JP2013545461A - 高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物 - Google Patents

高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物 Download PDF

Info

Publication number
JP2013545461A
JP2013545461A JP2013538190A JP2013538190A JP2013545461A JP 2013545461 A JP2013545461 A JP 2013545461A JP 2013538190 A JP2013538190 A JP 2013538190A JP 2013538190 A JP2013538190 A JP 2013538190A JP 2013545461 A JP2013545461 A JP 2013545461A
Authority
JP
Japan
Prior art keywords
glycerin
population
strain
locus
propanediol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013538190A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013545461A5 (https=
Inventor
ライナー、フィゲ
Original Assignee
メタボリック エクスプローラー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メタボリック エクスプローラー filed Critical メタボリック エクスプローラー
Publication of JP2013545461A publication Critical patent/JP2013545461A/ja
Publication of JP2013545461A5 publication Critical patent/JP2013545461A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/32Processes using, or culture media containing, lower alkanols, i.e. C1 to C6
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145Clostridium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013538190A 2010-11-10 2011-11-10 高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物 Pending JP2013545461A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41216210P 2010-11-10 2010-11-10
EP10306234 2010-11-10
US61/412,162 2010-11-10
EP10306234.5 2010-11-10
PCT/EP2011/069789 WO2012062832A1 (en) 2010-11-10 2011-11-10 Microorganisms for 1,3-propanediol production using high glycerine concentration

Publications (2)

Publication Number Publication Date
JP2013545461A true JP2013545461A (ja) 2013-12-26
JP2013545461A5 JP2013545461A5 (https=) 2016-05-12

Family

ID=43828229

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013538190A Pending JP2013545461A (ja) 2010-11-10 2011-11-10 高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物

Country Status (10)

Country Link
US (1) US20130177956A1 (https=)
EP (2) EP2638172A1 (https=)
JP (1) JP2013545461A (https=)
KR (1) KR20140005170A (https=)
CN (1) CN103298945A (https=)
AR (1) AR083799A1 (https=)
BR (1) BR112013011417A2 (https=)
CA (1) CA2814441A1 (https=)
TW (1) TWI542685B (https=)
WO (1) WO2012062832A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020529849A (ja) * 2017-08-04 2020-10-15 メタボリック エクスプローラー グリセリン高含有培養培地上での発酵による1,3−プロパンジオールの改良された生産を行うための微生物および方法
JP2021533764A (ja) * 2018-08-10 2021-12-09 メタボリック エクスプローラー 1,3−プロパンジオールおよび酪酸の生産が改善された微生物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015035266A1 (en) * 2013-09-06 2015-03-12 The Curators Of The University Of Missouri Conversion of glycerol to 1,3-propanediol under haloalkaline conditions
KR20190026851A (ko) 2016-07-08 2019-03-13 에보니크 데구사 게엠베하 당 포스포트랜스퍼라제 시스템 (pts)을 코딩하는 유전자를 포함하는 미생물에 의한 메티오닌 또는 그의 히드록시 유사체 형태의 발효적 생산을 위한 방법
CN106190901B (zh) 2016-07-15 2020-06-26 上海交通大学 一种菌及其获取方法和应用
CN106978380A (zh) * 2016-12-14 2017-07-25 天津科技大学 一株高木糖耐性肺炎克雷伯氏菌株及其构建方法
ES2893002T3 (es) * 2017-02-20 2022-02-07 Metabolic Explorer Sa Consorcio microbiano que comprende clostridia para la producción de 1,3-propanodiol a partir de glicerol
EP3692159A1 (en) 2017-10-02 2020-08-12 Metabolic Explorer Method for producing organic acid salts from fermentation broth
CN112358986B (zh) * 2020-11-09 2022-10-21 华南理工大学 一种丁酸梭菌及其在固定化发酵生产1,3-丙二醇的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796081B1 (fr) 1999-07-09 2003-09-26 Agronomique Inst Nat Rech Procede de preparation du 1,3-propanediol par un micro-organisme recombinant en l'absence de coenzyme b12 ou de l'un de ses precurseurs
CN1327001C (zh) 2005-06-03 2007-07-18 清华大学 利用生物柴油副产物甘油生产1,3-丙二醇的方法
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
WO2008040387A1 (en) 2006-10-03 2008-04-10 Metabolic Explorer Process for chromosomal integration and dna sequence replacement in clostridia
WO2008052595A1 (en) 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
KR101543485B1 (ko) 2007-11-30 2015-08-10 메타볼릭 익스플로러 발효 브로쓰로부터 알콜을 정제하는 방법
ES2401155T3 (es) 2008-10-03 2013-04-17 Metabolic Explorer Procedimiento para la purificación de un alcohol a partir de un caldo de fermentación que utiliza un evaporador de película descendente, de película renovada, de película fina o de recorrido corto
EP2248904A1 (en) * 2009-05-05 2010-11-10 Metabolic Explorer Continuous culture for 1,3-propanediol production using high glycerine concentration

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6015046535; GONZALEZ-PAJUELO, M., et al.: Metabolic Engineering 7, 2005, pp.329-336 *
JPN6015046537; GONZALEZ-PAJUELO, M., et al.: APPLIED AND ENVIRONMENTAL MICROBIOLOGY 72(1), 2006, pp.96-101 *
JPN6015046539; CELINSKA, E.: Biotechnology Advances 28, 20100331, pp.519-530 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020529849A (ja) * 2017-08-04 2020-10-15 メタボリック エクスプローラー グリセリン高含有培養培地上での発酵による1,3−プロパンジオールの改良された生産を行うための微生物および方法
JP7175961B2 (ja) 2017-08-04 2022-11-21 メタボリック エクスプローラー グリセリン高含有培養培地上での発酵による1,3-プロパンジオールの改良された生産を行うための微生物および方法
JP2021533764A (ja) * 2018-08-10 2021-12-09 メタボリック エクスプローラー 1,3−プロパンジオールおよび酪酸の生産が改善された微生物
JP7569783B2 (ja) 2018-08-10 2024-10-18 メタボリック エクスプローラー 1,3-プロパンジオールおよび酪酸の生産が改善された微生物

Also Published As

Publication number Publication date
WO2012062832A1 (en) 2012-05-18
CN103298945A (zh) 2013-09-11
TW201226563A (en) 2012-07-01
KR20140005170A (ko) 2014-01-14
AR083799A1 (es) 2013-03-20
US20130177956A1 (en) 2013-07-11
CA2814441A1 (en) 2012-05-18
EP3012325A1 (en) 2016-04-27
EP2638172A1 (en) 2013-09-18
BR112013011417A2 (pt) 2017-04-04
TWI542685B (zh) 2016-07-21

Similar Documents

Publication Publication Date Title
JP2013545461A (ja) 高グリセリン濃度を用いる1,3−プロパンジオール生産用微生物
EP2248904A1 (en) Continuous culture for 1,3-propanediol production using high glycerine concentration
JP2013532481A (ja) 新規細菌及びその使用方法
WO2008052595A1 (en) Process for the biological production of 1,3-propanediol from glycerol with high yield
CN107075462A (zh) 2,3‑丁二醇的生成能力得到增强的重组微生物及利用其的2,3‑丁二醇的生产方法
US11814663B2 (en) Microorganisms with improved 1,3-propanediol and butyric acid production
EP3662073B1 (en) Microorganism and method for improved 1,3-propanediol production by fermentation on a culture medium with high glycerine content
Goyal et al. Butanol tolerant bacteria: isolation and characterization of butanol tolerant Staphylococcus sciuri sp.
EP3583221B1 (en) Microbial consortium comprising clostridia for 1,3-propanediol production from glycerol
CN102395671B (zh) 用于制造1,3-丙二醇的丙三醇氧化途径中阻隔的突变体

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141107

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151117

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160217

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20160317

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160317

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160715

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161013

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161209

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170704