TWI369985B - Novel fused pyrazolyl compound - Google Patents
Novel fused pyrazolyl compoundInfo
- Publication number
- TWI369985B TWI369985B TW094109082A TW94109082A TWI369985B TW I369985 B TWI369985 B TW I369985B TW 094109082 A TW094109082 A TW 094109082A TW 94109082 A TW94109082 A TW 94109082A TW I369985 B TWI369985 B TW I369985B
- Authority
- TW
- Taiwan
- Prior art keywords
- novel fused
- fused pyrazolyl
- pyrazolyl compound
- compound
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55709804P | 2004-03-26 | 2004-03-26 | |
| US10/999,139 US7378532B2 (en) | 2004-03-26 | 2004-11-29 | Fused pyrazolyl compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200533347A TW200533347A (en) | 2005-10-16 |
| TWI369985B true TWI369985B (en) | 2012-08-11 |
Family
ID=34942048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094109082A TWI369985B (en) | 2004-03-26 | 2005-03-24 | Novel fused pyrazolyl compound |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7378532B2 (zh) |
| EP (1) | EP1586572A1 (zh) |
| JP (1) | JP4828142B2 (zh) |
| KR (1) | KR101127558B1 (zh) |
| CN (1) | CN1680334A (zh) |
| TW (1) | TWI369985B (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100516049C (zh) | 2004-11-16 | 2009-07-22 | 永信药品工业股份有限公司 | 抗血管生成药n2-(取代的芳基甲基)-3-(取代的苯基)吲唑的合成 |
| US7767707B2 (en) * | 2007-11-21 | 2010-08-03 | Yung Shin Pharm. Ind. Co., Ltd. | Fused pyrazolyl compounds having an aminoalkylcarbonyl group |
| TWI408141B (zh) * | 2010-07-02 | 2013-09-11 | Univ China Medical | 哂吩并吡唑衍生物及其作為抗癌劑的用途 |
| CN103140490A (zh) | 2010-07-15 | 2013-06-05 | 百时美施贵宝公司 | 氮杂吲唑化合物 |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| CA2907730A1 (en) * | 2013-03-21 | 2014-09-25 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
| TW201536281A (zh) * | 2013-05-30 | 2015-10-01 | Yung Shin Pharm Ind Co Ltd | 抑制乳癌細胞中的ｅｚｈ２表現之方法 |
| US10508113B2 (en) | 2018-03-12 | 2019-12-17 | Abbvie Inc. | Inhibitors of tyrosine kinase 2 mediated signaling |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006520A (en) * | 1987-10-13 | 1991-04-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused pyrazole compounds and pharmaceutical use thereof |
| WO1993023036A1 (en) * | 1992-05-21 | 1993-11-25 | Yoshitomi Pharmaceutical Industries, Ltd. | Optically active condensed pyrazole compound for use in treating thrombocytopenia and erythropenia |
| JPH06206872A (ja) * | 1992-10-06 | 1994-07-26 | Yoshitomi Pharmaceut Ind Ltd | 縮合型ピラゾール化合物 |
| DE19744026A1 (de) * | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| DE19744027A1 (de) * | 1997-10-06 | 1999-04-08 | Hoechst Marion Roussel De Gmbh | Substituierte Pyrazolo[3,4-b]pyridine, ihre Herstellung und Verwendung in Arzneimitteln |
| US6462036B1 (en) * | 1998-11-06 | 2002-10-08 | Basf Aktiengesellschaft | Tricyclic pyrazole derivatives |
| TWI262914B (en) * | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| GB0002666D0 (en) * | 2000-02-04 | 2000-03-29 | Univ London | Blockade of voltage dependent sodium channels |
| US6387942B2 (en) * | 2000-06-19 | 2002-05-14 | Yung Shin Pharmaceutical Ind. Co. Ltd | Method of treating disorders related to protease-activated receptors-induced cell activation |
| JP2002080367A (ja) * | 2000-06-23 | 2002-03-19 | Yung Shin Pharmaceutical Industry Co Ltd | プロテアーゼ活性化受容体誘導性の細胞活性を阻害する薬剤 |
| CN1300116C (zh) | 2001-04-16 | 2007-02-14 | 卫材株式会社 | 1h－吲唑化合物 |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| TWI264304B (en) * | 2002-01-25 | 2006-10-21 | Yung Shin Pharm Ind Co Ltd | Methods of treating sepsis |
| TW200302722A (en) | 2002-02-13 | 2003-08-16 | Astrazeneca Ab | Therapeutic agents |
| JP4499721B2 (ja) * | 2003-06-30 | 2010-07-07 | ヒフ バイオ，インク． | 化合物、組成物および方法 |
-
2004
- 2004-11-29 US US10/999,139 patent/US7378532B2/en active Active
-
2005
- 2005-03-24 TW TW094109082A patent/TWI369985B/zh active
- 2005-03-25 KR KR1020050024922A patent/KR101127558B1/ko active IP Right Grant
- 2005-03-25 JP JP2005088749A patent/JP4828142B2/ja active Active
- 2005-03-28 CN CNA2005100624241A patent/CN1680334A/zh active Pending
- 2005-03-29 EP EP05290694A patent/EP1586572A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP4828142B2 (ja) | 2011-11-30 |
| US20050215612A1 (en) | 2005-09-29 |
| TW200533347A (en) | 2005-10-16 |
| CN1680334A (zh) | 2005-10-12 |
| JP2005281309A (ja) | 2005-10-13 |
| KR101127558B1 (ko) | 2012-03-28 |
| EP1586572A1 (en) | 2005-10-19 |
| US7378532B2 (en) | 2008-05-27 |
| KR20060059768A (ko) | 2006-06-02 |
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