TWI649083B - 用於治療或預防乾眼症的方法 - Google Patents
用於治療或預防乾眼症的方法 Download PDFInfo
- Publication number
- TWI649083B TWI649083B TW105118931A TW105118931A TWI649083B TW I649083 B TWI649083 B TW I649083B TW 105118931 A TW105118931 A TW 105118931A TW 105118931 A TW105118931 A TW 105118931A TW I649083 B TWI649083 B TW I649083B
- Authority
- TW
- Taiwan
- Prior art keywords
- dry eye
- compound
- general formula
- treating
- eye
- Prior art date
Links
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- 206010013774 Dry eye Diseases 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title abstract description 9
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- 238000011200 topical administration Methods 0.000 claims 1
- JAYVHSBYKLLDJC-DSNJPTTOSA-N (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(O)C=C(O)C=C1\C=C\C1=CC=C(O)C=C1 JAYVHSBYKLLDJC-DSNJPTTOSA-N 0.000 abstract 1
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- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562180450P | 2015-06-16 | 2015-06-16 | |
| US62/180,450 | 2015-06-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201717965A TW201717965A (zh) | 2017-06-01 |
| TWI649083B true TWI649083B (zh) | 2019-02-01 |
Family
ID=57544797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW105118931A TWI649083B (zh) | 2015-06-16 | 2016-06-16 | 用於治療或預防乾眼症的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10383885B2 (https=) |
| EP (1) | EP3310361B1 (https=) |
| JP (1) | JP6960399B2 (https=) |
| KR (1) | KR102606948B1 (https=) |
| CN (1) | CN107921053B (https=) |
| AU (1) | AU2016279139B2 (https=) |
| CA (1) | CA2989341C (https=) |
| TW (1) | TWI649083B (https=) |
| WO (1) | WO2016201953A1 (https=) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1539844A (zh) * | 2003-10-24 | 2004-10-27 | 广州中医药大学热带医学研究所 | 降血脂药用2，3，5，4＇-四羟基二苯乙烯－2－O－β－D－葡萄糖苷 |
| CN102316873A (zh) * | 2008-12-24 | 2012-01-11 | 吴淑芬 | 促进红细胞生成的化合物和方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332726A (zh) * | 1998-11-02 | 2002-01-23 | 卫福有限公司 | 吡咯烷化合物及其药物用途 |
| NZ517556A (en) * | 1999-09-06 | 2003-08-29 | Ono Pharmaceutical Co | N-[o-(p-pivaloyloxybenzenesulphonyl-amino)benzoyl]glycine as preventive and therapeutic agents for eye diseases |
| US20060292099A1 (en) * | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
| CN101966193B (zh) * | 2010-10-29 | 2012-05-23 | 西南交通大学 | 2,3,5,4’-四羟基二苯乙烯-2-O-β-D-葡萄糖苷在制备治疗抑郁症药物中的应用 |
| US20120164242A1 (en) * | 2010-12-27 | 2012-06-28 | Wen-Jen Yu | Novel methods for modulating melanin production |
| AU2013384234A1 (en) * | 2013-03-28 | 2015-10-15 | Rong-Tsun Wu | Composition and method for inducing EPO-mediated haemoglobin expression and mitochondrial biogenesis in nonhaematopoietic cell |
| CN103524576A (zh) * | 2013-08-12 | 2014-01-22 | 天津中医药大学 | 2,3,5,4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的分离纯化工艺 |
-
2016
- 2016-06-16 EP EP16810694.6A patent/EP3310361B1/en active Active
- 2016-06-16 WO PCT/CN2016/000309 patent/WO2016201953A1/en not_active Ceased
- 2016-06-16 JP JP2018517468A patent/JP6960399B2/ja active Active
- 2016-06-16 CN CN201680035333.5A patent/CN107921053B/zh active Active
- 2016-06-16 KR KR1020187000291A patent/KR102606948B1/ko active Active
- 2016-06-16 US US15/737,072 patent/US10383885B2/en active Active
- 2016-06-16 AU AU2016279139A patent/AU2016279139B2/en active Active
- 2016-06-16 TW TW105118931A patent/TWI649083B/zh active
- 2016-06-16 CA CA2989341A patent/CA2989341C/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1539844A (zh) * | 2003-10-24 | 2004-10-27 | 广州中医药大学热带医学研究所 | 降血脂药用2，3，5，4＇-四羟基二苯乙烯－2－O－β－D－葡萄糖苷 |
| CN102316873A (zh) * | 2008-12-24 | 2012-01-11 | 吴淑芬 | 促进红细胞生成的化合物和方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180019151A (ko) | 2018-02-23 |
| AU2016279139B2 (en) | 2020-09-10 |
| EP3310361A1 (en) | 2018-04-25 |
| CA2989341C (en) | 2021-12-07 |
| JP6960399B2 (ja) | 2021-11-05 |
| TW201717965A (zh) | 2017-06-01 |
| AU2016279139A1 (en) | 2018-01-04 |
| EP3310361A4 (en) | 2019-01-23 |
| WO2016201953A1 (en) | 2016-12-22 |
| CN107921053A (zh) | 2018-04-17 |
| US10383885B2 (en) | 2019-08-20 |
| JP2018517776A (ja) | 2018-07-05 |
| US20180193369A1 (en) | 2018-07-12 |
| CA2989341A1 (en) | 2016-12-22 |
| KR102606948B1 (ko) | 2023-11-27 |
| CN107921053B (zh) | 2020-09-01 |
| EP3310361B1 (en) | 2022-05-11 |
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| Koçluk et al. | Ceratoconjuntivite atópica: resultados a longo prazo do tratamento clínico e da ceratoplastia penetrante |