CA3160848C - MOLECULAR TEST FOR MULTIPLE PREGNANCIES - Google Patents

MOLECULAR TEST FOR MULTIPLE PREGNANCIES

Info

Publication number
CA3160848C
CA3160848C CA3160848A CA3160848A CA3160848C CA 3160848 C CA3160848 C CA 3160848C CA 3160848 A CA3160848 A CA 3160848A CA 3160848 A CA3160848 A CA 3160848A CA 3160848 C CA3160848 C CA 3160848C
Authority
CA
Canada
Prior art keywords
fetuses
fetal dna
loci
allele
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3160848A
Other languages
English (en)
French (fr)
Other versions
CA3160848A1 (en
Inventor
Kwan Chee Chan
Peiyong Jiang
Tak Yeung Leung
Yuk Ming Dennis Lo
Rossa Wai Kwun Chiu
Original Assignee
Chinese University of Hong Kong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinese University of Hong Kong filed Critical Chinese University of Hong Kong
Priority to CA3252077A priority Critical patent/CA3252077A1/en
Priority to CA3160848A priority patent/CA3160848C/en
Publication of CA3160848A1 publication Critical patent/CA3160848A1/en
Application granted granted Critical
Publication of CA3160848C publication Critical patent/CA3160848C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40—Population genetics; Linkage disequilibrium
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Data Mining & Analysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Epidemiology (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CA3160848A 2011-02-24 2012-02-24 MOLECULAR TEST FOR MULTIPLE PREGNANCIES Active CA3160848C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA3252077A CA3252077A1 (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies
CA3160848A CA3160848C (en) 2011-02-24 2012-02-24 MOLECULAR TEST FOR MULTIPLE PREGNANCIES

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161446256P 2011-02-24 2011-02-24
US61/446,256 2011-02-24
CA3252077A CA3252077A1 (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies
CA2827873A CA2827873C (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies
CA3160848A CA3160848C (en) 2011-02-24 2012-02-24 MOLECULAR TEST FOR MULTIPLE PREGNANCIES

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2827873A Division CA2827873C (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3252077A Division CA3252077A1 (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies

Publications (2)

Publication Number Publication Date
CA3160848A1 CA3160848A1 (en) 2013-03-28
CA3160848C true CA3160848C (en) 2025-07-08

Family

ID=47753591

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3160848A Active CA3160848C (en) 2011-02-24 2012-02-24 MOLECULAR TEST FOR MULTIPLE PREGNANCIES
CA3252077A Pending CA3252077A1 (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies
CA2827873A Active CA2827873C (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA3252077A Pending CA3252077A1 (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies
CA2827873A Active CA2827873C (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies

Country Status (8)

Country Link
US (2) US10900080B2 (enExample)
EP (5) EP3202921B1 (enExample)
JP (2) JP5837622B2 (enExample)
CN (2) CN106011237B (enExample)
AU (1) AU2012311262C1 (enExample)
CA (3) CA3160848C (enExample)
TW (1) TWI611186B (enExample)
WO (1) WO2013041921A1 (enExample)

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LT3241914T (lt) 2009-11-05 2019-04-25 The Chinese University Of Hong Kong Vaisiaus genomo analizė iš motinos biologinio mėginio
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US20240158855A1 (en) 2010-05-18 2024-05-16 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US12545960B2 (en) 2010-05-18 2026-02-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12655483B2 (en) 2010-05-18 2026-06-16 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) * 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
AU2011348100B2 (en) 2010-12-22 2016-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
EP3202921B1 (en) 2011-02-24 2019-02-13 The Chinese University of Hong Kong Molecular testing of multiple pregnancies
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP2015517317A (ja) * 2012-05-23 2015-06-22 ビージーアイ ダイアグノーシス カンパニー リミテッドＢｇｉ Ｄｉａｇｎｏｓｉｓ Ｃｏ．， Ｌｔｄ． 双子の類型を鑑定する方法とシステム
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
TWI489305B (zh) * 2012-11-21 2015-06-21 Bgi Diagnosis Co Ltd 對胎兒遺傳異常的無創性檢測
ES2670544T3 (es) * 2013-02-28 2018-05-30 The Chinese University Of Hong Kong Análisis de transcriptoma de plasma materno por secuenciación masiva en paralelo de ARN
CN105121660B (zh) * 2013-03-15 2018-09-28 香港中文大学 确定多胎妊娠的胎儿基因组
DK3011051T3 (en) 2013-06-21 2019-04-23 Sequenom Inc Method for non-invasive evaluation of genetic variations
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
WO2017012544A1 (en) * 2015-07-20 2017-01-26 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
CA3037366A1 (en) 2016-09-29 2018-04-05 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
EP3998350B1 (en) 2017-03-17 2025-05-07 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
US11441174B2 (en) 2017-06-02 2022-09-13 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
WO2018223057A1 (en) * 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies
WO2018223055A1 (en) * 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
US11990208B2 (en) 2017-06-20 2024-05-21 Illumina, Inc. Methods for accurate computational decomposition of DNA mixtures from contributors of unknown genotypes
DK3781714T3 (da) 2018-04-14 2026-03-30 Natera Inc Fremgangsmåder til cancerpåvisning og -overvågning ved personlig påvisning af cirkulerende tumor-dna
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN112634986B (zh) * 2019-09-24 2024-07-26 厦门赛尔吉亚医学检验所有限公司 一种基于孕妇外周血对双胞胎合子性质的无创鉴定方法
KR102162831B1 (ko) 2019-12-26 2020-10-08 주식회사 마크로젠 혼합 모델을 이용한 쌍태아의 접합성 타입 결정 방법 및 분석 장치
US20230227897A1 (en) * 2020-12-16 2023-07-20 Seedna Inc. Method for calculating the fidelity of the signal of polymorphic genetic loci
CN114214425B (zh) * 2020-12-23 2024-01-19 上海亿康医学检验所有限公司 一种鉴定核酸样本的亲本倾向性的方法或装置
CN113981062B (zh) * 2021-10-14 2024-02-20 武汉蓝沙医学检验实验室有限公司 以非生父和母亲dna评估胎儿dna浓度的方法及应用
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CN105121660B (zh) 2013-03-15 2018-09-28 香港中文大学 确定多胎妊娠的胎儿基因组

Also Published As

Publication number Publication date
US10900080B2 (en) 2021-01-26
JP2016034282A (ja) 2016-03-17
AU2012311262A1 (en) 2013-05-02
AU2012311262C1 (en) 2017-06-29
CA3252077A1 (en) 2025-03-20
CN103492589B (zh) 2016-06-15
EP3202921B1 (en) 2019-02-13
TWI611186B (zh) 2018-01-11
EP3489368A1 (en) 2019-05-29
EP2678451A1 (en) 2014-01-01
CN106011237A (zh) 2016-10-12
EP2860265B1 (en) 2016-10-26
JP2014507158A (ja) 2014-03-27
CA2827873C (en) 2022-08-16
EP2678451A4 (en) 2014-10-22
US20210095340A1 (en) 2021-04-01
AU2012311262B2 (en) 2014-10-09
EP2682887A2 (en) 2014-01-08
CA2827873A1 (en) 2013-03-28
EP2860265A1 (en) 2015-04-15
EP3489368B1 (en) 2020-09-09
JP6068598B2 (ja) 2017-01-25
TW201243326A (en) 2012-11-01
JP5837622B2 (ja) 2015-12-24
EP2678451B1 (en) 2017-04-26
WO2013041921A1 (en) 2013-03-28
CN106011237B (zh) 2019-12-13
CA3160848A1 (en) 2013-03-28
CN103492589A (zh) 2014-01-01
US20130059733A1 (en) 2013-03-07
EP3202921A1 (en) 2017-08-09
HK1203567A1 (en) 2015-10-30

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