TWI386237B - 無硫酸烷基酯且無正磷酸鹽而包含氟離子源及二氧化矽牙科研磨劑之潔牙劑組合物 - Google Patents
無硫酸烷基酯且無正磷酸鹽而包含氟離子源及二氧化矽牙科研磨劑之潔牙劑組合物 Download PDFInfo
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- TWI386237B TWI386237B TW095109508A TW95109508A TWI386237B TW I386237 B TWI386237 B TW I386237B TW 095109508 A TW095109508 A TW 095109508A TW 95109508 A TW95109508 A TW 95109508A TW I386237 B TWI386237 B TW I386237B
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- Prior art keywords
- composition
- fluoride
- dentifrice
- potassium
- enamel
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- 239000000203 mixture Substances 0.000 title claims description 89
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title claims description 58
- 239000000551 dentifrice Substances 0.000 title claims description 49
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims description 6
- 150000008051 alkyl sulfates Chemical class 0.000 title claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title 2
- 239000000377 silicon dioxide Substances 0.000 title 1
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- 229910000420 cerium oxide Inorganic materials 0.000 claims description 9
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 239000003975 dentin desensitizing agent Substances 0.000 claims description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002280 amphoteric surfactant Substances 0.000 claims description 6
- 239000001103 potassium chloride Substances 0.000 claims description 5
- 235000011164 potassium chloride Nutrition 0.000 claims description 5
- 229960002816 potassium chloride Drugs 0.000 claims description 5
- 239000004323 potassium nitrate Substances 0.000 claims description 5
- 235000010333 potassium nitrate Nutrition 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
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- 239000002563 ionic surfactant Substances 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- HLCFGWHYROZGBI-JJKGCWMISA-M Potassium gluconate Chemical compound [K+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O HLCFGWHYROZGBI-JJKGCWMISA-M 0.000 claims description 2
- 229910001515 alkali metal fluoride Inorganic materials 0.000 claims description 2
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical group [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
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- 239000001508 potassium citrate Substances 0.000 claims description 2
- 229960002635 potassium citrate Drugs 0.000 claims description 2
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
- 235000011082 potassium citrates Nutrition 0.000 claims description 2
- 239000004224 potassium gluconate Substances 0.000 claims description 2
- 235000013926 potassium gluconate Nutrition 0.000 claims description 2
- 229960003189 potassium gluconate Drugs 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
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- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 2
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 claims 1
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- 229940091249 fluoride supplement Drugs 0.000 description 57
- 210000003298 dental enamel Anatomy 0.000 description 51
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- 239000002002 slurry Substances 0.000 description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
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- GBVKIUSFVYOQEA-UHFFFAOYSA-N 2-[3-[bis(2-hydroxyethyl)amino]propyl-octadecylamino]ethanol;hexadecan-1-amine;dihydrofluoride Chemical compound F.F.CCCCCCCCCCCCCCCCN.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO GBVKIUSFVYOQEA-UHFFFAOYSA-N 0.000 description 13
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- RVPHBKHKFNGAOI-UHFFFAOYSA-L calcium;carbonate;dihydrate Chemical compound O.O.[Ca+2].[O-]C([O-])=O RVPHBKHKFNGAOI-UHFFFAOYSA-L 0.000 description 1
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- CETPSERCERDGAM-UHFFFAOYSA-N ceric oxide Chemical compound O=[Ce]=O CETPSERCERDGAM-UHFFFAOYSA-N 0.000 description 1
- VYLVYHXQOHJDJL-UHFFFAOYSA-K cerium trichloride Chemical compound Cl[Ce](Cl)Cl VYLVYHXQOHJDJL-UHFFFAOYSA-K 0.000 description 1
- VGBWDOLBWVJTRZ-UHFFFAOYSA-K cerium(3+);triacetate Chemical compound [Ce+3].CC([O-])=O.CC([O-])=O.CC([O-])=O VGBWDOLBWVJTRZ-UHFFFAOYSA-K 0.000 description 1
- 229910000422 cerium(IV) oxide Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
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- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 235000013399 edible fruits Nutrition 0.000 description 1
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- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
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- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 238000004255 ion exchange chromatography Methods 0.000 description 1
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- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- NFFIWVVINABMKP-UHFFFAOYSA-N methylidynetantalum Chemical compound [Ta]#C NFFIWVVINABMKP-UHFFFAOYSA-N 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910000392 octacalcium phosphate Inorganic materials 0.000 description 1
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
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- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- FFUQCRZBKUBHQT-UHFFFAOYSA-N phosphoryl fluoride Chemical compound FP(F)(F)=O FFUQCRZBKUBHQT-UHFFFAOYSA-N 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
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- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- 230000002829 reductive effect Effects 0.000 description 1
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- 235000015067 sauces Nutrition 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
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- 235000010356 sorbitol Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229910003468 tantalcarbide Inorganic materials 0.000 description 1
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 125000003639 thymyl group Chemical class C1(=CC(C)=CC=C1C(C)C)* 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0505760A GB0505760D0 (en) | 2005-03-21 | 2005-03-21 | Novel composition |
| GB0525458A GB0525458D0 (en) | 2005-12-14 | 2005-12-14 | Novel composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200700105A TW200700105A (en) | 2007-01-01 |
| TWI386237B true TWI386237B (zh) | 2013-02-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| TW095109508A TWI386237B (zh) | 2005-03-21 | 2006-03-20 | 無硫酸烷基酯且無正磷酸鹽而包含氟離子源及二氧化矽牙科研磨劑之潔牙劑組合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9554975B2 (enExample) |
| EP (1) | EP1868689B1 (enExample) |
| JP (2) | JP2008533183A (enExample) |
| AR (1) | AR054332A1 (enExample) |
| AU (1) | AU2006226505B2 (enExample) |
| BR (1) | BRPI0609770B1 (enExample) |
| CA (1) | CA2602396C (enExample) |
| ES (1) | ES2544241T3 (enExample) |
| HU (1) | HUE025221T2 (enExample) |
| MX (1) | MX2007011687A (enExample) |
| MY (1) | MY162102A (enExample) |
| PL (1) | PL1868689T3 (enExample) |
| PT (1) | PT1868689E (enExample) |
| RU (1) | RU2431464C2 (enExample) |
| TW (1) | TWI386237B (enExample) |
| WO (1) | WO2006100071A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0706787D0 (en) * | 2007-04-05 | 2007-05-16 | Glaxo Group Ltd | Novel use |
| RU2460512C2 (ru) * | 2008-04-24 | 2012-09-10 | Габа Интернациональ Холдинг Аг | Композиция для ухода за полостью рта, включающая в себя растворенное олово и фторид |
| GB0822434D0 (en) * | 2008-12-09 | 2009-01-14 | Glaxo Group Ltd | Novel use |
| BRPI0924652B1 (pt) | 2009-04-01 | 2016-11-22 | Colgate Palmolive Co | composição de dentifrício e uso de pelo menos um material |
| RU2478364C1 (ru) * | 2012-02-06 | 2013-04-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский государственный педагогический университет им. А.И. Герцена" | Способ повышения микротвердости эмали зубов |
| WO2014124950A1 (en) | 2013-02-14 | 2014-08-21 | Glaxo Group Limited | Novel composition |
| AU2015374240B2 (en) | 2014-12-29 | 2021-11-11 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production |
| GB201811065D0 (en) * | 2018-07-05 | 2018-08-22 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Novel composition |
| GB201811061D0 (en) | 2018-07-05 | 2018-08-22 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Novel composition |
| CN109846780A (zh) * | 2019-03-06 | 2019-06-07 | 叶绿芝生物科技（中山）有限公司 | 一种液体牙膏 |
| EP4039338A4 (en) * | 2019-09-27 | 2024-05-22 | MMF&T Desenvolvimento Tecnológico e Inovação Ltda. | ORAL HEALTH COMPOSITION AND MANUFACTURING METHOD FOR THE ORAL HEALTH COMPOSITION |
| CA3138558C (en) | 2020-11-16 | 2024-01-30 | Church & Dwight Co., Inc. | Teeth cleaning composition comprising banana extract |
| FR3124356B1 (fr) * | 2021-06-23 | 2024-05-31 | Scea Du Chateau Montrose | Composition comprenant du bicarbonate de potassium et utilisation pour traiter et/ou protéger les cultures. |
| WO2024148007A1 (en) * | 2023-01-03 | 2024-07-11 | Unm Rainforest Innovations | Magnetic toothpaste and magnetic toothbrush |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2536657A1 (fr) * | 1982-11-26 | 1984-06-01 | Pierrel Spa | Nouvelle composition dentifrice fluoree |
| EP0263638A2 (en) * | 1986-10-02 | 1988-04-13 | Unilever Plc | Oral composition |
| US20040146466A1 (en) * | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE754431A (enExample) | 1969-08-05 | 1971-01-18 | Colgate Palmolive Co | |
| GB1476633A (en) * | 1973-10-03 | 1977-06-16 | Unilever Ltd | Dentifrice composition |
| US4340583A (en) | 1979-05-23 | 1982-07-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
| US4568540A (en) | 1984-04-18 | 1986-02-04 | Johnson & Johnson | Oral hygiene compositions |
| DE3685367D1 (de) | 1985-03-23 | 1992-06-25 | Beecham Group Plc | Orales hygienemittel. |
| US4666517A (en) * | 1986-06-04 | 1987-05-19 | Colgate-Palmolive Co. | Antiplaque oral composition |
| CA1322960C (en) | 1987-02-12 | 1993-10-12 | Domenico Caserio | Dentifrice composition for desensitising sensitive teeth |
| US4978522A (en) * | 1987-10-06 | 1990-12-18 | The Procter & Gamble Company | Oral compositions |
| DE364245T1 (de) | 1988-10-13 | 1990-08-16 | Beecham Group p.l.c., Brentford, Middlesex | Zahnreinigungsmittel. |
| GB8906914D0 (en) * | 1989-03-28 | 1989-05-10 | Beecham Group Plc | Novel compositions |
| JPH04143542A (ja) | 1990-10-01 | 1992-05-18 | Seiko Epson Corp | 加除湿装置 |
| ES2071336T3 (es) | 1990-10-25 | 1995-06-16 | Boots Co Plc | Colutorio. |
| GB9126686D0 (en) | 1991-12-17 | 1992-02-12 | Smithkline Beecham Plc | Novel compositions |
| WO1993025184A1 (en) | 1992-06-10 | 1993-12-23 | The Procter & Gamble Company | Dentifrice compositions |
| US5320830A (en) * | 1992-12-30 | 1994-06-14 | The Procter & Gamble Company | Oral compositions |
| WO1995022958A2 (en) * | 1994-02-24 | 1995-08-31 | Lingner + Fischer Gmbh | Transparent liquid dentifrice |
| US5560905A (en) * | 1994-05-13 | 1996-10-01 | The Proctor & Gamble Company | Oral compositions |
| DE69524747T2 (de) | 1994-06-06 | 2002-08-08 | Block Drug Co., Inc. | Linderung von dentinüberempfindlichkeit mit submikron-partikeln |
| US5939048A (en) * | 1994-09-20 | 1999-08-17 | Block Drug Co., Inc. | Taste masked desensitizing compositions |
| US5603920A (en) | 1994-09-26 | 1997-02-18 | The Proctor & Gamble Company | Dentifrice compositions |
| US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
| US5589159A (en) | 1995-04-11 | 1996-12-31 | Block Drug Company Inc. | Dispersible particulate system for desensitizing teeth |
| RU2171781C2 (ru) | 1995-06-30 | 2001-08-10 | Кросфилд Лимитед | Аморфные диоксиды кремния, способ получения аморфных диоксидов кремния и композиции для полости рта на их основе |
| US5820853A (en) * | 1997-03-27 | 1998-10-13 | The Procter & Gamble Company | Oral compositions forming a coacervate gel |
| US5993784A (en) * | 1997-07-24 | 1999-11-30 | Whitehill Oral Technologies | Low foaming therapeutic toothpastes with improved cleaning and abrasion performance |
| US5958381A (en) * | 1998-03-12 | 1999-09-28 | Colgate Palmolive Company | Bis-biguanide antiplaque dentifrice exhibiting reduced staining |
| US6346235B1 (en) | 1998-04-28 | 2002-02-12 | Colgate Palmolive Company | Dual component dentifrice composition for fluoridating teeth |
| ATE305290T1 (de) | 1999-03-12 | 2005-10-15 | Pfizer Prod Inc | Orale zübereitungen zür verringering der empfindlichkeit des zahnnervs und des zahnbeins kaliumsalze enthaltend |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| WO2002015809A2 (en) | 2000-08-21 | 2002-02-28 | Block Drug Company, Inc. | Dental composition for hypersensitive teeth |
| GB0027405D0 (en) | 2000-11-09 | 2000-12-27 | S P A | Composition |
| EP1399121B1 (en) * | 2001-06-25 | 2008-11-05 | The Procter & Gamble Company | Oral care compositions |
| US6682722B2 (en) * | 2001-09-19 | 2004-01-27 | The Procter & Gamble Company | Oral compositions providing enhanced overall cleaning |
| CN100534413C (zh) * | 2001-12-25 | 2009-09-02 | 花王株式会社 | 口腔用组合物 |
| ITBO20020083A1 (it) | 2002-02-19 | 2003-08-19 | Dalex S R L | Gruppo operativo per tendine a riavvolgimento automatico |
| ITMI20020884A1 (it) | 2002-04-23 | 2003-10-23 | Farmaceutici S R L | Composizione dentrifricia sbiancante non abrasiva |
| JP3855103B2 (ja) | 2002-06-10 | 2006-12-06 | サンスター株式会社 | 口腔用組成物 |
| DE60321580D1 (de) | 2002-08-05 | 2008-07-24 | Colgate Palmolive Co | Desensibilisierende zweikomponentenzahnpasta |
| RU2005107309A (ru) * | 2002-08-15 | 2005-08-20 | Дзе Проктер Энд Гэмбл Компани (US) | Способ отбеливания зубов |
| ES2291908T5 (es) * | 2003-06-23 | 2011-05-25 | Colgate-Palmolive Company | Composiciones dentífricas estables. |
| GB0400447D0 (en) * | 2004-01-09 | 2004-02-11 | Glaxo Group Ltd | Dentifrice compositions |
| AR062484A1 (es) * | 2006-08-24 | 2008-11-12 | Glaxo Group Ltd | Composicion de higiene bucal |
-
2006
- 2006-03-17 EP EP06723656.2A patent/EP1868689B1/en active Active
- 2006-03-17 RU RU2007135125/15A patent/RU2431464C2/ru active
- 2006-03-17 ES ES06723656.2T patent/ES2544241T3/es active Active
- 2006-03-17 CA CA2602396A patent/CA2602396C/en active Active
- 2006-03-17 WO PCT/EP2006/002665 patent/WO2006100071A1/en not_active Ceased
- 2006-03-17 PL PL06723656T patent/PL1868689T3/pl unknown
- 2006-03-17 PT PT67236562T patent/PT1868689E/pt unknown
- 2006-03-17 BR BRPI0609770A patent/BRPI0609770B1/pt active IP Right Grant
- 2006-03-17 AR ARP060101053A patent/AR054332A1/es not_active Application Discontinuation
- 2006-03-17 HU HUE06723656A patent/HUE025221T2/en unknown
- 2006-03-17 JP JP2008502325A patent/JP2008533183A/ja active Pending
- 2006-03-17 AU AU2006226505A patent/AU2006226505B2/en active Active
- 2006-03-17 MX MX2007011687A patent/MX2007011687A/es active IP Right Grant
- 2006-03-17 US US11/909,210 patent/US9554975B2/en active Active
- 2006-03-20 TW TW095109508A patent/TWI386237B/zh not_active IP Right Cessation
- 2006-03-20 MY MYPI20061222A patent/MY162102A/en unknown
-
2013
- 2013-02-27 JP JP2013036904A patent/JP2013136614A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2536657A1 (fr) * | 1982-11-26 | 1984-06-01 | Pierrel Spa | Nouvelle composition dentifrice fluoree |
| EP0263638A2 (en) * | 1986-10-02 | 1988-04-13 | Unilever Plc | Oral composition |
| US20040146466A1 (en) * | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006100071A1 (en) | 2006-09-28 |
| BRPI0609770A2 (pt) | 2011-10-18 |
| JP2013136614A (ja) | 2013-07-11 |
| US9554975B2 (en) | 2017-01-31 |
| BRPI0609770B1 (pt) | 2016-03-29 |
| CA2602396C (en) | 2013-12-03 |
| EP1868689B1 (en) | 2015-05-27 |
| MY162102A (en) | 2017-05-31 |
| AU2006226505A1 (en) | 2006-09-28 |
| HUE025221T2 (en) | 2016-02-29 |
| JP2008533183A (ja) | 2008-08-21 |
| PL1868689T3 (pl) | 2015-10-30 |
| TW200700105A (en) | 2007-01-01 |
| PT1868689E (pt) | 2015-09-25 |
| AU2006226505B2 (en) | 2012-04-19 |
| AR054332A1 (es) | 2007-06-20 |
| ES2544241T3 (es) | 2015-08-28 |
| CA2602396A1 (en) | 2006-09-28 |
| MX2007011687A (es) | 2008-04-07 |
| EP1868689A1 (en) | 2007-12-26 |
| US20080193391A1 (en) | 2008-08-14 |
| HK1113100A1 (en) | 2008-09-26 |
| RU2007135125A (ru) | 2009-04-27 |
| RU2431464C2 (ru) | 2011-10-20 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |