CA2956718A1 - An antagonistic pd-1 aptamer and its applications in cancer therapy related applications - Google Patents
An antagonistic pd-1 aptamer and its applications in cancer therapy related applications Download PDFInfo
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- CA2956718A1 CA2956718A1 CA2956718A CA2956718A CA2956718A1 CA 2956718 A1 CA2956718 A1 CA 2956718A1 CA 2956718 A CA2956718 A CA 2956718A CA 2956718 A CA2956718 A CA 2956718A CA 2956718 A1 CA2956718 A1 CA 2956718A1
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- aptamer
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- cancer
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| US62/031,427 | 2014-07-31 | ||
| PCT/US2015/043162 WO2016019270A1 (en) | 2014-07-31 | 2015-07-31 | An antagonistic pd-1 aptamer and its applications in cancer therapy related applications |
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| RU2711380C2 (ru) | 2015-07-16 | 2020-01-16 | Байоксэл Терапьютикс, Инк. | Новый подход к лечению рака с применением иммуномодуляции |
| WO2017143150A1 (en) | 2016-02-19 | 2017-08-24 | City Of Hope | Bi-specific aptamer |
| MX2019002618A (es) * | 2016-09-06 | 2019-09-09 | The Methodist Hospital System | Aptameros especificos para pd 1. |
| JP7560821B2 (ja) * | 2016-09-16 | 2024-10-03 | デューク ユニバーシティ | フォン・ビルブラント因子（ｖｗｆ）標的薬剤およびそれを用いる方法 |
| CN107794267B (zh) * | 2017-03-14 | 2021-03-26 | 湖南大学 | 一种靶向pd1-pdl1的双特异性核酸适体及其衍生物 |
| AU2018314236B2 (en) | 2017-08-11 | 2025-02-06 | Apterna Limited | RNA aptamers against transferrin receptor (TfR) |
| US11007211B2 (en) | 2018-01-07 | 2021-05-18 | City Of Hope | CCR7 aptamers and uses thereof |
| EP3683310A1 (en) | 2019-01-21 | 2020-07-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | Aptamer and use of the aptamer in the diagnosis and treatment of cancer |
| CN111154765B (zh) * | 2019-12-30 | 2023-08-01 | 广西医科大学 | T细胞免疫检查点pd-1的适配体筛选、鉴定方法及抗肿瘤应用 |
| MX2022010955A (es) | 2020-03-03 | 2022-10-07 | Array Biopharma Inc | Metodos para tratar el cancer usando (r)-n-(3-fluoro-4-((3- ((1-hidroxipropan-2-il)amino)-1h-pirazolo[3,4-b]piridin-4-il)oxi) fenil)-3-(4-fluorofenil)-1-isopropil-2,4-dioxo-1,2,3,4-tetrahidro pirimidin-5-carboxamida. |
| CN111593053B (zh) * | 2020-05-27 | 2022-02-15 | 武汉大学 | 识别人程序性死亡受体1的dna适配体及方法和应用 |
| EP4419112A4 (en) * | 2021-10-22 | 2025-08-27 | Ohio State Innovation Foundation | IMMUNOTHERAPY FOR CANCER TREATMENT |
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| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| WO1997031012A1 (en) * | 1996-02-22 | 1997-08-28 | The Regents Of The University Of Michigan | Gene specific universal mammalian sequence-tagged sites |
| US20040241651A1 (en) * | 2000-04-07 | 2004-12-02 | Alexander Olek | Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US8039443B2 (en) | 2002-11-21 | 2011-10-18 | Archemix Corporation | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| JP2006516151A (ja) * | 2002-11-21 | 2006-06-22 | アーケミックス コーポレイション | 改良された薬力学的特性を有する多価アプタマー治療剤ならびにそれらの作製方法および使用法 |
| EP1620547B1 (en) * | 2003-04-21 | 2014-06-18 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| RS20080075A (sr) * | 2005-08-26 | 2009-07-15 | Archemix Corp., | Aptameri koji vezuju trombin sa visokim afinitetom |
| EP2023940B1 (en) * | 2006-05-05 | 2011-06-22 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of sglt2 |
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| US20140148503A1 (en) * | 2011-07-20 | 2014-05-29 | University Of Iowa Research Foundation | Nucleic acid aptamers |
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| CA2873797A1 (en) * | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating utrn expression |
| EP2912182B1 (en) * | 2012-10-23 | 2021-12-08 | Caris Science, Inc. | Aptamers and uses thereof |
| EP2914722A1 (en) * | 2012-11-05 | 2015-09-09 | Pronai Therapeutics, Inc. | Dosing and administration of oligonucleotide cancer therapies |
| EP2922861A4 (en) * | 2012-11-26 | 2016-09-14 | Caris Life Sciences Switzerland Holdings Gmbh | BIOMARKER COMPOSITIONS AND METHODS |
| US11254933B2 (en) * | 2014-07-14 | 2022-02-22 | The Regents Of The University Of California | CRISPR/Cas transcriptional modulation |
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| CN107002083A (zh) | 2017-08-01 |
| WO2016019270A8 (en) | 2016-04-14 |
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