TWI510189B - 殺外寄生蟲之方法及調配物 - Google Patents
殺外寄生蟲之方法及調配物 Download PDFInfo
- Publication number
- TWI510189B TWI510189B TW099118946A TW99118946A TWI510189B TW I510189 B TWI510189 B TW I510189B TW 099118946 A TW099118946 A TW 099118946A TW 99118946 A TW99118946 A TW 99118946A TW I510189 B TWI510189 B TW I510189B
- Authority
- TW
- Taiwan
- Prior art keywords
- animal
- formulation
- pharmaceutically acceptable
- acceptable salt
- spinetoram
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 32
- 238000009472 formulation Methods 0.000 title claims description 30
- 238000000034 method Methods 0.000 title description 12
- 230000001984 ectoparasiticidal effect Effects 0.000 title description 2
- 241001465754 Metazoa Species 0.000 claims description 58
- 229930185156 spinosyn Natural products 0.000 claims description 46
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 24
- 241000282326 Felis catus Species 0.000 claims description 20
- 206010061217 Infestation Diseases 0.000 claims description 18
- 244000078703 ectoparasite Species 0.000 claims description 18
- 239000005929 Spinetoram Substances 0.000 claims description 15
- GOENIMGKWNZVDA-OAMCMWGQSA-N Spinetoram Chemical compound CO[C@@H]1[C@H](OCC)[C@@H](OC)[C@H](C)O[C@H]1OC1C[C@H]2[C@@H]3C=C4C(=O)[C@H](C)[C@@H](O[C@@H]5O[C@H](C)[C@H](CC5)N(C)C)CCC[C@H](CC)OC(=O)CC4[C@@H]3CC[C@@H]2C1 GOENIMGKWNZVDA-OAMCMWGQSA-N 0.000 claims description 15
- 239000007921 spray Substances 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 230000000699 topical effect Effects 0.000 claims description 10
- 241000282472 Canis lupus familiaris Species 0.000 claims description 7
- -1 conditioner Substances 0.000 claims description 6
- 230000037396 body weight Effects 0.000 claims description 5
- 241000258924 Ctenocephalides felis Species 0.000 claims description 4
- 208000006004 Flea Infestations Diseases 0.000 claims description 3
- 241000238631 Hexapoda Species 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 3
- 238000005470 impregnation Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- 238000005507 spraying Methods 0.000 claims 2
- 239000004909 Moisturizer Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 description 29
- 241000283690 Bos taurus Species 0.000 description 19
- 238000012360 testing method Methods 0.000 description 17
- 239000000463 material Substances 0.000 description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 15
- 241000255925 Diptera Species 0.000 description 13
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 241000258242 Siphonaptera Species 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 241000257159 Musca domestica Species 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 9
- JFLRKDZMHNBDQS-UCQUSYKYSA-N CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C Chemical class CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C JFLRKDZMHNBDQS-UCQUSYKYSA-N 0.000 description 8
- 239000005930 Spinosad Substances 0.000 description 8
- 229940014213 spinosad Drugs 0.000 description 8
- 241000238876 Acari Species 0.000 description 7
- 241000257226 Muscidae Species 0.000 description 7
- 239000002917 insecticide Substances 0.000 description 7
- 230000009885 systemic effect Effects 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 241000607479 Yersinia pestis Species 0.000 description 6
- 238000003197 gene knockdown Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241001674044 Blattodea Species 0.000 description 5
- 241000282412 Homo Species 0.000 description 5
- 206010036790 Productive cough Diseases 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 210000003802 sputum Anatomy 0.000 description 5
- 208000024794 sputum Diseases 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- WGYZMNBUZFHYRX-UHFFFAOYSA-N 1-(1-methoxypropan-2-yloxy)propan-2-ol Chemical compound COCC(C)OCC(C)O WGYZMNBUZFHYRX-UHFFFAOYSA-N 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 235000019445 benzyl alcohol Nutrition 0.000 description 4
- 229960004217 benzyl alcohol Drugs 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 239000000575 pesticide Substances 0.000 description 4
- 229940041677 topical spray Drugs 0.000 description 4
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 241000282324 Felis Species 0.000 description 3
- 239000005899 Fipronil Substances 0.000 description 3
- 241000628997 Flos Species 0.000 description 3
- 241000257232 Haematobia irritans Species 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 241001480837 Rhipicephalus annulatus Species 0.000 description 3
- 241000239226 Scorpiones Species 0.000 description 3
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 235000013601 eggs Nutrition 0.000 description 3
- 229940013764 fipronil Drugs 0.000 description 3
- 244000045947 parasite Species 0.000 description 3
- 229960000490 permethrin Drugs 0.000 description 3
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 239000011120 plywood Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000011200 topical administration Methods 0.000 description 3
- 229940100613 topical solution Drugs 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 230000003442 weekly effect Effects 0.000 description 3
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- 241000243985 Onchocerca volvulus Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 239000003517 fume Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000001418 larval effect Effects 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000003359 percent control normalization Methods 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000004546 suspension concentrate Substances 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- WEYSQARHSRZNTC-UHFFFAOYSA-N 1h-benzimidazol-2-ylcarbamic acid Chemical compound C1=CC=C2NC(NC(=O)O)=NC2=C1 WEYSQARHSRZNTC-UHFFFAOYSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- RFEJUZJILGIRHQ-XRIOVQLTSA-N 2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.OC(=O)C(O)C(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-XRIOVQLTSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000238682 Amblyomma americanum Species 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 240000005528 Arctium lappa Species 0.000 description 1
- 235000003130 Arctium lappa Nutrition 0.000 description 1
- 235000008078 Arctium minus Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- LSPHULWDVZXLIL-UHFFFAOYSA-N Camphoric acid Natural products CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 244000205754 Colocasia esculenta Species 0.000 description 1
- 235000006481 Colocasia esculenta Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 206010016675 Filariasis lymphatic Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 241000282375 Herpestidae Species 0.000 description 1
- 239000005906 Imidacloprid Substances 0.000 description 1
- 239000002310 Isopropyl citrate Substances 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 208000037263 Lymphatic filariasis Diseases 0.000 description 1
- 241000033974 Mauremys sinensis Species 0.000 description 1
- 239000005916 Methomyl Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000517307 Pediculus humanus Species 0.000 description 1
- 241001674048 Phthiraptera Species 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 241000517304 Pthirus pubis Species 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241001501942 Suricata suricatta Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229960002587 amitraz Drugs 0.000 description 1
- QXAITBQSYVNQDR-ZIOPAAQOSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1/N=C/N(C)\C=N\C1=CC=C(C)C=C1C QXAITBQSYVNQDR-ZIOPAAQOSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 238000011953 bioanalysis Methods 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- LSPHULWDVZXLIL-QUBYGPBYSA-N camphoric acid Chemical compound CC1(C)[C@H](C(O)=O)CC[C@]1(C)C(O)=O LSPHULWDVZXLIL-QUBYGPBYSA-N 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011461 current therapy Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000013057 ectoparasiticide Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 208000005239 filarial elephantiasis Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229940056881 imidacloprid Drugs 0.000 description 1
- YWTYJOPNNQFBPC-UHFFFAOYSA-N imidacloprid Chemical compound [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1 YWTYJOPNNQFBPC-UHFFFAOYSA-N 0.000 description 1
- 201000001371 inclusion conjunctivitis Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 235000019300 isopropyl citrate Nutrition 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 239000004611 light stabiliser Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- UHXUZOCRWCRNSJ-QPJJXVBHSA-N methomyl Chemical compound CNC(=O)O\N=C(/C)SC UHXUZOCRWCRNSJ-QPJJXVBHSA-N 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 208000003177 ocular onchocerciasis Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 208000002042 onchocerciasis Diseases 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 231100000272 reduced body weight Toxicity 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000010850 salt effect Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000936 topical exposure Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 206010044325 trachoma Diseases 0.000 description 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
- 201000002311 trypanosomiasis Diseases 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
- A01N45/02—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring having three carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21850209P | 2009-06-19 | 2009-06-19 | |
| US26225609P | 2009-11-18 | 2009-11-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201102000A TW201102000A (en) | 2011-01-16 |
| TWI510189B true TWI510189B (zh) | 2015-12-01 |
Family
ID=42657965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW099118946A TWI510189B (zh) | 2009-06-19 | 2010-06-10 | 殺外寄生蟲之方法及調配物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8871727B2 (enExample) |
| EP (1) | EP2442646B1 (enExample) |
| JP (1) | JP5738853B2 (enExample) |
| CN (2) | CN102802414B (enExample) |
| AU (1) | AU2010260102B2 (enExample) |
| CA (1) | CA2764401C (enExample) |
| ES (1) | ES2658155T3 (enExample) |
| IL (1) | IL216441A0 (enExample) |
| MX (1) | MX2011014028A (enExample) |
| NZ (2) | NZ596645A (enExample) |
| PL (1) | PL2442646T3 (enExample) |
| PT (1) | PT2442646T (enExample) |
| TW (1) | TWI510189B (enExample) |
| WO (1) | WO2010148053A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI510189B (zh) * | 2009-06-19 | 2015-12-01 | Lilly Co Eli | 殺外寄生蟲之方法及調配物 |
| JP6220403B2 (ja) * | 2012-11-14 | 2017-10-25 | イーライ リリー アンド カンパニー | 有害外部寄生虫駆除方法及び製剤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032716A1 (en) * | 2001-09-17 | 2005-02-10 | Lowe Lionel Barry | Pesticidal formulations |
| US20070104750A1 (en) * | 2005-11-01 | 2007-05-10 | Dow Agrosciences Llc | Pesticidally active compositions having enhanced activity |
| WO2008057520A1 (en) * | 2006-11-03 | 2008-05-15 | Dow Agrosciences Llc | Selective reduction of spinosyn factors et-j and et-l to spinetoram |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130369C (zh) * | 1995-06-14 | 2003-12-10 | 道农业科学公司 | 对刺糖多孢菌素化合物的合成修饰 |
| US6001981A (en) | 1996-06-13 | 1999-12-14 | Dow Agrosciences Llc | Synthetic modification of Spinosyn compounds |
| CA2337789C (en) | 1998-07-02 | 2010-10-26 | Eli Lilly And Company | Formulations for controlling human lice |
| WO2001011962A1 (en) * | 1999-08-12 | 2001-02-22 | Eli Lilly And Company | Topical treatment for insect pests in companion animals |
| ES2261229T3 (es) | 1999-08-12 | 2006-11-16 | Eli Lilly And Company | Uso de spinosad o de una formulacion que comprende spinosad. |
| US6927210B1 (en) | 1999-08-12 | 2005-08-09 | Eli Lilly And Company | Ectoparasiticidal aqueous suspension formulations of spinosyns |
| US6933318B1 (en) | 1999-08-12 | 2005-08-23 | Eli Lilly And Company | Topical organic ectoparasiticidal formulations |
| IL147829A0 (en) * | 1999-08-12 | 2002-08-14 | Lilly Co Eli | Topical organic ectoparasiticidal formulations |
| UA71997C2 (en) | 1999-09-13 | 2005-01-17 | Dow Agrosciences Llc | Pesticide macrolide, a method for the preparation thereof, strain saccharopolyspora producing macrolide and a mixture based thereon and a method for controlling insecticides and acaricides |
| US6727228B2 (en) | 2001-04-25 | 2004-04-27 | Johnson & Johnson Consumer Companies, Inc. | Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs |
| BR0104024C1 (pt) * | 2001-09-13 | 2003-11-04 | Albrecht Equip Ind Ltda | Equipamento e processo para beneficiamento de tecidos em geral |
| DE102004025321A1 (de) * | 2004-05-19 | 2005-12-08 | Alstom Technology Ltd | Strömungsmaschinenschaufel |
| EP1849363A1 (en) * | 2006-03-09 | 2007-10-31 | Cheminova A/S | Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin |
| WO2007123855A2 (en) * | 2006-04-20 | 2007-11-01 | E. I. Du Pont De Nemours And Company | Pyrazolines for controlling invertebrate pests |
| WO2007139872A2 (en) * | 2006-05-25 | 2007-12-06 | Dow Agrosciences Llc | Spinosyn fumigants |
| WO2007144786A2 (en) * | 2006-05-26 | 2007-12-21 | Entarco Sa | The vapor-phase application of spinosyn for the control of pests, and formulations and products utilizing the same |
| CA2676147C (en) * | 2007-02-09 | 2012-03-13 | Pfizer Limited | Antiparasitic agents |
| JP5315818B2 (ja) * | 2007-07-12 | 2013-10-16 | 住友化学株式会社 | 有害生物防除組成物 |
| EP2033518A1 (en) | 2007-09-06 | 2009-03-11 | Cheminova A/S | Pesticidal compositions |
| JP2009132670A (ja) * | 2007-11-09 | 2009-06-18 | Sumitomo Chemical Co Ltd | 有害生物防除組成物 |
| CN102137593A (zh) * | 2008-08-28 | 2011-07-27 | 巴斯夫欧洲公司 | 包含氰基亚砜亚胺化合物和乙基多杀菌素的杀虫混合物 |
| PL2334187T3 (pl) | 2008-09-12 | 2018-03-30 | Dow Agrosciences Llc | Stabilizowane kompozycje szkodnikobójcze |
| UA108200C2 (uk) * | 2009-05-08 | 2015-04-10 | Лікарські форми та способи застосування ектопаразитоцидів | |
| TWI510189B (zh) * | 2009-06-19 | 2015-12-01 | Lilly Co Eli | 殺外寄生蟲之方法及調配物 |
-
2010
- 2010-06-10 TW TW099118946A patent/TWI510189B/zh active
- 2010-06-16 PL PL10727315T patent/PL2442646T3/pl unknown
- 2010-06-16 JP JP2012516226A patent/JP5738853B2/ja active Active
- 2010-06-16 EP EP10727315.3A patent/EP2442646B1/en active Active
- 2010-06-16 NZ NZ596645A patent/NZ596645A/xx unknown
- 2010-06-16 CA CA2764401A patent/CA2764401C/en active Active
- 2010-06-16 US US12/816,400 patent/US8871727B2/en active Active
- 2010-06-16 MX MX2011014028A patent/MX2011014028A/es active IP Right Grant
- 2010-06-16 CN CN201080026479.6A patent/CN102802414B/zh active Active
- 2010-06-16 WO PCT/US2010/038768 patent/WO2010148053A1/en not_active Ceased
- 2010-06-16 AU AU2010260102A patent/AU2010260102B2/en active Active
- 2010-06-16 CN CN201410269641.7A patent/CN104115831A/zh active Pending
- 2010-06-16 ES ES10727315.3T patent/ES2658155T3/es active Active
- 2010-06-16 PT PT107273153T patent/PT2442646T/pt unknown
- 2010-06-16 NZ NZ614975A patent/NZ614975A/en unknown
-
2011
- 2011-11-17 IL IL216441A patent/IL216441A0/en unknown
-
2014
- 2014-10-28 US US14/525,939 patent/US20150045313A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032716A1 (en) * | 2001-09-17 | 2005-02-10 | Lowe Lionel Barry | Pesticidal formulations |
| US20070104750A1 (en) * | 2005-11-01 | 2007-05-10 | Dow Agrosciences Llc | Pesticidally active compositions having enhanced activity |
| WO2008057520A1 (en) * | 2006-11-03 | 2008-05-15 | Dow Agrosciences Llc | Selective reduction of spinosyn factors et-j and et-l to spinetoram |
Non-Patent Citations (1)
| Title |
|---|
| Huang KX. et al. "Recent advances in the biochemistry of spinosyns." Appl Microbiol Biotechnol. 2009, 82(1):13-23. Sparks TC. et al. "Neural network-based QSAR and insecticide discovery: spinetoram." J Comput Aided Mol Des. 2008, 22(6-7):393-401. * |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201102000A (en) | 2011-01-16 |
| NZ596645A (en) | 2013-09-27 |
| EP2442646B1 (en) | 2018-01-10 |
| US20150045313A1 (en) | 2015-02-12 |
| PT2442646T (pt) | 2018-03-26 |
| AU2010260102A1 (en) | 2011-12-08 |
| IL216441A0 (en) | 2012-02-29 |
| CN102802414A (zh) | 2012-11-28 |
| CN104115831A (zh) | 2014-10-29 |
| JP2012530709A (ja) | 2012-12-06 |
| AU2010260102B2 (en) | 2013-09-26 |
| MX2011014028A (es) | 2012-02-21 |
| PL2442646T3 (pl) | 2018-06-29 |
| US8871727B2 (en) | 2014-10-28 |
| WO2010148053A1 (en) | 2010-12-23 |
| NZ614975A (en) | 2014-12-24 |
| JP5738853B2 (ja) | 2015-06-24 |
| CN102802414B (zh) | 2014-07-23 |
| EP2442646A1 (en) | 2012-04-25 |
| ES2658155T3 (es) | 2018-03-08 |
| CA2764401C (en) | 2014-02-18 |
| US20100324129A1 (en) | 2010-12-23 |
| CA2764401A1 (en) | 2010-12-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20100197620A1 (en) | Pesticidal formulations | |
| AU2001291478A1 (en) | Pesticidal formulations | |
| TWI462696B (zh) | 殺外寄生蟲之方法及調配物 | |
| TWI510189B (zh) | 殺外寄生蟲之方法及調配物 | |
| US20030161854A1 (en) | Synergistic formulations | |
| AU2013224751B2 (en) | Ectoparasiticidal methods and formulations | |
| JP6220403B2 (ja) | 有害外部寄生虫駆除方法及び製剤 | |
| AU2001239017B2 (en) | Synergistic formulations | |
| AU2005202712A1 (en) | Synergistic formulations | |
| HK1162252B (en) | Spinetoram for use in controlling flea infestations in cat and dog | |
| AU2013273709A1 (en) | Ectoparasiticidal methods and formulations |