TWI442948B - 含活性劑層及活性劑轉化層之經皮組成物 - Google Patents

含活性劑層及活性劑轉化層之經皮組成物 Download PDF

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Publication number
TWI442948B
TWI442948B TW101110102A TW101110102A TWI442948B TW I442948 B TWI442948 B TW I442948B TW 101110102 A TW101110102 A TW 101110102A TW 101110102 A TW101110102 A TW 101110102A TW I442948 B TWI442948 B TW I442948B
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TW
Taiwan
Prior art keywords
active agent
layer
transdermal
composition
conversion layer
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TW101110102A
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English (en)
Chinese (zh)
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TW201309350A (zh
Inventor
Richard Hamlin
Jianye Wen
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Teikoku Pharma Usa Inc
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Publication of TW201309350A publication Critical patent/TW201309350A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
TW101110102A 2011-03-24 2012-03-23 含活性劑層及活性劑轉化層之經皮組成物 TWI442948B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161467337P 2011-03-24 2011-03-24

Publications (2)

Publication Number Publication Date
TW201309350A TW201309350A (zh) 2013-03-01
TWI442948B true TWI442948B (zh) 2014-07-01

Family

ID=46880045

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101110102A TWI442948B (zh) 2011-03-24 2012-03-23 含活性劑層及活性劑轉化層之經皮組成物

Country Status (7)

Country Link
US (2) US9119799B2 (https=)
EP (1) EP2688561B1 (https=)
JP (1) JP5906302B2 (https=)
KR (1) KR101853082B1 (https=)
CN (1) CN103476404B (https=)
TW (1) TWI442948B (https=)
WO (1) WO2012129429A2 (https=)

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CA2924233C (en) * 2013-10-07 2018-10-23 Teikoku Pharma Usa, Inc. Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
US20170291020A1 (en) * 2016-04-12 2017-10-12 Mylan Inc. Double disk transdermal system
CN107789628B (zh) * 2016-12-29 2021-07-23 天津键凯科技有限公司 一种聚乙二醇和局部麻醉药的结合物在非麻醉镇痛中的应用
US20220218689A1 (en) * 2018-10-24 2022-07-14 Saniona A/S Transdermal tropane compositions and methods for using the same
US11752114B2 (en) 2019-04-17 2023-09-12 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
EP3725306A1 (en) * 2019-04-17 2020-10-21 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system
US20220241218A1 (en) * 2019-04-17 2022-08-04 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
KR102155108B1 (ko) * 2019-11-27 2020-09-11 주식회사 우신라보타치 라사길린 또는 그의 약학적으로 허용가능한 염을 함유하는 경피흡수제제
CN117860708A (zh) * 2022-10-11 2024-04-12 姜钦治 含有普拉克索和雷沙吉兰的透皮贴片

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Also Published As

Publication number Publication date
EP2688561A2 (en) 2014-01-29
JP5906302B2 (ja) 2016-04-20
KR101853082B1 (ko) 2018-04-27
KR20140016293A (ko) 2014-02-07
WO2012129429A3 (en) 2012-11-29
US20160184240A1 (en) 2016-06-30
US20130072884A1 (en) 2013-03-21
TW201309350A (zh) 2013-03-01
EP2688561A4 (en) 2014-08-20
CN103476404B (zh) 2017-09-29
JP2014508810A (ja) 2014-04-10
EP2688561B1 (en) 2018-08-22
US9119799B2 (en) 2015-09-01
WO2012129429A2 (en) 2012-09-27
CN103476404A (zh) 2013-12-25

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