TWI374886B - Processes for preparing intermediates of pemetrexed - Google Patents

Processes for preparing intermediates of pemetrexed

Info

Publication number
TWI374886B
TWI374886B TW096130046A TW96130046A TWI374886B TW I374886 B TWI374886 B TW I374886B TW 096130046 A TW096130046 A TW 096130046A TW 96130046 A TW96130046 A TW 96130046A TW I374886 B TWI374886 B TW I374886B
Authority
TW
Taiwan
Prior art keywords
pemetrexed
processes
preparing intermediates
intermediates
preparing
Prior art date
Application number
TW096130046A
Other languages
English (en)
Other versions
TW200825088A (en
Inventor
Nicola Diulgheroff
Moran Pirkes
Alessandro Pontiroli
Marco Villa
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Publication of TW200825088A publication Critical patent/TW200825088A/zh
Application granted granted Critical
Publication of TWI374886B publication Critical patent/TWI374886B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW096130046A 2006-08-14 2007-08-14 Processes for preparing intermediates of pemetrexed TWI374886B (en)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US83730306P 2006-08-14 2006-08-14
US83763706P 2006-08-15 2006-08-15
US83955106P 2006-08-22 2006-08-22
US84503106P 2006-09-14 2006-09-14
US84729106P 2006-09-25 2006-09-25
US85513906P 2006-10-30 2006-10-30
US86055406P 2006-11-21 2006-11-21
US86055706P 2006-11-21 2006-11-21
US88017807P 2007-01-11 2007-01-11
US88017907P 2007-01-11 2007-01-11
US89992807P 2007-02-06 2007-02-06
US93655307P 2007-06-20 2007-06-20
US95832607P 2007-07-02 2007-07-02
US95821307P 2007-07-03 2007-07-03
US95841307P 2007-07-05 2007-07-05
PCT/US2007/018043 WO2008021385A2 (en) 2006-08-14 2007-08-14 Processes for preparing intermediates of pemetrexed

Publications (2)

Publication Number Publication Date
TW200825088A TW200825088A (en) 2008-06-16
TWI374886B true TWI374886B (en) 2012-10-21

Family

ID=49584973

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096130046A TWI374886B (en) 2006-08-14 2007-08-14 Processes for preparing intermediates of pemetrexed

Country Status (7)

Country Link
US (2) US7994180B2 (zh)
EP (1) EP1957497B1 (zh)
JP (1) JP2008543973A (zh)
KR (1) KR101101443B1 (zh)
ES (1) ES2555154T3 (zh)
TW (1) TWI374886B (zh)
WO (1) WO2008021385A2 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008543973A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド ペメトレキセドの中間体の調製方法
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
CN103582479A (zh) * 2011-06-03 2014-02-12 霍夫曼-拉罗奇有限公司 用pi3k抑制剂化合物治疗间皮瘤的方法
ITRM20120398A1 (it) * 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
CN103265428B (zh) * 2013-05-27 2014-11-26 苏州明锐医药科技有限公司 4-[(3-卤代-4-氧代)丁基]苯甲酸的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
CA2032695A1 (en) 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
AU4163197A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Nonclassical pyrrolo{2,3-d}pyrimidine antifolates
US6262262B1 (en) 1997-09-26 2001-07-17 Eli Lilly And Company Processes and intermediates useful to make antifolates
EP1212325A2 (en) 1999-08-23 2002-06-12 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
PT1259513E (pt) 2000-02-25 2004-02-27 Lilly Co Eli Nova forma cristalina de acido n-¬4- ¬2-amino-4,7-dihidro -4-oxo-3h-pirrolo¬2,3-d|pirimidin-5-il)etil| - benzoil|-l-glutamico e processo para a sua obtencao
JP2008543973A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド ペメトレキセドの中間体の調製方法
MX2009010568A (es) 2007-04-03 2009-10-22 Reddys Lab Ltd Dr Formas solidas de pemetrexed.

Also Published As

Publication number Publication date
US8362245B2 (en) 2013-01-29
US7994180B2 (en) 2011-08-09
KR101101443B1 (ko) 2012-01-03
WO2008021385A3 (en) 2008-05-15
JP2008543973A (ja) 2008-12-04
US20110263851A1 (en) 2011-10-27
EP1957497A2 (en) 2008-08-20
WO2008021385A2 (en) 2008-02-21
EP1957497B1 (en) 2015-09-30
US20080146799A1 (en) 2008-06-19
TW200825088A (en) 2008-06-16
KR20090053812A (ko) 2009-05-27
ES2555154T3 (es) 2015-12-29

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