TWI611186B - 多重妊娠之分子檢驗 - Google Patents
多重妊娠之分子檢驗 Download PDFInfo
- Publication number
- TWI611186B TWI611186B TW101106446A TW101106446A TWI611186B TW I611186 B TWI611186 B TW I611186B TW 101106446 A TW101106446 A TW 101106446A TW 101106446 A TW101106446 A TW 101106446A TW I611186 B TWI611186 B TW I611186B
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- fetuses
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/30—Unsupervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/40—Population genetics; Linkage disequilibrium
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Data Mining & Analysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Epidemiology (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
- Evolutionary Computation (AREA)
- Databases & Information Systems (AREA)
- Software Systems (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446256P | 2011-02-24 | 2011-02-24 | |
| US61/446,256 | 2011-02-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201243326A TW201243326A (en) | 2012-11-01 |
| TWI611186B true TWI611186B (zh) | 2018-01-11 |
Family
ID=47753591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101106446A TWI611186B (zh) | 2011-02-24 | 2012-02-24 | 多重妊娠之分子檢驗 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10900080B2 (enExample) |
| EP (5) | EP3202921B1 (enExample) |
| JP (2) | JP5837622B2 (enExample) |
| CN (2) | CN106011237B (enExample) |
| AU (1) | AU2012311262C1 (enExample) |
| CA (3) | CA3160848C (enExample) |
| TW (1) | TWI611186B (enExample) |
| WO (1) | WO2013041921A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3241914T (lt) | 2009-11-05 | 2019-04-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20240158855A1 (en) | 2010-05-18 | 2024-05-16 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12655483B2 (en) | 2010-05-18 | 2026-06-16 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) * | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| AU2011348100B2 (en) | 2010-12-22 | 2016-08-25 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| EP3202921B1 (en) | 2011-02-24 | 2019-02-13 | The Chinese University of Hong Kong | Molecular testing of multiple pregnancies |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| JP2015517317A (ja) * | 2012-05-23 | 2015-06-22 | ビージーアイ ダイアグノーシス カンパニー リミテッドＢｇｉ Ｄｉａｇｎｏｓｉｓ Ｃｏ．， Ｌｔｄ． | 双子の類型を鑑定する方法とシステム |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| TWI489305B (zh) * | 2012-11-21 | 2015-06-21 | Bgi Diagnosis Co Ltd | 對胎兒遺傳異常的無創性檢測 |
| ES2670544T3 (es) * | 2013-02-28 | 2018-05-30 | The Chinese University Of Hong Kong | Análisis de transcriptoma de plasma materno por secuenciación masiva en paralelo de ARN |
| CN105121660B (zh) * | 2013-03-15 | 2018-09-28 | 香港中文大学 | 确定多胎妊娠的胎儿基因组 |
| DK3011051T3 (en) | 2013-06-21 | 2019-04-23 | Sequenom Inc | Method for non-invasive evaluation of genetic variations |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| RU2717641C2 (ru) | 2014-04-21 | 2020-03-24 | Натера, Инк. | Обнаружение мутаций и плоидности в хромосомных сегментах |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| WO2017012544A1 (en) * | 2015-07-20 | 2017-01-26 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| CA3037366A1 (en) | 2016-09-29 | 2018-04-05 | Myriad Women's Health, Inc. | Noninvasive prenatal screening using dynamic iterative depth optimization |
| EP3998350B1 (en) | 2017-03-17 | 2025-05-07 | Sequenom, Inc. | Methods and processes for assessment of genetic mosaicism |
| US11441174B2 (en) | 2017-06-02 | 2022-09-13 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using differently labelled allele-specific probes |
| WO2018223057A1 (en) * | 2017-06-02 | 2018-12-06 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies |
| WO2018223055A1 (en) * | 2017-06-02 | 2018-12-06 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using differently labelled allele-specific probes |
| US11990208B2 (en) | 2017-06-20 | 2024-05-21 | Illumina, Inc. | Methods for accurate computational decomposition of DNA mixtures from contributors of unknown genotypes |
| DK3781714T3 (da) | 2018-04-14 | 2026-03-30 | Natera Inc | Fremgangsmåder til cancerpåvisning og -overvågning ved personlig påvisning af cirkulerende tumor-dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| CN112634986B (zh) * | 2019-09-24 | 2024-07-26 | 厦门赛尔吉亚医学检验所有限公司 | 一种基于孕妇外周血对双胞胎合子性质的无创鉴定方法 |
| KR102162831B1 (ko) | 2019-12-26 | 2020-10-08 | 주식회사 마크로젠 | 혼합 모델을 이용한 쌍태아의 접합성 타입 결정 방법 및 분석 장치 |
| US20230227897A1 (en) * | 2020-12-16 | 2023-07-20 | Seedna Inc. | Method for calculating the fidelity of the signal of polymorphic genetic loci |
| CN114214425B (zh) * | 2020-12-23 | 2024-01-19 | 上海亿康医学检验所有限公司 | 一种鉴定核酸样本的亲本倾向性的方法或装置 |
| CN113981062B (zh) * | 2021-10-14 | 2024-02-20 | 武汉蓝沙医学检验实验室有限公司 | 以非生父和母亲dna评估胎儿dna浓度的方法及应用 |
| WO2023120783A1 (ko) * | 2021-12-24 | 2023-06-29 | 주식회사 마크로젠 | 혼합 모델을 이용한 쌍태아의 접합성 타입 결정 방법 및 분석 장치 |
| CN116052766B (zh) * | 2023-01-09 | 2026-01-02 | 北京交通大学 | 一种染色体纯合区域的检测方法、系统及电子设备 |
| CN120412715B (zh) * | 2025-03-17 | 2025-11-28 | 上海蓝沙生物科技有限公司 | 一种通过多态性位点连锁区域块评估孕期母本游离血液中胎儿DNA浓度（cffDNA）的方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080070792A1 (en) * | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
| WO2010075459A1 (en) * | 2008-12-22 | 2010-07-01 | Celula, Inc. | Methods and genotyping panels for detecting alleles, genomes, and transcriptomes |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6013449A (en) * | 1997-11-26 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Probe-based analysis of heterozygous mutations using two-color labelling |
| CA2428757A1 (en) * | 2000-11-15 | 2002-07-18 | Roche Diagnostics Corporation | Methods and reagents for identifying rare fetal cells in the maternal circulation |
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| WO2003031646A1 (en) | 2001-10-12 | 2003-04-17 | The University Of Queensland | Multiple genetic marker selection and amplification |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
| ES2299059T3 (es) | 2004-07-01 | 2008-05-16 | Integragen | Gen de predisposicion al autismo humano que codifica para un factor de transcripcion y utilizaciones del mismo. |
| US7754428B2 (en) | 2006-05-03 | 2010-07-13 | The Chinese University Of Hong Kong | Fetal methylation markers |
| US12054776B2 (en) * | 2007-07-23 | 2024-08-06 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| LT3241914T (lt) | 2009-11-05 | 2019-04-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| US20110312503A1 (en) * | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
| US10316362B2 (en) * | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20120190021A1 (en) * | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Detection of genetic abnormalities |
| JP6153874B2 (ja) * | 2011-02-09 | 2017-06-28 | ナテラ， インコーポレイテッド | 非侵襲的出生前倍数性呼び出しのための方法 |
| EP3202921B1 (en) | 2011-02-24 | 2019-02-13 | The Chinese University of Hong Kong | Molecular testing of multiple pregnancies |
| ES2572912T3 (es) | 2011-04-12 | 2016-06-03 | Verinata Health, Inc | Resolución de fracciones de genoma mediante recuento de polimorfismos |
| CN102985561B (zh) | 2011-04-14 | 2015-04-01 | 维里纳塔健康公司 | 用于确定并且验证常见的和罕见的染色体非整倍性的归一化染色体 |
| WO2013052913A2 (en) * | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CN105121660B (zh) | 2013-03-15 | 2018-09-28 | 香港中文大学 | 确定多胎妊娠的胎儿基因组 |
-
2012
- 2012-02-24 EP EP17161168.4A patent/EP3202921B1/en active Active
- 2012-02-24 EP EP12834099.9A patent/EP2678451B1/en active Active
- 2012-02-24 US US13/405,073 patent/US10900080B2/en active Active
- 2012-02-24 WO PCT/IB2012/000344 patent/WO2013041921A1/en not_active Ceased
- 2012-02-24 AU AU2012311262A patent/AU2012311262C1/en active Active
- 2012-02-24 CN CN201610340015.1A patent/CN106011237B/zh active Active
- 2012-02-24 EP EP13187208.7A patent/EP2682887A2/en not_active Withdrawn
- 2012-02-24 JP JP2013554948A patent/JP5837622B2/ja active Active
- 2012-02-24 TW TW101106446A patent/TWI611186B/zh active
- 2012-02-24 EP EP14193704.5A patent/EP2860265B1/en active Active
- 2012-02-24 CA CA3160848A patent/CA3160848C/en active Active
- 2012-02-24 CA CA3252077A patent/CA3252077A1/en active Pending
- 2012-02-24 CN CN201280016005.2A patent/CN103492589B/zh active Active
- 2012-02-24 CA CA2827873A patent/CA2827873C/en active Active
- 2012-02-24 EP EP18213644.0A patent/EP3489368B1/en active Active
-
2015
- 2015-11-05 JP JP2015217329A patent/JP6068598B2/ja active Active
-
2020
- 2020-12-15 US US17/122,397 patent/US20210095340A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080070792A1 (en) * | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
| WO2010075459A1 (en) * | 2008-12-22 | 2010-07-01 | Celula, Inc. | Methods and genotyping panels for detecting alleles, genomes, and transcriptomes |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3160848C (en) | 2025-07-08 |
| US10900080B2 (en) | 2021-01-26 |
| JP2016034282A (ja) | 2016-03-17 |
| AU2012311262A1 (en) | 2013-05-02 |
| AU2012311262C1 (en) | 2017-06-29 |
| CA3252077A1 (en) | 2025-03-20 |
| CN103492589B (zh) | 2016-06-15 |
| EP3202921B1 (en) | 2019-02-13 |
| EP3489368A1 (en) | 2019-05-29 |
| EP2678451A1 (en) | 2014-01-01 |
| CN106011237A (zh) | 2016-10-12 |
| EP2860265B1 (en) | 2016-10-26 |
| JP2014507158A (ja) | 2014-03-27 |
| CA2827873C (en) | 2022-08-16 |
| EP2678451A4 (en) | 2014-10-22 |
| US20210095340A1 (en) | 2021-04-01 |
| AU2012311262B2 (en) | 2014-10-09 |
| EP2682887A2 (en) | 2014-01-08 |
| CA2827873A1 (en) | 2013-03-28 |
| EP2860265A1 (en) | 2015-04-15 |
| EP3489368B1 (en) | 2020-09-09 |
| JP6068598B2 (ja) | 2017-01-25 |
| TW201243326A (en) | 2012-11-01 |
| JP5837622B2 (ja) | 2015-12-24 |
| EP2678451B1 (en) | 2017-04-26 |
| WO2013041921A1 (en) | 2013-03-28 |
| CN106011237B (zh) | 2019-12-13 |
| CA3160848A1 (en) | 2013-03-28 |
| CN103492589A (zh) | 2014-01-01 |
| US20130059733A1 (en) | 2013-03-07 |
| EP3202921A1 (en) | 2017-08-09 |
| HK1203567A1 (en) | 2015-10-30 |
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