TWI349547B - Ptx3 gene expression suppressing method - Google Patents

Ptx3 gene expression suppressing method

Info

Publication number
TWI349547B
TWI349547B TW092108385A TW92108385A TWI349547B TW I349547 B TWI349547 B TW I349547B TW 092108385 A TW092108385 A TW 092108385A TW 92108385 A TW92108385 A TW 92108385A TW I349547 B TWI349547 B TW I349547B
Authority
TW
Taiwan
Prior art keywords
sup
sub
gene expression
suppressing method
expression suppressing
Prior art date
Application number
TW092108385A
Other languages
English (en)
Chinese (zh)
Other versions
TW200403990A (en
Inventor
Morikawa Shigeru
Izumi Akashi
Takao Hamakubo
Tatsuhiko Kodama
Original Assignee
Kowa Co
Nissan Chemical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co, Nissan Chemical Ind Ltd filed Critical Kowa Co
Publication of TW200403990A publication Critical patent/TW200403990A/zh
Application granted granted Critical
Publication of TWI349547B publication Critical patent/TWI349547B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW092108385A 2002-04-15 2003-04-11 Ptx3 gene expression suppressing method TWI349547B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37211402P 2002-04-15 2002-04-15
US10/196,428 US20030195167A1 (en) 2002-04-15 2002-07-17 PTX3-gene expression inhibitor

Publications (2)

Publication Number Publication Date
TW200403990A TW200403990A (en) 2004-03-16
TWI349547B true TWI349547B (en) 2011-10-01

Family

ID=28794074

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092108385A TWI349547B (en) 2002-04-15 2003-04-11 Ptx3 gene expression suppressing method

Country Status (9)

Country Link
US (2) US20030195167A1 (https=)
EP (1) EP1494661B1 (https=)
JP (1) JP4409295B2 (https=)
AT (1) ATE445395T1 (https=)
AU (1) AU2003226456A1 (https=)
DE (1) DE60329668D1 (https=)
MY (1) MY137134A (https=)
TW (1) TWI349547B (https=)
WO (1) WO2003086380A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4719572B2 (ja) * 2003-04-17 2011-07-06 興和株式会社 Ｌｋｌｆ／ｋｌｆ２遺伝子発現促進剤
WO2005053683A1 (en) 2003-11-26 2005-06-16 Duke University A method of preventing or treating glaucoma
ITRM20030596A1 (it) * 2003-12-23 2005-06-24 Sigma Tau Ind Farmaceuti Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3.
WO2005080981A1 (ja) * 2004-02-25 2005-09-01 Perseus Proteomics Inc. 血管障害の程度の判定方法
ES2311986T3 (es) * 2004-04-26 2009-02-16 Alcon, Inc. Estatinas para el tratamiento de la hipertension ocular y del glaucoma.
US20090203701A1 (en) * 2006-06-29 2009-08-13 Kowa Co., Ltd Prophylactic and/or therapeutic agent for rheumatoid arthritis
CN106950366B (zh) * 2017-02-15 2019-03-22 中国医学科学院北京协和医院 一种acpa阴性的ra诊断标志物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244916A (en) * 1992-01-31 1993-09-14 The Scripps Research Institute Inhibition of respiratory burst using posttranslational modification inhibitors
WO1999026657A1 (en) * 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
EP1163203A1 (en) * 1999-03-08 2001-12-19 Merck & Co., Inc. Crystalline hydrated dihydroxy open-acid simvastatin calcium salt
US6403637B1 (en) * 1999-08-09 2002-06-11 Univ Saint Louis Methods of modulating matrix metalloproteinase activity and uses thereof
WO2001058443A1 (fr) * 2000-02-10 2001-08-16 Takeda Chemical Industries, Ltd. INHIBITEURS DE TNF-$g(a)
US20020159974A1 (en) * 2000-09-19 2002-10-31 Francois Mach Treatment of multiple sclerosis with statins (HMG-CoA reductase inhibitors)
WO2002024194A2 (en) * 2000-09-19 2002-03-28 Novimmune S.A. Use of statins (hmg-coa reductase inhibitors) for the preparation of medicament as a novel type of immunomodulator, immunosuppressor and anti-inflammatory agent

Also Published As

Publication number Publication date
AU2003226456A8 (en) 2003-10-27
EP1494661B1 (en) 2009-10-14
JP2005522490A (ja) 2005-07-28
TW200403990A (en) 2004-03-16
WO2003086380A1 (en) 2003-10-23
ATE445395T1 (de) 2009-10-15
EP1494661A1 (en) 2005-01-12
AU2003226456A1 (en) 2003-10-27
US20080161348A1 (en) 2008-07-03
US20030195167A1 (en) 2003-10-16
JP4409295B2 (ja) 2010-02-03
DE60329668D1 (de) 2009-11-26
MY137134A (en) 2008-12-31

Similar Documents

Publication Publication Date Title
AU2003222450A1 (en) Stabilized ascorbic acid derivatives
TW200519088A (en) Aryl or heteroaryl amide compounds
TW200604175A (en) Ortho substituted aryl or heteroaryl amide compounds
TWI265929B (en) Triazinyl derivatives for inhibiting the production of IL-12
WO2005105732A8 (en) Substituted methyl aryl or heteroaryl amide compounds
IL150650A0 (en) Piperidine derivatives and pharmaceutical compositions containing the same
IL163629A0 (en) Glutaminyl derivatives and pharmaceutical compositions containing the same
TW200420542A (en) A compound having TGF β inhibition activity and a medicinal composition containing the same
NO20024424L (no) Glykopyranosyloksybenzylbenzenderivater, medisinske sammensetninger inneholdende slike, samt intermediater tilfremstilling av derivatene
CA2394086A1 (fr) Derives de 4-aminopiperidine et leur utilisation en tant que medicament
NZ505220A (en) Arylpiperazines having activity at the serotonin 1A receptor, processes for their preparation and intermediates
GR3029355T3 (en) New azolidinediones as antihyperglycemic agents
WO2005089256A3 (en) Antiangiogenic agents
EP0879841A3 (en) Silicon compound, method for making the same, and electroluminescent device using the same
TWI349547B (en) Ptx3 gene expression suppressing method
MXPA05013631A (es) Derivado heterociclico de metilsulfona.
WO2004080408A3 (en) Method of treating cancer with azaspirane compositions
AU2003254460A1 (en) Imaging compounds
NO982873L (no) 1-metylkarbapenemderivater
EP0792880A4 (en) OSTEOPOROSIS MEDICINE AND TRIAZEPINE COMPOUND
DE60325609D1 (en) Carbacyclisches phosphatidsäurederivat
DE69907387D1 (de) Verwendung von Hydantoin-Derivaten zur Herstellung eines Medikaments zur Behandlung von refraktärer Vasculitis.
AP2001002314A0 (en) Substituted benzolactam compounds.
DE60140333D1 (de) Lichtempfindliche Verbindung und lichtempfindliches Harz
AU2003264895A8 (en) Process for the preparation of fluorohaloalkanes

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees