TWI635864B - 寡核苷酸螯合複合物－多肽組合物及方法 - Google Patents

寡核苷酸螯合複合物－多肽組合物及方法 Download PDF

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Publication number
TWI635864B
TWI635864B TW102117594A TW102117594A TWI635864B TW I635864 B TWI635864 B TW I635864B TW 102117594 A TW102117594 A TW 102117594A TW 102117594 A TW102117594 A TW 102117594A TW I635864 B TWI635864 B TW I635864B
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TW
Taiwan
Prior art keywords
pharmaceutical composition
chelate complex
rep
seq
pegylated
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TW102117594A
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English (en)
Chinese (zh)
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TW201408308A (zh
Inventor
米歇爾 巴茲涅
安德魯 維隆
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雷普利可公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
TW102117594A 2012-05-18 2013-05-17 寡核苷酸螯合複合物－多肽組合物及方法 TWI635864B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261648711P 2012-05-18 2012-05-18
US61/648,711 2012-05-18
US201261695035P 2012-08-30 2012-08-30
US61/695,035 2012-08-30

Publications (2)

Publication Number Publication Date
TW201408308A TW201408308A (zh) 2014-03-01
TWI635864B true TWI635864B (zh) 2018-09-21

Family

ID=49581470

Family Applications (1)

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TW102117594A TWI635864B (zh) 2012-05-18 2013-05-17 寡核苷酸螯合複合物－多肽組合物及方法

Country Status (34)

Country Link
US (1) US9492506B2 (OSRAM)
EP (1) EP2849798B1 (OSRAM)
JP (1) JP2015517504A (OSRAM)
KR (1) KR102068109B1 (OSRAM)
CN (1) CN104349793B (OSRAM)
AU (1) AU2013262416B2 (OSRAM)
BR (1) BR112014028654A2 (OSRAM)
CA (1) CA2873529C (OSRAM)
CL (1) CL2014003134A1 (OSRAM)
CO (1) CO7131387A2 (OSRAM)
CR (1) CR20140527A (OSRAM)
CY (1) CY1124345T1 (OSRAM)
DK (1) DK2849798T3 (OSRAM)
DO (1) DOP2014000264A (OSRAM)
EA (1) EA035967B1 (OSRAM)
EC (1) ECSP14027694A (OSRAM)
ES (1) ES2873844T3 (OSRAM)
HR (1) HRP20210840T1 (OSRAM)
HU (1) HUE054875T2 (OSRAM)
IL (1) IL235548B (OSRAM)
LT (1) LT2849798T (OSRAM)
MX (1) MX346239B (OSRAM)
MY (1) MY168778A (OSRAM)
NZ (1) NZ703095A (OSRAM)
PH (1) PH12014502551B1 (OSRAM)
PL (1) PL2849798T3 (OSRAM)
PT (1) PT2849798T (OSRAM)
RS (1) RS62030B1 (OSRAM)
SG (1) SG11201407599SA (OSRAM)
SI (1) SI2849798T1 (OSRAM)
SM (1) SMT202100319T1 (OSRAM)
TW (1) TWI635864B (OSRAM)
WO (1) WO2013170386A1 (OSRAM)
ZA (1) ZA201408674B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2158316T3 (en) 2007-05-11 2015-07-20 Adynxx Inc Gene expression and pain
RU2668136C2 (ru) 2012-05-10 2018-09-26 Эйдинкс, Инк. Композиции для доставки активных ингредиентов
WO2014032176A1 (en) 2012-08-30 2014-03-06 Replicor Inc. Methods for the treatment of hepatitis b and hepatitis d infections
PT3166615T (pt) * 2014-07-10 2023-11-13 Replicor Inc Polímeros de ácidos nucleicos fosforotioados quelados para utilização em combinação com um inibidor da polimerase de hbv para o tratamento de infeções pelo vírus da hepatite b e hepatite d
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
MA53674A (fr) * 2018-11-08 2021-07-28 Aligos Therapeutics Inc Polymères oligonucléotidiques inhibant le transport de l'antigène s et procédés
US11166976B2 (en) 2018-11-08 2021-11-09 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
WO2024255846A1 (en) * 2023-06-16 2024-12-19 Ractigen Therapeutics Oligonucleotide formulation

Citations (2)

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WO2006042418A1 (en) * 2004-10-19 2006-04-27 Replicor Inc. Antiviral oligonucleotides
WO2012021985A1 (en) * 2010-08-20 2012-02-23 Replicor Inc. Oligonucleotide chelate complexes

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JP2769114B2 (ja) * 1993-10-29 1998-06-25 サイクローン・ファーマシューティカルズ ミニマルｂ型肝炎感染症治療用医薬組成物
UA78726C2 (en) * 2001-11-01 2007-04-25 Sciclone Pharmaceuticals Inc Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment
WO2004024919A1 (en) * 2002-09-13 2004-03-25 Replicor, Inc. Non-sequence complementary antiviral oligonucleotides
WO2004076474A2 (en) 2003-02-26 2004-09-10 Intermune, Inc. Polyethylene glycol modified interferon compositions and methods of use thereof
EP1677827B1 (en) * 2003-10-27 2008-12-10 Vertex Pharmaceuticals Incorporated Combinations for hcv treatment
WO2007022642A2 (en) * 2005-08-25 2007-03-01 Replicor Inc. Anti-inflammatory molecules and their uses
WO2007041279A2 (en) * 2005-09-29 2007-04-12 S-Cell Biosciences, Inc. Methods to treat t-cell disorders using tisf
WO2007036016A1 (en) * 2005-09-29 2007-04-05 Replicor Inc. Therapeutic molecules and their uses
GB0715383D0 (en) * 2007-08-08 2007-09-19 Asterion Ltd Interferon
WO2009065181A1 (en) * 2007-11-21 2009-05-28 Apollo Life Sciences Limited Nanostructures suitable for delivery of agents
AU2008334948B2 (en) * 2007-12-13 2014-11-20 Alnylam Pharmaceuticals, Inc. Methods and compositions for prevention or treatment of RSV infection
WO2009109665A1 (en) * 2008-03-07 2009-09-11 Santaris Pharma A/S Pharmaceutical compositions for treatment of microrna related diseases
WO2010138806A2 (en) * 2009-05-28 2010-12-02 Curna, Inc. Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
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WO2014032176A1 (en) 2012-08-30 2014-03-06 Replicor Inc. Methods for the treatment of hepatitis b and hepatitis d infections

Patent Citations (2)

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WO2006042418A1 (en) * 2004-10-19 2006-04-27 Replicor Inc. Antiviral oligonucleotides
WO2012021985A1 (en) * 2010-08-20 2012-02-23 Replicor Inc. Oligonucleotide chelate complexes

Also Published As

Publication number Publication date
KR20150013309A (ko) 2015-02-04
CA2873529C (en) 2020-08-18
HUE054875T2 (hu) 2021-10-28
ECSP14027694A (es) 2015-12-31
DK2849798T3 (da) 2021-05-31
JP2015517504A (ja) 2015-06-22
BR112014028654A2 (pt) 2017-10-10
IL235548A0 (en) 2015-01-29
AU2013262416B2 (en) 2017-05-11
EP2849798A4 (en) 2016-03-09
CN104349793A (zh) 2015-02-11
EP2849798A1 (en) 2015-03-25
WO2013170386A1 (en) 2013-11-21
CN104349793B (zh) 2017-11-10
CL2014003134A1 (es) 2015-02-13
EA201401278A1 (ru) 2015-04-30
LT2849798T (lt) 2021-08-10
AU2013262416A1 (en) 2014-12-18
US9492506B2 (en) 2016-11-15
CY1124345T1 (el) 2022-07-22
ES2873844T3 (es) 2021-11-04
SG11201407599SA (en) 2014-12-30
HK1204279A1 (en) 2015-11-13
HRP20210840T1 (hr) 2021-08-06
MY168778A (en) 2018-12-04
CO7131387A2 (es) 2014-12-01
ZA201408674B (en) 2016-01-27
MX2014014021A (es) 2015-02-10
SI2849798T1 (sl) 2021-08-31
DOP2014000264A (es) 2015-01-31
PT2849798T (pt) 2021-05-18
CR20140527A (es) 2014-12-15
CA2873529A1 (en) 2013-11-21
PH12014502551B1 (en) 2019-10-11
US20130309201A1 (en) 2013-11-21
MX346239B (es) 2017-03-13
EP2849798B1 (en) 2021-04-07
NZ703095A (en) 2016-07-29
EA035967B1 (ru) 2020-09-07
PH12014502551A1 (en) 2015-01-21
IL235548B (en) 2019-07-31
KR102068109B1 (ko) 2020-01-21
TW201408308A (zh) 2014-03-01
PL2849798T3 (pl) 2021-10-18
SMT202100319T1 (it) 2021-09-14
RS62030B1 (sr) 2021-07-30

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