 0.5 0.5 0.5 0.5 0.5 Purified water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Total amount 100mL 100mL 100mL 100mL 100mL

ingredient #6 #7 #8 #9 #10 Benzalkonium chloride 50% 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 glycerin 2 2 2 2 2 Propylene glycol 2 2 2 2 2 Trolamine 0.15 0.2 0.25 0.3 0.5 HPC 0.5 0.75 1.0 1.5 2.0 Lemon scent 0.5 0.5 0.5 0.5 0.5 Purified water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Total amount 100mL 100mL 100mL 100mL 100mL

ingredient #11 #12 #13 #14 #15 Benzalkonium chloride 50% 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 glycerin 2 2 2 2 2 Propylene glycol 2 2 2 2 2 Trolamine 0.15 0.2 0.25 0.3 0.5 HEC 0.5 0.75 1.0 1.5 2.0 Lemon scent 0.5 0.5 0.5 0.5 0.5 Purified water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Total amount 100mL 100mL 100mL 100mL 100mL

Tables 1 to 3 show a thickener screening experiment after preparing a transparent gel-like substrate with the corresponding components and contents. In addition, the base material was applied to the hands of 50 subjects, and the peeling properties, drying time, and degree of stickiness were confirmed.

As a result of the test according to Table 1, a number of bubbles were generated due to benzalkonium chloride, and as the viscosity increased, the bubbles were not removed and increased.

As a result of the test according to Table 2, a number of bubbles were generated due to benzalkonium chloride, and as the viscosity increased, the bubbles were not removed and increased. In particular, as a result of using HPC, which is a thickening agent, there was a stickiness, and the most residue was generated among Comparative Examples 1, 2, and 3 when applied to the skin.

As a result of testing according to Table 3, a number of bubbles were generated due to benzalkonium chloride, and as the viscosity increased, the bubbles were not removed and increased. In particular, as a result of using HEC, which is a thickening agent, there was stickiness, and a lot of residues occurred when applying the skin.

Therefore, when the disinfectant is prepared with this, benzalkonium chloride, it can be seen that foaming occurs more severely as the viscosity increases, and as a result of adding a thickener to reduce skin irritation and provide a moisturizing effect, stickiness and slipperiness occur. When applied to, it can be seen that residuals are generated and the feeling of use is deteriorated.

Table 4 is for Comparative Example 4, Comparative Example 4 uses benzalkonium chloride as a disinfectant and glycerin and propylene glycol as a moisturizing agent, but with polysorbate 80 or polysorbate 60 or polysorbate 20 of the present invention. Carbomer 940 was used as a thickener without containing cetanol, cetosteyl alcohol and stearyl alcohol, and at this time, Carbomer 940 was fixed at 0.3% by weight, which was confirmed to have the most suitable viscosity in Table 1. In addition, in the case of Comparative Example 4, dimethicone, which is an antifoaming agent, was further added thereto. At this time, the total amount of each sample of Comparative Example 4 is adjusted to 100 mL by filling purified water as necessary.

ingredient #16 #17 #18 #19 #20 Benzalkonium chloride 50% 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 glycerin 2 2 2 2 2 Propylene glycol 2 2 2 2 2 Trolamine 0.15 0.2 0.25 0.3 0.5 Carbomer940 0.3 0.3 0.3 0.3 0.3 Lemon scent 0.5 0.5 0.5 0.5 0.5 Dimethicone 0.1 0.15 0.2 0.3 0.5 Purified water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Total amount 100mL 100mL 100mL 100mL 100mL

As a result of the test according to Table 4, even when dimethicone, which is an antifoaming agent, was additionally added, the foam generated by benzalkonium chloride was not completely removed.

Table 5 is for an embodiment of the present invention, in which benzalkonium chloride is used as a disinfectant and contains cetanol, a nonionic surfactant, sorbitan monooleate, isopropyl myristate, liquid paraffin, etc. It is to include more. At this time, the total amount of each sample of Comparative Example 5 is adjusted to 100 mL by filling purified water as necessary.

ingredient #21 #22 #23 #24 #25 Benzalkonium chloride 50% 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 0.12~0.2 Sorbitan monooleate 1.0 1.2 1.2 One Cetanol 5 5 Cetyl Palmitate 3 3 One Stearin Polyoxy 40 One One Polysorbate 60 2 2 Polysorbate 80 2 2 2 Isopropyl myristic acid 3 3 3 3 3 Floating paraffin One 1.5 1.5 1.5 1.5 Carbomer 940 0.3 0.3 0.3 0.3 0.3 Methylparaben 0.1 0.1 0.1 0.1 0.1 Profile Paraben 0.05 0.05 0.05 0.05 0.05 Trolamine Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Purified water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Total amount 100mL 100mL 100mL 100mL 100mL

As a result of testing according to Table 5, no foam was generated due to benzalkonium chloride. In particular, in the case of #24, skin application, drying time, and stickiness were the best.

Table 6 below shows the results of testing to check the moisturizing power of the hand sanitizer of this embodiment. The basic ingredients were prepared with the ingredients and contents of #24 in Table 5 above.

ingredient #26 #27 #28 Jojoba Oil ○ ○ × Hyluronic acid ○ ○ ○ olive oil ○ × ×

Referring to Table 6, #26 includes all of jojoba oil, hyluronic acid and olive oil in the description of #24, #27 includes jojoba oil and hyluronic acid, and #28 includes only hyluronic acid. Is to do.

Table 7 below is for testing the moisturizing power of hand sanitizers each containing the ingredients of #26-28. #29 of this test is a non-treated membrane paper (blank) as a comparative group, #30 is 0.5g of hand sanitizer of #24 that does not contain natural oils, and #31 is #24. #26 was added to the hand sanitizer of #26 and then 0.5g was treated on the membrane paper, #32 was the #24 hand sanitizer was added to the #27 natural oil and then 0.5g was treated on the membrane paper, # 33 is obtained by adding the natural oils of #28 to the hand sanitizer of #24 and then treating 0.5g of the membrane paper.

And, after 2 hours elapsed, the moisture content was measured and shown for each sample using the Karl Fischer method.

Blank
#29 No natural oil added
#30 #31 #32 #33

Weight of membrane paper (g) 0.24±0.1 0.24±0.1 0.24±0.1 0.24±0.1 0.24±0.1 Lotion weight (g) - 0.5 0.5 0.5 0.5 Weight sum (g) 0.24±0.1 0.74±0.1 0.74±0.1 0.74±0.1 0.74±0.1 moisture(%) 2.8 3.4 4.5 3.8 3.6

Referring to Table 7, there was no change in weight for all samples after 2 hours. However, in the case of #30, which is a membrane paper treated with the hand sanitizer of #24, which is a basic embodiment of the present invention, it can be seen that the moisture content is increased compared to the comparative soldier #29.

In addition, in the case of #31, #32, and #33 to which one or more natural oils were added, it can be seen that the moisture content was increased compared to #30 as well as #29 of the comparative soldier. In particular, in the case of #31, in which all three natural oils were added, the rate of increase in moisture content was greatest.

1 is a test of the sterilizing power of a hand sanitizer according to #24 as 0.1% benzalkonium chloride. Here, the strains used in the test are classified into bacteria, spore-generating bacteria, and fungi, where Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella sp. were used as the bacteria, and Bacillus subtillis was used as the spore-generating bacteria, and Candidaalbicans and Aspergillus niger were used as the fungi.

에서 배지에 세균이 1분간 접촉되도록 시켜 실험하였다, 이때, 인젝션(Injection)은 100㎕도말로 하였다.Among the hand sanitizers of #24, 0.1% belsalkonium chloride is the dilution factor of 5X, and the ratio of culture solution to disinfectant is 25 at room temperature under the conditions of culture solution: disinfectant (1:4).

In this experiment, the bacteria were brought into contact with the medium for 1 minute. At this time, injection was performed with 100 µl smear.

As a result, as can be seen in Figure 1, when compared to the control group (Control sample), the test group of the present invention did not show the growth of microorganisms, and it was found that the bactericidal power was more than 5-log reduction (99.999%). I can.

Figure 2 is a test of the sterilizing power of the hand sanitizer by #24 as 0.06% benzalkonium chloride. Here, the strains used in the test are classified into bacteria, spore-generating bacteria, and fungi, where Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella sp. were used as the bacteria, and Bacillus subtillis was used as the spore-generating bacteria, and Candidaalbicans and Aspergillus niger were used as the fungi.

에서 배지에 세균이 1분간 접촉되도록 시켜 실험하였다, 이때, 인젝션(Injection)은 100㎕도말로 하였다.Among the hand sanitizers of #24, 0.06% belsalkonium chloride is the dilution factor of 10X, and the ratio of culture solution to disinfectant is 25 at room temperature under the conditions of culture solution: disinfectant (1:4).

In this experiment, the bacteria were brought into contact with the medium for 1 minute. At this time, injection was performed with 100 µl smear.

As a result, as can be seen in Figure 2, when compared to the control group (Control sample), the test group of the present invention did not show the growth of microorganisms, and it was found that the bactericidal power was more than 5-log reduction (99.999%). I can.

Method of manufacturing hand sanitizer

Hereinafter, a description will be given of a method of manufacturing the hand sanitizer of the present invention.

First, the raw materials contained in the hand sanitizer are weighed. At this time, the raw material is divided into water phase and oil phase. The water phase includes benzalkonium chloride or cetylpyridinium chloride as the main component, hyaluronic acid as a moisturizing agent, purified water as a solvent, and carbomer as a thickener. The oil phase includes nonionic surfactants such as polysorbate 60, polysorbate 40, polysorbate 20, and sorbitan monooleate as an emulsifier.

In this embodiment, first, 0.01 to 0.5% by weight of benzalkonium chloride or cetylpyridinium chloride and 0.01 to 0.5% by weight of cetylpyridinium chloride are mixed and dissolved in purified water to prepare an aqueous mixture, and at least one of cetanol, cetosteyl alcohol, and stearyl alcohol is 0.1 A first step of preparing an oily mixture is performed by mixing and dissolving 0.1 to 6.0% by weight of polysorbate 80 or polysorbate 60 or polysorbate 20 with 20% by weight.

At this time, the aqueous mixture may be obtained by heating the component at 75 to 80° C. in a homomixer and completely dissolving at a high speed of 1000 to 1500 RPM. In addition, the oily mixture can be obtained by heating the component at 75 to 80°C in a homomixer and completely dissolving it at a low speed of about 100 RPM.

Next, the second step of preparing the first mixture is carried out by putting both the oily mixture and the aqueous mixture into a production tank, mixing, and stirring in a homomixer at a rate of 2500RPM at a temperature of 75 to 80°C for 5 minutes.

Next, the first mixture is stirred at 100 RPM in a vacuum state and cooled to lower the temperature to 40° C. to prepare a second mixture.

Next, trollamine and a natural moisturizer are added to the second mixture, firstly stirred at 2500RPM for 5 minutes, and then vacuum defoamed to lower the temperature to 25°C at 100RPM, and cooled to prepare a third mixture. Proceed to the fourth step. At this time, if necessary, a flavoring agent such as a combination perfume may be added.

Next, it can be completed into a final product through the process of filtration, filling and packaging.

The present invention is not limited by the above-described embodiments. Therefore, various types of substitutions, modifications and changes will be possible by those of ordinary skill in the art within the scope not departing from the technical spirit of the present invention described in the claims, and this also belongs to the scope of the present invention. something to do.

Claims (6)

Purified water;
0.01 to 0.5% by weight of benzalkonium chloride or cetylpyridinium chloride;
0.1 to 20% by weight of at least one of cetanol, cetosteyl alcohol and stearyl alcohol;
0.1 to 6.0% by weight of polysorbate 80 or polysorbate 60 or polysorbate 20;
Natural moisturizer; And
Thickener; Including,
It is formed in an emulsified type formulation,
An ethanol-free hand sanitizer that does not contain ethanol and has both moisturizing and sterilizing effects. The ethanol-free hand sanitizer according to claim 1, wherein the benzalkonium chloride or cetylpyridinium chloride is contained in an amount of 0.01 to 0.2% by weight. The method of claim 1, wherein the thickener is 0.1 to 5% by weight of Carbomer (Acrylates/C10-30 Alkyl Acrylate Cross-polymer) or 0.1 to 10% by weight of HPC (Hydroxypropyl Cellulose) or 0.1 to 10% by weight of Hydroxyethyl Cellulose (HEC) An ethanol-free hand sanitizer having both moisturizing and sterilizing effects, characterized in that it contains %. The method of claim 1,
The natural moisturizer, jojoba oil 0.1 to 10% by weight, hyaluronic acid 0.1 to 10% by weight, and an ethanol-free hand sanitizer having both a moisturizing and sterilizing action, characterized in that it comprises 0.1 to 10% by weight of olive oil. The method of claim 1,
0.5 to 5% by weight of sorbitan monooleate;
0.5 to 5% by weight of isopropyl myristic acid; And
0.5 to 5% by weight of liquid paraffin; An ethanol-free hand sanitizer having a moisturizing action and a sterilizing action at the same time, characterized in that it further comprises. Benzalkonium chloride or 0.01 to 0.5% by weight of cetylpyridinium chloride and 0.01 to 0.5% by weight of a thickener are mixed and dissolved in purified water to prepare an aqueous mixture, and 0.1 to 20% by weight of at least one of cetanol, cetosteyl alcohol and stearyl alcohol and poly A first step of preparing an oily mixture by mixing and dissolving 0.1 to 6.0% by weight of sorbate 80 or polysorbate 60 or polysorbate 20;
A second step of preparing a first mixture by mixing the aqueous mixture and the oily mixture with each other and stirring at a temperature of 75 to 80° C. at a speed of 2500 RPM for 5 minutes;
A third step of preparing a second mixture by stirring and cooling the first mixture at 100 RPM in a vacuum state to lower the temperature to 40°C;
In the second mixture, trolamine and a natural moisturizer are added, firstly stirred at 2500RPM for 5 minutes, and then vacuum degassed to lower the temperature to 25°C at 100RPM, stirred, and cooled to prepare a third mixture. step; And
A fifth step of filtering and filling the third mixture; Including,
A method for producing an ethanol-free hand sanitizer that is formed in an emulsifying-type formulation and has both a moisturizing and sterilizing action to prevent ethanol from being contained.

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