TWI362944B - - Google Patents

Description

1362944 IX. INSTRUCTIONS OF THE INVENTION [Technical Field] The present invention relates to a hair cosmetic, and in detail, by mixing an acetamidine semi-ascorbate with a specific polyoxyalkylene-based chimeric copolymer, and imparting hair change The hair straightening feeling (straight hair feeling) has a superior effect, and is a hair cosmetic which has an effect of preventing hair damage and has a superior smoothing and combing effect. [Prior Art] Hair hair is neat and non-knotted, and has a glossy, smooth and combable hair. It is considered to be representative of the condition of beautiful hair. However, the hair is often exposed to sunlight and the atmosphere, or is subjected to fading, drying, split ends, and hair breakage due to the heat of the hair dryer. In addition, in order to make the hair look beautiful, it is known that the hair is flowing straight, and the hair is straight into the straight hair perm, but the straight hair perm makes the hair itself straight, but it is caused by the usual perm and dyeing hair. Also, the chemical treatment of applying the medicine to the hair for a certain period of time is actually applied to the hair. In the damaged hair, the keratin fibers inside the scales and hair have been damaged. The melanin pigment is easily dissolved, and the hair pigments such as hair dyes and lipids are contained in the hair. And if the hair that suffers from these injuries is ignored, it will further deepen the damage of the hair. In the past, many attempts have been made to prevent and protect hair from being on the hair composition. For example, a water-soluble polymer, a protein derivative, a polyoxyalkylene-4- 1362944 type, and a plant extract are mixed for the purpose of protecting hair and preventing the elution of components in the hair (for example, refer to Patent Document 丨~5) . Further, in order to protect against hair damage caused by sun exposure, an ultraviolet absorber is mixed (for example, refer to Patent Document 6). However, when a mixture of a water-soluble polymer and a protein derivative is intended to have a sufficient effect and a large amount of these components are mixed, a dandruff-like sheet is caused in the hair. In addition, among these components, the effect of preventing hair damage is not sufficient. Further, when the ultraviolet absorber is mixed, although the effect of preventing the fading of the hair due to the sun exposure is prevented, it is intended to obtain a sufficient effect, and when the component is mixed in a large amount, the stability of the product is impaired. On the other hand, it has been used as a 5s original in the perm and straightening perm agents in the past; the i-breasted sulphate compound thiol compound has been used (for example, refer to Patent Documents 7 and 8) . It is reported that the combination of the thiol compound and the polyoxyalkylene, together with the ultraviolet absorber, can suppress the effect of hair damage, for example, revealing the use of amine-modified polyoxyl and N-acetyl cystein Hair cosmetic (refer to Patent Document 9). However, these amine-modified polyfluorenes which do not contain polyoxyalkylene doping do not provide sufficient and satisfactory effects for imparting a straight hair feeling effect, a hair damage preventing effect, and a smoothness. Patent Document 1: Japanese Laid-Open Patent Publication No. Hei No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. 5: Japanese Patent Laid-Open No. Hei 8: 2 3 1 3 4 No. 8362944 Patent Document 6: Japanese Patent Laid-Open No. Hei 7-22 8 5 1 0 Patent Document 7: JP-A-8-269003 Patent Document 8: Special Kaiping 5 - 3 In the case of a chemical treatment such as a straight hair perm that causes damage, it is desirable to develop a hair tidy feeling that can impart a straightening hair to a curled hair ( It is a hair cosmetic which is excellent in smoothing and easy combing effect, and it is a subject of the present invention to provide such a hair cosmetic. SUMMARY OF THE INVENTION In view of the current state of the art, the inventors of the present invention have found that the results of the above-mentioned problems should be solved by finding that acetylcysteine is chimeric with a specific polyoxalate in a specific amount. The polymer is used in combination, on the one hand, does not change the hair which is chemically straightened like a straight hair perm, and gives the hair of the curled hair straightening hair (hereinafter referred to as "straight hair"), The present invention has been completed on the basis of the discovery that it has a superior effect on the damage of the hair and also has a hair cosmetic which is excellent in smoothing and combing the hair. That is, the present invention is characterized in that the following components (a) and (b (a) acetylcysteine are 0.05 to 1.0% by mass (b): 1:362944 [Chemical 2] R1 R2 R1

I I I -[(SiO) a (SiO) bSiYO (CnH2nO) cY 】d -

I I I

Rl X1 R1 [wherein R1 is independent of each other, does not contain a monovalent hydrocarbon group of an unsaturated aliphatic group, a hydroxyl group or an alkoxy group, and X1 represents a general formula: a r3_zI (wherein R3 represents a direct bond) Or a divalent hydrocarbon group having a carbon number of 1 to 20, 'Z1 represents a functional group represented by an amino group-containing group or an ammonium group-containing group, and R2 is independent of each other, and represents either R1 or X1, and η is 2 to 4 The integer 'a is an integer of at least 1 or more, c is an integer of at least 2 or more, d is at least an integer of 2 or more, bxd is at least 1 or more, and Y represents a bond between carbon and fluorene and an adjacent ruthenium atom. Further, by the oxygen atom and the polyoxyalkylene, the divalent organic group is chiralally bonded, and the average molecular weight of each of the oxanes is from about 250 to about 1,000,000, and the average molecular weight of each polyoxyalkylene is from about 200 to about Φ 1 0,000, the oxane is chitocomposed to form from about 25 to about 95% by weight of the copolymer 'and the chimeric copolymer has an average molecular weight of at least about 5,000." The polyoxyalkylene-based chimeric copolymer is shown. Hair cosmetics. The hair cosmetic of the present invention imparts a straight hair feel to the hair on the one hand, and has a superior effect on the damage of the hair, and also has a superior smoothing and combing effect. The following description will be made on the constitution of the present invention. The component (a) acetaminophen-like perm agent used in the present invention is mixed as a reducing agent for the active ingredient of straight hair perm, and cut 1362944 to break the disulfide bond in the hair. The ingredients that curl hair straightens. The component (a) used in the present invention is 0.05 to 1.0% by mass in the hair-mixing cosmetic (hereinafter, only "% 0.1 to 0.5% is more preferable. If it is in this range, there is no general perm. When the hair is damaged, it is possible to feel the straight hair feeling and it is not effective. Moreover, by repeating the use, a further effect can be obtained, and the function of the component (b) having the composition used in the present invention can be introduced. A specific polyoxyalkylene-based chimeric copolymer based on the formula.

Rl R2 R1

I I I -[(SiO) a (SiO) bSiYO (CnH2nO) cY J d -

I I I

Rl X» R1 In the above formula, R1 is independently represented by each other, and does not contain an unsaturated aliphatic φ 1 valent hydrocarbon group, a hydroxyl group or an alkoxy group, wherein the unsaturated fatty acid-free hydrocarbon group is, for example, a methyl group, an ethyl group, or a propyl group. , butyl, octyl, decaphenyl, phenethyl, etc., especially methyl, phenyl is preferred. Further, an alkane such as a methoxy group, an ethoxy group, a propoxy group, a butoxy group, a isopropenyloxyethoxy group, a phenoxy group, an ethyloxy group, a cyclohexyloxy group, and a carbon number of twelve are 1~ 12, a carbon number of 1 to 8 is preferred, and a carbon number of 1 to 6 alkane is preferred, particularly preferably a methoxy group or an ethoxy group. X 1 is a general formula: The combined system j ), the reaction of stimulating knotting is as follows: 1 of the following aliphatic group, the oxy group, the methoxyxyoxy group is 1362944 -R3 - Z1 (R3 It means a direct bond or a divalent hydrocarbon group having 1 to 20 carbon atoms, and Z1 represents a functional group represented by an amino group-containing group or an ammonium group-containing group. Specific examples of R3 are, for example, -CH2-, -CH2CH2-, _CH2CH2CH2-, one CH(CH3)CH2-, -(C Η 2) 4

—(CH2)6—, one (C Η 2 ) 8 —, _ C Η 2 C Η 2 C 6 Η 4 —, —(CH 2 ) 12 —, —(CH 2 ) 16 —, preferably an acryl group. Specific examples of the X1 group include, for example, one (CH2)3NH2—, one (CH2)3NH(CH2)2NH2-, -(CH2)3N(CH3)2-, and -(ch2)3n(ch3)(ch2). 2n(ch3)2 -, -(CH2)3N*(CH3)3Cr, -(CH2)3N(CH3)(CH2)2N(CH3)C=o(ch3), and the like. R2 is independent of each other and represents either R1 or x1, n is an integer of 2 to 4, a is an integer of at least 1 or more, c is an integer of at least 2, d is at least an integer of 2 or more, and bxd is at least It is 1 or more. Examples of the divalent organic group represented by Y are -R4-, -R4-CO-, one r4-nhco-, one r4-nhconhr5-nhco- or -R4-OOCNH-R5-NHCO- (wherein R4 is a divalent alkyl group, for example, an ethyl group, a propyl group, a butyl group, etc., and R5 is a divalent alkyl group, for example, R4 is exemplified or a divalent propynyl group, for example, a C6H4-, A 〇6Η4 — C6H4-, a C 6 Η 4 _ C Η 2 _ C 6 Η 4 _, -C6H4-CH(CH3)-C6H4-, etc.). The following are examples of suitable bases. -CH2CH2- '-CH2CH2CH2-'-CH2CHCH3CH2-'-(CH2)4-, one (CH2)2CO-, one (CH2)3NHCO-, 1362944-(CH2)3NHCONHC6H4CO- or -(CH2)3OOCNHC6H4NHCO-. Particularly preferably, the Y group is a divalent alkyl group, -ch2ch2, - ch2ch2ch2, -CH2CH(CH3)CH2, etc., but -CH2CH(CH3)CH2- is preferred. The most preferable examples of the polyoxyalkylene-based chimeric copolymer of the component (b) of the present invention can be exemplified below.

Ch3

Si-C4HeO(OC2H4)g (〇C3H6)hC4H8--CH3 i In the above formula, e is an integer from 1 to 600, f is a number from 0.1 to 20, and g and h are each an integer from 1 to 60, i is 2 An integer of ~50, fxi is at least 1 or more.

Other specific examples of the polyoxyalkylene-based chimeric copolymer of the component (b) of the present invention include the following formulas. 〔化5〕 CHs CHa CHa

I I I —[(SiO) is (SiO) i-SiCHaCH(CHa)CHiO<CiH4〇)3(CH2CH(CH3)0)3Cii2CH(CH3)CHa] ·-

I I I CH3 (CHjJaNHi CHa -10- 1362944 [Chem. 6] CHa CHa CHa

I I I -[(SiO) 39SiO- SiCHiCH2CH2〇(CiH4〇)2〇(C3Hs〇)i〇CH2CH2CHi] u-

I I I CHa (CH〇3NH(CH2)2NH2 ch3 [化7] CHa OCHa CHi CHa

III I -[(SiO)«j (SiO)jo (SiO)a-SiCHjCHiCHaJCHsOCCjHiOMCHjCHiCHaJCHi] e-

III I CHa CeHs (CH2)3NH(CHs): NH2CH3 CHs • [Chemical 8] CHa CHa CH3

II I CHaCHsO-[ (SiO) iso (SiO) j- SiCH2CH(CH3)CH:0(C2H&lt;0)M(GiH6〇)i〇C&lt;Helj〇-

III CHa (CHJ3N+(CH3)3Cl·CHa The polyoxyalkylene-based chimeric copolymer of the component (b) of the present invention has a molecular weight of 5,000 to 2,000,000, preferably 10,000 to 15,000,000, more preferably 20,000 to 1,000,000. The effect of giving a straight hair feeling and imparting a smooth feeling cannot be sufficiently obtained. The polyoxyalkylene-based chimeric copolymer used in the present invention is sold as SILSTYLE 401 (made by Dongli Dow Corning Polysiloxane) (old name) : Japanese uni ca)), etc. The mixing amount of the component (b) in the hair cosmetic of the present invention is not particularly limited, and is preferably 0.01 to 20% in terms of a pure portion, and particularly preferably 0.1 to 1% by weight. In the range, by using the component (a), it does not feel a sticky feeling such as stickiness and oily feeling, and can give a straight hair feeling effect, and has superior defensive hair damage effect, so that the hair is smooth and does not hit. The hair cosmetic of the present invention, in addition to the above-mentioned essential components (a) and (b -11 - 1362944), can be used for the purpose of not impairing the amount and quality of the present invention. Van, with anionic surfactants, cationic interface Surfactants such as sex agents, amphoteric surfactants, nonionic surfactants, oils such as ester oils, higher fatty acids, higher alcohols, hydrocarbons, oils and fats, polyoxyalkylenes other than component (b), natural Aqueous components such as a water-soluble polymer, a semi-synthetic water-soluble polymer, a synthetic water-soluble polymer, a water-soluble polymer such as a polyol, a saccharide or a lower alcohol, an amino acid, an amino acid derivative, a peptide, and a peptide $ Hair cosmetic ingredients such as derivatives and plant extracts, metal chelating agents such as ethyl citrate, pH adjusters for citric acid, lactic acid, phosphoric acid, or salts thereof, perfumes, preservatives, bactericides, UV absorbers, oxidation Further, the preparation method of the hair cosmetic of the present invention is not particularly limited, and may be produced according to a usual method, and may be based on other ingredients. The mechanism for the use of the container and the container can be carried out in various forms such as liquid, emulsion, cream, gel, mist, foam (bubble) φ, etc. More specifically, it can be used as a wash. Fine, moisturizing, hair lotion 'curing hair' hair lotion, hair cream, hair gel, etc., can also be filled with aerosols such as liquefied petroleum gas, dimethyl ether, nitrogen, carbonic acid gas, etc. In the container, it is used as a hair spray or hair gel (mousse). It can be applied to any method by applying it after washing, or by applying it to dry hair. It is better to express the effect of the hair cosmetic which does not need to be washed out, such as a hair spray, a hair styling, a hair styling (mousse), etc. The hair cosmetic of the present invention thus obtained gives a straight hair -12- on the one hand. 1362944 'The superior defensive hair damage effect makes the hair smooth and easy to comb the effect. The effect of this is made more remarkable by repeating the continuous use of the hair cosmetic of the present invention. The period of continuous use varies depending on the composition, dosage form, amount of use, and the hair to be applied. The shampoo and other types of washing are used once a day, and it is better to use more than two weeks of hair spray. The model is used once a day, and it is better to use it continuously for more than one week. In addition, it is better to use a wash-off type and a wash-free type. [Embodiment] EXAMPLES Hereinafter, the present invention will be further described by way of examples. Moreover, these examples are not intended to limit the invention. The hair styling materials of Examples 1 to 5 and Comparative Examples 1 to 4 were prepared by the composition shown in Table 1 and the following production method. For each of the obtained hair styling materials, the evaluation method (1) is given to the straight hair sensation effect '(B) to prevent hair damage effect '(C) smoothness' (D) easy combing degree The results, in the table (composition and results) -13- 1362944 (B) to prevent hair damage effect (B-Sliding _ (D) easy combing results

◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ X X X ◎ υ ◎ ◎ ◎ ◎ 〇 X X △ Δ --- 〇 ◎ 〇 ◎ ◎ ◎ ◎ △ X [Table 1] (%)

(a) giving a straight hair sensation effect Note 1: SILSTYLE 401 (曰本 unica) (21.5% aqueous solution) Note 2: SM8904C (Dongli.D〇wCorning) (pure portion; 40%) (manufacturing method) A. Heating and dissolving Ingredients (1) to (5). B. Heat the dissolved components (9) to (12). C · Add A to B and mix it evenly. After cooling, add ingredients (6) to (8). D. Fill the C to the container to get the whole hair. -14- 1362944 (Evaluation Method 1) <Evaluation of hair straightening effect, prevention of hair damage, giving gloss effect, evaluation of easy combing degree> About 20 years old with curly hair that has not been subjected to chemical treatment such as cold ironing and bleaching Japanese female subjects, wash the hair with a commercially available shampoo. After wiping the water with a towel, the hair on the left side is not coated with any substance (blank group). The right half of the hair is coated with the examples. After comparing 1 to 5 and comparing 2 g of each of φ Examples 1 to 4, the hair was dried with a hair dryer while combing the hair with a comb. The method of self-washing to drying is carried out once a day for five times, giving a straight hair feeling to (a), (b) preventing hair damage, (c) smoothness, (d) easy combing, each with left The half hair (blank group) comparison was evaluated using the following evaluation criteria. The same test was carried out on the other samples, and the average 値 of each subject was judged based on the following criteria. φ <Evaluation Criteria> (A) Give a straight hair feeling effect (evaluation basis) (Judgement) Very straight hair feeling and hair is not knotted: 4 There is a straight hair feeling and the hair is not knotted: 3 There is almost no straight hair and hair Knot: 2 No straight hair feeling and hair knotting: 1 (B) Prevent hair damage effect (evaluation basis) (Judgement) -15- 41362944 No damage and very shiny, no damage and luster, no damage, but almost no Glossy damage and dullness (C) smoothness (evaluation basis) Very smooth and smooth Almost smooth and not smooth (D) Easy combing (evaluation basis) Very good combing 2 (Judgement): 4 (Judgement): 4 Good grooming

Not very good combing: 2 Bad combing: 1 <Judgment criteria> (Average 评 of each subject) (Judgement) Average point of 3.5 or more: ◎ Average point of 2.5 or more is less than 3.5: 〇 Average point of 1.5 or more is less than 2.5 : Δ The average point is less than 1.5: X. As is apparent from the results of Table 1, the hair styling of the present invention has superior straight hair sensation as compared with any of the products of Comparative Examples 1 to 4, and the hair is not knotted. At the same time, and -16- 1362944 to defend against the superior effects of hair damage, hair is shiny, smooth, and also makes the hair easy to comb. (Evaluation Method 2) With respect to Example 1 described above, it was further evaluated that it was given a straight hair feeling combability. Using 20 hairs of a Japanese woman of about 20 years old who has not been subjected to cold scalding and bleaching, etc., about 30cm 10g of hair, washed with a commercially available shampoo, and dried with a towel, 1 bunch of white group, The other sample was coated with 2 g of each sample of Example 1, and then, while the hair was combed with a comb, the hair was dried by a hair dryer for 1 minute, and the step of washing from the washing to drying was repeated five times. The straight hair feeling effect and the easy combing feeling were visually evaluated. The state of the bundle after the treatment of the bundle state and the repeated application of the coating sample five times is shown in Fig. 1. It is apparent from Fig. 1 that the whole hair material and the blank of Example 1 are clearly seen by using the whole hair material of Example 1, It has a superior φ sensation effect, and the hair bundle is less open, and the carding effect becomes good. Example 6 Shampoo The shampoo was prepared in the following composition and preparation method. (composition) (ingredient) (%) (1) PEG-60 butylamino dimethyl polyoxy siloxane emulsion (Note) 〇〇 (2) Polyethylene oxide (3E.O.) lauric acid sulphate It has a superior effect and it has two bundles of hair as an empty hair clock. The former hair B 1 ° group was given straight -17-1362944 (3) sodium tetradecene sulfonate 2.0 (4) N-coconut oil fatty acid 醯-L-glutamic acid triethanolamine 7.0 (5) coconut oil Fatty acid guanamine dimethylamine acetate trimethylglycine 1.0 (6) coconut oil fatty acid diethanol decylamine 5.0 (7) ethylene glycol distearate 0.5 (8) cationized cellulose 0.2 (9) Propylene glycol 1.8 (1 〇) sodium chloride 0.8 (11) Disodium edetate (EDTA*2Na) 0.2 (12) Acetylcysteine 0.5 (1 3 ) Preservatives (1 4 ) Proper amount (1 5 ) Refined water balance (manufacturing method) A. Mix components (1) to (15) uniformly. B. Shampoo is obtained by filling A into a container. The shampoo of Example 6 has a superior hair damage defense effect, and the hair straightening is good, and is a shampoo which has a very high gloss and is easy to comb. Stomach Example 7 Hair Care Lotion The hair lotion is prepared by the following composition and preparation method. -18- 1362944 (composition) (ingredient) (%) (1) PEG-60 butylamino dimethylpolysiloxane emulsion (Note 1) 5.0 (2) 1,3-butanediol 2.0 (3) glycerin 1.0 (4) Trimethylglycine 1.0 (5) Xanthan gum 0.01 (6) Acetylcysteine 0.2

(7) stearyl decyltrimethylammonium chloride 0.4 (8) gasification 16th hospital trimethylmethanol 0.1 (9) methyl phenyl polyoxy siloxane 1.0 (1 0 ) propylene glycol 0.2 (1 1 ) ethanol 2 0.0 (1 2 ) Preservatives (1 3 ) Proper amount of spices *

(1 4) Refined water balance (manufacturing method) A. Mix dissolved components (1) to (6) and (14). B · Mix dissolved components (7) to (1 3 ). C. Mix A with B and mix evenly. D. Fill the C to the oil mist spray container to get a hair lotion. The hair lotion lotion of the seventh embodiment obtained above is suitable for hair use in a mist form, has superior hair damage defense effect, and has a straight hair feeling, and has a high gloss of -19-1362944, so that the hair is glossy and easy to comb. Hair care lotion. By using it continuously, a sense of straightness can be felt. Example 8 Hair Care A hair conditioner was prepared by the following composition and preparation method. (Composition) (%)

(1) PEG-60 butylamino dimethyl polyoxy siloxane emulsion (Note) 3 · 〇 (2) cetyl alcohol 2.0 (3) stearyl alcohol 2.0 (4) stearic acid hardened castor oil 1. 〇 (5) Isopropyl myristate 1.0 (6) Polyethylene oxide (20 Ε.Ο.) Hardened castor oil 1. 〇 (7) Distearyl dimethyl dimethyl ammonium chloride 2.0 (8) Bromination Stearic acid trimethylammonium 2.0 (9) cationized guar gum 〇. 5 (10) 1,3-butanediol 10·0 (1 1 ) preservatives (1 2 ) amine modified poly Oxygen (Note 3) 2.0

(13) Acetylcysteine iO (1 4 ) Perfume amount (1 5 ) Refined water balance Note 3: SM8704C (40% emulsion) (Dong. Dow Corning) The amount of the formula is pure amine The enthalpy of the polyoxygen moiety. -20- 1362944 (Manufacturing Method) A_ Heat the dissolved components (2) to (8). B. Heating the dissolved components (9) to (11) and (15) one part C. Adding A to B and uniformly emulsifying and mixing 'after cooling, adding components (1), (1 2 ), (14) and (15) The remaining part is (13) ° D after dissolution. • C is filled into the container to obtain a hair care lotion. The hair conditioner of Example 8 has a superior hair damage defense effect, and has a superior straight hair feeling effect, and is a hair care product which has a high gloss and is smooth and easy to care for. By using it continuously, a sense of straightness can be felt. Bao Shi Example 9 hair spray

The hair gel was prepared in the following composition and preparation method. (composition) (ingredient) (%) 1) PEG-60 butylamino dimethylpolysiloxane emulsion (Note) 10 0 2) Carboxyvinyl polymer 〇.5 3) Polyvinylpyrrolidone 3.0 4) Glycerol 1.0 5) Sodium Hydroxide Appropriate 6) Sodium Alginate 20.0 7) Ethanol-21 - 1362944 (8) Chlorostearyltrimethylammonium Chloride 0.2 (9) Dimethylpolyoxane 1.0 (1 〇) Preservative Appropriate amount (11) Acetylcysteine 0.1 (12) Proper amount (1 3 ) Refined water balance

(Manufacturing Method) Α·Alternatively mix one part of the component (13) and the components (1), (2), and (6) 〇 Β • uniformly mix one of the components (1 3 ) and the components (3) and (4). C_ mixed dissolved components (7) to (10). D. Mixing the dissolved component (5) and a portion of the component (13). E·mix and dissolve A, B, and C and add D. F. Add (1 1 ) and (1 2 ) dissolved in the remainder of (1 3 ) to E and mix. G. Hair is dispensed by filling F into the container. The hair gel of the embodiment 9 is added as a hair styling ability, has an excellent hair damage defense effect, has a superior straight hair feeling, and has a high gloss and a smooth and easy combing effect. According to the present invention, it is possible to provide a hair cosmetic which imparts a straight hair sensation on the one hand and which has a superior effect in defending hair damage, and which has a superior hair smoothing and combing effect. -22- 1362944 [Simplified description of the drawings] [Fig. 1] Fig. 1 is a whole hair material produced in the first embodiment, the state of the hair bundle before and after the treatment, and the state of each unprocessed hair bundle (blank group) ) Comparison photos.

-twenty three-

Claims (1)

13.62944 Patent No. 0951 1 1016 Patent Application Revision of the Chinese Patent Application Revision of the Republic of China on February 7, 101. Amendment 10, Patent Application Range k 1. A hair cosmetic characterized by mixing (a) acetaminophen and carnitine is 0.05 ～1.0% by mass and (b) a polyoxalate block copolymer represented by the following formula, wherein (b) is a formula (Chemical Formula 1), [Chemical Formula 1] R1 R2 R* III - [(SiO a (SiO) bSiYO (CnH2nO) cY J d - III Ri X» Rl [wherein R1 is independent of each other] does not contain an unsaturated aliphatic monovalent hydrocarbon group, a hydroxyl group or an alkoxy group, and X1 represents a general Formula: -V-Z1 (wherein R3 represents a direct bond or a divalent hydrocarbon group having 1 to 20 carbon atoms, Z1 represents an amino group-containing group or an ammonium group-containing group), and R2 is a mutual Independently, it represents either R1 or X1, η is an integer of 2 to 4, a is an integer of at least 1 or more, c is an integer of at least 2 or more, d is at least an integer of 2 or more, and bxd is at least 1 or more. , γ represents a divalent organic group bonded to an adjacent ruthenium atom by a carbon ruthenium and bonded to a polyoxyalkylene block by an oxygen atom, The average molecular weight is from about 250 to about 1,000,000'. The average molecular weight of each polyoxyalkylene block is from about 2 Torr to about 10,000'. The oxalate block constitutes from about 25 to about 95% by weight of the copolymer, and the blocks are The polymer has an average molecular weight of at least about 5,000].