TWI703214B - 具拮抗ｐｄ-１功能的適體分子於癌症治療相關之應用 - Google Patents

具拮抗ｐｄ-１功能的適體分子於癌症治療相關之應用 Download PDF

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TWI703214B
TWI703214B TW104124956A TW104124956A TWI703214B TW I703214 B TWI703214 B TW I703214B TW 104124956 A TW104124956 A TW 104124956A TW 104124956 A TW104124956 A TW 104124956A TW I703214 B TWI703214 B TW I703214B
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aptamer
seq
nucleic acid
dimer
peg
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TW104124956A
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TW201617449A (zh
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楊泮池
張翼中
賴薇云
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中央研究院
國立台灣大學
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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TW104124956A 2014-07-31 2015-07-31 具拮抗ｐｄ-１功能的適體分子於癌症治療相關之應用 TWI703214B (zh)

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US201462031427P 2014-07-31 2014-07-31
US62/031,427 2014-07-31

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TW201617449A TW201617449A (zh) 2016-05-16
TWI703214B true TWI703214B (zh) 2020-09-01

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TW104124956A TWI703214B (zh) 2014-07-31 2015-07-31 具拮抗ｐｄ-１功能的適體分子於癌症治療相關之應用

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US (1) US10329570B2 (enExample)
EP (1) EP3174985A4 (enExample)
JP (1) JP6680760B2 (enExample)
KR (1) KR20170055474A (enExample)
CN (1) CN107002083A (enExample)
CA (1) CA2956718A1 (enExample)
TW (1) TWI703214B (enExample)
WO (1) WO2016019270A1 (enExample)

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HK1248115A1 (zh) 2015-07-16 2018-10-12 Bioxcel Therapeutics, Inc. 一种使用免疫调节治疗癌症的新颖方法
US11219635B2 (en) 2016-02-19 2022-01-11 City Of Hope Bi-specific aptamer
WO2018048888A1 (en) * 2016-09-06 2018-03-15 The Methodist Hospital System Pd-1 specific aptamers
US10889816B2 (en) * 2016-09-16 2021-01-12 Duke University Von Willebrand Factor (VWF)—targeting agents and methods of using the same
CN107794267B (zh) * 2017-03-14 2021-03-26 湖南大学 一种靶向pd1-pdl1的双特异性核酸适体及其衍生物
EP3664814A4 (en) 2017-08-11 2021-05-05 City of Hope Rna aptamers against transferrin receptor (tfr)
US11007211B2 (en) * 2018-01-07 2021-05-18 City Of Hope CCR7 aptamers and uses thereof
EP3683310A1 (en) 2019-01-21 2020-07-22 Rheinische Friedrich-Wilhelms-Universität Bonn Aptamer and use of the aptamer in the diagnosis and treatment of cancer
CN111154765B (zh) * 2019-12-30 2023-08-01 广西医科大学 T细胞免疫检查点pd-1的适配体筛选、鉴定方法及抗肿瘤应用
US20230117328A1 (en) 2020-03-03 2023-04-20 Array Biopharma Inc. Methods to treat cancer using (r)-n-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1h-pyrazolo[3,4-b]pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CN111593053B (zh) * 2020-05-27 2022-02-15 武汉大学 识别人程序性死亡受体1的dna适配体及方法和应用
US20240417738A1 (en) * 2021-10-22 2024-12-19 Ohio State Innovation Foundation Immunotherapies for the treatment of cancer

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WO2010103292A2 (en) * 2009-03-12 2010-09-16 Brainco Biopharma S.L. A genotyping tool for improving the prognostic and clinical management of ms patients
WO2011099857A1 (en) * 2010-02-11 2011-08-18 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for typing a sample for rheumatoid arthritis or spondyloarthritis
US20130209514A1 (en) * 2009-06-09 2013-08-15 Eli Gilboa Aptamer-targeted costimulatory ligand aptamer
WO2013122720A2 (en) * 2012-02-16 2013-08-22 Syngenta Participations Ag Engineered pesticidal proteins
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WO2011099857A1 (en) * 2010-02-11 2011-08-18 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for typing a sample for rheumatoid arthritis or spondyloarthritis
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KR20170055474A (ko) 2017-05-19
WO2016019270A1 (en) 2016-02-04
EP3174985A1 (en) 2017-06-07
TW201617449A (zh) 2016-05-16
CA2956718A1 (en) 2016-02-04
JP6680760B2 (ja) 2020-04-15
JP2017523781A (ja) 2017-08-24
EP3174985A4 (en) 2018-04-04
WO2016019270A8 (en) 2016-04-14
CN107002083A (zh) 2017-08-01
US10329570B2 (en) 2019-06-25
US20170218369A1 (en) 2017-08-03

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