TWI465469B - 具有化學附著潤濕劑之聚矽氧水凝膠材料 - Google Patents

具有化學附著潤濕劑之聚矽氧水凝膠材料 Download PDF

Info

Publication number
TWI465469B
TWI465469B TW098138725A TW98138725A TWI465469B TW I465469 B TWI465469 B TW I465469B TW 098138725 A TW098138725 A TW 098138725A TW 98138725 A TW98138725 A TW 98138725A TW I465469 B TWI465469 B TW I465469B
Authority
TW
Taiwan
Prior art keywords
group
vinyl
hydrophilic
prepolymer
alkyl
Prior art date
Application number
TW098138725A
Other languages
English (en)
Chinese (zh)
Other versions
TW201030034A (en
Inventor
John Christopher Phelan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TW201030034A publication Critical patent/TW201030034A/zh
Application granted granted Critical
Publication of TWI465469B publication Critical patent/TWI465469B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
    • C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
    • C08F230/08—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Eyeglasses (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
TW098138725A 2008-11-13 2009-11-13 具有化學附著潤濕劑之聚矽氧水凝膠材料 TWI465469B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11422808P 2008-11-13 2008-11-13

Publications (2)

Publication Number Publication Date
TW201030034A TW201030034A (en) 2010-08-16
TWI465469B true TWI465469B (zh) 2014-12-21

Family

ID=41566234

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098138725A TWI465469B (zh) 2008-11-13 2009-11-13 具有化學附著潤濕劑之聚矽氧水凝膠材料

Country Status (7)

Country Link
US (2) US8404759B2 (cg-RX-API-DMAC7.html)
EP (2) EP2356497B8 (cg-RX-API-DMAC7.html)
JP (1) JP5748224B2 (cg-RX-API-DMAC7.html)
AR (1) AR074111A1 (cg-RX-API-DMAC7.html)
CA (1) CA2739102C (cg-RX-API-DMAC7.html)
TW (1) TWI465469B (cg-RX-API-DMAC7.html)
WO (1) WO2010056687A2 (cg-RX-API-DMAC7.html)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009010109A (es) * 2007-03-22 2009-10-12 Novartis Ag Prepolimeros que contienen silicona con cadenas polimericas hidrofilicas.
TWI613067B (zh) 2008-12-18 2018-02-01 諾華公司 適合製造聚矽氧水凝膠隱形眼鏡的形成鏡片組合物
TWI836373B (zh) * 2010-07-30 2024-03-21 瑞士商愛爾康公司 水合隱形鏡片
PT2598937T (pt) 2010-07-30 2016-10-04 Novartis Ag Pré-polímeros de polissiloxano anfifílicos e suas utilizações
SG188507A1 (en) * 2010-10-06 2013-04-30 Novartis Ag Water-processable silicone-containing prepolymers and uses thereof
US9244195B2 (en) * 2011-06-09 2016-01-26 Novartis Ag Silicone hydrogel lenses with nano-textured surfaces
CN104321352B (zh) 2012-03-22 2017-09-26 莫门蒂夫性能材料股份有限公司 可聚合的含酰胺基的有机硅化合物、含硅聚合物以及由其制备的生物医学装置
WO2013142055A2 (en) * 2012-03-22 2013-09-26 Momentive Performance Materials Inc. Organo-modified silicone polymers
JP5964721B2 (ja) * 2012-10-25 2016-08-03 富士フイルム株式会社 インクジェット記録装置及びインクジェット記録方法
TWI496838B (zh) * 2012-11-30 2015-08-21 Pegavision Corp 矽水膠組成物及以該組成物製備之矽水膠鏡片
JP6065988B2 (ja) 2012-12-14 2017-01-25 ノバルティス アーゲー トリス（トリメチルシロキシ）シランビニル系モノマー及びその用途
JP6154022B2 (ja) 2012-12-14 2017-06-28 ノバルティス アーゲー 両親媒性シロキサン含有（メタ）アクリルアミド及びこれらの使用
WO2014093756A1 (en) 2012-12-14 2014-06-19 Novartis Ag Actinically-crosslinkable amphiphilic prepolymers
EP2931732B1 (en) 2012-12-14 2020-11-25 Alcon Inc. Amphiphilic siloxane-containing vinylic monomers and uses thereof
JP5651718B2 (ja) * 2013-01-16 2015-01-14 富士フイルム株式会社 化合物及び樹脂
EP2945994B1 (en) 2013-01-18 2018-07-11 Basf Se Acrylic dispersion-based coating compositions
US10118994B2 (en) 2013-01-31 2018-11-06 Momentive Performance Materials Inc. Water soluble silicone material
WO2014152017A1 (en) 2013-03-21 2014-09-25 Shifamed Holdings, Llc Accommodating intraocular lens
US9486311B2 (en) 2013-02-14 2016-11-08 Shifamed Holdings, Llc Hydrophilic AIOL with bonding
US10195018B2 (en) 2013-03-21 2019-02-05 Shifamed Holdings, Llc Accommodating intraocular lens
HUE033384T2 (en) 2013-04-30 2017-11-28 Coopervision Int Holding Co Lp Primary amine-containing silicone hydrogel contact lenses and related compositions and methods
JP5452756B1 (ja) 2013-07-02 2014-03-26 Ｈｏｙａ株式会社 親水性表面を有するシリコーン含有共重合体成形品を作製する方法及び親水性表面を有するシリコーンハイドロゲルコンタクトレンズ
WO2015164630A1 (en) 2014-04-25 2015-10-29 Novartis Ag Carbosiloxane vinylic monomers
CA2940207C (en) 2014-04-25 2019-09-10 Novartis Ag Hydrophilized carbosiloxane vinylic monomers
CN107106293B (zh) 2014-08-26 2019-07-12 施菲姆德控股有限责任公司 调节性人工晶状体
NZ728772A (en) 2014-09-26 2018-10-26 Novartis Ag Polymerizable polysiloxanes with hydrophilic substituents
EP3268804B1 (en) 2015-03-11 2020-11-04 University of Florida Research Foundation, Inc. Mesh size control of lubrication in gemini hydrogels
GB201512725D0 (en) * 2015-07-20 2015-08-26 Life Technologies As Polymeric particles
WO2017015614A1 (en) * 2015-07-23 2017-01-26 The University Of North Carolina At Chapel Hill Solvent-free supersoft and superelastic materials
US11141263B2 (en) 2015-11-18 2021-10-12 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
AU2016358160B2 (en) 2015-11-18 2021-07-29 Shifamed Holdings, Llc Multi-piece accommodating intraocular lens
JP6615349B2 (ja) 2015-12-15 2019-12-04 ノバルティス アーゲー 両親媒性分枝鎖状ポリジオルガノシロキサンマクロマー
US10081142B2 (en) 2015-12-15 2018-09-25 Novartis Ag Method for producing contact lenses with a lubricious surface
US10371865B2 (en) 2016-07-06 2019-08-06 Johnson & Johnson Vision Care, Inc. Silicone hydrogels comprising polyamides
US10370476B2 (en) 2016-07-06 2019-08-06 Johnson & Johnson Vision Care, Inc. Silicone hydrogels comprising high levels of polyamides
US11021558B2 (en) 2016-08-05 2021-06-01 Johnson & Johnson Vision Care, Inc. Polymer compositions containing grafted polymeric networks and processes for their preparation and use
WO2018078543A1 (en) 2016-10-26 2018-05-03 Novartis Ag Amphiphilic branched polydiorganosiloxane macromers
SG11201902351YA (en) * 2016-10-26 2019-05-30 Novartis Ag Soft contact lenses with a lubricious coating covalently-attached thereon
US10350056B2 (en) 2016-12-23 2019-07-16 Shifamed Holdings, Llc Multi-piece accommodating intraocular lenses and methods for making and using same
CN120000379A (zh) 2016-12-23 2025-05-16 施菲姆德控股有限责任公司 多片式调节性人工晶状体及其制造和使用方法
TWI626253B (zh) * 2017-05-25 2018-06-11 晶碩光學股份有限公司 水溶性矽高聚物、矽水膠組成物、矽水膠鏡片及其製造方法
US10987214B2 (en) 2017-05-30 2021-04-27 Shifamed Holdings, Llc Surface treatments for accommodating intraocular lenses and associated methods and devices
EP3634309B1 (en) 2017-06-07 2023-05-24 Shifamed Holdings, LLC Adjustable optical power intraocular lenses
US10809181B2 (en) 2017-08-24 2020-10-20 Alcon Inc. Method and apparatus for determining a coefficient of friction at a test site on a surface of a contact lens
US10961341B2 (en) * 2018-01-30 2021-03-30 Johnson & Johnson Vision Care, Inc. Ophthalmic devices derived from grafted polymeric networks and processes for their preparation and use
US11034789B2 (en) 2018-01-30 2021-06-15 Johnson & Johnson Vision Care, Inc. Ophthalmic devices containing localized grafted networks and processes for their preparation and use
CN109400802B (zh) * 2018-10-25 2020-12-25 中国科学技术大学 疏水疏油改性剂及其制备方法、改性粉体的制备方法
US12178938B2 (en) * 2018-12-10 2024-12-31 Seed Co., Ltd. UV absorbing ocular lens
US12384934B2 (en) 2019-10-09 2025-08-12 Nof Corporation Surface treatment agent for soft contact lens
TWI859401B (zh) 2020-01-27 2024-10-21 新加坡商科萊博新加坡私人有限公司 光化可交聯的聚矽氧烷－聚甘油嵌段共聚物及其製造和使用方法
TWI841916B (zh) 2021-02-23 2024-05-11 晶碩光學股份有限公司 隱形眼鏡材料及隱形眼鏡鏡片
US20230176251A1 (en) * 2021-09-29 2023-06-08 Johnson & Johnson Vision Care, Inc. Ophthalmic lenses and their manufacture by in-mold modification
US11912800B2 (en) 2021-09-29 2024-02-27 Johnson & Johnson Vision Care, Inc. Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197842B1 (en) * 1996-06-27 2001-03-06 Essilor International Compagnie Generale D'optique Material based on crosslinked silicone polymer comprising an attached photoinitiator, process for the preparation thereof, hydrophilic polymeric product obtained from this material and process for the preparation thereof, and novel photoinitiators
WO2008116131A2 (en) * 2007-03-22 2008-09-25 Novartis Ag Prepolymers with dangling polysiloxane-containing polymer chains

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312575A (en) 1979-09-18 1982-01-26 Peyman Gholam A Soft corneal contact lens with tightly cross-linked polymer coating and method of making same
US4444711A (en) 1981-12-21 1984-04-24 Husky Injection Molding Systems Ltd. Method of operating a two-shot injection-molding machine
US4467082A (en) * 1982-03-15 1984-08-21 Dow Corning Corporation Organopolysiloxane photosensitizers and methods for their preparation
US4460534A (en) 1982-09-07 1984-07-17 International Business Machines Corporation Two-shot injection molding
JPS60163901A (ja) 1984-02-04 1985-08-26 Japan Synthetic Rubber Co Ltd プラズマ重合処理方法
US4666953A (en) * 1985-03-28 1987-05-19 Loctite Corporation Silicone polyphotoinitiators
DE3710343A1 (de) 1987-03-28 1988-10-06 Basf Lacke & Farben Verzweigtes acrylatcopolymerisat mit polisierbaren doppelbindungen und verfahren zur herstellung des acrylatcopolymerisats
US5034461A (en) 1989-06-07 1991-07-23 Bausch & Lomb Incorporated Novel prepolymers useful in biomedical devices
US5079319A (en) 1989-10-25 1992-01-07 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5010141A (en) 1989-10-25 1991-04-23 Ciba-Geigy Corporation Reactive silicone and/or fluorine containing hydrophilic prepolymers and polymers thereof
US5244981A (en) 1990-04-10 1993-09-14 Permeable Technologies, Inc. Silicone-containing contact lens polymers, oxygen permeable contact lenses and methods for making these lenses and treating patients with visual impairment
US5314960A (en) 1990-04-10 1994-05-24 Permeable Technologies, Inc. Silicone-containing polymers, oxygen permeable hydrophilic contact lenses and methods for making these lenses and treating patients with visual impairment
US5314961A (en) 1990-10-11 1994-05-24 Permeable Technologies, Inc. Silicone-containing polymers, compositions and improved oxygen permeable hydrophilic contact lenses
US5310779A (en) 1991-11-05 1994-05-10 Bausch & Lomb Incorporated UV curable crosslinking agents useful in copolymerization
US5358995A (en) 1992-05-15 1994-10-25 Bausch & Lomb Incorporated Surface wettable silicone hydrogels
JP3195662B2 (ja) 1992-08-24 2001-08-06 株式会社メニコン 眼用レンズ材料
TW328535B (en) 1993-07-02 1998-03-21 Novartis Ag Functional photoinitiators and their manufacture
US5894002A (en) 1993-12-13 1999-04-13 Ciba Vision Corporation Process and apparatus for the manufacture of a contact lens
US5843346A (en) 1994-06-30 1998-12-01 Polymer Technology Corporation Method of cast molding contact lenses
US5760100B1 (en) 1994-09-06 2000-11-14 Ciba Vision Corp Extended wear ophthalmic lens
TW434456B (en) 1994-12-30 2001-05-16 Novartis Ag A compound as functionalized photoinitiator, its production process, its corresponding oligomers or polymers and its application in coating a substrate
AUPN354595A0 (en) 1995-06-14 1995-07-06 Ciba-Geigy Ag Novel materials
TW429327B (en) 1997-10-21 2001-04-11 Novartis Ag Single mould alignment
US5981669A (en) 1997-12-29 1999-11-09 Bausch & Lomb Incorporated Silicone-containing prepolymers and low water materials
US6451871B1 (en) 1998-11-25 2002-09-17 Novartis Ag Methods of modifying surface characteristics
US6849671B2 (en) 1998-03-02 2005-02-01 Johnson & Johnson Vision Care, Inc. Contact lenses
US7461937B2 (en) 2001-09-10 2008-12-09 Johnson & Johnson Vision Care, Inc. Soft contact lenses displaying superior on-eye comfort
US7052131B2 (en) 2001-09-10 2006-05-30 J&J Vision Care, Inc. Biomedical devices containing internal wetting agents
US20070043140A1 (en) 1998-03-02 2007-02-22 Lorenz Kathrine O Method for the mitigation of symptoms of contact lens related dry eye
US5998498A (en) 1998-03-02 1999-12-07 Johnson & Johnson Vision Products, Inc. Soft contact lenses
US6943203B2 (en) 1998-03-02 2005-09-13 Johnson & Johnson Vision Care, Inc. Soft contact lenses
US6367929B1 (en) 1998-03-02 2002-04-09 Johnson & Johnson Vision Care, Inc. Hydrogel with internal wetting agent
US6822016B2 (en) 2001-09-10 2004-11-23 Johnson & Johnson Vision Care, Inc. Biomedical devices containing internal wetting agents
US5959117A (en) 1998-08-10 1999-09-28 Bausch & Lomb Monomers useful for contact lens materials
JP3105871B2 (ja) 1998-09-25 2000-11-06 埼玉日本電気株式会社 無線装置とその無線受信方法
US5981675A (en) 1998-12-07 1999-11-09 Bausch & Lomb Incorporated Silicone-containing macromonomers and low water materials
CA2379244C (en) 1999-07-27 2007-09-18 Jay F. Kunzler Contact lens material
US6376568B1 (en) 1999-07-29 2002-04-23 Ciba Specialty Chemicals Corporation Surface-active photoinitiators
EP1754728B1 (en) * 1999-10-07 2010-02-24 Johson & Johnson Vision Care Inc. Soft contact lenses
US6719929B2 (en) 2000-02-04 2004-04-13 Novartis Ag Method for modifying a surface
US6793973B2 (en) 2000-02-04 2004-09-21 Novartis Ag Single-dip process for achieving a layer-by-layer-like coating
WO2001071392A1 (en) 2000-03-24 2001-09-27 Novartis Ag Crosslinkable or polymerizable prepolymers
US6881269B2 (en) 2000-08-17 2005-04-19 Novartis Ag Lens plasma coating system
US6852353B2 (en) 2000-08-24 2005-02-08 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
US20040213827A1 (en) 2000-12-21 2004-10-28 Enns John B. Antimicrobial contact lenses and methods for their production
US20050260249A1 (en) 2000-12-21 2005-11-24 Neely Frank L Antimicrobial contact lenses and methods for their production
US20040115242A1 (en) 2001-12-20 2004-06-17 Meyers Ann-Marie W. Antimicrobial contact lenses and methods for their production
US20030044447A1 (en) 2000-12-21 2003-03-06 Diana Zanini Antimicrobial contact lenses and methods for their production
US20040151755A1 (en) 2000-12-21 2004-08-05 Osman Rathore Antimicrobial lenses displaying extended efficacy, processes to prepare them and methods of their use
JP2003066381A (ja) 2001-05-23 2003-03-05 Novartis Ag 流体で物品を処理するためのシステム及び方法
US6811805B2 (en) 2001-05-30 2004-11-02 Novatis Ag Method for applying a coating
TWI255224B (en) 2002-01-09 2006-05-21 Novartis Ag Polymeric articles having a lubricious coating and method for making the same
US20040150788A1 (en) 2002-11-22 2004-08-05 Ann-Margret Andersson Antimicrobial lenses, processes to prepare them and methods of their use
US20080299179A1 (en) 2002-09-06 2008-12-04 Osman Rathore Solutions for ophthalmic lenses containing at least one silicone containing component
US20070138692A1 (en) 2002-09-06 2007-06-21 Ford James D Process for forming clear, wettable silicone hydrogel articles
US6926965B2 (en) 2002-09-11 2005-08-09 Novartis Ag LbL-coated medical device and method for making the same
US6896926B2 (en) 2002-09-11 2005-05-24 Novartis Ag Method for applying an LbL coating onto a medical device
US7416737B2 (en) 2003-11-18 2008-08-26 Johnson & Johnson Vision Care, Inc. Antimicrobial lenses, processes to prepare them and methods of their use
US7214809B2 (en) 2004-02-11 2007-05-08 Johnson & Johnson Vision Care, Inc. (Meth)acrylamide monomers containing hydroxy and silicone functionalities
US7074839B2 (en) * 2004-03-01 2006-07-11 3M Innovative Properties Company Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups
US7550519B2 (en) 2004-04-21 2009-06-23 Novartis Ag Curable colored inks for making colored silicone hydrogel lenses
US7249848B2 (en) 2004-09-30 2007-07-31 Johnson & Johnson Vision Care, Inc. Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents
WO2007017243A1 (en) * 2005-08-10 2007-02-15 Novartis Ag Silicone hydrogels
US20070077498A1 (en) * 2005-09-30 2007-04-05 Fuji Photo Film Co., Ltd. Optical recording composition, optical recording medium and production method thereof, optical recording method and optical recording apparatus
US7423108B2 (en) * 2005-12-16 2008-09-09 Bausch & Lomb Incorporated High refractive-index siloxy-containing monomers and polymers, and ophthalmic devices comprising such polymers
JP2009535464A (ja) * 2006-05-03 2009-10-01 ビジョン シーアールシー リミティド 生物系ポリシロキサン
US7858000B2 (en) 2006-06-08 2010-12-28 Novartis Ag Method of making silicone hydrogel contact lenses
JP5087952B2 (ja) * 2007-02-28 2012-12-05 コニカミノルタホールディングス株式会社 組成物、液体及びゲル形成方法
MX2009010109A (es) * 2007-03-22 2009-10-12 Novartis Ag Prepolimeros que contienen silicona con cadenas polimericas hidrofilicas.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197842B1 (en) * 1996-06-27 2001-03-06 Essilor International Compagnie Generale D'optique Material based on crosslinked silicone polymer comprising an attached photoinitiator, process for the preparation thereof, hydrophilic polymeric product obtained from this material and process for the preparation thereof, and novel photoinitiators
WO2008116131A2 (en) * 2007-03-22 2008-09-25 Novartis Ag Prepolymers with dangling polysiloxane-containing polymer chains

Also Published As

Publication number Publication date
AR074111A1 (es) 2010-12-22
EP3598181A1 (en) 2020-01-22
EP3598181B1 (en) 2021-06-23
WO2010056687A3 (en) 2010-07-22
CA2739102C (en) 2016-06-21
WO2010056687A2 (en) 2010-05-20
JP2012508902A (ja) 2012-04-12
TW201030034A (en) 2010-08-16
US8404759B2 (en) 2013-03-26
CA2739102A1 (en) 2010-05-20
EP2356497A2 (en) 2011-08-17
EP2356497B8 (en) 2020-03-11
EP2356497B1 (en) 2019-12-25
US20130172504A1 (en) 2013-07-04
JP5748224B2 (ja) 2015-07-15
US20100120939A1 (en) 2010-05-13

Similar Documents

Publication Publication Date Title
TWI465469B (zh) 具有化學附著潤濕劑之聚矽氧水凝膠材料
TWI476218B (zh) 具有終端親水聚合物鏈之聚矽氧烷共聚物
JP5653624B2 (ja) 親水性ポリマー鎖を有するシリコーン含有プレポリマー
JP5484916B2 (ja) ダングリングポリシロキサン含有ポリマー鎖を有するプレポリマー
CN103917899B (zh) 通过涂布制备uv吸收性眼用透镜的方法
CA2671960C (en) Production of ophthalmic devices based on photo-induced step growth polymerization
TW202500366A (zh) 用於製造嵌入式水凝膠接觸鏡片之方法
US20230105992A1 (en) Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses
HK1157367B (en) Polysiloxane copolymers with terminal hydrophilic polymer chains

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees