TWI683662B - 抗癌症組成物(一) - Google Patents

抗癌症組成物(一) Download PDF

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Publication number
TWI683662B
TWI683662B TW104140458A TW104140458A TWI683662B TW I683662 B TWI683662 B TW I683662B TW 104140458 A TW104140458 A TW 104140458A TW 104140458 A TW104140458 A TW 104140458A TW I683662 B TWI683662 B TW I683662B
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TW
Taiwan
Prior art keywords
arn
solid dispersion
patent application
poly
meth
Prior art date
Application number
TW104140458A
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English (en)
Chinese (zh)
Other versions
TW201632187A (zh
Inventor
吉爾特 凡瑞克
Original Assignee
美商艾瑞岡醫藥公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52006905&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI683662(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 美商艾瑞岡醫藥公司 filed Critical 美商艾瑞岡醫藥公司
Publication of TW201632187A publication Critical patent/TW201632187A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW104140458A 2014-12-05 2015-12-03 抗癌症組成物(一) TWI683662B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196591 2014-12-05
EP14196591.3 2014-12-05

Publications (2)

Publication Number Publication Date
TW201632187A TW201632187A (zh) 2016-09-16
TWI683662B true TWI683662B (zh) 2020-02-01

Family

ID=52006905

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104140458A TWI683662B (zh) 2014-12-05 2015-12-03 抗癌症組成物(一)

Country Status (31)

Country Link
US (3) US20170360707A1 (enExample)
EP (2) EP3226842B1 (enExample)
JP (1) JP6767368B2 (enExample)
KR (1) KR102348325B1 (enExample)
CN (2) CN106999430A (enExample)
AR (1) AR102924A1 (enExample)
AU (1) AU2015358493B2 (enExample)
CA (1) CA2969661C (enExample)
CL (1) CL2017001372A1 (enExample)
CO (1) CO2017005573A2 (enExample)
CR (1) CR20170217A (enExample)
CY (1) CY1123856T1 (enExample)
DK (1) DK3226842T3 (enExample)
EA (1) EA035988B1 (enExample)
ES (2) ES3021508T3 (enExample)
HR (1) HRP20201902T1 (enExample)
HU (1) HUE051888T2 (enExample)
IL (1) IL252324B (enExample)
LT (1) LT3226842T (enExample)
MA (2) MA55404A (enExample)
MD (1) MD3226842T2 (enExample)
MX (1) MX384382B (enExample)
NI (1) NI201700069A (enExample)
PL (1) PL3226842T3 (enExample)
PT (1) PT3226842T (enExample)
RS (1) RS61466B1 (enExample)
SG (1) SG11201704264UA (enExample)
SI (1) SI3226842T1 (enExample)
TW (1) TWI683662B (enExample)
UA (1) UA121123C2 (enExample)
WO (1) WO2016090101A1 (enExample)

Families Citing this family (17)

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WO2014052237A1 (en) 2012-09-26 2014-04-03 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
CN114886852A (zh) 2014-12-05 2022-08-12 阿拉贡药品公司 抗癌组合物
RS62421B1 (sr) 2014-12-05 2021-10-29 Aragon Pharmaceuticals Inc Anti-kancerogeni sastavi
KR20240096623A (ko) 2017-10-16 2024-06-26 아라곤 파마슈티컬스, 인코포레이티드 비-전이성 거세-저항성 전립선암의 치료를 위한 항-안드로겐
EP3773509B1 (en) * 2018-04-06 2023-11-01 Capsugel Belgium NV Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)]
WO2020144649A1 (en) 2019-01-10 2020-07-16 Aragon Pharmaceuticals, Inc. Pharmaceutical composition comprising enzalutamide dispersed in apple sauce
KR20210122275A (ko) 2019-01-30 2021-10-08 얀센 파마슈티카 엔.브이. 분자 아형에 기초하여 전립선암을 치료하는 방법
SG11202107712SA (en) 2019-01-30 2021-08-30 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of metastatic castration-sensitive prostate cancer
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
DK4054572T3 (da) 2019-11-04 2026-08-03 Aragon Pharmaceuticals Inc Apalutanid til behandling af ikke-metastatisk kastrationsresistent prostatacancer hos subjekter med svært nedsat leverfunktion
WO2021245285A1 (en) 2020-06-05 2021-12-09 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
WO2022049523A1 (en) 2020-09-04 2022-03-10 Aragon Pharmaceuticals, Inc. Methods for treating prostate cancer
WO2022195407A1 (en) 2021-03-19 2022-09-22 Aragon Pharmaceuticals, Inc. Methods for treating prostate cancer
WO2023152611A1 (en) 2022-02-11 2023-08-17 Aragon Pharmaceuticals, Inc. Apalutamide and relugolix for the treatment of prostate cancer
WO2023209555A1 (en) 2022-04-26 2023-11-02 Aragon Pharmaceuticals, Inc. Approved drug products and methods for treating prostate cancer
JP2026515598A (ja) 2023-03-16 2026-05-19 バイエル・コンシューマー・ケア・アクチェンゲゼルシャフト ホルモン感受性前立腺がんの生化学的再発を有する患者の処置のためのアンドロゲン受容体アンタゴニスト
WO2026052846A1 (en) 2024-09-09 2026-03-12 Synthon B.V. Pharmaceutical formulation comprising apalutamide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005055987A1 (en) * 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER
WO2012174436A1 (en) * 2011-06-15 2012-12-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer

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CZ20032647A3 (cs) 2001-04-02 2004-09-15 Astrazeneca Ab Pevná farmaceutická kompozice obsahující 4-kyanotrifluor-3-(4-fluorfenylsulfonyl)-2-hydroxy-2-methylpropiono-m-toluidin a PVP
JPWO2003077827A1 (ja) * 2002-03-19 2005-07-14 日本新薬株式会社 医薬固体分散体の製造方法
BRPI0709771B1 (pt) * 2006-03-27 2022-01-25 The Regents Of The University Of California Composto e composição farmacêutica
EP3124481B1 (en) * 2010-02-16 2018-03-28 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
WO2013152342A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
UA123142C2 (uk) 2012-06-07 2021-02-24 Арагон Фармасьютікалз, Інк. Кристалічні форми модулятора андрогенного рецептора
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
TWI673051B (zh) * 2012-09-11 2019-10-01 美商梅維森前列腺療法有限責任公司 恩雜魯它脈(enzalutamide)之調和物
WO2014052237A1 (en) * 2012-09-26 2014-04-03 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
EP2945628B1 (en) * 2013-01-15 2020-04-15 Aragon Pharmaceuticals, Inc. Androgen receptor modulator in combination with abiraterone acetate and prednisone for treating prostate cancer
NZ708272A (en) * 2013-01-22 2020-07-31 Hoffmann La Roche Pharmaceutical composition with improved bioavailability
WO2014167428A2 (en) 2013-04-10 2014-10-16 Shilpa Medicare Limited Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide
KR20160058774A (ko) * 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
CN106102716A (zh) * 2014-02-05 2016-11-09 斯洛文尼亚莱柯制药股份有限公司 雄激素受体拮抗剂的固体药物组合物

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2005055987A1 (en) * 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research TASTE MASKED PHARMACEUTICAL COMPOSITIONS COMPRISING BITTER DRUG AND pH SENSITIVE POLYMER
WO2012174436A1 (en) * 2011-06-15 2012-12-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer

Non-Patent Citations (1)

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Title
Clegg NJ, et al."ARN-509: a novel antiandrogen for prostate cancer treatment.", Cancer Res. 2012 Mar 15;72(6):1494-1503. *

Also Published As

Publication number Publication date
MX384382B (es) 2025-03-14
US20220151931A1 (en) 2022-05-19
DK3226842T3 (da) 2021-01-25
CN115837010B (zh) 2025-03-14
KR20170086657A (ko) 2017-07-26
EA201791252A1 (ru) 2017-10-31
SI3226842T1 (sl) 2021-04-30
KR102348325B1 (ko) 2022-01-06
NI201700069A (es) 2017-10-31
MA41108A (fr) 2016-06-09
CO2017005573A2 (es) 2017-09-29
AR102924A1 (es) 2017-04-05
CY1123856T1 (el) 2022-05-27
EP3842034B1 (en) 2025-02-12
EP3226842A1 (en) 2017-10-11
BR112017011787A2 (pt) 2017-12-26
MA55404A (fr) 2022-02-02
ES2839128T3 (es) 2021-07-05
CL2017001372A1 (es) 2018-01-05
HUE051888T2 (hu) 2021-03-29
CA2969661A1 (en) 2016-06-09
JP6767368B2 (ja) 2020-10-14
EA035988B1 (ru) 2020-09-09
RS61466B1 (sr) 2021-03-31
AU2015358493A1 (en) 2017-06-08
AU2015358493B2 (en) 2021-05-06
UA121123C2 (uk) 2020-04-10
EP3226842B1 (en) 2020-11-25
IL252324A0 (en) 2017-07-31
SG11201704264UA (en) 2017-06-29
ES3021508T3 (en) 2025-05-27
CR20170217A (es) 2017-08-30
MD3226842T2 (ro) 2021-03-31
MA41108B1 (fr) 2021-03-31
HRP20201902T1 (hr) 2021-07-23
US20170360707A1 (en) 2017-12-21
MX2017007201A (es) 2018-01-30
IL252324B (en) 2021-10-31
WO2016090101A1 (en) 2016-06-09
PL3226842T3 (pl) 2021-07-12
JP2017536401A (ja) 2017-12-07
US20240293321A1 (en) 2024-09-05
TW201632187A (zh) 2016-09-16
LT3226842T (lt) 2021-03-25
CA2969661C (en) 2023-04-25
EP3842034A1 (en) 2021-06-30
CN115837010A (zh) 2023-03-24
CN106999430A (zh) 2017-08-01
PT3226842T (pt) 2020-12-23

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