TWI519326B - 用於方便取出植入物的自分離層 - Google Patents
用於方便取出植入物的自分離層 Download PDFInfo
- Publication number
- TWI519326B TWI519326B TW100124399A TW100124399A TWI519326B TW I519326 B TWI519326 B TW I519326B TW 100124399 A TW100124399 A TW 100124399A TW 100124399 A TW100124399 A TW 100124399A TW I519326 B TWI519326 B TW I519326B
- Authority
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- Taiwan
- Prior art keywords
- layer
- bone implant
- thickness
- implant
- bone
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims description 96
- 239000000463 material Substances 0.000 claims description 56
- 210000000988 bone and bone Anatomy 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 18
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 17
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000010521 absorption reaction Methods 0.000 claims description 9
- 239000000560 biocompatible material Substances 0.000 claims description 9
- 238000004090 dissolution Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002195 soluble material Substances 0.000 claims description 9
- 210000001124 body fluid Anatomy 0.000 claims description 8
- 239000010839 body fluid Substances 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 6
- 238000002513 implantation Methods 0.000 claims description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 6
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 6
- 239000010936 titanium Substances 0.000 claims description 6
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
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- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229910001092 metal group alloy Inorganic materials 0.000 claims description 4
- 229910045601 alloy Inorganic materials 0.000 claims description 3
- 239000000956 alloy Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- 239000002198 insoluble material Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 11
- 239000000758 substrate Substances 0.000 description 7
- 230000035876 healing Effects 0.000 description 4
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
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- 238000005240 physical vapour deposition Methods 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 229910010038 TiAl Inorganic materials 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
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- 238000009830 intercalation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000001755 magnetron sputter deposition Methods 0.000 description 1
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- 238000002844 melting Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
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- 238000011084 recovery Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- 238000002207 thermal evaporation Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36292310P | 2010-07-09 | 2010-07-09 |
Publications (2)
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| TW201206509A TW201206509A (en) | 2012-02-16 |
| TWI519326B true TWI519326B (zh) | 2016-02-01 |
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| TW100124399A TWI519326B (zh) | 2010-07-09 | 2011-07-11 | 用於方便取出植入物的自分離層 |
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| EP (2) | EP2590596B1 (enExample) |
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| CA (1) | CA2803262C (enExample) |
| TW (1) | TWI519326B (enExample) |
| WO (1) | WO2012006334A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103908328A (zh) * | 2013-01-06 | 2014-07-09 | 香港中文大学 | 骨植入物 |
| CN104740692B (zh) * | 2013-12-31 | 2017-09-05 | 上海微创骨科医疗科技有限公司 | 一种骨内固定植入物及其制备方法 |
| WO2016159493A1 (ko) * | 2015-03-31 | 2016-10-06 | (주)웹스 | 생분해성 임플란트 구조체 |
| JP7222217B2 (ja) | 2018-10-30 | 2023-02-15 | Tdk株式会社 | 積層コイル部品 |
| US11998192B2 (en) | 2021-05-10 | 2024-06-04 | Cilag Gmbh International | Adaptive control of surgical stapling instrument based on staple cartridge type |
| US12622731B2 (en) * | 2023-11-01 | 2026-05-12 | Vanderbilt University | Hinged dorsal spanning plate |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0523926A3 (en) * | 1991-07-15 | 1993-12-01 | Smith & Nephew Richards Inc | Prosthetic implants with bioabsorbable coating |
| US6214049B1 (en) * | 1999-01-14 | 2001-04-10 | Comfort Biomedical, Inc. | Method and apparatus for augmentating osteointegration of prosthetic implant devices |
| US6277150B1 (en) * | 1999-06-11 | 2001-08-21 | Gore Enterprise Holdings, Inc. | Facial implant having one porous surface |
| DE10206627A1 (de) | 2002-02-15 | 2003-08-28 | Diocom B V | Körpergelenk ersetzendes Titanimplantat mit einem oder mehreren Grundkörpern |
| DK1545389T3 (da) * | 2002-07-31 | 2020-07-20 | Mast Biosurgery Ag | Indretning til forebyggelse af adhæsioner mellem et implantat og omgivende væv |
| CN100515364C (zh) * | 2002-07-31 | 2009-07-22 | 马斯特生物外科股份公司 | 用于防止植入物与周围组织之间的粘附的装置 |
| EP1572258A1 (en) * | 2002-11-25 | 2005-09-14 | Yissum Research Development Company, of The Hebrew University of Jerusalem | Organic-inorganic nanocomposite coatings for implant materials and methods of preparation thereof |
| US9119901B2 (en) * | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
| US20070038176A1 (en) * | 2005-07-05 | 2007-02-15 | Jan Weber | Medical devices with machined layers for controlled communications with underlying regions |
| DE102005032604A1 (de) * | 2005-07-13 | 2007-01-18 | Gfe Medizintechnik Gmbh | Resorbierbares, in den Körper einsetzbares medizinisches Element, insbesondere resorbierbares Implantat |
| WO2008005509A2 (en) * | 2006-07-06 | 2008-01-10 | Massachusetts Institute Of Technology | Methods and compositions for altering biological surfaces |
| WO2008022932A2 (en) * | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | Controlled release system and method for manufacturing the same |
| DE102006044415B4 (de) * | 2006-09-18 | 2013-03-21 | Aap Implantate Ag | Titanhaltiges Implantat zur temporären Implantation |
| CN101003889A (zh) * | 2007-02-05 | 2007-07-25 | 陈鸿文 | 纳米金刚石镀膜人工关节、骨板及骨钉的表面处理技术 |
| US8273402B2 (en) * | 2007-02-26 | 2012-09-25 | Medtronic Vascular, Inc. | Drug coated stent with magnesium topcoat |
| EP2211926A2 (en) | 2007-10-10 | 2010-08-04 | Miv Therapeutics Inc. | Lipid coatings for implantable medical devices |
| CN101411899B (zh) * | 2007-10-17 | 2012-07-04 | 上海交通大学医学院附属仁济医院 | 一种血管内涂层支架 |
| US20090186068A1 (en) * | 2008-01-18 | 2009-07-23 | Chameleon Scientific Corporation | Atomic plasma deposited coatings for drug release |
| EP2257971A4 (en) | 2008-01-18 | 2012-11-28 | Nanosurface Technologies Llc | NANO FILM PROTECTION AND REMOVAL MATERIALS |
| US20100129626A1 (en) * | 2008-11-24 | 2010-05-27 | Langhorn Jason B | Multilayer Coatings |
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2011
- 2011-07-06 US US13/177,179 patent/US20120172997A1/en not_active Abandoned
- 2011-07-06 CA CA2803262A patent/CA2803262C/en not_active Expired - Fee Related
- 2011-07-06 WO PCT/US2011/043048 patent/WO2012006334A1/en not_active Ceased
- 2011-07-06 EP EP11731609.1A patent/EP2590596B1/en not_active Not-in-force
- 2011-07-06 BR BR112012033415A patent/BR112012033415A2/pt active Search and Examination
- 2011-07-06 CN CN201180031623.XA patent/CN102958470B/zh not_active Expired - Fee Related
- 2011-07-06 KR KR1020187001560A patent/KR101882667B1/ko not_active Expired - Fee Related
- 2011-07-06 EP EP15179931.9A patent/EP2982343B1/en not_active Not-in-force
- 2011-07-06 JP JP2013518802A patent/JP5873490B2/ja not_active Expired - Fee Related
- 2011-07-06 CN CN201610187056.1A patent/CN105749345B/zh not_active Expired - Fee Related
- 2011-07-06 KR KR1020137000534A patent/KR101826590B1/ko not_active Expired - Fee Related
- 2011-07-11 TW TW100124399A patent/TWI519326B/zh not_active IP Right Cessation
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2016
- 2016-01-14 JP JP2016005066A patent/JP6199419B2/ja not_active Expired - Fee Related
- 2016-08-22 US US15/243,548 patent/US10166105B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016105789A (ja) | 2016-06-16 |
| EP2982343B1 (en) | 2017-01-04 |
| KR20180008937A (ko) | 2018-01-24 |
| CA2803262C (en) | 2018-09-11 |
| TW201206509A (en) | 2012-02-16 |
| JP6199419B2 (ja) | 2017-09-20 |
| JP2013535239A (ja) | 2013-09-12 |
| CN102958470B (zh) | 2016-04-20 |
| BR112012033415A2 (pt) | 2016-11-29 |
| EP2590596B1 (en) | 2015-08-26 |
| US20160354208A1 (en) | 2016-12-08 |
| KR101882667B1 (ko) | 2018-07-30 |
| WO2012006334A1 (en) | 2012-01-12 |
| CA2803262A1 (en) | 2012-01-12 |
| CN102958470A (zh) | 2013-03-06 |
| EP2590596A1 (en) | 2013-05-15 |
| JP5873490B2 (ja) | 2016-03-01 |
| EP2982343A1 (en) | 2016-02-10 |
| US10166105B2 (en) | 2019-01-01 |
| US20120172997A1 (en) | 2012-07-05 |
| KR20130139831A (ko) | 2013-12-23 |
| CN105749345A (zh) | 2016-07-13 |
| CN105749345B (zh) | 2019-10-25 |
| KR101826590B1 (ko) | 2018-02-07 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |