CN103492589B - 多胎妊娠的分子测试 - Google Patents

多胎妊娠的分子测试 Download PDF

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CN103492589B
CN103492589B CN201280016005.2A CN201280016005A CN103492589B CN 103492589 B CN103492589 B CN 103492589B CN 201280016005 A CN201280016005 A CN 201280016005A CN 103492589 B CN103492589 B CN 103492589B
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locus
allele
fetus
biological sample
amount
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CN103492589A (zh
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卢煜明
赵慧君
陈君赐
梁德杨
江培勇
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Chinese University of Hong Kong CUHK
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    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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    • C12Q2600/00Oligonucleotides characterized by their use
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    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40Population genetics; Linkage disequilibrium
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CN201280016005.2A 2011-02-24 2012-02-24 多胎妊娠的分子测试 Active CN103492589B (zh)

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US201161446256P 2011-02-24 2011-02-24
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PCT/IB2012/000344 WO2013041921A1 (en) 2011-02-24 2012-02-24 Molecular testing of multiple pregnancies

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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057094A1 (en) 2009-11-05 2011-05-12 The Chinese University Of Hong Kong Fetal genomic analysis from a maternal biological sample
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) * 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2678451B1 (en) 2011-02-24 2017-04-26 The Chinese University Of Hong Kong Molecular testing of multiple pregnancies
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2012380897B2 (en) * 2012-05-23 2017-03-30 Bgi Diagnosis Co., Ltd. Method and system for identifying types of twins
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
TWI489305B (zh) * 2012-11-21 2015-06-21 Bgi Diagnosis Co Ltd 對胎兒遺傳異常的無創性檢測
KR102241051B1 (ko) 2013-02-28 2021-04-16 더 차이니즈 유니버시티 오브 홍콩 대량 동시 rna 서열분석에 의한 모체 혈장 전사물 분석
JP2016518811A (ja) * 2013-03-15 2016-06-30 ザ チャイニーズ ユニバーシティ オブ ホンコン 多胎妊娠における胎児ゲノムの決定
DK3011051T3 (en) 2013-06-21 2019-04-23 Sequenom Inc Method for non-invasive evaluation of genetic variations
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
AU2015249846B2 (en) 2014-04-21 2021-07-22 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
EP3325663B1 (en) 2015-07-20 2020-08-19 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
EP3518974A4 (en) 2016-09-29 2020-05-27 Myriad Women's Health, Inc. NON-INVASIVE PRENATAL SCREENING USING DYNAMIC ITERATIVE DEEP OPTIMIZATION
EP3998350B1 (en) 2017-03-17 2025-05-07 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
EP3631008B1 (en) * 2017-06-02 2025-12-03 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
US11441174B2 (en) 2017-06-02 2022-09-13 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
US11535886B2 (en) * 2017-06-02 2022-12-27 Affymetrix, Inc. Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies
SG11201911530RA (en) * 2017-06-20 2020-01-30 Illumina Inc Methods for accurate computational decomposition of dna mixtures from contributors of unknown genotypes
CA3090426A1 (en) 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN112634986B (zh) * 2019-09-24 2024-07-26 厦门赛尔吉亚医学检验所有限公司 一种基于孕妇外周血对双胞胎合子性质的无创鉴定方法
KR102162831B1 (ko) 2019-12-26 2020-10-08 주식회사 마크로젠 혼합 모델을 이용한 쌍태아의 접합성 타입 결정 방법 및 분석 장치
WO2022131328A1 (ja) * 2020-12-16 2022-06-23 株式会社seeDNA 多型座位の信号の信頼性値の算出方法
CN114214425B (zh) * 2020-12-23 2024-01-19 上海亿康医学检验所有限公司 一种鉴定核酸样本的亲本倾向性的方法或装置
CN113981062B (zh) * 2021-10-14 2024-02-20 武汉蓝沙医学检验实验室有限公司 以非生父和母亲dna评估胎儿dna浓度的方法及应用
WO2023120783A1 (ko) * 2021-12-24 2023-06-29 주식회사 마크로젠 혼합 모델을 이용한 쌍태아의 접합성 타입 결정 방법 및 분석 장치
CN120412715B (zh) * 2025-03-17 2025-11-28 上海蓝沙生物科技有限公司 一种通过多态性位点连锁区域块评估孕期母本游离血液中胎儿DNA浓度(cffDNA)的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010075459A1 (en) * 2008-12-22 2010-07-01 Celula, Inc. Methods and genotyping panels for detecting alleles, genomes, and transcriptomes

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6013449A (en) 1997-11-26 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Probe-based analysis of heterozygous mutations using two-color labelling
CA2428757A1 (en) 2000-11-15 2002-07-18 Roche Diagnostics Corporation Methods and reagents for identifying rare fetal cells in the maternal circulation
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
EP1442139A4 (en) 2001-10-12 2005-01-26 Univ Queensland SELECTION AND AMPLIFICATION OF MULTIPLE GENETIC MARKERS
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20100216153A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
ATE382101T1 (de) 2004-07-01 2008-01-15 Integragen Sa Einen transkriptionsfaktor kodierendes humanes prädispositionsgen für autismus sowie dessen verwendungen
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
US20080070792A1 (en) * 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
CN106886688B (zh) * 2007-07-23 2020-07-10 香港中文大学 用于分析癌症相关的遗传变异的系统
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2011057094A1 (en) 2009-11-05 2011-05-12 The Chinese University Of Hong Kong Fetal genomic analysis from a maternal biological sample
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US20110312503A1 (en) * 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US10316362B2 (en) * 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
WO2012103031A2 (en) * 2011-01-25 2012-08-02 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
JP6153874B2 (ja) * 2011-02-09 2017-06-28 ナテラ, インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
EP2678451B1 (en) 2011-02-24 2017-04-26 The Chinese University Of Hong Kong Molecular testing of multiple pregnancies
DK2697392T3 (en) 2011-04-12 2016-03-29 Verinata Health Inc SOLUTION OF GENOME FRACTIONS USING Polymorphism COUNTS
WO2012141712A1 (en) 2011-04-14 2012-10-18 Verinata Health, Inc. Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
AU2012318371B2 (en) 2011-10-06 2018-03-22 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP2016518811A (ja) 2013-03-15 2016-06-30 ザ チャイニーズ ユニバーシティ オブ ホンコン 多胎妊娠における胎児ゲノムの決定

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010075459A1 (en) * 2008-12-22 2010-07-01 Celula, Inc. Methods and genotyping panels for detecting alleles, genomes, and transcriptomes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Detection of male and female fetal DNA in maternal plasma by multiplex fluorescent polymerase chain reaction amptification of short tandem repeats;PERTL B ET AL;《HUMAN GENETICS》;20001231;第106卷(第1期);45-49 *
Non-invasive fetal sex determination using a conventional nested PCR analysis of fetal DNA in maternal plasma;TUNGWIWAT W ET AL;《CLINICA CHIMICA ACTA》;20031231;第334卷(第1-2期);173-177 *

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CA2827873C (en) 2022-08-16
JP2014507158A (ja) 2014-03-27
TWI611186B (zh) 2018-01-11
CA3160848C (en) 2025-07-08
JP6068598B2 (ja) 2017-01-25
AU2012311262B2 (en) 2014-10-09
US20130059733A1 (en) 2013-03-07
EP3489368A1 (en) 2019-05-29
EP2682887A2 (en) 2014-01-08
CN103492589A (zh) 2014-01-01
CN106011237B (zh) 2019-12-13
HK1203567A1 (en) 2015-10-30
US20210095340A1 (en) 2021-04-01
US10900080B2 (en) 2021-01-26
EP2678451A1 (en) 2014-01-01
WO2013041921A1 (en) 2013-03-28
CA3252077A1 (en) 2025-03-20
JP5837622B2 (ja) 2015-12-24
AU2012311262A1 (en) 2013-05-02
JP2016034282A (ja) 2016-03-17
EP3489368B1 (en) 2020-09-09
AU2012311262C1 (en) 2017-06-29
CA3160848A1 (en) 2013-03-28
EP2678451B1 (en) 2017-04-26
EP2860265A1 (en) 2015-04-15
TW201243326A (en) 2012-11-01
EP3202921B1 (en) 2019-02-13
EP3202921A1 (en) 2017-08-09
EP2678451A4 (en) 2014-10-22
CN106011237A (zh) 2016-10-12
CA2827873A1 (en) 2013-03-28
EP2860265B1 (en) 2016-10-26

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