TWI646094B - Crystal form of inhibitory protein kinase active compound and application thereof - Google Patents
Crystal form of inhibitory protein kinase active compound and application thereof Download PDFInfo
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- TWI646094B TWI646094B TW106117900A TW106117900A TWI646094B TW I646094 B TWI646094 B TW I646094B TW 106117900 A TW106117900 A TW 106117900A TW 106117900 A TW106117900 A TW 106117900A TW I646094 B TWI646094 B TW I646094B
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- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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| CNPCT/CN2016/084300 | 2016-06-01 | ||
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| TW201742865A TW201742865A (zh) | 2017-12-16 |
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| IL279579B2 (en) | 2018-06-21 | 2023-02-01 | Betta Pharmaceuticals Co Ltd | Crystalline form of a compound to inhibit the activity of cdk4/6 and its use |
| EP4188922A1 (en) | 2020-08-03 | 2023-06-07 | Teva Pharmaceuticals International GmbH | Solid state forms of ensartinib and ensartinib salts |
| EP4385510A4 (en) * | 2021-08-10 | 2025-08-20 | Betta Pharmaceuticals Co Ltd | USE OF ENSARTINIB OR A CORRESPONDING SALT IN THE TREATMENT OF A DISEASE CARRYING A MET EXON 14 SKIPPING MUTATION |
| KR102851417B1 (ko) * | 2022-08-16 | 2025-08-28 | 제이투에이치바이오텍 (주) | 피리미딘-4-카복사마이드 화합물의 결정형 및 이를 포함하는 경구용 약학 제제 |
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| CN102098917A (zh) * | 2008-06-19 | 2011-06-15 | 艾科睿控股公司 | 作为激酶抑制剂化合物的取代的哒嗪羧酰胺化合物 |
| CN103298806A (zh) * | 2010-10-08 | 2013-09-11 | 艾科睿控股公司 | 取代的哒嗪羧酰胺化合物 |
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| PL358271A1 (pl) * | 2000-03-06 | 2004-08-09 | Warner-Lambert Company | 5-alkilopirydo[2,3-D]pirymidyny jako inhibitory kinazy tyrozyny |
| CA2517256C (en) * | 2003-02-26 | 2013-04-30 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
| US8414489B2 (en) | 2003-11-13 | 2013-04-09 | Medtronic Minimed, Inc. | Fabrication of multi-sensor arrays |
| ME01309B (me) * | 2004-08-26 | 2013-12-20 | Pfizer | Pirazolom supstituirani heteroarilni spojevi kao inhibitori proteinskih kinaza |
| BRPI0514687A (pt) | 2004-08-26 | 2008-06-17 | Pfizer | compostos amino heteroarila como inibidores de proteìna tirosina cinase |
| KR101146852B1 (ko) * | 2005-12-05 | 2012-05-16 | 화이자 프로덕츠 인크. | Ｃ?ｍｅｔ／ｈｇｆｒ 억제제의 다형체 |
| CN101652068A (zh) * | 2007-01-19 | 2010-02-17 | 艾科睿制药公司 | 激酶抑制物化合物 |
| WO2012048258A2 (en) * | 2010-10-08 | 2012-04-12 | Xcovery Holding Company, Llc | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102098917A (zh) * | 2008-06-19 | 2011-06-15 | 艾科睿控股公司 | 作为激酶抑制剂化合物的取代的哒嗪羧酰胺化合物 |
| CN103298806A (zh) * | 2010-10-08 | 2013-09-11 | 艾科睿控股公司 | 取代的哒嗪羧酰胺化合物 |
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| CN109195964A (zh) | 2019-01-11 |
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| KR102466958B1 (ko) | 2022-11-14 |
| US10899744B2 (en) | 2021-01-26 |
| KR20190012231A (ko) | 2019-02-08 |
| WO2017206924A1 (zh) | 2017-12-07 |
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