TWI492707B - 治療心臟疾病之藥品配方 - Google Patents
治療心臟疾病之藥品配方 Download PDFInfo
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- TWI492707B TWI492707B TW099116052A TW99116052A TWI492707B TW I492707 B TWI492707 B TW I492707B TW 099116052 A TW099116052 A TW 099116052A TW 99116052 A TW99116052 A TW 99116052A TW I492707 B TWI492707 B TW I492707B
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| US9765298B2 (en) | 2006-07-24 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Methods and materials for providing cardiac cells |
| WO2009145761A1 (en) * | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
| US20120321595A1 (en) * | 2009-11-09 | 2012-12-20 | The Brigham And Women's Hospital, Inc. | Treatment of heart disease |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| WO2013007284A1 (en) * | 2011-07-08 | 2013-01-17 | Mikael Sigvardsson | A method for enriching mesenchymal stem cells and applications thereof |
| CN104822384A (zh) * | 2012-03-30 | 2015-08-05 | 南加州大学 | 用于间充质干细胞诱导的免疫调节的组合物和治疗方法 |
| JP6133402B2 (ja) * | 2012-04-25 | 2017-05-24 | ゲネラ・イストラジヴァンジャ・ディーオーオー | 急性心筋梗塞を処置および診断するための方法および組成物 |
| US9943545B2 (en) | 2013-03-15 | 2018-04-17 | Fate Therapeutics, Inc. | Stem cell culture media and methods of enhancing cell survival |
| SG11201510045TA (en) * | 2013-06-28 | 2016-01-28 | Otsuka Pharma Co Ltd | Trehalose and dextran-containing solution for transplanting mammalian cells |
| CN103667440A (zh) * | 2013-09-05 | 2014-03-26 | 谢小冬 | Gata4基因snp位点的用途 |
| CN104922155A (zh) * | 2014-03-18 | 2015-09-23 | 中山大学孙逸仙纪念医院 | 治疗心脏疾病的细胞输送方法 |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US10363278B2 (en) | 2014-06-15 | 2019-07-30 | Amnio Technology Llc | Frozen therapeutic dose and package |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| MX2017008737A (es) | 2014-12-30 | 2018-01-25 | Cell Cure Neurosciences Ltd | Poblaciones de celulas rpe y metodos para generar las mismas. |
| RU2017132331A (ru) | 2015-03-03 | 2019-04-03 | Реджентс Оф Зэ Юниверсити Оф Миннесота | Etv2 и его применения |
| EP3316899A4 (en) * | 2015-06-30 | 2019-04-03 | Regents of the University of Minnesota | HUMANIZED CARDIAC MUSCLE |
| EP3316898A4 (en) | 2015-06-30 | 2019-02-27 | Regents of the University of Minnesota | HUMANIZED SKELETON MUSCLE |
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| US11534466B2 (en) | 2016-03-09 | 2022-12-27 | Aal Scientifics, Inc. | Pancreatic stem cells and uses thereof |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| CN106474456A (zh) * | 2016-10-18 | 2017-03-08 | 广州赛莱拉干细胞科技股份有限公司 | 一种细胞制剂及其制备方法和应用 |
| CN106619718A (zh) * | 2016-10-18 | 2017-05-10 | 广州赛莱拉干细胞科技股份有限公司 | 一种细胞制剂及其制备方法和应用 |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| CN108070645A (zh) * | 2016-11-11 | 2018-05-25 | 中国科学院上海生命科学研究院 | Stx-t在预防和/或治疗贫血或其相关疾病的应用 |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| DE102017116204B4 (de) | 2017-07-18 | 2024-06-27 | Universität Rostock | Verfahren zur Vorhersage der Antwort auf die kardiovaskuläre Regeneration |
| CN109497038A (zh) * | 2017-09-14 | 2019-03-22 | 青岛瑞思德生物科技有限公司 | 一种脂肪保存液及其制备方法 |
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| CN107648592B (zh) * | 2017-11-13 | 2021-05-14 | 深圳市喆邦生物工程有限公司 | 趋化因子ccl4作为制备治疗骨折药物的应用 |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
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| CN109769799A (zh) * | 2019-03-20 | 2019-05-21 | 江苏瑞思坦生物科技有限公司 | 一种人脂肪组织保存液及其制备方法 |
| CN111939245B (zh) * | 2019-05-16 | 2024-03-01 | 龚笑海 | 一种心脏治疗和保护的药物组合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080019944A1 (en) * | 2006-07-24 | 2008-01-24 | Mayo Foundation For Medical Education And Research | Methods and Materials for Providing Cardiac Cells |
| US20080276643A1 (en) * | 2005-09-12 | 2008-11-13 | Adam Heroux | Thermally Insulated Transport Container For Cell-Based Products and Related Methods |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6045990A (en) * | 1998-07-09 | 2000-04-04 | Baust; John M. | Inclusion of apoptotic regulators in solutions for cell storage at low temperature |
| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| US20040071665A1 (en) | 2000-09-05 | 2004-04-15 | Yong-Fu Xiao | Method for therapeutically treating a clinically recognized form of cardiopathology in a living mammal |
| US6921633B2 (en) * | 2002-11-18 | 2005-07-26 | Biolife Solutions Incorporated | Methods and compositions for the preservation of cells, tissues or organs in the vitreous state |
| KR100674783B1 (ko) * | 2003-12-09 | 2007-01-25 | (주)안트로젠 | 세포 이식을 위한 세포의 생산 방법 |
| ES2532909T3 (es) | 2004-07-30 | 2015-04-01 | Mayo Foundation For Medical Education And Research | Tratamiento de tejido cardiovascular |
| WO2006080434A1 (ja) | 2005-01-27 | 2006-08-03 | Japan Health Sciences Foundation | 間葉系幹細胞を含む細胞シート |
| EP1865992A2 (en) * | 2005-03-31 | 2007-12-19 | Mytogen Inc. | Treatment for heart disease |
| NZ578728A (en) | 2007-01-09 | 2012-01-12 | Lead Pharma Cel Models Ip B V | Provision of new cardiomyocyte progenitor cells and cardiomyocytes derived therefrom |
| WO2008109839A1 (en) * | 2007-03-07 | 2008-09-12 | Mayo Foundation For Medical Education And Research | Cardiac-specific progenitor cells |
| KR20080103637A (ko) | 2007-05-25 | 2008-11-28 | 주식회사 알앤엘바이오 | 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물 |
| FR2917381B1 (fr) | 2007-06-15 | 2009-10-16 | Ceva Sante Animale Sa | Conditionnement plastique multicouche pour la conservation d'une composition pharmaceutique |
| KR101828421B1 (ko) * | 2007-12-04 | 2018-02-12 | 프로테오바이오엑티브스 피티와이 엘티디 | 전구 세포의 보호 및 그의 분화 조절 |
| EP2100954A1 (en) * | 2008-03-10 | 2009-09-16 | Assistance Publique - Hopitaux de Paris | Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications |
| EP2271209B1 (en) * | 2008-03-27 | 2016-07-13 | Biolife Solutions, Inc. | Materials and methods for hypothermic collection of whole blood |
| WO2009145761A1 (en) | 2008-05-27 | 2009-12-03 | Mayo Foundation For Medical Education And Research | Methods and materials for using cells to treat heart tissue |
| BE1018733A3 (fr) | 2009-04-29 | 2011-07-05 | Cardio3 Biosciences Sa | Dispositif pour la delivrance d'un agent therapeutique. |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080276643A1 (en) * | 2005-09-12 | 2008-11-13 | Adam Heroux | Thermally Insulated Transport Container For Cell-Based Products and Related Methods |
| US20080019944A1 (en) * | 2006-07-24 | 2008-01-24 | Mayo Foundation For Medical Education And Research | Methods and Materials for Providing Cardiac Cells |
Non-Patent Citations (1)
| Title |
|---|
| Baust et al.,"Modulation of the cryopreservation cap:elevated survival with reduced dimethyl sulfoxide concentration＂Cryobiology 2002 Vol.45 pp97-108. * |
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| KR101689415B1 (ko) | 2016-12-23 |
| HK1163500A1 (en) | 2012-09-14 |
| AU2010251151B2 (en) | 2015-08-20 |
| CA2762584A1 (en) | 2010-11-25 |
| WO2010133686A1 (en) | 2010-11-25 |
| US10086016B2 (en) | 2018-10-02 |
| WO2010133686A8 (en) | 2012-03-08 |
| JP6029468B2 (ja) | 2016-11-24 |
| BRPI1012116A2 (pt) | 2016-03-15 |
| JP2012527432A (ja) | 2012-11-08 |
| NZ596162A (en) | 2014-06-27 |
| TW201108935A (en) | 2011-03-16 |
| CN107028980A (zh) | 2017-08-11 |
| RU2595801C2 (ru) | 2016-08-27 |
| US9446076B2 (en) | 2016-09-20 |
| AU2010251151A1 (en) | 2011-11-24 |
| MX2011012183A (es) | 2012-03-06 |
| US20160279168A1 (en) | 2016-09-29 |
| ES2541212T3 (es) | 2015-07-16 |
| IL216399A0 (en) | 2012-01-31 |
| SG175880A1 (en) | 2011-12-29 |
| RU2011145370A (ru) | 2013-06-27 |
| US20120128638A1 (en) | 2012-05-24 |
| NZ623454A (en) | 2015-12-24 |
| CN102438636A (zh) | 2012-05-02 |
| KR20120046107A (ko) | 2012-05-09 |
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