TWI496888B - 免疫抑制相關疾病之治療 - Google Patents
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Classifications
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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| US8563307B2 (en) | 2009-02-24 | 2013-10-22 | James Wang | Treatment of immunosuppression-related disorders |
| US8679474B2 (en) | 2010-08-04 | 2014-03-25 | StemBios Technologies, Inc. | Somatic stem cells |
| WO2012054792A2 (en) * | 2010-10-22 | 2012-04-26 | Virginia Commonwealth University | Composition and method for immunological treatment of cancer, prevention of cancer recurrence and metastasis, and overcoming immune suppressor cells |
| TWI614340B (zh) | 2011-09-28 | 2018-02-11 | 幹細胞生物科技股份有限公司 | 體幹細胞及其製備方法 |
| WO2013176785A1 (en) * | 2012-05-21 | 2013-11-28 | The Trustees Of Columbia University In The City Of New York | Trefoil family factor and uses thereof |
| CN104822827B (zh) | 2012-12-06 | 2020-01-21 | 干细胞生物科技公司 | Lgr5+体干细胞 |
| EP2746770A1 (en) * | 2012-12-21 | 2014-06-25 | Stembios Technologies, Inc. | Method for evaluating effect of action on subject based on stem celldynamics |
| US9212225B1 (en) * | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| JP2018516248A (ja) | 2015-05-29 | 2018-06-21 | アンフィヴェナ セラピューティクス，インク． | 二重特異性のｃｄ３３およびｃｄ３結合タンパク質を使用する方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006028723A1 (en) * | 2004-09-03 | 2006-03-16 | Moraga Biotechnology Inc. | Non-embryonic totipotent blastomer-like stem cells and methods therefor |
| WO2007100845A2 (en) * | 2006-02-27 | 2007-09-07 | Moraga Biotechnology Corporation | Non-embryonic totipotent blastomere-like stem cells and methods therefor |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2936171B2 (ja) | 1989-09-01 | 1999-08-23 | 東ソー株式会社 | 血清アルブミンの製造方法 |
| US6004807A (en) | 1992-03-30 | 1999-12-21 | Schering Corporation | In vitro generation of human dendritic cells |
| US6916654B1 (en) * | 1992-06-29 | 2005-07-12 | Oklahoma Medical Research Foundation | Universal donor cells |
| WO1998042838A1 (en) * | 1997-03-25 | 1998-10-01 | Morphogenesis, Inc. | Universal stem cells |
| AU1705599A (en) | 1997-11-26 | 1999-06-15 | Allegheny University Of The Health Sciences | Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood |
| CA2347067C (en) | 1998-03-31 | 2013-09-17 | Geron Corporation | Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer |
| US6080399A (en) | 1998-04-23 | 2000-06-27 | Arch Development Corporation | Vaccine adjuvants for immunotherapy of melanoma |
| JP3553858B2 (ja) | 1999-08-25 | 2004-08-11 | 東洋紡績株式会社 | 血管網類似構造体を有する細胞培養用モジュール |
| US20030161817A1 (en) | 2001-03-28 | 2003-08-28 | Young Henry E. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
| US7575921B2 (en) | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| WO2002057428A1 (en) | 2000-10-30 | 2002-07-25 | University Of Massachusetts | Isolation of spore-like cells from tissues exposed to extreme conditions |
| JP3977136B2 (ja) | 2001-05-22 | 2007-09-19 | キヤノン株式会社 | コイルユニット |
| US7316932B2 (en) | 2001-10-01 | 2008-01-08 | Stemcell Technologies Inc. | Method for separating cells |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| WO2003075016A1 (en) | 2002-03-07 | 2003-09-12 | Cambridge University Technical Services Limited (Cuts) | Scd fingerprints |
| DK1509244T3 (da) | 2002-06-06 | 2011-10-24 | Immunicum Ab | Ny fremgangsmåde og præparat til at producere en cellulær allogen vaccine |
| AU2003287429A1 (en) * | 2002-11-01 | 2004-06-07 | Five Prime Therapeutics, Inc. | Stem cell libraries |
| US20060252150A1 (en) * | 2002-11-08 | 2006-11-09 | Linzhao Cheng | Human embryonic stem cell cultures, and compositions and methods for growing same |
| US20050003533A1 (en) | 2003-05-08 | 2005-01-06 | Pawel Kalinski | Mature type-1 polarized dendritic cells with enhanced IL-12 production and methods of serum-free production and use |
| US20090004661A1 (en) | 2003-05-26 | 2009-01-01 | Reliance Life Sciences Pvt Ltd. | Method of growing mesenchymal stem cells from bone marrow |
| ES2265199B1 (es) | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| ES2433493T3 (es) * | 2003-06-25 | 2013-12-11 | Ottawa Hospital Research Institute | Métodos y composiciones para modular el crecimiento de células pluripotenciales y la diferenciación |
| US7622108B2 (en) | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
| EP2410044B1 (en) | 2004-12-29 | 2022-06-22 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
| US8846395B2 (en) | 2005-06-01 | 2014-09-30 | Wisconsin Alumni Research Foundation | Generation of mature myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+progenitors |
| US7651690B2 (en) | 2005-06-24 | 2010-01-26 | Desert Lake Technologies | Purified component of blue-green algae and method of use |
| EP3354723B1 (en) | 2005-08-29 | 2023-12-13 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
| WO2009059032A2 (en) | 2007-10-30 | 2009-05-07 | University Of Louisville Research Foundation, Inc. | Uses and isolation of very small embryonic-like (vsel) stem cells |
| WO2007082177A2 (en) * | 2006-01-06 | 2007-07-19 | Mount Sinai School Of Medicine Of New York University | Myeloid suppressor cells, methods for preparing them, and methods for using them for treating autoimmunity |
| US7939057B2 (en) | 2006-01-25 | 2011-05-10 | Mount Sinai School Of Medicine | Methods and compositions for modulating the mobilization of stem cells |
| AU2007264043B2 (en) | 2006-06-27 | 2012-03-15 | Nutratec S.R.L. | Extracts of Aphanizomenon Flos Aquae and nutritional, cosmetic and pharmaceutical compositions containing the same |
| EP1894941A1 (en) * | 2006-09-01 | 2008-03-05 | Institut Pasteur | Treatment of cervical carcinoma with a recombinant adenylate cyclase carrying HPV antigens |
| US8759090B2 (en) * | 2006-10-30 | 2014-06-24 | University Of Central Florida Research Foundation, Inc. | Stem cell banking system |
| US20090104160A1 (en) | 2007-02-01 | 2009-04-23 | Moraga Biotechnology Corporation | Mobilization of Stem Cells After Trauma and Methods Therefor |
| WO2008148105A1 (en) | 2007-05-25 | 2008-12-04 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
| EP3424529A1 (en) | 2007-07-02 | 2019-01-09 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
| EP2676678A1 (en) | 2007-07-17 | 2013-12-25 | The General Hospital Corporation | Methods to identify and enrich populations of ovarian cancer stem cells and somatic stem cells and uses thereof |
| EP2205724B1 (en) | 2007-11-09 | 2016-04-27 | RNL Bio Co., Ltd. | Method for isolating and culturing adult stem cells derived from human amniotic epithelium |
| EP2294185A2 (en) | 2008-05-08 | 2011-03-16 | Coretherapix Slu | Multipotent adult stem cell population |
| CN102333861A (zh) | 2008-09-30 | 2012-01-25 | 路易斯维尔大学研究基金会有限公司 | 用于分离非常小的胚胎样(vsel)干细胞的方法 |
| WO2010056341A2 (en) | 2008-11-12 | 2010-05-20 | The University Of Vermont And State Agriculture College | Compositions and methods for tissue repair |
| EP2387609B1 (en) | 2009-01-13 | 2018-05-16 | Stembios Technologies, Inc. | Non-embryonic stem cells and uses thereof |
| EP3061808B1 (en) | 2009-02-03 | 2020-08-12 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US8563307B2 (en) | 2009-02-24 | 2013-10-22 | James Wang | Treatment of immunosuppression-related disorders |
| US20140219952A1 (en) | 2010-03-23 | 2014-08-07 | The Johns Hopkins University | Methods of treatment using stem cell mobilizers |
| WO2011137540A1 (en) | 2010-05-07 | 2011-11-10 | Institut De Recherches Cliniques De Montréal | Gfi1b modulation and uses thereof |
| TWI686202B (zh) | 2010-08-04 | 2020-03-01 | 幹細胞生物科技公司 | 體幹細胞 |
| US8679474B2 (en) | 2010-08-04 | 2014-03-25 | StemBios Technologies, Inc. | Somatic stem cells |
| CN102008650B (zh) | 2010-12-16 | 2017-02-15 | 天津市医药科学研究所 | 一种治疗肿瘤的复方中药制剂及其制备方法 |
| TWI614340B (zh) | 2011-09-28 | 2018-02-11 | 幹細胞生物科技股份有限公司 | 體幹細胞及其製備方法 |
| CN104822827B (zh) | 2012-12-06 | 2020-01-21 | 干细胞生物科技公司 | Lgr5+体干细胞 |
| EP2818544A1 (en) | 2013-06-24 | 2014-12-31 | Stembios Technologies, Inc. | Method for counting number of stem cells in human or animal samples |
| CN105687245A (zh) | 2014-12-13 | 2016-06-22 | 干细胞生物科技公司 | 制备注射液的方法 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006028723A1 (en) * | 2004-09-03 | 2006-03-16 | Moraga Biotechnology Inc. | Non-embryonic totipotent blastomer-like stem cells and methods therefor |
| WO2007100845A2 (en) * | 2006-02-27 | 2007-09-07 | Moraga Biotechnology Corporation | Non-embryonic totipotent blastomere-like stem cells and methods therefor |
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| TW201040278A (en) | 2010-11-16 |
| JP5809068B2 (ja) | 2015-11-10 |
| WO2010099044A2 (en) | 2010-09-02 |
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| CN102325537B (zh) | 2014-07-30 |
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| EP2400971A4 (en) | 2013-03-27 |
| ES2582582T3 (es) | 2016-09-13 |
| US8563307B2 (en) | 2013-10-22 |
| US9770473B2 (en) | 2017-09-26 |
| JP2012518646A (ja) | 2012-08-16 |
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| US20100215622A1 (en) | 2010-08-26 |
| EP2400971B1 (en) | 2016-05-18 |
| EP2400971A1 (en) | 2012-01-04 |
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