TWI421095B - 包含亞錫及硝酸鹽離子之口腔保健組成物 - Google Patents
包含亞錫及硝酸鹽離子之口腔保健組成物 Download PDFInfo
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- TWI421095B TWI421095B TW100111803A TW100111803A TWI421095B TW I421095 B TWI421095 B TW I421095B TW 100111803 A TW100111803 A TW 100111803A TW 100111803 A TW100111803 A TW 100111803A TW I421095 B TWI421095 B TW I421095B
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- Taiwan
- Prior art keywords
- nitrate
- amount
- aqueous phase
- dissolved
- stannous
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 120
- 229910002651 NO3 Inorganic materials 0.000 title claims description 79
- 230000036541 health Effects 0.000 title claims description 37
- -1 nitrate ions Chemical class 0.000 title claims description 23
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 82
- 150000002500 ions Chemical class 0.000 claims description 65
- 239000008346 aqueous phase Substances 0.000 claims description 64
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 47
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims description 35
- 229910052757 nitrogen Inorganic materials 0.000 claims description 26
- 238000003860 storage Methods 0.000 claims description 26
- 239000002324 mouth wash Substances 0.000 claims description 19
- 229940051866 mouthwash Drugs 0.000 claims description 14
- 238000011049 filling Methods 0.000 claims description 12
- 230000003647 oxidation Effects 0.000 claims description 12
- 238000007254 oxidation reaction Methods 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 239000007789 gas Substances 0.000 claims description 7
- 239000011261 inert gas Substances 0.000 claims description 7
- 239000012071 phase Substances 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 230000000087 stabilizing effect Effects 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 34
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 12
- 238000009472 formulation Methods 0.000 description 11
- 150000002823 nitrates Chemical class 0.000 description 11
- 239000004323 potassium nitrate Substances 0.000 description 10
- 235000010333 potassium nitrate Nutrition 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- 239000007787 solid Substances 0.000 description 9
- 239000000523 sample Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 150000001412 amines Chemical class 0.000 description 7
- 230000003078 antioxidant effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 7
- 229960002799 stannous fluoride Drugs 0.000 description 7
- 239000000606 toothpaste Substances 0.000 description 7
- 229940034610 toothpaste Drugs 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 5
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 150000001768 cations Chemical class 0.000 description 5
- 239000000975 dye Substances 0.000 description 5
- 229910017604 nitric acid Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 239000001119 stannous chloride Substances 0.000 description 5
- 235000011150 stannous chloride Nutrition 0.000 description 5
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 4
- 150000005215 alkyl ethers Chemical class 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 4
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- 150000005846 sugar alcohols Chemical class 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 230000036962 time dependent Effects 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229910021607 Silver chloride Inorganic materials 0.000 description 3
- 239000003082 abrasive agent Substances 0.000 description 3
- 239000008135 aqueous vehicle Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- 229910052750 molybdenum Inorganic materials 0.000 description 3
- 239000011733 molybdenum Substances 0.000 description 3
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 3
- 229960001245 olaflur Drugs 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 125000000954 2-hydroxyethyl group Chemical class [H]C([*])([H])C([H])([H])O[H] 0.000 description 2
- GTLGHKNKLRZSMO-UHFFFAOYSA-N 4-(3-hydroxybutyl)-2-methoxyphenol Chemical compound COC1=CC(CCC(C)O)=CC=C1O GTLGHKNKLRZSMO-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- WHKRHBLAJFYZKF-UHFFFAOYSA-N 5-(hydroxymethyl)-2-methoxyphenol Chemical compound COC1=CC=C(CO)C=C1O WHKRHBLAJFYZKF-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 240000004160 Capsicum annuum Species 0.000 description 2
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 235000019499 Citrus oil Nutrition 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 235000019502 Orange oil Nutrition 0.000 description 2
- BHUIUXNAPJIDOG-UHFFFAOYSA-N Piperonol Chemical compound OCC1=CC=C2OCOC2=C1 BHUIUXNAPJIDOG-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 239000001511 capsicum annuum Substances 0.000 description 2
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- 235000019438 castor oil Nutrition 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000010630 cinnamon oil Substances 0.000 description 2
- 239000010500 citrus oil Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000006184 cosolvent Substances 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000010642 eucalyptus oil Substances 0.000 description 2
- 229940044949 eucalyptus oil Drugs 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 238000004255 ion exchange chromatography Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 239000001683 mentha spicata herb oil Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- YNBADRVTZLEFNH-UHFFFAOYSA-N methyl nicotinate Chemical compound COC(=O)C1=CC=CN=C1 YNBADRVTZLEFNH-UHFFFAOYSA-N 0.000 description 2
- 239000010502 orange oil Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 229910001961 silver nitrate Inorganic materials 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
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- 238000004448 titration Methods 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
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- CKUJRAYMVVJDMG-IYEMJOQQSA-L (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;tin(2+) Chemical compound [Sn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O CKUJRAYMVVJDMG-IYEMJOQQSA-L 0.000 description 1
- XSJPRWBZLUYOOI-UHFFFAOYSA-N (5-methyl-2-propan-2-ylcyclohexyl) 3-hydroxybutanoate Chemical compound CC(O)CC(=O)OC1CC(C)CCC1C(C)C XSJPRWBZLUYOOI-UHFFFAOYSA-N 0.000 description 1
- OQWKEEOHDMUXEO-UHFFFAOYSA-N (6)-shogaol Natural products CCCCCC=CC(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-UHFFFAOYSA-N 0.000 description 1
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- YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-L 2-(carboxymethyl)-2-hydroxysuccinate Chemical compound [O-]C(=O)CC(O)(C(=O)O)CC([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-L 0.000 description 1
- GEZAUFNYMZVOFV-UHFFFAOYSA-J 2-[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetan-2-yl)oxy]-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetane 2-oxide Chemical compound [Sn+2].[Sn+2].[O-]P([O-])(=O)OP([O-])([O-])=O GEZAUFNYMZVOFV-UHFFFAOYSA-J 0.000 description 1
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10159201A EP2374446B1 (en) | 2010-04-07 | 2010-04-07 | Oral care composition comprising stannous and nitrate ions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201201850A TW201201850A (en) | 2012-01-16 |
| TWI421095B true TWI421095B (zh) | 2014-01-01 |
Family
ID=44486427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW100111803A TWI421095B (zh) | 2010-04-07 | 2011-04-06 | 包含亞錫及硝酸鹽離子之口腔保健組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8926950B2 (https=) |
| EP (1) | EP2374446B1 (https=) |
| JP (1) | JP5695733B2 (https=) |
| CN (1) | CN102946844B (https=) |
| AR (1) | AR081529A1 (https=) |
| AU (1) | AU2011237825B2 (https=) |
| BR (1) | BR112012023843A2 (https=) |
| CA (1) | CA2793769C (https=) |
| CO (1) | CO6551662A2 (https=) |
| DK (1) | DK2374446T3 (https=) |
| ES (1) | ES2407858T3 (https=) |
| MX (1) | MX344204B (https=) |
| PH (1) | PH12012501903A1 (https=) |
| PL (1) | PL2374446T3 (https=) |
| RU (1) | RU2548752C2 (https=) |
| SG (1) | SG184082A1 (https=) |
| TW (1) | TWI421095B (https=) |
| WO (1) | WO2011124659A1 (https=) |
| ZA (1) | ZA201207379B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103930429A (zh) * | 2011-09-09 | 2014-07-16 | 加巴国际控股有限公司 | 稳定的组合物和用于制备所述组合物的方法 |
| MX353100B (es) * | 2012-12-24 | 2017-12-19 | Gaba Int Holding Ag | Composición para el cuidado oral. |
| RU2680065C1 (ru) * | 2017-09-09 | 2019-02-14 | Федеральное государственное бюджетное образовательное учреждение высшего образования " Юго-Западный государственный университет" (ЮЗГУ) | Способ получения основного нитрата олова (IV) Sn(OH)2(NO3)2 |
| AU2019403912B2 (en) * | 2018-12-20 | 2022-09-29 | Colgate-Palmolive Company | Dentifrice containing sodium bicarbonate and stannous fluoride |
| EP4599896A3 (en) | 2019-07-01 | 2025-11-05 | Colgate-Palmolive Company | Oral care compositions and methods |
| US20240050333A1 (en) * | 2020-12-21 | 2024-02-15 | Colgate-Palmolive Company | Oral Care Compositions Comprising Stannous Pyrophosphate and a Water-Soluble Alkali Metal Polyphosphate, and Methods |
| CA3226927A1 (en) | 2021-08-23 | 2023-03-02 | Carl MYERS | Oral care compositions and methods |
| US20240173220A1 (en) | 2022-11-22 | 2024-05-30 | Colgate-Palmolive Company | Oral Care Compositions |
| WO2024123731A1 (en) | 2022-12-05 | 2024-06-13 | Colgate-Palmolive Company | Oral care compositions containing stannous ion source |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2057978A1 (en) * | 2007-11-09 | 2009-05-13 | The Procter and Gamble Company | Oral stannous compositions |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE569397A (https=) | 1957-07-13 | |||
| US3182795A (en) * | 1963-03-01 | 1965-05-11 | Olin Mathieson | Container for toothpaste containing stannous fluoride and process for reducing corrosion thereof |
| GB1239748A (https=) * | 1967-08-14 | 1971-07-21 | ||
| ATE11010T1 (de) | 1979-10-02 | 1985-01-15 | Gaba International Ag | Orale kompositionen mit stabilisierten zinnsalzen. |
| US5004597A (en) | 1987-09-14 | 1991-04-02 | The Procter & Gamble Company | Oral compositions comprising stannous flouride and stannous gluconate |
| GB9110721D0 (en) * | 1991-05-17 | 1991-07-10 | Unilever Plc | Dentifrice compositions |
| US5843409A (en) | 1994-08-08 | 1998-12-01 | Colgate Palmolive Company | Two component dentifrice for the treatment of dentinal hypersensitivity |
| US5603922A (en) | 1995-08-08 | 1997-02-18 | Enamelon Inc. | Processes and compositions for the remineralization of teeth |
| AU3404797A (en) * | 1996-07-15 | 1998-02-09 | Gillette Canada Inc. | Stabilized stannous-containing compositions for oral care |
| HUP0000377A2 (hu) | 1996-11-18 | 2000-06-28 | Gaba International Ag | Amin-hidrofluoridok és felhasználásuk szájápoló szerként |
| US6464963B1 (en) | 1998-04-23 | 2002-10-15 | Colgate Palmolive Company | Desensitizing dentifrice containing potassium and tin salts |
| US6280708B1 (en) * | 1999-09-23 | 2001-08-28 | Unilever Home & Personal Care Usa, Division Of Conopco | Stable peroxide dental compositions |
| US20070025928A1 (en) | 1999-11-12 | 2007-02-01 | The Procter & Gamble Company | Stannous oral care compositions |
| US6500409B1 (en) * | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| JPWO2007020939A1 (ja) * | 2005-08-16 | 2009-02-26 | ビタミンＣ６０バイオリサーチ株式会社 | 研磨スラリー |
| CA2663913A1 (en) * | 2006-10-02 | 2008-04-10 | The Procter & Gamble Company | Stannous oral care compositions |
| EP2288329B1 (en) | 2008-04-24 | 2017-03-01 | GABA International Holding AG | Oral care composition comprising dissolved tin and fluoride |
| EP2281543A1 (en) * | 2009-07-27 | 2011-02-09 | The Procter & Gamble Company | Oral care compositions which comprise stannous and potassium salts |
| EP2281544A1 (en) | 2009-07-27 | 2011-02-09 | The Procter & Gamble Company | Oral care compositions which comprise stannous, potassium and monoflurophosphate |
-
2010
- 2010-04-07 ES ES10159201T patent/ES2407858T3/es active Active
- 2010-04-07 PL PL10159201T patent/PL2374446T3/pl unknown
- 2010-04-07 DK DK10159201.2T patent/DK2374446T3/da active
- 2010-04-07 EP EP10159201A patent/EP2374446B1/en active Active
-
2011
- 2011-04-06 AR ARP110101157A patent/AR081529A1/es unknown
- 2011-04-06 TW TW100111803A patent/TWI421095B/zh not_active IP Right Cessation
- 2011-04-07 PH PH1/2012/501903A patent/PH12012501903A1/en unknown
- 2011-04-07 RU RU2012147276/15A patent/RU2548752C2/ru not_active IP Right Cessation
- 2011-04-07 BR BR112012023843A patent/BR112012023843A2/pt not_active Application Discontinuation
- 2011-04-07 SG SG2012068375A patent/SG184082A1/en unknown
- 2011-04-07 US US13/639,974 patent/US8926950B2/en active Active
- 2011-04-07 CA CA2793769A patent/CA2793769C/en not_active Expired - Fee Related
- 2011-04-07 CN CN201180016764.4A patent/CN102946844B/zh active Active
- 2011-04-07 MX MX2012011169A patent/MX344204B/es active IP Right Grant
- 2011-04-07 AU AU2011237825A patent/AU2011237825B2/en active Active
- 2011-04-07 JP JP2013503120A patent/JP5695733B2/ja not_active Expired - Fee Related
- 2011-04-07 WO PCT/EP2011/055458 patent/WO2011124659A1/en not_active Ceased
-
2012
- 2012-10-01 CO CO12171895A patent/CO6551662A2/es unknown
- 2012-10-02 ZA ZA2012/07379A patent/ZA201207379B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2057978A1 (en) * | 2007-11-09 | 2009-05-13 | The Procter and Gamble Company | Oral stannous compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| US8926950B2 (en) | 2015-01-06 |
| HK1162330A1 (en) | 2012-08-31 |
| MX2012011169A (es) | 2012-12-05 |
| ZA201207379B (en) | 2014-06-25 |
| AU2011237825A1 (en) | 2012-10-11 |
| RU2548752C2 (ru) | 2015-04-20 |
| EP2374446A1 (en) | 2011-10-12 |
| EP2374446B1 (en) | 2013-03-20 |
| SG184082A1 (en) | 2012-10-30 |
| RU2012147276A (ru) | 2014-05-20 |
| TW201201850A (en) | 2012-01-16 |
| CN102946844B (zh) | 2015-07-29 |
| PL2374446T3 (pl) | 2013-08-30 |
| CN102946844A (zh) | 2013-02-27 |
| PH12012501903A1 (en) | 2012-12-17 |
| JP5695733B2 (ja) | 2015-04-08 |
| ES2407858T3 (es) | 2013-06-14 |
| DK2374446T3 (da) | 2013-05-13 |
| AR081529A1 (es) | 2012-10-03 |
| JP2013526483A (ja) | 2013-06-24 |
| WO2011124659A1 (en) | 2011-10-13 |
| BR112012023843A2 (pt) | 2016-08-02 |
| US20130039867A1 (en) | 2013-02-14 |
| AU2011237825B2 (en) | 2013-07-04 |
| CA2793769C (en) | 2015-01-06 |
| CA2793769A1 (en) | 2011-10-13 |
| CO6551662A2 (es) | 2012-10-31 |
| MX344204B (es) | 2016-11-04 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |