TWI654192B - ６－硝基－２，３－二氫咪唑并［２，１－ｂ］噁唑及其製備方法 - Google Patents

６－硝基－２，３－二氫咪唑并［２，１－ｂ］噁唑及其製備方法

Info

Publication number
TWI654192B
TWI654192B TW103120596A TW103120596A TWI654192B TW I654192 B TWI654192 B TW I654192B TW 103120596 A TW103120596 A TW 103120596A TW 103120596 A TW103120596 A TW 103120596A TW I654192 B TWI654192 B TW I654192B
Authority
TW
Taiwan
Prior art keywords
compound
methyl
oxazole
dihydro
phenoxymethyl
Prior art date
Application number
TW103120596A
Other languages
English (en)
Chinese (zh)
Other versions
TW201514184A (zh
Inventor
帕芬德鮑 辛
Parvinder Pal SINGH
古魯納罕 慕那加拉
Gurunadham MUNAGALA
雷迪業帕拉 古夏拉法
Reddy Yempalla KUSHALAVA
英夏阿里 可汗
Inshad Ali Khan
尼丁帕 卡利亞
Nitin Pal Kalia
威朗辛 拉傑普
Vikrant Singh RAJPUT
阿米特 納果塔
Amit NARGOTRA
參波達摩哈 薩旺
Sanghapal Damodhar Sawant
蘭阿斯瑞 維斯瓦卡馬
Ram Asrey Vishwakarma
Original Assignee
印度科學與工業研究理事會
Council Of Scientific & Industrial Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 印度科學與工業研究理事會, Council Of Scientific & Industrial Research filed Critical 印度科學與工業研究理事會
Publication of TW201514184A publication Critical patent/TW201514184A/zh
Application granted granted Critical
Publication of TWI654192B publication Critical patent/TWI654192B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW103120596A 2013-10-04 2014-06-13 ６－硝基－２，３－二氫咪唑并［２，１－ｂ］噁唑及其製備方法 TWI654192B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2954/DEL/2013 2013-10-04
IN2954DE2013 IN2013DE02954A (https=) 2013-10-04 2014-03-31

Publications (2)

Publication Number Publication Date
TW201514184A TW201514184A (zh) 2015-04-16
TWI654192B true TWI654192B (zh) 2019-03-21

Family

ID=50771310

Family Applications (1)

Application Number Title Priority Date Filing Date
TW103120596A TWI654192B (zh) 2013-10-04 2014-06-13 ６－硝基－２，３－二氫咪唑并［２，１－ｂ］噁唑及其製備方法

Country Status (7)

Country Link
US (1) US9845330B2 (https=)
EP (1) EP3052503B1 (https=)
JP (1) JP6532457B2 (https=)
ES (1) ES2707362T3 (https=)
IN (1) IN2013DE02954A (https=)
TW (1) TWI654192B (https=)
WO (1) WO2015049693A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3209669B1 (en) * 2014-10-21 2018-11-07 Council of Scientific and Industrial Research Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof
CN108059623B (zh) * 2016-11-07 2021-07-13 浙江省化工研究院有限公司 一类含取代芳基联异噁唑芳基脒类化合物、其制备方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200528460A (en) 2003-10-31 2005-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound
CN1705670A (zh) 2002-10-11 2005-12-07 大塚制药株式会社 2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4761756B2 (ja) * 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
JP4787529B2 (ja) * 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
US7049876B2 (en) 2004-10-25 2006-05-23 Delphi Technologies, Inc. Level shift circuits and related methods
PT1906926E (pt) 2005-07-28 2011-01-26 Otsuka Pharma Co Ltd Composição farmacêutica que contém derivados de 2,3-di-hidro-6-nitroimidazo[2,1-b]oxazole
JP5613656B2 (ja) * 2008-03-26 2014-10-29 グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705670A (zh) 2002-10-11 2005-12-07 大塚制药株式会社 2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物
TW200528460A (en) 2003-10-31 2005-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole compound

Also Published As

Publication number Publication date
JP2016531898A (ja) 2016-10-13
EP3052503A1 (en) 2016-08-10
ES2707362T3 (es) 2019-04-03
US20160244462A1 (en) 2016-08-25
WO2015049693A1 (en) 2015-04-09
US9845330B2 (en) 2017-12-19
JP6532457B2 (ja) 2019-06-19
EP3052503B1 (en) 2018-10-24
IN2013DE02954A (https=) 2015-04-10
TW201514184A (zh) 2015-04-16

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