TWI503539B - 利用時間解析電流測定法測定分析物濃度之生物感測器、系統及方法 - Google Patents
利用時間解析電流測定法測定分析物濃度之生物感測器、系統及方法 Download PDFInfo
- Publication number
- TWI503539B TWI503539B TW099104136A TW99104136A TWI503539B TW I503539 B TWI503539 B TW I503539B TW 099104136 A TW099104136 A TW 099104136A TW 99104136 A TW99104136 A TW 99104136A TW I503539 B TWI503539 B TW I503539B
- Authority
- TW
- Taiwan
- Prior art keywords
- analyte
- current
- concentration
- time period
- fluid sample
- Prior art date
Links
- 239000012491 analyte Substances 0.000 title claims description 152
- 238000000034 method Methods 0.000 title claims description 72
- 238000004082 amperometric method Methods 0.000 title description 3
- 238000012360 testing method Methods 0.000 claims description 140
- 239000012530 fluid Substances 0.000 claims description 62
- 238000011088 calibration curve Methods 0.000 claims description 55
- 238000005534 hematocrit Methods 0.000 claims description 39
- 238000009792 diffusion process Methods 0.000 claims description 27
- 230000005284 excitation Effects 0.000 claims description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims description 20
- 238000005259 measurement Methods 0.000 claims description 19
- 210000000601 blood cell Anatomy 0.000 claims description 14
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 229940088598 enzyme Drugs 0.000 claims description 8
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 7
- -1 potassium ferricyanide Chemical compound 0.000 claims description 7
- 108010015776 Glucose oxidase Proteins 0.000 claims description 6
- 239000004366 Glucose oxidase Substances 0.000 claims description 6
- 229940116332 glucose oxidase Drugs 0.000 claims description 6
- 235000019420 glucose oxidase Nutrition 0.000 claims description 6
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 6
- 238000013213 extrapolation Methods 0.000 claims description 4
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 1
- 239000000523 sample Substances 0.000 description 109
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 61
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 60
- 239000008103 glucose Substances 0.000 description 60
- 239000010410 layer Substances 0.000 description 51
- 210000004369 blood Anatomy 0.000 description 48
- 239000008280 blood Substances 0.000 description 48
- 238000001514 detection method Methods 0.000 description 18
- 125000006850 spacer group Chemical group 0.000 description 15
- 239000000306 component Substances 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- 238000003556 assay Methods 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 10
- 230000007704 transition Effects 0.000 description 10
- 238000005070 sampling Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 210000003743 erythrocyte Anatomy 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 230000000875 corresponding effect Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000012086 standard solution Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 5
- 239000004020 conductor Substances 0.000 description 5
- 230000002596 correlated effect Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000012790 adhesive layer Substances 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 4
- 239000004312 hexamethylene tetramine Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 239000012503 blood component Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 239000012777 electrically insulating material Substances 0.000 description 3
- 238000003487 electrochemical reaction Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 230000012292 cell migration Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000006479 redox reaction Methods 0.000 description 2
- 230000027756 respiratory electron transport chain Effects 0.000 description 2
- 230000003678 scratch resistant effect Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- NECRQCBKTGZNMH-UHFFFAOYSA-N 3,5-dimethylhex-1-yn-3-ol Chemical compound CC(C)CC(C)(O)C#C NECRQCBKTGZNMH-UHFFFAOYSA-N 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000016222 Pancreatic disease Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002210 biocatalytic effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000000840 electrochemical analysis Methods 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 239000012992 electron transfer agent Substances 0.000 description 1
- 238000006056 electrooxidation reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 238000009532 heart rate measurement Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000024691 pancreas disease Diseases 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005596 polymer binder Polymers 0.000 description 1
- 239000002491 polymer binding agent Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- YBCAZPLXEGKKFM-UHFFFAOYSA-K ruthenium(iii) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Ru+3] YBCAZPLXEGKKFM-UHFFFAOYSA-K 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0295—Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/410,048 US8101062B2 (en) | 2007-07-26 | 2009-03-24 | System and methods for determination of analyte concentration using time resolved amperometry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201037299A TW201037299A (en) | 2010-10-16 |
| TWI503539B true TWI503539B (zh) | 2015-10-11 |
Family
ID=42153885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW099104136A TWI503539B (zh) | 2009-03-24 | 2010-02-10 | 利用時間解析電流測定法測定分析物濃度之生物感測器、系統及方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8101062B2 (enExample) |
| EP (1) | EP2411797B1 (enExample) |
| JP (2) | JP2012521564A (enExample) |
| AU (1) | AU2010229211B2 (enExample) |
| BR (1) | BRPI1009874B1 (enExample) |
| MX (1) | MX2011009756A (enExample) |
| TW (1) | TWI503539B (enExample) |
| WO (1) | WO2010110945A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005078118A1 (en) | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
| CN103048442B (zh) | 2005-09-30 | 2015-04-08 | 拜尔健康护理有限责任公司 | 门控伏特安培法 |
| US8101062B2 (en) * | 2007-07-26 | 2012-01-24 | Nipro Diagnostics, Inc. | System and methods for determination of analyte concentration using time resolved amperometry |
| TWI453401B (zh) * | 2007-07-26 | 2014-09-21 | Nipro Diagnostics Inc | 使用時間解析電流測定法之用於分析物濃度測定的系統及方法（一） |
| WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
| RU2491549C2 (ru) | 2007-12-10 | 2013-08-27 | БАЙЕР ХЕЛТКЭА ЭлЭлСи | Амперометрия со стробированием и быстрым считыванием |
| CN102089650B (zh) | 2008-07-10 | 2014-01-29 | 拜尔健康护理有限责任公司 | 具有电流分析法及伏安分析法的工作循环的系统及方法 |
| US20120011125A1 (en) | 2008-12-23 | 2012-01-12 | Roche Diagnostics Operations, Inc. | Management method and system for implementation, execution, data collection, and data analysis of a structured collection procedure which runs on a collection device |
| WO2010072386A2 (en) | 2008-12-23 | 2010-07-01 | Roche Diagnostics Gmbh | Structured testing method for diagnostic or therapy support of a patient with a chronic disease and devices thereof |
| US9918635B2 (en) * | 2008-12-23 | 2018-03-20 | Roche Diabetes Care, Inc. | Systems and methods for optimizing insulin dosage |
| ES2886462T3 (es) * | 2009-09-15 | 2021-12-20 | Agamatrix Inc | Sistema y método biosensor electroquímico implantable |
| EP3106871B1 (en) * | 2009-11-30 | 2021-10-27 | Intuity Medical, Inc. | A method of verifying the accuracy of the operation of an analyte monitoring device |
| EP2550530A1 (en) * | 2010-03-22 | 2013-01-30 | Bayer HealthCare LLC | Residual compensation for a biosensor |
| EP2615976B1 (en) * | 2010-09-13 | 2019-07-24 | Lifescan Scotland Limited | Analyte measurement method and system with hematocrit compensation |
| US8560251B2 (en) | 2011-08-16 | 2013-10-15 | Instrumentation Laboratory Company | System and method of increasing sample throughput by estimation of a sensor endpoint |
| EP2745110B1 (en) | 2011-08-16 | 2016-10-05 | Instrumentation Laboratory Company | Extrapolation of interpolated sensor data to increase sample throughput |
| EP3586831A1 (en) | 2011-09-21 | 2020-01-01 | Ascensia Diabetes Care Holdings AG | Analysis compensation including segmented signals |
| US8534115B2 (en) * | 2011-10-17 | 2013-09-17 | Schlumberger Technology Corporation | Systems and methods of determining parameter values in a downhole environment |
| US9903830B2 (en) | 2011-12-29 | 2018-02-27 | Lifescan Scotland Limited | Accurate analyte measurements for electrochemical test strip based on sensed physical characteristic(s) of the sample containing the analyte |
| WO2014072820A2 (en) * | 2012-11-08 | 2014-05-15 | Thomas William Beck | Chronoamperometric methods and devices for electrochemical quantification of analytes |
| WO2014100423A1 (en) * | 2012-12-21 | 2014-06-26 | Abbott Diabetes Care Inc. | Method for improving measurement accuracy and devices and systems related thereto |
| US9835578B2 (en) | 2013-06-27 | 2017-12-05 | Lifescan Scotland Limited | Temperature compensation for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte |
| US9435764B2 (en) | 2013-06-27 | 2016-09-06 | Lifescan Scotland Limited | Transient signal error trap for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte |
| US9435762B2 (en) | 2013-06-27 | 2016-09-06 | Lifescan Scotland Limited | Fill error trap for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte |
| US9459231B2 (en) | 2013-08-29 | 2016-10-04 | Lifescan Scotland Limited | Method and system to determine erroneous measurement signals during a test measurement sequence |
| US9243276B2 (en) | 2013-08-29 | 2016-01-26 | Lifescan Scotland Limited | Method and system to determine hematocrit-insensitive glucose values in a fluid sample |
| US9828621B2 (en) | 2013-09-10 | 2017-11-28 | Lifescan Scotland Limited | Anomalous signal error trap for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte |
| WO2015134779A1 (en) | 2014-03-07 | 2015-09-11 | Bayer Healthcare Llc | Biosensor calibration coding systems and methods |
| US20160091451A1 (en) | 2014-09-25 | 2016-03-31 | Lifescan Scotland Limited | Accurate analyte measurements for electrochemical test strip to determine analyte measurement time based on measured temperature, physical characteristic and estimated analyte value |
| US20160091450A1 (en) | 2014-09-25 | 2016-03-31 | Lifescan Scotland Limited | Accurate analyte measurements for electrochemical test strip to determine analyte measurement time based on measured temperature, physical characteristic and estimated analyte value and their temperature compensated values |
| GB201420982D0 (en) * | 2014-11-26 | 2015-01-07 | Inside Biometrics Ltd | Verifying operation of a meter |
| US9423374B2 (en) | 2015-01-26 | 2016-08-23 | Lifescan Scotland Limited | Reference electrode error trap determined from a specified sampling time and a pre-determined sampling time |
| US9904890B2 (en) | 2015-03-13 | 2018-02-27 | Instrumentation Laboratory Company | Detecting a transient error in a body fluid sample |
| US10907192B2 (en) * | 2015-04-07 | 2021-02-02 | Polymer Technology Systems, Inc. | Systems and methods for artificial test strip controls |
| TWI609182B (zh) * | 2016-11-04 | 2017-12-21 | 五鼎生物技術股份有限公司 | 葡萄糖量測裝置與設備 |
| JPWO2018116887A1 (ja) * | 2016-12-20 | 2019-10-24 | 株式会社堀場製作所 | 測定装置、校正方法、及び、測定装置用プログラム |
| US20180217079A1 (en) * | 2017-01-31 | 2018-08-02 | Cilag Gmbh International | Determining an analyte concentration of a physiological fluid having an interferent |
| ES3074709T3 (es) * | 2017-06-30 | 2026-07-22 | Abbott Diabetes Care Inc | Procedimiento y aparato para la detección de analito utilizando un biosensor electroquímico |
| DE102017121303A1 (de) | 2017-09-14 | 2019-03-14 | Arntz Beteiligungs Gmbh & Co. Kg | Gummiertes Textilmaterial für eine Riemenlage, zugehörige Kautschukmischung und Riemen |
| CN111683592B (zh) * | 2017-10-30 | 2023-11-03 | 加利福尼亚大学董事会 | 使用电化学传感器对分析物进行无校正的体内测量 |
| US11382541B2 (en) * | 2018-11-16 | 2022-07-12 | Medtronic Minimed, Inc. | Miniaturized analyte sensor |
| CN113340970A (zh) * | 2019-06-24 | 2021-09-03 | 深圳硅基传感科技有限公司 | 基于电化学参数的葡萄糖传感器的出厂校准方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080149480A1 (en) * | 2006-12-22 | 2008-06-26 | Home Diagnostics, Inc. | Gel formation to reduce hematocrit sensitivity in electrochemical test |
| US20090026094A1 (en) * | 2007-05-11 | 2009-01-29 | Home Diagnostics, Inc. | Two-pulse systems and methods for determining analyte concentration |
| WO2009015316A1 (en) * | 2007-07-26 | 2009-01-29 | Home Diagnostics, Inc, | System and methods for determination of analyte concentration using time resolved amperometry |
| TW200912314A (en) * | 2007-06-18 | 2009-03-16 | Home Diagnostics Inc | Biosensor and ultrasonic method of making a biosensor |
| TW200912308A (en) * | 2007-05-21 | 2009-03-16 | Delta Electronics Inc | Biosensor and composition thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0672845B2 (ja) | 1986-09-01 | 1994-09-14 | 富士写真フイルム株式会社 | 分析方法 |
| US5352351A (en) | 1993-06-08 | 1994-10-04 | Boehringer Mannheim Corporation | Biosensing meter with fail/safe procedures to prevent erroneous indications |
| US6153069A (en) * | 1995-02-09 | 2000-11-28 | Tall Oak Ventures | Apparatus for amperometric Diagnostic analysis |
| AUPN661995A0 (en) * | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
| JPH09292387A (ja) | 1996-04-25 | 1997-11-11 | Kdk Corp | 被測定成分量の測定方法及び被測定成分量の測定装置 |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| US6251260B1 (en) * | 1998-08-24 | 2001-06-26 | Therasense, Inc. | Potentiometric sensors for analytic determination |
| US7276146B2 (en) | 2001-11-16 | 2007-10-02 | Roche Diagnostics Operations, Inc. | Electrodes, methods, apparatuses comprising micro-electrode arrays |
| US20060091006A1 (en) * | 1999-11-04 | 2006-05-04 | Yi Wang | Analyte sensor with insertion monitor, and methods |
| CN100346158C (zh) | 2000-11-30 | 2007-10-31 | 松下电器产业株式会社 | 基质的定量方法 |
| WO2003000127A2 (en) * | 2001-06-22 | 2003-01-03 | Cygnus, Inc. | Method for improving the performance of an analyte monitoring system |
| US7018843B2 (en) * | 2001-11-07 | 2006-03-28 | Roche Diagnostics Operations, Inc. | Instrument |
| KR100475634B1 (ko) * | 2001-12-24 | 2005-03-15 | 주식회사 아이센스 | 일정 소량의 시료를 빠르게 도입할 수 있는 시료도입부를구비한 바이오 센서 |
| US6863800B2 (en) * | 2002-02-01 | 2005-03-08 | Abbott Laboratories | Electrochemical biosensor strip for analysis of liquid samples |
| CA2480550C (en) * | 2002-03-22 | 2011-07-12 | Cygnus, Inc. | Improving performance of an analyte monitoring device |
| US6743635B2 (en) | 2002-04-25 | 2004-06-01 | Home Diagnostics, Inc. | System and methods for blood glucose sensing |
| KR100729307B1 (ko) | 2002-06-17 | 2007-06-15 | 아크레이 인코퍼레이티드 | 글루코스 탈수소효소를 이용한 글루코스 농도 측정방법 및글루코스 센서 |
| CN100510733C (zh) | 2002-11-01 | 2009-07-08 | 爱科来株式会社 | 具有固体成分浓缩机构的测量用具 |
| ES2709991T3 (es) * | 2003-08-21 | 2019-04-22 | Agamatrix Inc | Método y aparato para el análisis de propiedades electroquímicas |
| JP4469983B2 (ja) * | 2004-04-23 | 2010-06-02 | 独立行政法人産業技術総合研究所 | 多項目同時測定用バイオセンサおよび該多項目同時測定用バイオセンサの使用方法 |
| EP1924848A2 (en) | 2005-08-16 | 2008-05-28 | Home Diagnostics, Inc. | Method for test strip manufacturing and analysis |
| ES2535657T3 (es) | 2005-09-14 | 2015-05-13 | Sumitomo Electric Industries, Ltd. | Dispositivo de medición por biosensor, sistema de medición por biosensor, y método de medición por biosensor |
| US7749371B2 (en) | 2005-09-30 | 2010-07-06 | Lifescan, Inc. | Method and apparatus for rapid electrochemical analysis |
| US20080020452A1 (en) | 2006-07-18 | 2008-01-24 | Natasha Popovich | Diagnostic strip coding system with conductive layers |
| US7822557B2 (en) * | 2006-10-31 | 2010-10-26 | Abbott Diabetes Care Inc. | Analyte sensors and methods |
| US8101062B2 (en) * | 2007-07-26 | 2012-01-24 | Nipro Diagnostics, Inc. | System and methods for determination of analyte concentration using time resolved amperometry |
-
2009
- 2009-03-24 US US12/410,048 patent/US8101062B2/en active Active
-
2010
- 2010-02-04 EP EP10705219.3A patent/EP2411797B1/en active Active
- 2010-02-04 BR BRPI1009874A patent/BRPI1009874B1/pt active IP Right Grant
- 2010-02-04 WO PCT/US2010/023199 patent/WO2010110945A1/en not_active Ceased
- 2010-02-04 MX MX2011009756A patent/MX2011009756A/es active IP Right Grant
- 2010-02-04 JP JP2012502028A patent/JP2012521564A/ja not_active Withdrawn
- 2010-02-04 AU AU2010229211A patent/AU2010229211B2/en active Active
- 2010-02-10 TW TW099104136A patent/TWI503539B/zh active
-
2011
- 2011-12-20 US US13/331,346 patent/US8574424B2/en active Active
-
2013
- 2013-08-29 JP JP2013177623A patent/JP2013238623A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080149480A1 (en) * | 2006-12-22 | 2008-06-26 | Home Diagnostics, Inc. | Gel formation to reduce hematocrit sensitivity in electrochemical test |
| US20090026094A1 (en) * | 2007-05-11 | 2009-01-29 | Home Diagnostics, Inc. | Two-pulse systems and methods for determining analyte concentration |
| TW200912308A (en) * | 2007-05-21 | 2009-03-16 | Delta Electronics Inc | Biosensor and composition thereof |
| TW200912314A (en) * | 2007-06-18 | 2009-03-16 | Home Diagnostics Inc | Biosensor and ultrasonic method of making a biosensor |
| WO2009015316A1 (en) * | 2007-07-26 | 2009-01-29 | Home Diagnostics, Inc, | System and methods for determination of analyte concentration using time resolved amperometry |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2411797B1 (en) | 2014-10-08 |
| US20120234700A1 (en) | 2012-09-20 |
| EP2411797A1 (en) | 2012-02-01 |
| JP2013238623A (ja) | 2013-11-28 |
| AU2010229211B2 (en) | 2014-02-20 |
| WO2010110945A1 (en) | 2010-09-30 |
| BRPI1009874A2 (pt) | 2016-03-08 |
| MX2011009756A (es) | 2011-09-29 |
| TW201037299A (en) | 2010-10-16 |
| AU2010229211A1 (en) | 2011-10-13 |
| US8574424B2 (en) | 2013-11-05 |
| BRPI1009874B1 (pt) | 2020-01-28 |
| JP2012521564A (ja) | 2012-09-13 |
| US8101062B2 (en) | 2012-01-24 |
| US20090194432A1 (en) | 2009-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2010229211B2 (en) | System and methods for determination of analyte concentration using time resolved amperometry | |
| EP2176652B1 (en) | System and methods for determination of analyte concentration using time resolved amperometry | |
| US9632054B2 (en) | Systems and methods for high accuracy analyte measurement | |
| US9347910B2 (en) | Systems and methods for improved stability of electrochemical sensors | |
| US20090026094A1 (en) | Two-pulse systems and methods for determining analyte concentration | |
| US20120111739A1 (en) | Dual Frequency Impedance Measurement of Hematocrit in Strips | |
| EP3438661A1 (en) | Slope-based compensation | |
| JP6680702B2 (ja) | 高精度分析物測定用システム及び方法 | |
| HK1187985B (en) | System and method for improved stability of electrochemical sensors | |
| HK1187985A (en) | System and method for improved stability of electrochemical sensors |