TWI386201B - N-鹵化胺基酸、n,n-二鹵化胺基酸與其衍生物;以及使用其之組合物與方法 - Google Patents

N-鹵化胺基酸、n,n-二鹵化胺基酸與其衍生物;以及使用其之組合物與方法 Download PDF

Info

Publication number
TWI386201B
TWI386201B TW095102567A TW95102567A TWI386201B TW I386201 B TWI386201 B TW I386201B TW 095102567 A TW095102567 A TW 095102567A TW 95102567 A TW95102567 A TW 95102567A TW I386201 B TWI386201 B TW I386201B
Authority
TW
Taiwan
Prior art keywords
group
acid
composition
solution
derivative
Prior art date
Application number
TW095102567A
Other languages
English (en)
Chinese (zh)
Other versions
TW200640445A (en
Inventor
Ramin Najafi
Mansour Bassiri
Lu Wang
Behzad Khosrovi
Original Assignee
Novabay Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novabay Pharmaceuticals Inc filed Critical Novabay Pharmaceuticals Inc
Publication of TW200640445A publication Critical patent/TW200640445A/zh
Application granted granted Critical
Publication of TWI386201B publication Critical patent/TWI386201B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/16Fluorine compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/18Iodine; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/20Elemental chlorine; Inorganic compounds releasing chlorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW095102567A 2005-01-25 2006-01-24 N-鹵化胺基酸、n,n-二鹵化胺基酸與其衍生物;以及使用其之組合物與方法 TWI386201B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64736605P 2005-01-25 2005-01-25

Publications (2)

Publication Number Publication Date
TW200640445A TW200640445A (en) 2006-12-01
TWI386201B true TWI386201B (zh) 2013-02-21

Family

ID=36441417

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095102567A TWI386201B (zh) 2005-01-25 2006-01-24 N-鹵化胺基酸、n,n-二鹵化胺基酸與其衍生物;以及使用其之組合物與方法

Country Status (14)

Country Link
US (1) US7846971B2 (cg-RX-API-DMAC7.html)
EP (1) EP1896001B1 (cg-RX-API-DMAC7.html)
JP (1) JP5329095B2 (cg-RX-API-DMAC7.html)
KR (1) KR20070098947A (cg-RX-API-DMAC7.html)
CN (1) CN101132785A (cg-RX-API-DMAC7.html)
AU (1) AU2006208046B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0607302A2 (cg-RX-API-DMAC7.html)
CA (1) CA2595889C (cg-RX-API-DMAC7.html)
ES (1) ES2421157T3 (cg-RX-API-DMAC7.html)
IL (1) IL184771A (cg-RX-API-DMAC7.html)
MX (1) MX2007008928A (cg-RX-API-DMAC7.html)
TW (1) TWI386201B (cg-RX-API-DMAC7.html)
WO (1) WO2006081392A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200706402B (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1656095T3 (en) * 2003-08-18 2014-03-10 Novabay Pharmaceuticals Inc N, N-DIHALOGENG-GENERATED AMINO ACIDS AND DERIVATIVES
US8747882B2 (en) 2005-04-21 2014-06-10 Astra Tech Ab Catheter assembly with bactericidal effect
US20090221989A1 (en) * 2005-09-21 2009-09-03 Novabay Pharmaceuticals Inc System and method for the prevention and treatment of bacterial and fungal infections including urinary tract infections (uti) using a hypohalous acid composition
JP2009511493A (ja) * 2005-10-06 2009-03-19 ノバベイ・ファーマシューティカルズ・インコーポレイテッド N−ハロゲン化アミノ酸を使用する、尿路感染症(uti)を含む細菌感染症および真菌感染症の予防のためのシステムおよび方法
TW200843787A (en) * 2006-12-29 2008-11-16 Novabay Pharmaceuticals Inc N-halogenated amino compounds and derivatives; compositions and methods of using them
EP2111252A4 (en) * 2007-01-31 2010-12-01 Adam Heller MANAGEMENT OF PAIN BY ELECTROCHEMICAL PATHWAY
UY31057A1 (es) * 2007-05-01 2008-10-31 Alcon Res Ltd Formulaciones de aminoacido n-halogenado que contiene acido alifatico
UY31058A1 (es) * 2007-05-01 2008-10-31 Alcon Res Ltd Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios
UY31056A1 (es) * 2007-05-01 2008-10-31 Alcon Res Ltd Fromulaciones aminocido n-halogenado y metodos de limpieza y desinfeccion
UY31059A1 (es) * 2007-05-01 2008-10-31 Alcon Res Ltd Formulaciones de aminoacido n-halogenado
UY31055A1 (es) * 2008-02-01 2008-10-31 Alcon Res Ltd Sales antimicrobianas de aminoacido n-halogenado
JP2011516578A (ja) * 2008-04-10 2011-05-26 ノバベイ・ファーマシューティカルズ・インコーポレイテッド 気管支肺感染症の治療および予防のための組成物および方法
CA2723262A1 (en) * 2008-04-15 2009-10-22 Waldemar Gottardi Compositions and devices for antisepsis and anticoagulation
IL192262A (en) * 2008-06-17 2016-05-31 Z H T Eng Equipment And Tech Ltd A polymer that releases drugs into the animal body, a medicinal product containing it and a method for its preparation
WO2010017405A1 (en) * 2008-08-06 2010-02-11 Adam Heller Methods and compositions for the treatment of pain
US20100076089A1 (en) * 2008-08-12 2010-03-25 Novabay Pharmaceuticals, Inc. Antimicrobial gel formulations
WO2010044862A1 (en) 2008-10-17 2010-04-22 Ai Medical Devices, Inc. Endotracheal intubation device
CA2741667A1 (en) 2008-11-07 2010-05-14 Novabay Pharmaceuticals, Inc. Antimicrobial n-chlorinated compositions
WO2010054009A1 (en) * 2008-11-07 2010-05-14 Novabay Pharmaceuticals, Inc. Antimicrobial oxazolidinone, hydantoin and imidazolidinone compositions
WO2010091280A1 (en) 2009-02-06 2010-08-12 Alcon Research, Ltd. N-halogenated amino acid formulations comprising phosphine or amine oxides
RU2520034C2 (ru) * 2009-03-18 2014-06-20 ОЛАТЕК ИНДАСТРИЗ ЭлЭлСи Соединения для лечения воспаления
US20100272783A1 (en) * 2009-04-24 2010-10-28 Novabay Pharmaceuticals, Inc. Methods of Treating Infections of the Nail
US20110020474A1 (en) * 2009-07-27 2011-01-27 Novabay Pharmaceuticals, Inc. Methods of Treating Infections of the Nail or Skin Using Hypohalite
EP2531026A4 (en) * 2010-02-04 2013-09-25 Novabay Pharmaceuticals Inc ANTIMICROBIAL FORMULATIONS ON POLYSACCHARID BASE
US9888832B2 (en) 2010-09-24 2018-02-13 Blink Device LLC Endotracheal intubation device
TWI407907B (zh) 2010-10-04 2013-09-11 Far Eastern New Century Corp An antibacterial agent with water solubility and biodegradability
JP5952899B2 (ja) 2011-06-15 2016-07-13 アルエルエス グローバル アーベー う蝕象牙質組織の検出と除去
SE536581C2 (sv) 2012-07-24 2014-03-11 Rls Global Ab Ett kit för behandling av sår eller liknande och ett preparat och metoder därav
US11814739B2 (en) 2016-06-09 2023-11-14 De Nora Holdings Us, Inc. Electrolytic production of organic chloramine solutions
EP3745861A1 (en) * 2018-01-30 2020-12-09 Buckman Laboratories International, Inc. Synergistic combinations of monochloramine and organic acid, and methods of using the same for microbial control
CN113729039A (zh) * 2021-08-27 2021-12-03 上海罗克环控节能科技股份有限公司 一种绿色环保消毒液及其制造方法
US12251486B2 (en) 2021-09-09 2025-03-18 Toyota Motor North America, Inc. Vehicle sanitizing systems and methods for using the same

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998945A (en) * 1972-06-12 1976-12-21 National Patent Development Corporation Dental treatment
JPH07206609A (ja) * 1994-01-13 1995-08-08 Sogo Yatsukou Kk 殺菌剤
DE19816102C1 (de) * 1998-04-10 1999-09-16 Waldemar Gottardi Verfahren zum Inaktivieren von Viren in Proteinlösungen, Verwendung von N-Chlortaurin in dem Verfahren sowie nach dem Verfahren hergestellte Proteinlösungen
WO2002058692A2 (fr) * 2001-01-23 2002-08-01 Arnaud Mainnemare Composition halogenee de hypohalites avec n-chloramine taurine, procede de preparation et ses utilisations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950536A (en) 1974-02-01 1976-04-13 Sol Joseph Barer N,N-Dichloro substituted aminocarboxylic acids as bactericides and fungicides
US4015008A (en) 1974-02-01 1977-03-29 National Patent Development Corporation N,N-dichloro substituted aminocarboxylic acids as microbiocides
US3966796A (en) 1974-06-14 1976-06-29 Interx Research Corporation N-chloro-amino acid derivatives activity
US4045578A (en) 1974-06-14 1977-08-30 Interx Research Corporation N-chloro-amino acid derivatives exhibiting antibacterial activity
US4386103A (en) 1981-01-30 1983-05-31 Merck & Co., Inc. Dichloroamino acid derivatives useful as potent germicidal and fungicidal agents
US5096700A (en) 1990-09-28 1992-03-17 The Procter & Gamble Company Halogenated aminohexanoates and aminobutyrates antimicrobial agents
DE4041703C2 (de) 1990-12-24 1993-10-21 Waldemar Dr Gottardi Alkalimetallsalze des N-Chlortaurins in kristalliner Form, Verfahren zu deren Herstellung und deren Verwendung
US5753701A (en) 1996-10-25 1998-05-19 University Of Kentucky N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters as novel safe agents for water disinfection
DE19712565A1 (de) * 1997-03-25 1998-10-01 Thomas W Dr Stief Arzneimittel auf der Basis eines Singulett-Sauerstoff erzeugenden Agenzes
CA2320556A1 (en) 1999-09-29 2001-03-29 Queen's University At Kingston N,n-dichlorinated omega amino acids and uses thereof
AU2001285944A1 (en) 2000-09-14 2002-03-26 Waldemar Gottardi Fungicidal agent containing n-chlorotaurine and use thereof
WO2004003702A2 (en) * 2002-06-27 2004-01-08 Geranio Nicholas L Integrated property database and search engine
DK1656095T3 (en) 2003-08-18 2014-03-10 Novabay Pharmaceuticals Inc N, N-DIHALOGENG-GENERATED AMINO ACIDS AND DERIVATIVES
EP1713785A1 (en) 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
TW200843787A (en) 2006-12-29 2008-11-16 Novabay Pharmaceuticals Inc N-halogenated amino compounds and derivatives; compositions and methods of using them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998945A (en) * 1972-06-12 1976-12-21 National Patent Development Corporation Dental treatment
JPH07206609A (ja) * 1994-01-13 1995-08-08 Sogo Yatsukou Kk 殺菌剤
DE19816102C1 (de) * 1998-04-10 1999-09-16 Waldemar Gottardi Verfahren zum Inaktivieren von Viren in Proteinlösungen, Verwendung von N-Chlortaurin in dem Verfahren sowie nach dem Verfahren hergestellte Proteinlösungen
WO2002058692A2 (fr) * 2001-01-23 2002-08-01 Arnaud Mainnemare Composition halogenee de hypohalites avec n-chloramine taurine, procede de preparation et ses utilisations

Also Published As

Publication number Publication date
CN101132785A (zh) 2008-02-27
AU2006208046A2 (en) 2006-08-03
US20060247209A1 (en) 2006-11-02
WO2006081392A1 (en) 2006-08-03
TW200640445A (en) 2006-12-01
IL184771A (en) 2013-04-30
ES2421157T3 (es) 2013-08-29
EP1896001A1 (en) 2008-03-12
ZA200706402B (en) 2011-12-28
AU2006208046B2 (en) 2011-03-24
US7846971B2 (en) 2010-12-07
AU2006208046A1 (en) 2006-08-03
CA2595889C (en) 2013-11-19
KR20070098947A (ko) 2007-10-05
MX2007008928A (es) 2007-12-10
CA2595889A1 (en) 2006-08-03
JP5329095B2 (ja) 2013-10-30
JP2008531479A (ja) 2008-08-14
EP1896001B1 (en) 2013-06-19
BRPI0607302A2 (pt) 2009-08-25
IL184771A0 (en) 2007-12-03

Similar Documents

Publication Publication Date Title
TWI386201B (zh) N-鹵化胺基酸、n,n-二鹵化胺基酸與其衍生物;以及使用其之組合物與方法
JP4994033B2 (ja) N,n−ジハロゲン化アミノ酸および誘導体
EP3125952B1 (en) Stable compositions of uncomplexed iodine and methods of use
JP5564264B2 (ja) N−ハロゲン化アミノ化合物および誘導体
WO2008146030A1 (en) An antibacterial formulation comprising a dialkyl sulphosuccinate and a carbanilide antibacterial agent
HK1117748A (en) N-halogenated amino acids and n, n-dihalogenated amino acids in combination with hypohalous acids
HK1103713B (en) N,n-dihalogenated amino acids and derivatives

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees