TWI542685B - 供使用高甘油濃度製備1,3-丙二醇用之微生物 - Google Patents

供使用高甘油濃度製備1,3-丙二醇用之微生物 Download PDF

Info

Publication number
TWI542685B
TWI542685B TW100140808A TW100140808A TWI542685B TW I542685 B TWI542685 B TW I542685B TW 100140808 A TW100140808 A TW 100140808A TW 100140808 A TW100140808 A TW 100140808A TW I542685 B TWI542685 B TW I542685B
Authority
TW
Taiwan
Prior art keywords
genbank
atcc824
locus
replacing
encodes
Prior art date
Application number
TW100140808A
Other languages
English (en)
Chinese (zh)
Other versions
TW201226563A (en
Inventor
瑞勒 裴基
Original Assignee
代謝探索公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 代謝探索公司 filed Critical 代謝探索公司
Publication of TW201226563A publication Critical patent/TW201226563A/zh
Application granted granted Critical
Publication of TWI542685B publication Critical patent/TWI542685B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/32Processes using, or culture media containing, lower alkanols, i.e. C1 to C6
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145Clostridium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
TW100140808A 2010-11-10 2011-11-09 供使用高甘油濃度製備1,3-丙二醇用之微生物 TWI542685B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41216210P 2010-11-10 2010-11-10
EP10306234 2010-11-10

Publications (2)

Publication Number Publication Date
TW201226563A TW201226563A (en) 2012-07-01
TWI542685B true TWI542685B (zh) 2016-07-21

Family

ID=43828229

Family Applications (1)

Application Number Title Priority Date Filing Date
TW100140808A TWI542685B (zh) 2010-11-10 2011-11-09 供使用高甘油濃度製備1,3-丙二醇用之微生物

Country Status (10)

Country Link
US (1) US20130177956A1 (https=)
EP (2) EP2638172A1 (https=)
JP (1) JP2013545461A (https=)
KR (1) KR20140005170A (https=)
CN (1) CN103298945A (https=)
AR (1) AR083799A1 (https=)
BR (1) BR112013011417A2 (https=)
CA (1) CA2814441A1 (https=)
TW (1) TWI542685B (https=)
WO (1) WO2012062832A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015035266A1 (en) * 2013-09-06 2015-03-12 The Curators Of The University Of Missouri Conversion of glycerol to 1,3-propanediol under haloalkaline conditions
KR20190026851A (ko) 2016-07-08 2019-03-13 에보니크 데구사 게엠베하 당 포스포트랜스퍼라제 시스템 (pts)을 코딩하는 유전자를 포함하는 미생물에 의한 메티오닌 또는 그의 히드록시 유사체 형태의 발효적 생산을 위한 방법
CN106190901B (zh) 2016-07-15 2020-06-26 上海交通大学 一种菌及其获取方法和应用
CN106978380A (zh) * 2016-12-14 2017-07-25 天津科技大学 一株高木糖耐性肺炎克雷伯氏菌株及其构建方法
ES2893002T3 (es) * 2017-02-20 2022-02-07 Metabolic Explorer Sa Consorcio microbiano que comprende clostridia para la producción de 1,3-propanodiol a partir de glicerol
EP3438270A1 (en) 2017-08-04 2019-02-06 Metabolic Explorer Microorganism and method for improved 1,3-propanediol production by fermentation on a culture medium with high glycerine content
EP3692159A1 (en) 2017-10-02 2020-08-12 Metabolic Explorer Method for producing organic acid salts from fermentation broth
US11814663B2 (en) * 2018-08-10 2023-11-14 Metabolic Explorer Microorganisms with improved 1,3-propanediol and butyric acid production
CN112358986B (zh) * 2020-11-09 2022-10-21 华南理工大学 一种丁酸梭菌及其在固定化发酵生产1,3-丙二醇的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796081B1 (fr) 1999-07-09 2003-09-26 Agronomique Inst Nat Rech Procede de preparation du 1,3-propanediol par un micro-organisme recombinant en l'absence de coenzyme b12 ou de l'un de ses precurseurs
CN1327001C (zh) 2005-06-03 2007-07-18 清华大学 利用生物柴油副产物甘油生产1,3-丙二醇的方法
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
WO2008040387A1 (en) 2006-10-03 2008-04-10 Metabolic Explorer Process for chromosomal integration and dna sequence replacement in clostridia
WO2008052595A1 (en) 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
KR101543485B1 (ko) 2007-11-30 2015-08-10 메타볼릭 익스플로러 발효 브로쓰로부터 알콜을 정제하는 방법
ES2401155T3 (es) 2008-10-03 2013-04-17 Metabolic Explorer Procedimiento para la purificación de un alcohol a partir de un caldo de fermentación que utiliza un evaporador de película descendente, de película renovada, de película fina o de recorrido corto
EP2248904A1 (en) * 2009-05-05 2010-11-10 Metabolic Explorer Continuous culture for 1,3-propanediol production using high glycerine concentration

Also Published As

Publication number Publication date
WO2012062832A1 (en) 2012-05-18
CN103298945A (zh) 2013-09-11
JP2013545461A (ja) 2013-12-26
TW201226563A (en) 2012-07-01
KR20140005170A (ko) 2014-01-14
AR083799A1 (es) 2013-03-20
US20130177956A1 (en) 2013-07-11
CA2814441A1 (en) 2012-05-18
EP3012325A1 (en) 2016-04-27
EP2638172A1 (en) 2013-09-18
BR112013011417A2 (pt) 2017-04-04

Similar Documents

Publication Publication Date Title
TWI542685B (zh) 供使用高甘油濃度製備1,3-丙二醇用之微生物
González-Pajuelo et al. Metabolic engineering of Clostridium acetobutylicum for the industrial production of 1, 3-propanediol from glycerol
KR20200091458A (ko) 에틸렌 글리콜의 생물학적 생성을 위한 미생물 및 방법
EP2248904A1 (en) Continuous culture for 1,3-propanediol production using high glycerine concentration
KR101005453B1 (ko) 신규 글리세롤 탈수 효소
CN102388141A (zh) 使用丙三醇氧化途径被阻断的重组菌株生产1,3-丙二醇的方法
US20160319308A1 (en) Recombinant microorganism having enhanced 1,3-propanediol producing ability and method for producing 1,3-propanediol using the same
US11814663B2 (en) Microorganisms with improved 1,3-propanediol and butyric acid production
EP3662073B1 (en) Microorganism and method for improved 1,3-propanediol production by fermentation on a culture medium with high glycerine content
CN102395671B (zh) 用于制造1,3-丙二醇的丙三醇氧化途径中阻隔的突变体
KR102620924B1 (ko) 글리세롤로부터의 1,3-프로판디올 생산을 위한 클로스트리디아를 포함하는 미생물 컨소시엄
CN104611383A (zh) 重组生物体3 - 羟基丙酸的制备方法