TWI469792B - 新穎之抗cxcr4抗體及其於治療癌症之用途 - Google Patents

新穎之抗cxcr4抗體及其於治療癌症之用途 Download PDF

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Publication number
TWI469792B
TWI469792B TW98133164A TW98133164A TWI469792B TW I469792 B TWI469792 B TW I469792B TW 98133164 A TW98133164 A TW 98133164A TW 98133164 A TW98133164 A TW 98133164A TW I469792 B TWI469792 B TW I469792B
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sequence
cxcr4
antibody
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cdr
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TW98133164A
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TW201018483A (en
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Christine Klinguer-Hamour
Grenier-Caussanel Veronique
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Pf Medicament
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
TW98133164A 2008-10-01 2009-09-30 新穎之抗cxcr4抗體及其於治療癌症之用途 TWI469792B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13677208P 2008-10-01 2008-10-01
EP08305631A EP2172485A1 (en) 2008-10-01 2008-10-01 Novel anti CXCR4 antibodies and their use for the treatment of cancer
US17374309P 2009-04-29 2009-04-29

Publications (2)

Publication Number Publication Date
TW201018483A TW201018483A (en) 2010-05-16
TWI469792B true TWI469792B (zh) 2015-01-21

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TW98133164A TWI469792B (zh) 2008-10-01 2009-09-30 新穎之抗cxcr4抗體及其於治療癌症之用途

Country Status (28)

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US (4) US8557964B2 (OSRAM)
EP (2) EP2172485A1 (OSRAM)
JP (1) JP5723279B2 (OSRAM)
KR (1) KR101671039B1 (OSRAM)
CN (1) CN102209730B (OSRAM)
AR (1) AR073748A1 (OSRAM)
AU (1) AU2009299787B2 (OSRAM)
BR (1) BRPI0920531A2 (OSRAM)
CA (1) CA2738782C (OSRAM)
CL (1) CL2011000730A1 (OSRAM)
CY (1) CY1115572T1 (OSRAM)
DK (1) DK2342233T3 (OSRAM)
ES (1) ES2503732T3 (OSRAM)
GE (1) GEP20146084B (OSRAM)
HR (1) HRP20140899T1 (OSRAM)
IL (1) IL212066A (OSRAM)
MA (1) MA32928B1 (OSRAM)
MX (1) MX2011003509A (OSRAM)
NZ (1) NZ592363A (OSRAM)
PL (1) PL2342233T3 (OSRAM)
PT (1) PT2342233E (OSRAM)
RS (1) RS53578B1 (OSRAM)
RU (1) RU2573897C2 (OSRAM)
SI (1) SI2342233T1 (OSRAM)
TW (1) TWI469792B (OSRAM)
UA (1) UA102867C2 (OSRAM)
WO (1) WO2010037831A1 (OSRAM)
ZA (1) ZA201102969B (OSRAM)

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EP2246364A1 (en) * 2009-04-29 2010-11-03 Pierre Fabre Médicament Anti CXCR4 antibodies for the treatment of HIV
EP2371863A1 (en) * 2010-03-30 2011-10-05 Pierre Fabre Médicament Humanized anti CXCR4 antibodies for the treatment of cancer
AU2011322508A1 (en) * 2010-10-27 2013-05-02 Pierre Fabre Medicament Antibodies for the treatment of HIV
US20140120555A1 (en) 2011-06-20 2014-05-01 Pierre Fabre Medicament Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer
EP2723380B1 (en) 2011-06-24 2019-08-21 Stephen D. Gillies Light chain immunoglobulin fusion proteins and methods of use thereof
AR087364A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres
AR087363A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
NL2010658C2 (en) * 2013-04-18 2014-10-21 Bosch Gmbh Robert Thermostat for a hvac.
EP3027653A2 (en) * 2013-08-02 2016-06-08 Pfizer Inc Anti-cxcr4 antibodies and antibody-drug conjugates
EP3858997A1 (en) * 2013-09-23 2021-08-04 Wilson Wolf Manufacturing Corporation Improved methods of genetically modifying animal cells
TWI740824B (zh) * 2015-04-27 2021-10-01 法商皮爾法伯製藥公司 新穎的igf-1r抗體及其用於癌症診斷之用途(一)
JP2018516969A (ja) 2015-06-12 2018-06-28 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Pd−1およびcxcr4シグナル伝達経路の組合せ遮断による癌の処置
CN108350053A (zh) * 2015-11-09 2018-07-31 英属哥伦比亚大学 淀粉样蛋白β表位及其抗体
JP7448174B2 (ja) 2015-11-09 2024-03-12 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア アミロイドベータ中間領域エピトープおよびそれに対する立体配座選択的抗体
EP3408378B1 (en) 2016-01-25 2022-01-12 NantCell, Inc. Nk cells with altered cxcl12/cxcr4 signaling
EP3467995A4 (en) * 2016-05-25 2020-03-04 Kabushiki Kaisha Toshiba ENERGY MANAGEMENT DEVICE, MANAGEMENT SYSTEM, ENERGY CONSUMPTION MONITORING METHOD AND PROGRAM
JP7461741B2 (ja) 2016-06-20 2024-04-04 カイマブ・リミテッド 抗pd-l1およびil-2サイトカイン
US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
RU2748233C2 (ru) * 2017-01-31 2021-05-21 Мсм Протеин Текнолоджиз Инк. Антитела против cxcr4
US12286469B2 (en) 2017-07-18 2025-04-29 The University Of British Columbia Humanized antibodies binding to amyloid-beta (A-beta)
ES2973728T3 (es) 2018-03-13 2024-06-24 Fundacion Para La Investigacion Biomedica Del Hospital Univ La Paz Anticuerpo anti-CXCR4 combinado con linfocitos citolíticos naturales activados y expandidos para inmunoterapia contra el cáncer
CN110804100A (zh) * 2019-11-01 2020-02-18 中国人民解放军陆军特色医学中心 融合多肽及其在增强干细胞归巢能力和抗凋亡能力中的应用和药物组合物
US11883432B2 (en) 2020-12-18 2024-01-30 Century Therapeutics, Inc. Chimeric antigen receptor system with adaptable receptor specificity
CN112521500B (zh) * 2020-12-25 2022-06-24 暨南大学 与cxcr4结合的亲和力成熟结合蛋白及应用
CN112661845B (zh) * 2020-12-25 2022-06-21 暨南大学 与cxcr4结合的亲和力成熟结合蛋白及其应用
WO2025049591A1 (en) * 2023-08-28 2025-03-06 Regeneron Pharmaceuticals, Inc. Anti-cxcr4 antibodies and uses thereof
CN118255888A (zh) * 2023-08-31 2024-06-28 恺佧生物科技(上海)有限公司 一种Anti-CXCR4膜蛋白抗体及其制备方法和应用

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Also Published As

Publication number Publication date
AU2009299787B2 (en) 2015-06-18
KR20110081229A (ko) 2011-07-13
US20140050661A1 (en) 2014-02-20
EP2172485A1 (en) 2010-04-07
ZA201102969B (en) 2011-12-28
HRP20140899T1 (hr) 2014-11-07
HK1163119A1 (en) 2012-09-07
BRPI0920531A2 (pt) 2021-02-23
CA2738782A1 (en) 2010-04-08
TW201018483A (en) 2010-05-16
US20110287451A1 (en) 2011-11-24
EP2342233B1 (en) 2014-06-25
MA32928B1 (fr) 2012-01-02
JP5723279B2 (ja) 2015-05-27
PT2342233E (pt) 2014-10-03
RS53578B1 (sr) 2015-02-27
US8557964B2 (en) 2013-10-15
NZ592363A (en) 2012-08-31
MX2011003509A (es) 2011-05-02
KR101671039B1 (ko) 2016-11-01
US20110294156A1 (en) 2011-12-01
CY1115572T1 (el) 2017-01-04
DK2342233T3 (da) 2014-09-29
RU2573897C2 (ru) 2016-01-27
EP2342233A1 (en) 2011-07-13
AR073748A1 (es) 2010-12-01
US9388248B2 (en) 2016-07-12
CA2738782C (en) 2017-11-28
ES2503732T3 (es) 2014-10-07
CN102209730A (zh) 2011-10-05
PL2342233T3 (pl) 2014-11-28
AU2009299787A2 (en) 2011-06-02
CN102209730B (zh) 2014-11-05
IL212066A0 (en) 2011-06-30
RU2011115559A (ru) 2012-11-10
IL212066A (en) 2015-05-31
US20110020218A1 (en) 2011-01-27
CL2011000730A1 (es) 2012-02-03
JP2012504401A (ja) 2012-02-23
WO2010037831A1 (en) 2010-04-08
GEP20146084B (en) 2014-05-13
SI2342233T1 (sl) 2014-10-30
AU2009299787A1 (en) 2010-04-08
UA102867C2 (uk) 2013-08-27

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