TWI300414B - Modified peptide yy and conjugates thereof - Google Patents

Info

Publication number

TWI300414B

TWI300414B TW094112549A TW94112549A TWI300414B TW I300414 B TWI300414 B TW I300414B TW 094112549 A TW094112549 A TW 094112549A TW 94112549 A TW94112549 A TW 94112549A TW I300414 B TWI300414 B TW I300414B

Authority

TW

Taiwan

Prior art keywords

peptide

fmoc

group

therapeutic

acid

Prior art date

1999-05-17

Links

• Espacenet
• Global Dossier
• Discuss

• 108091005601 modified peptides Proteins 0.000 title claims description 12
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 500
• 230000001225 therapeutic effect Effects 0.000 claims description 259
• 150000001413 amino acids Chemical class 0.000 claims description 137
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 105
• 238000000034 method Methods 0.000 claims description 83
• 239000012634 fragment Substances 0.000 claims description 64
• 239000000562 conjugate Substances 0.000 claims description 49
• 239000002253 acid Substances 0.000 claims description 44
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 44
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 39
• 238000001727 in vivo Methods 0.000 claims description 39
• 150000001412 amines Chemical class 0.000 claims description 32
• 125000000524 functional group Chemical group 0.000 claims description 32
• 102000009027 Albumins Human genes 0.000 claims description 31
• 108010088751 Albumins Proteins 0.000 claims description 31
• 125000005647 linker group Chemical group 0.000 claims description 27
• 230000008878 coupling Effects 0.000 claims description 23
• 238000010168 coupling process Methods 0.000 claims description 23
• 238000005859 coupling reaction Methods 0.000 claims description 23
• 230000001965 increasing effect Effects 0.000 claims description 23
• 125000003396 thiol group Chemical group [H]S* 0.000 claims description 22
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 19
• 238000000338 in vitro Methods 0.000 claims description 19
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
• PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 14
• YZGQDNOIGFBYKF-UHFFFAOYSA-N Ethoxyacetic acid Chemical compound CCOCC(O)=O YZGQDNOIGFBYKF-UHFFFAOYSA-N 0.000 claims description 12
• 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims description 10
• 230000008901 benefit Effects 0.000 claims description 9
• QGOKIEUFWNCGFO-UHFFFAOYSA-N propanoic acid;pyrrole-2,5-dione Chemical compound CCC(O)=O.O=C1NC(=O)C=C1 QGOKIEUFWNCGFO-UHFFFAOYSA-N 0.000 claims description 8
• 239000000863 peptide conjugate Substances 0.000 claims description 7
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 5
• RAABOESOVLLHRU-UHFFFAOYSA-N diazene Chemical compound N=N RAABOESOVLLHRU-UHFFFAOYSA-N 0.000 claims description 3
• 229910000071 diazene Inorganic materials 0.000 claims description 3
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 3
• MHZGKXUYDGKKIU-UHFFFAOYSA-N Decylamine Chemical compound CCCCCCCCCCN MHZGKXUYDGKKIU-UHFFFAOYSA-N 0.000 claims description 2
• 239000004472 Lysine Substances 0.000 claims 5
• GNRLUBOJIGSVNT-UHFFFAOYSA-N Aminoethoxyacetic acid Chemical compound NCCOCC(O)=O GNRLUBOJIGSVNT-UHFFFAOYSA-N 0.000 claims 4
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
• 239000005642 Oleic acid Substances 0.000 claims 2
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
• IAQRGUVFOMOMEM-ARJAWSKDSA-N cis-but-2-ene Chemical group C\C=C/C IAQRGUVFOMOMEM-ARJAWSKDSA-N 0.000 claims 1
• 229910052734 helium Inorganic materials 0.000 claims 1
• 239000001307 helium Substances 0.000 claims 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
• 239000011976 maleic acid Substances 0.000 claims 1
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 description 155
• 229940024606 amino acid Drugs 0.000 description 155
• -1 amino lecithin Chemical compound 0.000 description 95
• 210000004027 cell Anatomy 0.000 description 90
• 239000011347 resin Substances 0.000 description 79
• 229920005989 resin Polymers 0.000 description 79
• 229940088597 hormone Drugs 0.000 description 73
• 239000005556 hormone Substances 0.000 description 73
• 108090000623 proteins and genes Proteins 0.000 description 70
• 230000000694 effects Effects 0.000 description 67
• 102000004169 proteins and genes Human genes 0.000 description 61
• 235000018102 proteins Nutrition 0.000 description 60
• 239000000047 product Substances 0.000 description 52
• 230000015572 biosynthetic process Effects 0.000 description 47
• 210000004369 blood Anatomy 0.000 description 47
• 239000008280 blood Substances 0.000 description 47
• 239000012503 blood component Substances 0.000 description 44
• 230000028327 secretion Effects 0.000 description 44
• 238000003786 synthesis reaction Methods 0.000 description 43
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 41
• 125000006239 protecting group Chemical group 0.000 description 41
• 239000000126 substance Substances 0.000 description 41
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 38
• 230000001681 protective effect Effects 0.000 description 38
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 37
• 238000011282 treatment Methods 0.000 description 37
• 125000003277 amino group Chemical group 0.000 description 35
• 230000001976 improved effect Effects 0.000 description 35
• 206010036790 Productive cough Diseases 0.000 description 34
• 208000024794 sputum Diseases 0.000 description 34
• 102000005962 receptors Human genes 0.000 description 33
• 108020003175 receptors Proteins 0.000 description 33
• 238000006243 chemical reaction Methods 0.000 description 32
• 210000003802 sputum Anatomy 0.000 description 31
• 210000001519 tissue Anatomy 0.000 description 31
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 30
• 239000003112 inhibitor Substances 0.000 description 30
• 235000018417 cysteine Nutrition 0.000 description 29
• 102000035195 Peptidases Human genes 0.000 description 28
• 108091005804 Peptidases Proteins 0.000 description 28
• 150000001875 compounds Chemical class 0.000 description 28
• 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 27
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 27
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 26
• 238000004519 manufacturing process Methods 0.000 description 26
• 239000000199 parathyroid hormone Substances 0.000 description 25
• 229960001319 parathyroid hormone Drugs 0.000 description 25
• 241000282414 Homo sapiens Species 0.000 description 24
• 102000003982 Parathyroid hormone Human genes 0.000 description 24
• 108090000445 Parathyroid hormone Proteins 0.000 description 24
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 24
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 23
• 230000006872 improvement Effects 0.000 description 23
• 239000000243 solution Substances 0.000 description 23
• 239000000306 component Substances 0.000 description 22
• 230000006870 function Effects 0.000 description 22
• 235000019833 protease Nutrition 0.000 description 22
• 108010051696 Growth Hormone Proteins 0.000 description 21
• 102100038803 Somatotropin Human genes 0.000 description 21
• 239000000122 growth hormone Substances 0.000 description 21
• 238000004128 high performance liquid chromatography Methods 0.000 description 21
• 239000007787 solid Substances 0.000 description 21
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 20
• 201000010099 disease Diseases 0.000 description 20
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 19
• 102000004877 Insulin Human genes 0.000 description 19
• 108090001061 Insulin Proteins 0.000 description 19
• 239000002585 base Substances 0.000 description 19
• 230000033228 biological regulation Effects 0.000 description 19
• 229940125396 insulin Drugs 0.000 description 19
• 230000001105 regulatory effect Effects 0.000 description 19
• 229910001868 water Inorganic materials 0.000 description 19
• 125000000539 amino acid group Chemical group 0.000 description 18
• 210000000988 bone and bone Anatomy 0.000 description 18
• 210000004556 brain Anatomy 0.000 description 18
• 210000004899 c-terminal region Anatomy 0.000 description 18
• 239000000203 mixture Substances 0.000 description 18
• 229920001184 polypeptide Polymers 0.000 description 18
• 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 description 17
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 17
• 230000027455 binding Effects 0.000 description 17
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
• 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 description 16
• 102000002045 Endothelin Human genes 0.000 description 16
• 108050009340 Endothelin Proteins 0.000 description 16
• 108090000790 Enzymes Proteins 0.000 description 16
• 102000004190 Enzymes Human genes 0.000 description 16
• 229940088598 enzyme Drugs 0.000 description 16
• 230000002496 gastric effect Effects 0.000 description 16
• 230000004913 activation Effects 0.000 description 15
• 238000001994 activation Methods 0.000 description 15
• ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 15
• 210000003016 hypothalamus Anatomy 0.000 description 15
• 230000005764 inhibitory process Effects 0.000 description 15
• 238000002347 injection Methods 0.000 description 15
• 239000007924 injection Substances 0.000 description 15
• 239000000543 intermediate Substances 0.000 description 15
• 229910052757 nitrogen Inorganic materials 0.000 description 15
• KSDTXRUIZMTBNV-INIZCTEOSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)butanedioic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CC(=O)O)C(O)=O)C3=CC=CC=C3C2=C1 KSDTXRUIZMTBNV-INIZCTEOSA-N 0.000 description 14
• 101800001288 Atrial natriuretic factor Proteins 0.000 description 14
• 102400001282 Atrial natriuretic peptide Human genes 0.000 description 14
• 101800001890 Atrial natriuretic peptide Proteins 0.000 description 14
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 14
• 238000010511 deprotection reaction Methods 0.000 description 14
• 210000002784 stomach Anatomy 0.000 description 14
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 14
• 239000003053 toxin Substances 0.000 description 14
• 231100000765 toxin Toxicity 0.000 description 14
• 108700012359 toxins Proteins 0.000 description 14
• DVBUCBXGDWWXNY-SFHVURJKSA-N (2s)-5-(diaminomethylideneamino)-2-(9h-fluoren-9-ylmethoxycarbonylamino)pentanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCCN=C(N)N)C(O)=O)C3=CC=CC=C3C2=C1 DVBUCBXGDWWXNY-SFHVURJKSA-N 0.000 description 13
• 230000009471 action Effects 0.000 description 13
• 230000036772 blood pressure Effects 0.000 description 13
• NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 description 13
• 210000004185 liver Anatomy 0.000 description 13
• 238000004007 reversed phase HPLC Methods 0.000 description 13
• 210000002966 serum Anatomy 0.000 description 13
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
• 206010028980 Neoplasm Diseases 0.000 description 12
• GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 12
• 108010004977 Vasopressins Proteins 0.000 description 12
• 102000002852 Vasopressins Human genes 0.000 description 12
• KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 12
• 229940079593 drug Drugs 0.000 description 12
• 239000003814 drug Substances 0.000 description 12
• 150000002148 esters Chemical class 0.000 description 12
• 230000012010 growth Effects 0.000 description 12
• 230000002401 inhibitory effect Effects 0.000 description 12
• 210000000056 organ Anatomy 0.000 description 12
• 210000002381 plasma Anatomy 0.000 description 12
• 238000002360 preparation method Methods 0.000 description 12
• 210000003491 skin Anatomy 0.000 description 12
• 230000004936 stimulating effect Effects 0.000 description 12
• 210000001541 thymus gland Anatomy 0.000 description 12
• 229960003726 vasopressin Drugs 0.000 description 12
• JDDWRLPTKIOUOF-UHFFFAOYSA-N 9h-fluoren-9-ylmethyl n-[[4-[2-[bis(4-methylphenyl)methylamino]-2-oxoethoxy]phenyl]-(2,4-dimethoxyphenyl)methyl]carbamate Chemical compound COC1=CC(OC)=CC=C1C(C=1C=CC(OCC(=O)NC(C=2C=CC(C)=CC=2)C=2C=CC(C)=CC=2)=CC=1)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 JDDWRLPTKIOUOF-UHFFFAOYSA-N 0.000 description 11
• 101800000407 Brain natriuretic peptide 32 Proteins 0.000 description 11
• 102400000739 Corticotropin Human genes 0.000 description 11
• 101800000414 Corticotropin Proteins 0.000 description 11
• 241001465754 Metazoa Species 0.000 description 11
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 11
• 229960000258 corticotropin Drugs 0.000 description 11
• 210000000936 intestine Anatomy 0.000 description 11
• 210000003734 kidney Anatomy 0.000 description 11
• 238000010647 peptide synthesis reaction Methods 0.000 description 11
• JAUKCFULLJFBFN-VWLOTQADSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid Chemical compound C1=CC(OC(C)(C)C)=CC=C1C[C@@H](C(O)=O)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 JAUKCFULLJFBFN-VWLOTQADSA-N 0.000 description 10
• 102400000667 Brain natriuretic peptide 32 Human genes 0.000 description 10
• 101800002247 Brain natriuretic peptide 45 Proteins 0.000 description 10
• 108010065372 Dynorphins Proteins 0.000 description 10
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 10
• 102000043299 Parathyroid hormone-related Human genes 0.000 description 10
• 101710123753 Parathyroid hormone-related protein Proteins 0.000 description 10
• 108010071390 Serum Albumin Proteins 0.000 description 10
• 102000007562 Serum Albumin Human genes 0.000 description 10
• 125000000217 alkyl group Chemical group 0.000 description 10
• BJDCWCLMFKKGEE-CMDXXVQNSA-N chembl252518 Chemical compound C([C@@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2O[C@H](O)[C@@H]4C BJDCWCLMFKKGEE-CMDXXVQNSA-N 0.000 description 10
• 210000001035 gastrointestinal tract Anatomy 0.000 description 10
• OXKUGIFNIUUKAW-UHFFFAOYSA-N n,n-dimethylformamide;hydrazine Chemical compound NN.CN(C)C=O OXKUGIFNIUUKAW-UHFFFAOYSA-N 0.000 description 10
• 210000000496 pancreas Anatomy 0.000 description 10
• 239000002243 precursor Substances 0.000 description 10
• 239000011734 sodium Substances 0.000 description 10
• 229910052708 sodium Inorganic materials 0.000 description 10
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 9
• 102100024622 Proenkephalin-B Human genes 0.000 description 9
• 241000700605 Viruses Species 0.000 description 9
• 230000006907 apoptotic process Effects 0.000 description 9
• 230000004071 biological effect Effects 0.000 description 9
• 230000015556 catabolic process Effects 0.000 description 9
• 210000000170 cell membrane Anatomy 0.000 description 9
• 230000021615 conjugation Effects 0.000 description 9
• 238000011161 development Methods 0.000 description 9
• 230000018109 developmental process Effects 0.000 description 9
• 206010012601 diabetes mellitus Diseases 0.000 description 9
• 239000003102 growth factor Substances 0.000 description 9
• 210000000265 leukocyte Anatomy 0.000 description 9
• 210000004379 membrane Anatomy 0.000 description 9
• 210000005036 nerve Anatomy 0.000 description 9
• HPNRHPKXQZSDFX-OAQDCNSJSA-N nesiritide Chemical compound C([C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 HPNRHPKXQZSDFX-OAQDCNSJSA-N 0.000 description 9
• 238000001556 precipitation Methods 0.000 description 9
• 230000008569 process Effects 0.000 description 9
• 230000002485 urinary effect Effects 0.000 description 9
• 241001116389 Aloe Species 0.000 description 8
• 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 description 8
• 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 description 8
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
• NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 8
• 102000003946 Prolactin Human genes 0.000 description 8
• 108010057464 Prolactin Proteins 0.000 description 8
• 241000239226 Scorpiones Species 0.000 description 8
• 235000011399 aloe vera Nutrition 0.000 description 8
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 8
• 210000003169 central nervous system Anatomy 0.000 description 8
• 230000008602 contraction Effects 0.000 description 8
• 239000007789 gas Substances 0.000 description 8
• 239000008103 glucose Substances 0.000 description 8
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
• 230000000968 intestinal effect Effects 0.000 description 8
• 239000012528 membrane Substances 0.000 description 8
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 8
• 230000000144 pharmacologic effect Effects 0.000 description 8
• 238000002953 preparative HPLC Methods 0.000 description 8
• 229940097325 prolactin Drugs 0.000 description 8
• 230000000638 stimulation Effects 0.000 description 8
• 208000024891 symptom Diseases 0.000 description 8
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 7
• 102400000344 Angiotensin-1 Human genes 0.000 description 7
• 101800000734 Angiotensin-1 Proteins 0.000 description 7
• 102000015427 Angiotensins Human genes 0.000 description 7
• 108010064733 Angiotensins Proteins 0.000 description 7
• 102000044503 Antimicrobial Peptides Human genes 0.000 description 7
• 108700042778 Antimicrobial Peptides Proteins 0.000 description 7
• 241000894006 Bacteria Species 0.000 description 7
• 102000004506 Blood Proteins Human genes 0.000 description 7
• 108010017384 Blood Proteins Proteins 0.000 description 7
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 7
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 7
• 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 7
• 102000007079 Peptide Fragments Human genes 0.000 description 7
• 108010033276 Peptide Fragments Proteins 0.000 description 7
• 150000001408 amides Chemical class 0.000 description 7
• ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 description 7
• 239000005557 antagonist Substances 0.000 description 7
• 230000006399 behavior Effects 0.000 description 7
• 150000001768 cations Chemical class 0.000 description 7
• 238000006731 degradation reaction Methods 0.000 description 7
• 230000002124 endocrine Effects 0.000 description 7
• 230000003511 endothelial effect Effects 0.000 description 7
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 7
• 210000000232 gallbladder Anatomy 0.000 description 7
• 210000003630 histaminocyte Anatomy 0.000 description 7
• 229910052739 hydrogen Inorganic materials 0.000 description 7
• 230000006698 induction Effects 0.000 description 7
• 208000015181 infectious disease Diseases 0.000 description 7
• 230000007246 mechanism Effects 0.000 description 7
• 230000004048 modification Effects 0.000 description 7
• 238000012986 modification Methods 0.000 description 7
• 239000012071 phase Substances 0.000 description 7
• 150000003839 salts Chemical class 0.000 description 7
• 230000003248 secreting effect Effects 0.000 description 7
• 239000007790 solid phase Substances 0.000 description 7
• 238000010532 solid phase synthesis reaction Methods 0.000 description 7
• 150000003573 thiols Chemical class 0.000 description 7
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
• 108010073385 Fibrin Proteins 0.000 description 6
• 102000009123 Fibrin Human genes 0.000 description 6
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical group CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 6
• 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 6
• 101000715592 Homo sapiens Cocaine- and amphetamine-regulated transcript protein Proteins 0.000 description 6
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
• 206010020772 Hypertension Diseases 0.000 description 6
• 102000016267 Leptin Human genes 0.000 description 6
• 108010092277 Leptin Proteins 0.000 description 6
• 102000009151 Luteinizing Hormone Human genes 0.000 description 6
• 108010073521 Luteinizing Hormone Proteins 0.000 description 6
• SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 6
• 240000005373 Panax quinquefolius Species 0.000 description 6
• 235000003140 Panax quinquefolius Nutrition 0.000 description 6
• 102100022831 Somatoliberin Human genes 0.000 description 6
• 101710142969 Somatoliberin Proteins 0.000 description 6
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
• 125000003118 aryl group Chemical group 0.000 description 6
• 210000001772 blood platelet Anatomy 0.000 description 6
• 230000001413 cellular effect Effects 0.000 description 6
• 239000003795 chemical substances by application Substances 0.000 description 6
• XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 6
• OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 6
• 230000007423 decrease Effects 0.000 description 6
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 6
• 210000002919 epithelial cell Anatomy 0.000 description 6
• 210000003743 erythrocyte Anatomy 0.000 description 6
• 239000012530 fluid Substances 0.000 description 6
• 230000014509 gene expression Effects 0.000 description 6
• 210000002216 heart Anatomy 0.000 description 6
• 201000001421 hyperglycemia Diseases 0.000 description 6
• 238000002372 labelling Methods 0.000 description 6
• NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 6
• 229940039781 leptin Drugs 0.000 description 6
• 239000011159 matrix material Substances 0.000 description 6
• 210000000653 nervous system Anatomy 0.000 description 6
• 230000001272 neurogenic effect Effects 0.000 description 6
• 239000002858 neurotransmitter agent Substances 0.000 description 6
• 230000003647 oxidation Effects 0.000 description 6
• 238000007254 oxidation reaction Methods 0.000 description 6
• 230000004044 response Effects 0.000 description 6
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 6
• 238000006467 substitution reaction Methods 0.000 description 6
• 210000002700 urine Anatomy 0.000 description 6
• VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 description 5
• 241000283690 Bos taurus Species 0.000 description 5
• 102000014914 Carrier Proteins Human genes 0.000 description 5
• 102100035932 Cocaine- and amphetamine-regulated transcript protein Human genes 0.000 description 5
• 101710095468 Cyclase Proteins 0.000 description 5
• 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 5
• 108010049140 Endorphins Proteins 0.000 description 5
• 102000009025 Endorphins Human genes 0.000 description 5
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
• 102000051325 Glucagon Human genes 0.000 description 5
• 108060003199 Glucagon Proteins 0.000 description 5
• 102000006771 Gonadotropins Human genes 0.000 description 5
• 108010086677 Gonadotropins Proteins 0.000 description 5
• 241000725303 Human immunodeficiency virus Species 0.000 description 5
• 206010062767 Hypophysitis Diseases 0.000 description 5
• 102000002419 Motilin Human genes 0.000 description 5
• 101800002372 Motilin Proteins 0.000 description 5
• 108090000189 Neuropeptides Proteins 0.000 description 5
• 208000008589 Obesity Diseases 0.000 description 5
• 241000283973 Oryctolagus cuniculus Species 0.000 description 5
• 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 5
• 229920002472 Starch Polymers 0.000 description 5
• 210000001744 T-lymphocyte Anatomy 0.000 description 5
• 210000004404 adrenal cortex Anatomy 0.000 description 5
• 230000001919 adrenal effect Effects 0.000 description 5
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 5
• 230000001588 bifunctional effect Effects 0.000 description 5
• 230000005540 biological transmission Effects 0.000 description 5
• 230000000903 blocking effect Effects 0.000 description 5
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
• 230000008859 change Effects 0.000 description 5
• 230000001054 cortical effect Effects 0.000 description 5
• 230000006378 damage Effects 0.000 description 5
• 230000007812 deficiency Effects 0.000 description 5
• 230000004069 differentiation Effects 0.000 description 5
• 229950003499 fibrin Drugs 0.000 description 5
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 5
• 229960004666 glucagon Drugs 0.000 description 5
• XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 5
• 239000002622 gonadotropin Substances 0.000 description 5
• 230000028993 immune response Effects 0.000 description 5
• 210000000987 immune system Anatomy 0.000 description 5
• 230000003993 interaction Effects 0.000 description 5
• 229940040129 luteinizing hormone Drugs 0.000 description 5
• 230000004060 metabolic process Effects 0.000 description 5
• 235000013336 milk Nutrition 0.000 description 5
• 210000004080 milk Anatomy 0.000 description 5
• 239000008267 milk Substances 0.000 description 5
• 210000002569 neuron Anatomy 0.000 description 5
• 235000020824 obesity Nutrition 0.000 description 5
• 239000000813 peptide hormone Substances 0.000 description 5
• 210000003635 pituitary gland Anatomy 0.000 description 5
• 239000008107 starch Substances 0.000 description 5
• 235000019698 starch Nutrition 0.000 description 5
• 230000009885 systemic effect Effects 0.000 description 5
• PVGATNRYUYNBHO-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O PVGATNRYUYNBHO-UHFFFAOYSA-N 0.000 description 4
• AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 4
• 150000003923 2,5-pyrrolediones Chemical class 0.000 description 4
• LVRVABPNVHYXRT-BQWXUCBYSA-N 52906-92-0 Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)C1=CC=CC=C1 LVRVABPNVHYXRT-BQWXUCBYSA-N 0.000 description 4
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 4
• 208000006386 Bone Resorption Diseases 0.000 description 4
• 108060001064 Calcitonin Proteins 0.000 description 4
• 102100038518 Calcitonin Human genes 0.000 description 4
• 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 description 4
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
• 108020004414 DNA Proteins 0.000 description 4
• 241000196324 Embryophyta Species 0.000 description 4
• 108010092674 Enkephalins Proteins 0.000 description 4
• 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 4
• 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 4
• 102100036519 Gastrin-releasing peptide Human genes 0.000 description 4
• 102000003886 Glycoproteins Human genes 0.000 description 4
• 108090000288 Glycoproteins Proteins 0.000 description 4
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 4
• 241000282412 Homo Species 0.000 description 4
• 108060003951 Immunoglobulin Proteins 0.000 description 4
• 206010061218 Inflammation Diseases 0.000 description 4
• 101710151321 Melanostatin Proteins 0.000 description 4
• 102000003797 Neuropeptides Human genes 0.000 description 4
• 208000001132 Osteoporosis Diseases 0.000 description 4
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 4
• 206010057190 Respiratory tract infections Diseases 0.000 description 4
• 108010046075 Thymosin Proteins 0.000 description 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 4
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 4
• 206010047139 Vasoconstriction Diseases 0.000 description 4
• 229940037003 alum Drugs 0.000 description 4
• 239000003963 antioxidant agent Substances 0.000 description 4
• 230000003078 antioxidant effect Effects 0.000 description 4
• 210000000941 bile Anatomy 0.000 description 4
• 108091008324 binding proteins Proteins 0.000 description 4
• 230000008827 biological function Effects 0.000 description 4
• 230000017531 blood circulation Effects 0.000 description 4
• 210000001124 body fluid Anatomy 0.000 description 4
• 239000010839 body fluid Substances 0.000 description 4
• 230000024279 bone resorption Effects 0.000 description 4
• 239000011575 calcium Substances 0.000 description 4
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 4
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
• 238000004587 chromatography analysis Methods 0.000 description 4
• 230000000295 complement effect Effects 0.000 description 4
• 230000001276 controlling effect Effects 0.000 description 4
• 239000003246 corticosteroid Substances 0.000 description 4
• PKAZBZIEOSJIDC-UHFFFAOYSA-N decylsulfanylbenzene Chemical compound CCCCCCCCCCSC1=CC=CC=C1 PKAZBZIEOSJIDC-UHFFFAOYSA-N 0.000 description 4
• 238000010790 dilution Methods 0.000 description 4
• 239000012895 dilution Substances 0.000 description 4
• DXVWRJRZCMCNEU-UHFFFAOYSA-N dimercaptoamine Chemical compound SNS DXVWRJRZCMCNEU-UHFFFAOYSA-N 0.000 description 4
• 238000012377 drug delivery Methods 0.000 description 4
• 210000002889 endothelial cell Anatomy 0.000 description 4
• 210000003038 endothelium Anatomy 0.000 description 4
• 210000003414 extremity Anatomy 0.000 description 4
• 229940028334 follicle stimulating hormone Drugs 0.000 description 4
• 229960001340 histamine Drugs 0.000 description 4
• 230000003054 hormonal effect Effects 0.000 description 4
• 102000018358 immunoglobulin Human genes 0.000 description 4
• 229940072221 immunoglobulins Drugs 0.000 description 4
• 230000002757 inflammatory effect Effects 0.000 description 4
• 230000004054 inflammatory process Effects 0.000 description 4
• 230000003834 intracellular effect Effects 0.000 description 4
• 238000001990 intravenous administration Methods 0.000 description 4
• 210000004072 lung Anatomy 0.000 description 4
• 230000014759 maintenance of location Effects 0.000 description 4
• 102000006240 membrane receptors Human genes 0.000 description 4
• 230000011164 ossification Effects 0.000 description 4
• 230000035790 physiological processes and functions Effects 0.000 description 4
• 239000002504 physiological saline solution Substances 0.000 description 4
• 230000035755 proliferation Effects 0.000 description 4
• 230000001737 promoting effect Effects 0.000 description 4
• 230000009257 reactivity Effects 0.000 description 4
• 210000002460 smooth muscle Anatomy 0.000 description 4
• 150000003431 steroids Chemical class 0.000 description 4
• 238000001308 synthesis method Methods 0.000 description 4
• 230000002194 synthesizing effect Effects 0.000 description 4
• IPOBMWQSKXACEW-UHFFFAOYSA-N tetradecylurea Chemical compound CCCCCCCCCCCCCCNC(N)=O IPOBMWQSKXACEW-UHFFFAOYSA-N 0.000 description 4
• 238000002560 therapeutic procedure Methods 0.000 description 4
• 230000032258 transport Effects 0.000 description 4
• RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
• 230000002792 vascular Effects 0.000 description 4
• 230000025033 vasoconstriction Effects 0.000 description 4
• SWZCTMTWRHEBIN-QFIPXVFZSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxyphenyl)propanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)C1=CC=C(O)C=C1 SWZCTMTWRHEBIN-QFIPXVFZSA-N 0.000 description 3
• CUKWUWBLQQDQAC-VEQWQPCFSA-N (3s)-3-amino-4-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s,3s)-1-[[(2s)-1-[(2s)-2-[[(1s)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-ox Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 CUKWUWBLQQDQAC-VEQWQPCFSA-N 0.000 description 3
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 3
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 3
• 102400000345 Angiotensin-2 Human genes 0.000 description 3
• 101800000733 Angiotensin-2 Proteins 0.000 description 3
• 102000055006 Calcitonin Human genes 0.000 description 3
• 108010035532 Collagen Proteins 0.000 description 3
• 102000008186 Collagen Human genes 0.000 description 3
• 102400000686 Endothelin-1 Human genes 0.000 description 3
• 101800004490 Endothelin-1 Proteins 0.000 description 3
• 108090000387 Endothelin-2 Proteins 0.000 description 3
• 102100029110 Endothelin-2 Human genes 0.000 description 3
• 102100029109 Endothelin-3 Human genes 0.000 description 3
• 108010072844 Endothelin-3 Proteins 0.000 description 3
• 101710091045 Envelope protein Proteins 0.000 description 3
• 101800000164 FMRF-amide Proteins 0.000 description 3
• 108091006027 G proteins Proteins 0.000 description 3
• 102000030782 GTP binding Human genes 0.000 description 3
• 108091000058 GTP-Binding Proteins 0.000 description 3
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 description 3
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
• VXKCPBPQEKKERH-IUCAKERBSA-N Gly-Arg-Pro Chemical compound NC(N)=NCCC[C@H](NC(=O)CN)C(=O)N1CCC[C@H]1C(O)=O VXKCPBPQEKKERH-IUCAKERBSA-N 0.000 description 3
• 229910004373 HOAc Inorganic materials 0.000 description 3
• 206010019280 Heart failures Diseases 0.000 description 3
• 101001090065 Homo sapiens Peroxiredoxin-2 Proteins 0.000 description 3
• 206010061598 Immunodeficiency Diseases 0.000 description 3
• 208000029462 Immunodeficiency disease Diseases 0.000 description 3
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
• URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
• 108020001621 Natriuretic Peptide Proteins 0.000 description 3
• 102000004571 Natriuretic peptide Human genes 0.000 description 3
• 102400000064 Neuropeptide Y Human genes 0.000 description 3
• 108010093625 Opioid Peptides Proteins 0.000 description 3
• 102400000050 Oxytocin Human genes 0.000 description 3
• 101800000989 Oxytocin Proteins 0.000 description 3
• XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 3
• 208000002193 Pain Diseases 0.000 description 3
• NFHFRUOZVGFOOS-UHFFFAOYSA-N Pd(PPh3)4 Substances [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 3
• 108090000284 Pepsin A Proteins 0.000 description 3
• 102000057297 Pepsin A Human genes 0.000 description 3
• 102100034763 Peroxiredoxin-2 Human genes 0.000 description 3
• 108091000080 Phosphotransferase Proteins 0.000 description 3
• 102000013566 Plasminogen Human genes 0.000 description 3
• 108010051456 Plasminogen Proteins 0.000 description 3
• 102100024304 Protachykinin-1 Human genes 0.000 description 3
• 239000004365 Protease Substances 0.000 description 3
• 108010029485 Protein Isoforms Proteins 0.000 description 3
• 102000001708 Protein Isoforms Human genes 0.000 description 3
• 101710188315 Protein X Proteins 0.000 description 3
• 208000001647 Renal Insufficiency Diseases 0.000 description 3
• 108090000783 Renin Proteins 0.000 description 3
• 102100028255 Renin Human genes 0.000 description 3
• 108090000190 Thrombin Proteins 0.000 description 3
• 102000007501 Thymosin Human genes 0.000 description 3
• 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 description 3
• 102400000015 Vasoactive intestinal peptide Human genes 0.000 description 3
• 230000009102 absorption Effects 0.000 description 3
• 238000010521 absorption reaction Methods 0.000 description 3
• 210000004100 adrenal gland Anatomy 0.000 description 3
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 3
• 238000004458 analytical method Methods 0.000 description 3
• 229950006323 angiotensin ii Drugs 0.000 description 3
• 230000000845 anti-microbial effect Effects 0.000 description 3
• 239000004599 antimicrobial Substances 0.000 description 3
• 230000001640 apoptogenic effect Effects 0.000 description 3
• 210000001367 artery Anatomy 0.000 description 3
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 3
• 210000003969 blast cell Anatomy 0.000 description 3
• 210000000601 blood cell Anatomy 0.000 description 3
• 210000004204 blood vessel Anatomy 0.000 description 3
• 210000000481 breast Anatomy 0.000 description 3
• BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 3
• 229960004015 calcitonin Drugs 0.000 description 3
• 229910052791 calcium Inorganic materials 0.000 description 3
• SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical compound C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 description 3
• 230000035605 chemotaxis Effects 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000001816 cooling Methods 0.000 description 3
• 229960001334 corticosteroids Drugs 0.000 description 3
• 210000000805 cytoplasm Anatomy 0.000 description 3
• 229940104302 cytosine Drugs 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 230000002950 deficient Effects 0.000 description 3
• 238000003745 diagnosis Methods 0.000 description 3
• 230000001079 digestive effect Effects 0.000 description 3
• 235000013601 eggs Nutrition 0.000 description 3
• 239000003792 electrolyte Substances 0.000 description 3
• 235000013305 food Nutrition 0.000 description 3
• 238000004108 freeze drying Methods 0.000 description 3
• 239000003862 glucocorticoid Substances 0.000 description 3
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
• 229910052737 gold Inorganic materials 0.000 description 3
• 239000010931 gold Substances 0.000 description 3
• 239000003163 gonadal steroid hormone Substances 0.000 description 3
• 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 3
• 125000000623 heterocyclic group Chemical group 0.000 description 3
• 239000001257 hydrogen Substances 0.000 description 3
• 150000002466 imines Chemical class 0.000 description 3
• 230000007813 immunodeficiency Effects 0.000 description 3
• 229910052500 inorganic mineral Inorganic materials 0.000 description 3
• 210000002011 intestinal secretion Anatomy 0.000 description 3
• VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 description 3
• 150000002500 ions Chemical class 0.000 description 3
• 230000000302 ischemic effect Effects 0.000 description 3
• 201000006370 kidney failure Diseases 0.000 description 3
• 230000006651 lactation Effects 0.000 description 3
• 239000003446 ligand Substances 0.000 description 3
• 239000000463 material Substances 0.000 description 3
• 230000010534 mechanism of action Effects 0.000 description 3
• 230000002503 metabolic effect Effects 0.000 description 3
• 239000011707 mineral Substances 0.000 description 3
• QUSNBJAOOMFDIB-UHFFFAOYSA-N monoethyl amine Natural products CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 3
• 229960005181 morphine Drugs 0.000 description 3
• 239000000692 natriuretic peptide Substances 0.000 description 3
• URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 description 3
• 210000004940 nucleus Anatomy 0.000 description 3
• XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 3
• 229960001723 oxytocin Drugs 0.000 description 3
• 230000036407 pain Effects 0.000 description 3
• 230000001575 pathological effect Effects 0.000 description 3
• 230000037361 pathway Effects 0.000 description 3
• 229940111202 pepsin Drugs 0.000 description 3
• 230000002093 peripheral effect Effects 0.000 description 3
• 230000035699 permeability Effects 0.000 description 3
• 102000020233 phosphotransferase Human genes 0.000 description 3
• 230000004962 physiological condition Effects 0.000 description 3
• 230000001817 pituitary effect Effects 0.000 description 3
• 150000003141 primary amines Chemical class 0.000 description 3
• 235000019260 propionic acid Nutrition 0.000 description 3
• 230000017854 proteolysis Effects 0.000 description 3
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 3
• 230000009103 reabsorption Effects 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 229940076279 serotonin Drugs 0.000 description 3
• IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 3
• 210000000813 small intestine Anatomy 0.000 description 3
• 210000000329 smooth muscle myocyte Anatomy 0.000 description 3
• NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 3
• 229960000553 somatostatin Drugs 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 108010004034 stable plasma protein solution Proteins 0.000 description 3
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 3
• 238000001356 surgical procedure Methods 0.000 description 3
• 208000011580 syndromic disease Diseases 0.000 description 3
• 230000035922 thirst Effects 0.000 description 3
• 229960004072 thrombin Drugs 0.000 description 3
• LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 3
• 239000000724 thymus hormone Substances 0.000 description 3
• 231100000419 toxicity Toxicity 0.000 description 3
• 230000001988 toxicity Effects 0.000 description 3
• 238000013518 transcription Methods 0.000 description 3
• 230000035897 transcription Effects 0.000 description 3
• 238000002054 transplantation Methods 0.000 description 3
• 238000012384 transportation and delivery Methods 0.000 description 3
• 210000004291 uterus Anatomy 0.000 description 3
• 230000024883 vasodilation Effects 0.000 description 3
• CBPJQFCAFFNICX-IBGZPJMESA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CC(C)C)C(O)=O)C3=CC=CC=C3C2=C1 CBPJQFCAFFNICX-IBGZPJMESA-N 0.000 description 2
• QWXZOFZKSQXPDC-NSHDSACASA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](C)C(O)=O)C3=CC=CC=C3C2=C1 QWXZOFZKSQXPDC-NSHDSACASA-N 0.000 description 2
• AYMLQYFMYHISQO-QMMMGPOBSA-N (2s)-3-(1h-imidazol-3-ium-5-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC1=CN=CN1 AYMLQYFMYHISQO-QMMMGPOBSA-N 0.000 description 2
• HNICLNKVURBTKV-NDEPHWFRSA-N (2s)-5-[[amino-[(2,2,4,6,7-pentamethyl-3h-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9h-fluoren-9-ylmethoxycarbonylamino)pentanoic acid Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1COC(=O)N[C@H](C(O)=O)CCCN=C(N)NS(=O)(=O)C1=C(C)C(C)=C2OC(C)(C)CC2=C1C HNICLNKVURBTKV-NDEPHWFRSA-N 0.000 description 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
• ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 description 2
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
• HFDKKNHCYWNNNQ-YOGANYHLSA-N 75976-10-2 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 HFDKKNHCYWNNNQ-YOGANYHLSA-N 0.000 description 2
• 102400001318 Adrenomedullin Human genes 0.000 description 2
• 101800004616 Adrenomedullin Proteins 0.000 description 2
• 108010090849 Amyloid beta-Peptides Proteins 0.000 description 2
• 102000013455 Amyloid beta-Peptides Human genes 0.000 description 2
• 208000019901 Anxiety disease Diseases 0.000 description 2
• IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 2
• 206010003805 Autism Diseases 0.000 description 2
• 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
• 235000017491 Bambusa tulda Nutrition 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• 108010001857 Cell Surface Receptors Proteins 0.000 description 2
• 101800001982 Cholecystokinin Proteins 0.000 description 2
• 102100025841 Cholecystokinin Human genes 0.000 description 2
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
• 108010038447 Chromogranin A Proteins 0.000 description 2
• 102000010792 Chromogranin A Human genes 0.000 description 2
• 102100024539 Chymase Human genes 0.000 description 2
• 108090000227 Chymases Proteins 0.000 description 2
• 101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 description 2
• 208000032170 Congenital Abnormalities Diseases 0.000 description 2
• 241000238424 Crustacea Species 0.000 description 2
• 206010011732 Cyst Diseases 0.000 description 2
• 108010052832 Cytochromes Proteins 0.000 description 2
• 102000018832 Cytochromes Human genes 0.000 description 2
• 102000004127 Cytokines Human genes 0.000 description 2
• 108090000695 Cytokines Proteins 0.000 description 2
• 108010016626 Dipeptides Proteins 0.000 description 2
• 108050001739 Endothelin receptor Proteins 0.000 description 2
• 101710121417 Envelope glycoprotein Proteins 0.000 description 2
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
• 239000005977 Ethylene Substances 0.000 description 2
• 108050000784 Ferritin Proteins 0.000 description 2
• 102000008857 Ferritin Human genes 0.000 description 2
• 238000008416 Ferritin Methods 0.000 description 2
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 description 2
• 101800004295 Glucagon-like peptide 1(7-36) Proteins 0.000 description 2
• 229920002527 Glycogen Polymers 0.000 description 2
• 102000002812 Heat-Shock Proteins Human genes 0.000 description 2
• 108010004889 Heat-Shock Proteins Proteins 0.000 description 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
• 108050008546 Hyperglycemic hormone Proteins 0.000 description 2
• 206010020850 Hyperthyroidism Diseases 0.000 description 2
• 206010020880 Hypertrophy Diseases 0.000 description 2
• 108010004250 Inhibins Proteins 0.000 description 2
• 102000014150 Interferons Human genes 0.000 description 2
• 108010050904 Interferons Proteins 0.000 description 2
• 102000036770 Islet Amyloid Polypeptide Human genes 0.000 description 2
• 108010041872 Islet Amyloid Polypeptide Proteins 0.000 description 2
• OTAMFXXAGYBAQL-YXMSTPNBSA-N Kentsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O OTAMFXXAGYBAQL-YXMSTPNBSA-N 0.000 description 2
• 241000124008 Mammalia Species 0.000 description 2
• 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 description 2
• 108010052285 Membrane Proteins Proteins 0.000 description 2
• 241000237852 Mollusca Species 0.000 description 2
• 102400000097 Neurokinin A Human genes 0.000 description 2
• 101800000399 Neurokinin A Proteins 0.000 description 2
• 102100023206 Neuromodulin Human genes 0.000 description 2
• 101710144282 Neuromodulin Proteins 0.000 description 2
• 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 2
• 102000008299 Nitric Oxide Synthase Human genes 0.000 description 2
• 108010021487 Nitric Oxide Synthase Proteins 0.000 description 2
• 102000001490 Opioid Peptides Human genes 0.000 description 2
• 102000004067 Osteocalcin Human genes 0.000 description 2
• 108090000573 Osteocalcin Proteins 0.000 description 2
• 102000018886 Pancreatic Polypeptide Human genes 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 244000082204 Phyllostachys viridis Species 0.000 description 2
• 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
• 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
• 235000011613 Pinus brutia Nutrition 0.000 description 2
• 241000018646 Pinus brutia Species 0.000 description 2
• 102000002808 Pituitary adenylate cyclase-activating polypeptide Human genes 0.000 description 2
• 108010004684 Pituitary adenylate cyclase-activating polypeptide Proteins 0.000 description 2
• 108010003044 Placental Lactogen Proteins 0.000 description 2
• 102000004576 Placental Lactogen Human genes 0.000 description 2
• 239000000381 Placental Lactogen Substances 0.000 description 2
• 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 2
• 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 2
• 239000004793 Polystyrene Substances 0.000 description 2
• 102100040918 Pro-glucagon Human genes 0.000 description 2
• 102100027467 Pro-opiomelanocortin Human genes 0.000 description 2
• 102000001253 Protein Kinase Human genes 0.000 description 2
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
• 206010037660 Pyrexia Diseases 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 2
• TUDIUWZXQPVWJK-UHFFFAOYSA-N SNS.NN Chemical compound SNS.NN TUDIUWZXQPVWJK-UHFFFAOYSA-N 0.000 description 2
• 241000270295 Serpentes Species 0.000 description 2
• 206010041277 Sodium retention Diseases 0.000 description 2
• 108010056088 Somatostatin Proteins 0.000 description 2
• 102000005157 Somatostatin Human genes 0.000 description 2
• 241000282887 Suidae Species 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• 101000983124 Sus scrofa Pancreatic prohormone precursor Proteins 0.000 description 2
• 102000004338 Transferrin Human genes 0.000 description 2
• 108090000901 Transferrin Proteins 0.000 description 2
• 206010047163 Vasospasm Diseases 0.000 description 2
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
• 108070000030 Viral receptors Proteins 0.000 description 2
• 238000002679 ablation Methods 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 230000001154 acute effect Effects 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 230000000996 additive effect Effects 0.000 description 2
• UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 2
• 102000030621 adenylate cyclase Human genes 0.000 description 2
• 108060000200 adenylate cyclase Proteins 0.000 description 2
• ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 description 2
• 238000005377 adsorption chromatography Methods 0.000 description 2
• 230000004520 agglutination Effects 0.000 description 2
• 150000001298 alcohols Chemical class 0.000 description 2
• 125000003342 alkenyl group Chemical group 0.000 description 2
• 125000003545 alkoxy group Chemical group 0.000 description 2
• 229910021529 ammonia Inorganic materials 0.000 description 2
• 230000036592 analgesia Effects 0.000 description 2
• 230000003042 antagnostic effect Effects 0.000 description 2
• 210000004198 anterior pituitary gland Anatomy 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 239000002260 anti-inflammatory agent Substances 0.000 description 2
• 229940088710 antibiotic agent Drugs 0.000 description 2
• 230000000890 antigenic effect Effects 0.000 description 2
• 239000002246 antineoplastic agent Substances 0.000 description 2
• 230000036506 anxiety Effects 0.000 description 2
• 235000019789 appetite Nutrition 0.000 description 2
• 230000036528 appetite Effects 0.000 description 2
• 125000003710 aryl alkyl group Chemical group 0.000 description 2
• 235000003704 aspartic acid Nutrition 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 239000011425 bamboo Substances 0.000 description 2
• 210000000270 basal cell Anatomy 0.000 description 2
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
• 230000000975 bioactive effect Effects 0.000 description 2
• 238000004166 bioassay Methods 0.000 description 2
• 230000031018 biological processes and functions Effects 0.000 description 2
• 230000008512 biological response Effects 0.000 description 2
• 229940088623 biologically active substance Drugs 0.000 description 2
• 230000008416 bone turnover Effects 0.000 description 2
• 239000000872 buffer Substances 0.000 description 2
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 2
• 201000011510 cancer Diseases 0.000 description 2
• 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 description 2
• 229960004424 carbon dioxide Drugs 0.000 description 2
• 235000011089 carbon dioxide Nutrition 0.000 description 2
• 210000000845 cartilage Anatomy 0.000 description 2
• 239000005018 casein Substances 0.000 description 2
• 230000030833 cell death Effects 0.000 description 2
• 230000024245 cell differentiation Effects 0.000 description 2
• 230000032823 cell division Effects 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 230000002490 cerebral effect Effects 0.000 description 2
• 238000002512 chemotherapy Methods 0.000 description 2
• 229940107137 cholecystokinin Drugs 0.000 description 2
• 235000012000 cholesterol Nutrition 0.000 description 2
• 238000004140 cleaning Methods 0.000 description 2
• 229920001436 collagen Polymers 0.000 description 2
• 239000004074 complement inhibitor Substances 0.000 description 2
• 230000001268 conjugating effect Effects 0.000 description 2
• 239000000470 constituent Substances 0.000 description 2
• 239000003433 contraceptive agent Substances 0.000 description 2
• 230000002254 contraceptive effect Effects 0.000 description 2
• 238000012258 culturing Methods 0.000 description 2
• ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 description 2
• 125000004122 cyclic group Chemical group 0.000 description 2
• 125000000753 cycloalkyl group Chemical group 0.000 description 2
• NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
• 208000031513 cyst Diseases 0.000 description 2
• 231100000135 cytotoxicity Toxicity 0.000 description 2
• 230000003013 cytotoxicity Effects 0.000 description 2
• 206010061428 decreased appetite Diseases 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 230000008021 deposition Effects 0.000 description 2
• 238000013461 design Methods 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• 230000029087 digestion Effects 0.000 description 2
• 210000002249 digestive system Anatomy 0.000 description 2
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 239000002934 diuretic Substances 0.000 description 2
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
• 210000001198 duodenum Anatomy 0.000 description 2
• 230000002526 effect on cardiovascular system Effects 0.000 description 2
• 210000003372 endocrine gland Anatomy 0.000 description 2
• 230000007071 enzymatic hydrolysis Effects 0.000 description 2
• 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 2
• CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 description 2
• 125000004494 ethyl ester group Chemical group 0.000 description 2
• 210000003722 extracellular fluid Anatomy 0.000 description 2
• 230000035558 fertility Effects 0.000 description 2
• 239000000835 fiber Substances 0.000 description 2
• 210000002950 fibroblast Anatomy 0.000 description 2
• 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
• 210000005095 gastrointestinal system Anatomy 0.000 description 2
• 210000004907 gland Anatomy 0.000 description 2
• 230000000762 glandular Effects 0.000 description 2
• 230000006377 glucose transport Effects 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical group OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• 150000004676 glycans Chemical class 0.000 description 2
• 229940096919 glycogen Drugs 0.000 description 2
• 210000002149 gonad Anatomy 0.000 description 2
• 229940094892 gonadotropins Drugs 0.000 description 2
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 210000002837 heart atrium Anatomy 0.000 description 2
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
• 125000001165 hydrophobic group Chemical group 0.000 description 2
• 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 2
• 230000001631 hypertensive effect Effects 0.000 description 2
• 230000002267 hypothalamic effect Effects 0.000 description 2
• 150000003949 imides Chemical class 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 2
• 230000001506 immunosuppresive effect Effects 0.000 description 2
• 210000003552 inferior colliculi Anatomy 0.000 description 2
• 230000028709 inflammatory response Effects 0.000 description 2
• 239000000893 inhibin Substances 0.000 description 2
• ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 2
• 208000014674 injury Diseases 0.000 description 2
• 230000002608 insulinlike Effects 0.000 description 2
• 229940079322 interferon Drugs 0.000 description 2
• 238000001361 intraarterial administration Methods 0.000 description 2
• 208000002551 irritable bowel syndrome Diseases 0.000 description 2
• 210000004153 islets of langerhan Anatomy 0.000 description 2
• 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
• 108010043612 kentsin Proteins 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 230000004130 lipolysis Effects 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 239000007791 liquid phase Substances 0.000 description 2
• 230000033001 locomotion Effects 0.000 description 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• 210000002540 macrophage Anatomy 0.000 description 2
• 210000005075 mammary gland Anatomy 0.000 description 2
• 230000035800 maturation Effects 0.000 description 2
• 230000003061 melanogenesis Effects 0.000 description 2
• VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 description 2
• 108020004084 membrane receptors Proteins 0.000 description 2
• 108020004999 messenger RNA Proteins 0.000 description 2
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 2
• CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
• 230000005012 migration Effects 0.000 description 2
• 238000013508 migration Methods 0.000 description 2
• 230000011278 mitosis Effects 0.000 description 2
• 210000003205 muscle Anatomy 0.000 description 2
• 210000000663 muscle cell Anatomy 0.000 description 2
• 210000000822 natural killer cell Anatomy 0.000 description 2
• 230000001537 neural effect Effects 0.000 description 2
• 210000004412 neuroendocrine cell Anatomy 0.000 description 2
• 230000000926 neurological effect Effects 0.000 description 2
• 230000003955 neuronal function Effects 0.000 description 2
• 239000003399 opiate peptide Substances 0.000 description 2
• 230000003204 osmotic effect Effects 0.000 description 2
• 210000000963 osteoblast Anatomy 0.000 description 2
• 210000002997 osteoclast Anatomy 0.000 description 2
• 230000016087 ovulation Effects 0.000 description 2
• 150000002923 oximes Chemical class 0.000 description 2
• 229910052760 oxygen Inorganic materials 0.000 description 2
• 239000001301 oxygen Substances 0.000 description 2
• 210000001711 oxyntic cell Anatomy 0.000 description 2
• 230000001354 painful effect Effects 0.000 description 2
• 210000001819 pancreatic juice Anatomy 0.000 description 2
• 210000002990 parathyroid gland Anatomy 0.000 description 2
• 244000052769 pathogen Species 0.000 description 2
• 210000004197 pelvis Anatomy 0.000 description 2
• 210000001428 peripheral nervous system Anatomy 0.000 description 2
• 230000036581 peripheral resistance Effects 0.000 description 2
• 230000008855 peristalsis Effects 0.000 description 2
• HYCHUWFLXGGFDZ-UHFFFAOYSA-N phenyl carbamimidothioate Chemical compound NC(=N)SC1=CC=CC=C1 HYCHUWFLXGGFDZ-UHFFFAOYSA-N 0.000 description 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
• 239000002953 phosphate buffered saline Substances 0.000 description 2
• XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
• 230000019612 pigmentation Effects 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 229940002612 prodrug Drugs 0.000 description 2
• 239000000651 prodrug Substances 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
• WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
• 235000019419 proteases Nutrition 0.000 description 2
• 108060006633 protein kinase Proteins 0.000 description 2
• 239000011541 reaction mixture Substances 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 230000000306 recurrent effect Effects 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 238000007670 refining Methods 0.000 description 2
• 239000003488 releasing hormone Substances 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 238000002271 resection Methods 0.000 description 2
• 230000000717 retained effect Effects 0.000 description 2
• 230000002207 retinal effect Effects 0.000 description 2
• 229910052707 ruthenium Inorganic materials 0.000 description 2
• 239000000523 sample Substances 0.000 description 2
• 230000036186 satiety Effects 0.000 description 2
• 201000000980 schizophrenia Diseases 0.000 description 2
• 230000035945 sensitivity Effects 0.000 description 2
• 238000000926 separation method Methods 0.000 description 2
• 230000016160 smooth muscle contraction Effects 0.000 description 2
• 239000002689 soil Substances 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• 239000003270 steroid hormone Substances 0.000 description 2
• 238000003860 storage Methods 0.000 description 2
• 230000035882 stress Effects 0.000 description 2
• 238000010254 subcutaneous injection Methods 0.000 description 2
• 239000007929 subcutaneous injection Substances 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
• 229960002317 succinimide Drugs 0.000 description 2
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
• RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 2
• 229910052717 sulfur Inorganic materials 0.000 description 2
• 239000011593 sulfur Substances 0.000 description 2
• 229910021653 sulphate ion Inorganic materials 0.000 description 2
• 239000003930 superacid Substances 0.000 description 2
• 238000010189 synthetic method Methods 0.000 description 2
• 108010073085 tachykinin neuropeptide gamma Proteins 0.000 description 2
• 230000008685 targeting Effects 0.000 description 2
• 238000011191 terminal modification Methods 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• 150000007970 thio esters Chemical group 0.000 description 2
• HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 2
• PSWFFKRAVBDQEG-YGQNSOCVSA-N thymopentin Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 PSWFFKRAVBDQEG-YGQNSOCVSA-N 0.000 description 2
• 231100000331 toxic Toxicity 0.000 description 2
• 230000002588 toxic effect Effects 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 239000012581 transferrin Substances 0.000 description 2
• 239000002753 trypsin inhibitor Substances 0.000 description 2
• 210000004881 tumor cell Anatomy 0.000 description 2
• DZGWFCGJZKJUFP-UHFFFAOYSA-N tyramine Chemical compound NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 description 2
• 210000003556 vascular endothelial cell Anatomy 0.000 description 2
• 230000006442 vascular tone Effects 0.000 description 2
• 210000003462 vein Anatomy 0.000 description 2
• 230000003442 weekly effect Effects 0.000 description 2
• YFGBQHOOROIVKG-BHDDXSALSA-N (2R)-2-[[(2R)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid Chemical compound C([C@H](C(=O)N[C@H](CCSC)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 YFGBQHOOROIVKG-BHDDXSALSA-N 0.000 description 1
• QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 1
• SBKVPJHMSUXZTA-MEJXFZFPSA-N (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 SBKVPJHMSUXZTA-MEJXFZFPSA-N 0.000 description 1
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 1
• REITVGIIZHFVGU-IBGZPJMESA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](COC(C)(C)C)C(O)=O)C3=CC=CC=C3C2=C1 REITVGIIZHFVGU-IBGZPJMESA-N 0.000 description 1
• UGNIYGNGCNXHTR-SFHVURJKSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](C(C)C)C(O)=O)C3=CC=CC=C3C2=C1 UGNIYGNGCNXHTR-SFHVURJKSA-N 0.000 description 1
• FODJWPHPWBKDON-IBGZPJMESA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CC(=O)OC(C)(C)C)C(O)=O)C3=CC=CC=C3C2=C1 FODJWPHPWBKDON-IBGZPJMESA-N 0.000 description 1
• OTKXCALUHMPIGM-FQEVSTJZSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(O)=O)C3=CC=CC=C3C2=C1 OTKXCALUHMPIGM-FQEVSTJZSA-N 0.000 description 1
• UMRUUWFGLGNQLI-QFIPXVFZSA-N (2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound C1=CC=C2C(COC(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(O)=O)C3=CC=CC=C3C2=C1 UMRUUWFGLGNQLI-QFIPXVFZSA-N 0.000 description 1
• CNBUSIJNWNXLQQ-NSHDSACASA-N (2s)-3-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CNBUSIJNWNXLQQ-NSHDSACASA-N 0.000 description 1
• CNYIEQNFOBBXCP-CJMGQXRASA-N (2s)-6-amino-2-[[(2s,7s)-8-[[(1s)-5-amino-1-carboxypentyl]amino]-2,7-bis[[(2s)-3-carboxy-2-[[(2s)-4-carboxy-2-[[(2s)-5-oxopyrrolidine-2-carbonyl]amino]butanoyl]amino]propanoyl]amino]-8-oxooctanoyl]amino]hexanoic acid Chemical compound N([C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCC[C@@H](C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1NC(=O)CC1)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)[C@@H]1CCC(=O)N1 CNYIEQNFOBBXCP-CJMGQXRASA-N 0.000 description 1
• SDAFHXYVWUEZIJ-LRHNFOCQSA-N (2s)-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[2-[[(2s)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminom Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C1=CC=CC=C1 SDAFHXYVWUEZIJ-LRHNFOCQSA-N 0.000 description 1
• COABRICCWCYCPI-ZYLNUDMXSA-N (2s,3s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamin Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCN=C(N)N)[C@@H](C)O)C(C)C)CC1=CC=C(O)C=C1 COABRICCWCYCPI-ZYLNUDMXSA-N 0.000 description 1
• PLSDWRYNZIVQKX-BGKYVOMCSA-N (3S)-3-amino-4-[[(2S)-1-[[2-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S,3R)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(1S)-1-carboxy-3-methylsulfanylpropyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CC4=CNC=N4)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)N PLSDWRYNZIVQKX-BGKYVOMCSA-N 0.000 description 1
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 description 1
• NURUARRJQOZSIF-DXIBHZBQSA-N (3s)-3-[[(2s)-2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-[[(2s)-1-[[(2s)-4-amino-1-[[2-[[2-[[2-[[(2s)-1-(carboxymethylamino)-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl Chemical compound OC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CC=CC=C1 NURUARRJQOZSIF-DXIBHZBQSA-N 0.000 description 1
• HEAUFJZALFKPBA-JPQUDPSNSA-N (3s)-3-[[(2s,3r)-2-[[(2s)-6-amino-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-4-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[(2s)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-JPQUDPSNSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• GGYWLZFXFKFWKL-GLWNXGLNSA-N (3s,6s,9r,12s,15r,23s)-15-[[(2r)-2-acetamidohexanoyl]amino]-6-[3-(diaminomethylideneamino)propyl]-12-(1h-imidazol-5-ylmethyl)-3-(1h-indol-3-ylmethyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide Chemical compound C([C@H]1C(=O)N[C@H](CC=2C=C3C=CC=CC3=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCNC(=O)C[C@H](C(N1)=O)NC(=O)[C@H](NC(C)=O)CCCC)C(N)=O)C1=CNC=N1 GGYWLZFXFKFWKL-GLWNXGLNSA-N 0.000 description 1
• NGJOFQZEYQGZMB-KTKZVXAJSA-N (4S)-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[2-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NGJOFQZEYQGZMB-KTKZVXAJSA-N 0.000 description 1
• JYGRAOYMDDFOSM-FQJIPJFPSA-N (4s)-4-[[(2s)-4-carboxy-2-[[(2s)-3-carboxy-2-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]propanoyl]amino]butanoyl]amino]-5-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentano Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN JYGRAOYMDDFOSM-FQJIPJFPSA-N 0.000 description 1
• 230000006269 (delayed) early viral mRNA transcription Effects 0.000 description 1
• 108010032599 (prolyl-hydroxylprolyl-glycine)10 Proteins 0.000 description 1
• BZSXSIQTILQTNQ-SCWOKBSMSA-N (prolyl-hydroxylprolyl-glycine)10 Chemical compound N1([C@@H](C[C@H](C1)O)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(O)=O)C(=O)C1CCCN1 BZSXSIQTILQTNQ-SCWOKBSMSA-N 0.000 description 1
• BDNKZNFMNDZQMI-UHFFFAOYSA-N 1,3-diisopropylcarbodiimide Chemical compound CC(C)N=C=NC(C)C BDNKZNFMNDZQMI-UHFFFAOYSA-N 0.000 description 1
• VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 1
• TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
• INJPEINGXBVKEB-RTBURBONSA-N 1-[[(2r,3r)-3-[(2,6-difluorophenyl)methoxy]-5-fluoro-2,3-dihydro-1-benzothiophen-2-yl]methyl]imidazole Chemical compound C([C@H]1SC2=CC=C(C=C2[C@H]1OCC=1C(=CC=CC=1F)F)F)N1C=CN=C1 INJPEINGXBVKEB-RTBURBONSA-N 0.000 description 1
• LOWMYOWHQMKBTM-UHFFFAOYSA-N 1-butylsulfinylbutane Chemical compound CCCCS(=O)CCCC LOWMYOWHQMKBTM-UHFFFAOYSA-N 0.000 description 1
• QMKXYMHNAGNKTM-UHFFFAOYSA-N 1-phenylsulfanylpyrene Chemical compound C1(=CC=C2C=CC3=CC=CC4=CC=C1C2=C34)SC1=CC=CC=C1 QMKXYMHNAGNKTM-UHFFFAOYSA-N 0.000 description 1
• NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical group O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 description 1
• JRQDGUSHUYLSHC-UHFFFAOYSA-N 148067-21-4 Chemical compound C1CCC(C(=O)N2C(CCC2)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(O)=O)C(=O)NC(C)C(=O)NC(CCSC)C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(CCSC)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCC(O)=O)NC(=O)C(CC(N)=O)NC(=O)C(C(C)CC)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(N)C(C)CC)CC1=CC=CC=C1 JRQDGUSHUYLSHC-UHFFFAOYSA-N 0.000 description 1
• YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 1
• SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
• PIFBMJMXJMZZRG-UHFFFAOYSA-N 2,2,4,6,6-pentamethyl-1,5-dihydropyrimidine Chemical compound CC1=NC(C)(C)NC(C)(C)C1 PIFBMJMXJMZZRG-UHFFFAOYSA-N 0.000 description 1
• 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 description 1
• DIBAKBGYJUCGDL-UHFFFAOYSA-N 2,6-diamino-n-[1-[(2-amino-2-oxoethyl)amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCCC(N)C(=O)NC(C(=O)NCC(N)=O)CC1=CN=CN1 DIBAKBGYJUCGDL-UHFFFAOYSA-N 0.000 description 1
• NDKDFTQNXLHCGO-UHFFFAOYSA-N 2-(9h-fluoren-9-ylmethoxycarbonylamino)acetic acid Chemical compound C1=CC=C2C(COC(=O)NCC(=O)O)C3=CC=CC=C3C2=C1 NDKDFTQNXLHCGO-UHFFFAOYSA-N 0.000 description 1
• HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 description 1
• RUVRGYVESPRHSZ-UHFFFAOYSA-N 2-[2-(2-azaniumylethoxy)ethoxy]acetate Chemical compound NCCOCCOCC(O)=O RUVRGYVESPRHSZ-UHFFFAOYSA-N 0.000 description 1
• WIGDGIGALMYEBW-LLINQDLYSA-N 2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]acetic acid Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O WIGDGIGALMYEBW-LLINQDLYSA-N 0.000 description 1
• KREXTMSNGTWUJT-YWPYICTPSA-N 2-[[2-[[(2r,3s,5r)-3-[[2-(carboxymethylamino)-2-oxoethyl]carbamoyloxy]-5-[2-(2-methylpropanoylamino)-6-oxo-3h-purin-9-yl]oxolan-2-yl]methoxycarbonylamino]acetyl]amino]acetic acid Chemical compound C1=NC=2C(=O)NC(NC(=O)C(C)C)=NC=2N1[C@H]1C[C@H](OC(=O)NCC(=O)NCC(O)=O)[C@@H](COC(=O)NCC(=O)NCC(O)=O)O1 KREXTMSNGTWUJT-YWPYICTPSA-N 0.000 description 1
• RVYGUKZYSYVROS-UHFFFAOYSA-N 2-[[2-[[2-[[6-amino-2-[[2-[[6-amino-2-[[6-amino-2-[[6-amino-2-[[1-[2-[[2-[[2-[(2-amino-3-sulfanylpropanoyl)amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-(diaminom Chemical compound OC(=O)CNC(=O)CNC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)CNC(=O)C(NC(=O)CNC(=O)C(N)CS)CC1=CC=C(O)C=C1 RVYGUKZYSYVROS-UHFFFAOYSA-N 0.000 description 1
• UPGATMBHQQONPH-UHFFFAOYSA-N 2-aminooxycarbonylbenzoic acid Chemical compound NOC(=O)C1=CC=CC=C1C(O)=O UPGATMBHQQONPH-UHFFFAOYSA-N 0.000 description 1
• KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 description 1
• JRMAQQQTXDJDNC-UHFFFAOYSA-M 2-ethoxy-2-oxoacetate Chemical compound CCOC(=O)C([O-])=O JRMAQQQTXDJDNC-UHFFFAOYSA-M 0.000 description 1
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
• PJRGDKFLFAYRBV-UHFFFAOYSA-N 2-phenylthiophene Chemical compound C1=CSC(C=2C=CC=CC=2)=C1 PJRGDKFLFAYRBV-UHFFFAOYSA-N 0.000 description 1
• LBVZCSKDTGDAQW-UHFFFAOYSA-N 3-[(2-oxo-1,3-oxazolidin-3-yl)phosphanyl]-1,3-oxazolidin-2-one;hydrochloride Chemical compound [Cl-].O=C1OCCN1[PH2+]N1C(=O)OCC1 LBVZCSKDTGDAQW-UHFFFAOYSA-N 0.000 description 1
• NHXYSAFTNPANFK-UHFFFAOYSA-N 3-amino-4-[[1-[[1-[[1-[[1-[[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-ox Chemical compound C=1C=CC=CC=1CC(NC(=O)C(CC(O)=O)NC(=O)C(CC=1NC=NC=1)NC(=O)C(CCSC)NC(=O)C(N)CC(O)=O)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O)C(C)C)CC1=CC=CC=C1 NHXYSAFTNPANFK-UHFFFAOYSA-N 0.000 description 1
• 101710171349 3-deoxy-manno-octulosonate cytidylyltransferase 1 Proteins 0.000 description 1
• FAXDZWQIWUSWJH-UHFFFAOYSA-N 3-methoxypropan-1-amine Chemical compound COCCCN FAXDZWQIWUSWJH-UHFFFAOYSA-N 0.000 description 1
• QXZBMSIDSOZZHK-DOPDSADYSA-N 31362-50-2 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CNC=N1 QXZBMSIDSOZZHK-DOPDSADYSA-N 0.000 description 1
• MZCACYLMMMXSKC-UHFFFAOYSA-N 32 amino acid peptide Chemical compound C=1C=CC=CC=1CC(C(=O)NC(CC=1C2=CC=CC=C2NC=1)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C1N(CCC1)C(=O)C1NCCC1)C(C)O)CC1=CC=CC=C1 MZCACYLMMMXSKC-UHFFFAOYSA-N 0.000 description 1
• QGHDLJAZIIFENW-UHFFFAOYSA-N 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxy-3-prop-2-enylphenyl)propan-2-yl]-2-prop-2-enylphenol Chemical group C1=C(CC=C)C(O)=CC=C1C(C(F)(F)F)(C(F)(F)F)C1=CC=C(O)C(CC=C)=C1 QGHDLJAZIIFENW-UHFFFAOYSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• UZEFHQIOSJWWSB-UHFFFAOYSA-N 4-azidobenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=C(N=[N+]=[N-])C=C1 UZEFHQIOSJWWSB-UHFFFAOYSA-N 0.000 description 1
• 229960000549 4-dimethylaminophenol Drugs 0.000 description 1
• KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
• 208000030507 AIDS Diseases 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 241000242759 Actiniaria Species 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 102100035785 Acyl-CoA-binding protein Human genes 0.000 description 1
• 229930024421 Adenine Natural products 0.000 description 1
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
• 102100022455 Adrenocorticotropic hormone receptor Human genes 0.000 description 1
• 101000939674 Agelena orientalis U2-agatoxin-Ao1a Proteins 0.000 description 1
• PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 description 1
• PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 description 1
• 101000939684 Allagelena opulenta U2-agatoxin-Aop1a Proteins 0.000 description 1
• 102100033312 Alpha-2-macroglobulin Human genes 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 208000024827 Alzheimer disease Diseases 0.000 description 1
• 108010048112 Amyloidogenic Proteins Proteins 0.000 description 1
• 102000009091 Amyloidogenic Proteins Human genes 0.000 description 1
• 108050000824 Angiotensin II receptor Proteins 0.000 description 1
• 102000008873 Angiotensin II receptor Human genes 0.000 description 1
• 102000004881 Angiotensinogen Human genes 0.000 description 1
• 108090001067 Angiotensinogen Proteins 0.000 description 1
• 101800000068 Antioxidant peptide Proteins 0.000 description 1
• 101710081722 Antitrypsin Proteins 0.000 description 1
• 101710126338 Apamin Proteins 0.000 description 1
• 102400000059 Arg-vasopressin Human genes 0.000 description 1
• 101800001144 Arg-vasopressin Proteins 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• 206010003178 Arterial thrombosis Diseases 0.000 description 1
• QCWJKJLNCFEVPQ-WHFBIAKZSA-N Asn-Gln Chemical compound NC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(N)=O QCWJKJLNCFEVPQ-WHFBIAKZSA-N 0.000 description 1
• 108091005502 Aspartic proteases Proteins 0.000 description 1
• 102000035101 Aspartic proteases Human genes 0.000 description 1
• 201000001320 Atherosclerosis Diseases 0.000 description 1
• 208000020706 Autistic disease Diseases 0.000 description 1
• 208000037157 Azotemia Diseases 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
• ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 description 1
• 102000013585 Bombesin Human genes 0.000 description 1
• 108010051479 Bombesin Proteins 0.000 description 1
• 108050007957 Cadherin Proteins 0.000 description 1
• 102000000905 Cadherin Human genes 0.000 description 1
• 108010001789 Calcitonin Receptors Proteins 0.000 description 1
• 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 description 1
• 101710117582 Calcitonin gene-related peptide 1 Proteins 0.000 description 1
• 101710117581 Calcitonin gene-related peptide 2 Proteins 0.000 description 1
• 102100038521 Calcitonin gene-related peptide 2 Human genes 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 102000019025 Calcium-Calmodulin-Dependent Protein Kinases Human genes 0.000 description 1
• 108010026870 Calcium-Calmodulin-Dependent Protein Kinases Proteins 0.000 description 1
• 229940121926 Calpain inhibitor Drugs 0.000 description 1
• 102100035037 Calpastatin Human genes 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 206010007134 Candida infections Diseases 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 101710184216 Cardioactive peptide Proteins 0.000 description 1
• 208000024172 Cardiovascular disease Diseases 0.000 description 1
• 108010078791 Carrier Proteins Proteins 0.000 description 1
• 108010076119 Caseins Proteins 0.000 description 1
• 108050004290 Cecropin Proteins 0.000 description 1
• 206010057248 Cell death Diseases 0.000 description 1
• 229930186147 Cephalosporin Natural products 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 101710091342 Chemotactic peptide Proteins 0.000 description 1
• 241001000171 Chira Species 0.000 description 1
• GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• 206010008617 Cholecystitis chronic Diseases 0.000 description 1
• 108010077544 Chromatin Proteins 0.000 description 1
• 108010007718 Chromogranins Proteins 0.000 description 1
• 102000007345 Chromogranins Human genes 0.000 description 1
• 235000007516 Chrysanthemum Nutrition 0.000 description 1
• 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
• 229940119334 Chymase inhibitor Drugs 0.000 description 1
• 108010003422 Circulating Thymic Factor Proteins 0.000 description 1
• 108090000197 Clusterin Proteins 0.000 description 1
• 102000003780 Clusterin Human genes 0.000 description 1
• UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 description 1
• 244000205754 Colocasia esculenta Species 0.000 description 1
• 235000006481 Colocasia esculenta Nutrition 0.000 description 1
• 206010010774 Constipation Diseases 0.000 description 1
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
• OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 description 1
• 108010074311 Corticotropin Receptors Proteins 0.000 description 1
• MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
• 239000004971 Cross linker Substances 0.000 description 1
• 241000223935 Cryptosporidium Species 0.000 description 1
• 102000001189 Cyclic Peptides Human genes 0.000 description 1
• 108010069514 Cyclic Peptides Proteins 0.000 description 1
• IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
• 102100034501 Cyclin-dependent kinases regulatory subunit 1 Human genes 0.000 description 1
• 101710171649 Cyclin-dependent kinases regulatory subunit 1 Proteins 0.000 description 1
• 201000003883 Cystic fibrosis Diseases 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 230000006820 DNA synthesis Effects 0.000 description 1
• 108010002069 Defensins Proteins 0.000 description 1
• 102000000541 Defensins Human genes 0.000 description 1
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 1
• 206010012289 Dementia Diseases 0.000 description 1
• 208000020401 Depressive disease Diseases 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• 208000002249 Diabetes Complications Diseases 0.000 description 1
• 206010012655 Diabetic complications Diseases 0.000 description 1
• 108010039287 Diazepam Binding Inhibitor Proteins 0.000 description 1
• RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
• 241000790917 Dioxys <bee> Species 0.000 description 1
• YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 1
• 206010058314 Dysplasia Diseases 0.000 description 1
• 108010024212 E-Selectin Proteins 0.000 description 1
• 102100023471 E-selectin Human genes 0.000 description 1
• 241000257465 Echinoidea Species 0.000 description 1
• 102400001047 Endostatin Human genes 0.000 description 1
• 108010079505 Endostatins Proteins 0.000 description 1
• 102000010180 Endothelin receptor Human genes 0.000 description 1
• 229910052691 Erbium Inorganic materials 0.000 description 1
• 108010011459 Exenatide Proteins 0.000 description 1
• 206010015995 Eyelid ptosis Diseases 0.000 description 1
• 239000001263 FEMA 3042 Substances 0.000 description 1
• 108010022355 Fibroins Proteins 0.000 description 1
• 108010067306 Fibronectins Proteins 0.000 description 1
• 102000016359 Fibronectins Human genes 0.000 description 1
• 206010016654 Fibrosis Diseases 0.000 description 1
• KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• 108700012941 GNRH1 Proteins 0.000 description 1
• 102400001370 Galanin Human genes 0.000 description 1
• 101800002068 Galanin Proteins 0.000 description 1
• 102400000921 Gastrin Human genes 0.000 description 1
• 108010052343 Gastrins Proteins 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 108010001483 Glycogen Synthase Proteins 0.000 description 1
• 102000002068 Glycopeptides Human genes 0.000 description 1
• 108010015899 Glycopeptides Proteins 0.000 description 1
• 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 description 1
• 102100020948 Growth hormone receptor Human genes 0.000 description 1
• 101710099093 Growth hormone receptor Proteins 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 241000700721 Hepatitis B virus Species 0.000 description 1
• 208000005176 Hepatitis C Diseases 0.000 description 1
• 241000238631 Hexapoda Species 0.000 description 1
• 241000545744 Hirudinea Species 0.000 description 1
• 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 description 1
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 1
• 101000605528 Homo sapiens Kallikrein-2 Proteins 0.000 description 1
• 101001124867 Homo sapiens Peroxiredoxin-1 Proteins 0.000 description 1
• 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 description 1
• 101000825742 Homo sapiens Somatoliberin Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
• 241000257303 Hymenoptera Species 0.000 description 1
• RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
• 208000037147 Hypercalcaemia Diseases 0.000 description 1
• 201000002980 Hyperparathyroidism Diseases 0.000 description 1
• 208000013016 Hypoglycemia Diseases 0.000 description 1
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
• 206010021333 Ileus paralytic Diseases 0.000 description 1
• 108010058683 Immobilized Proteins Proteins 0.000 description 1
• 206010062016 Immunosuppression Diseases 0.000 description 1
• 102100039813 Inactive tyrosine-protein kinase 7 Human genes 0.000 description 1
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
• 102100037852 Insulin-like growth factor I Human genes 0.000 description 1
• 102000006992 Interferon-alpha Human genes 0.000 description 1
• 108010047761 Interferon-alpha Proteins 0.000 description 1
• 108010002350 Interleukin-2 Proteins 0.000 description 1
• 102000000588 Interleukin-2 Human genes 0.000 description 1
• 108090000862 Ion Channels Proteins 0.000 description 1
• 102000004310 Ion Channels Human genes 0.000 description 1
• 102100038356 Kallikrein-2 Human genes 0.000 description 1
• 102000010638 Kinesin Human genes 0.000 description 1
• 108010063296 Kinesin Proteins 0.000 description 1
• LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
• XNSAINXGIQZQOO-UHFFFAOYSA-N L-pyroglutamyl-L-histidyl-L-proline amide Natural products NC(=O)C1CCCN1C(=O)C(NC(=O)C1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-UHFFFAOYSA-N 0.000 description 1
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
• 101150118523 LYS4 gene Proteins 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• 108090001090 Lectins Proteins 0.000 description 1
• 102000004856 Lectins Human genes 0.000 description 1
• 241000270322 Lepidosauria Species 0.000 description 1
• 102400000243 Leu-enkephalin Human genes 0.000 description 1
• 108010022337 Leucine Enkephalin Proteins 0.000 description 1
• ATIPDCIQTUXABX-UWVGGRQHSA-N Lys-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN ATIPDCIQTUXABX-UWVGGRQHSA-N 0.000 description 1
• 229940126661 MC4 antagonist Drugs 0.000 description 1
• 101150060255 MZB1 gene Proteins 0.000 description 1
• 108060003100 Magainin Proteins 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 108010038049 Mating Factor Proteins 0.000 description 1
• 102100023726 Melanocortin receptor 3 Human genes 0.000 description 1
• 101710085774 Melanocortin receptor 3 Proteins 0.000 description 1
• 108010008364 Melanocortins Proteins 0.000 description 1
• YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 description 1
• 108010036176 Melitten Proteins 0.000 description 1
• 102000018697 Membrane Proteins Human genes 0.000 description 1
• 208000036626 Mental retardation Diseases 0.000 description 1
• 102400000988 Met-enkephalin Human genes 0.000 description 1
• 102000005741 Metalloproteases Human genes 0.000 description 1
• 108010006035 Metalloproteases Proteins 0.000 description 1
• LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
• 108010042237 Methionine Enkephalin Proteins 0.000 description 1
• 102000013967 Monokines Human genes 0.000 description 1
• 108010050619 Monokines Proteins 0.000 description 1
• 101100462550 Mus musculus Adcyap1 gene Proteins 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 241000186359 Mycobacterium Species 0.000 description 1
• 101001055320 Myxine glutinosa Insulin-like growth factor Proteins 0.000 description 1
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
• MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
• NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
• ORDDGAKVEOTVKV-UHFFFAOYSA-N N1C=CC2=CC=CC=C12.NN Chemical compound N1C=CC2=CC=CC=C12.NN ORDDGAKVEOTVKV-UHFFFAOYSA-N 0.000 description 1
• LOJFGJZQOKTUBR-XAQOOIOESA-N NC(N)=NCCC[C@@H](C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(O)=O)C)CC1=CN=CN1 Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCC(O)=O)C)CC1=CN=CN1 LOJFGJZQOKTUBR-XAQOOIOESA-N 0.000 description 1
• 229940099433 NMDA receptor antagonist Drugs 0.000 description 1
• 206010028851 Necrosis Diseases 0.000 description 1
• HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 description 1
• 101800002813 Neurokinin-B Proteins 0.000 description 1
• 101710138657 Neurotoxin Proteins 0.000 description 1
• 101100248354 Nicotiana plumbaginifolia RHN1 gene Proteins 0.000 description 1
• 101800001020 Non-structural protein 4A Proteins 0.000 description 1
• 102000007999 Nuclear Proteins Human genes 0.000 description 1
• 108010089610 Nuclear Proteins Proteins 0.000 description 1
• 206010030302 Oliguria Diseases 0.000 description 1
• 239000008896 Opium Substances 0.000 description 1
• 102000002512 Orexin Human genes 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 102400000203 Pancreastatin Human genes 0.000 description 1
• 101800005322 Pancreastatin Proteins 0.000 description 1
• 206010033645 Pancreatitis Diseases 0.000 description 1
• 108010058828 Parathyroid Hormone Receptors Proteins 0.000 description 1
• 102000006461 Parathyroid Hormone Receptors Human genes 0.000 description 1
• 108700020797 Parathyroid Hormone-Related Proteins 0.000 description 1
• 102100032256 Parathyroid hormone/parathyroid hormone-related peptide receptor Human genes 0.000 description 1
• 101710180613 Parathyroid hormone/parathyroid hormone-related peptide receptor Proteins 0.000 description 1
• 241000606860 Pasteurella Species 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
• 229940122344 Peptidase inhibitor Drugs 0.000 description 1
• 108010071384 Peptide T Proteins 0.000 description 1
• 229940083963 Peptide antagonist Drugs 0.000 description 1
• 101710191547 Peptidyl-tRNA hydrolase 1 Proteins 0.000 description 1
• 102100029139 Peroxiredoxin-1 Human genes 0.000 description 1
• 102100029251 Phagocytosis-stimulating peptide Human genes 0.000 description 1
• XMQSOOJRRVEHRO-ULQDDVLXSA-N Phe-Leu-Arg Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC1=CC=CC=C1 XMQSOOJRRVEHRO-ULQDDVLXSA-N 0.000 description 1
• 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
• 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
• NQRYJNQNLNOLGT-UHFFFAOYSA-O Piperidinium(1+) Chemical compound C1CC[NH2+]CC1 NQRYJNQNLNOLGT-UHFFFAOYSA-O 0.000 description 1
• 102000006877 Pituitary Hormones Human genes 0.000 description 1
• 108010047386 Pituitary Hormones Proteins 0.000 description 1
• 229940122791 Plasmin inhibitor Drugs 0.000 description 1
• 108010003541 Platelet Activating Factor Proteins 0.000 description 1
• 101000939724 Plectreurys tristis Omega-plectoxin-Pt1a Proteins 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 229920000388 Polyphosphate Polymers 0.000 description 1
• 208000004880 Polyuria Diseases 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 108010015078 Pregnancy-Associated alpha 2-Macroglobulins Proteins 0.000 description 1
• ORNBQBCIOKFOEO-YQUGOWONSA-N Pregnenolone Natural products O=C(C)[C@@H]1[C@@]2(C)[C@H]([C@H]3[C@@H]([C@]4(C)C(=CC3)C[C@@H](O)CC4)CC2)CC1 ORNBQBCIOKFOEO-YQUGOWONSA-N 0.000 description 1
• 108091000054 Prion Proteins 0.000 description 1
• 102000029797 Prion Human genes 0.000 description 1
• ICTZKEXYDDZZFP-SRVKXCTJSA-N Pro-Arg-Pro Chemical compound N([C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(O)=O)C(=O)[C@@H]1CCCN1 ICTZKEXYDDZZFP-SRVKXCTJSA-N 0.000 description 1
• 102100024028 Progonadoliberin-1 Human genes 0.000 description 1
• 108010087786 Prolactin-Releasing Hormone Proteins 0.000 description 1
• 102100028850 Prolactin-releasing peptide Human genes 0.000 description 1
• 101710188053 Protein D Proteins 0.000 description 1
• 108090000315 Protein Kinase C Proteins 0.000 description 1
• 102000003923 Protein Kinase C Human genes 0.000 description 1
• 108010076504 Protein Sorting Signals Proteins 0.000 description 1
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
• 201000004681 Psoriasis Diseases 0.000 description 1
• 208000030555 Pygmy Diseases 0.000 description 1
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
• 101710132893 Resolvase Proteins 0.000 description 1
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
• 102100037968 Ribonuclease inhibitor Human genes 0.000 description 1
• 102000009738 Ribosomal Protein S6 Kinases Human genes 0.000 description 1
• 108010034782 Ribosomal Protein S6 Kinases Proteins 0.000 description 1
• UEJYSALTSUZXFV-SRVKXCTJSA-N Rigin Chemical compound NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O UEJYSALTSUZXFV-SRVKXCTJSA-N 0.000 description 1
• 239000012327 Ruthenium complex Substances 0.000 description 1
• 108010021820 SHU 9119 Proteins 0.000 description 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
• 101710205037 Sarafotoxin Proteins 0.000 description 1
• 108010086019 Secretin Proteins 0.000 description 1
• 102100037505 Secretin Human genes 0.000 description 1
• 108091058545 Secretory proteins Proteins 0.000 description 1
• 102000040739 Secretory proteins Human genes 0.000 description 1
• 229920005654 Sephadex Polymers 0.000 description 1
• 239000012507 Sephadex™ Substances 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
• 108010022999 Serine Proteases Proteins 0.000 description 1
• 102000012479 Serine Proteases Human genes 0.000 description 1
• 101710145752 Serine recombinase gin Proteins 0.000 description 1
• 208000020221 Short stature Diseases 0.000 description 1
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
• 108010087230 Sincalide Proteins 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 208000010340 Sleep Deprivation Diseases 0.000 description 1
• 206010041067 Small cell lung cancer Diseases 0.000 description 1
• 101800004925 Speract Proteins 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 241000242736 Stichodactyla Species 0.000 description 1
• 208000005718 Stomach Neoplasms Diseases 0.000 description 1
• 208000007107 Stomach Ulcer Diseases 0.000 description 1
• 241000194017 Streptococcus Species 0.000 description 1
• 101800003906 Substance P Proteins 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• 108090001076 Synaptophysin Proteins 0.000 description 1
• 102000004874 Synaptophysin Human genes 0.000 description 1
• 102000003141 Tachykinin Human genes 0.000 description 1
• 102100033009 Tachykinin-3 Human genes 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 108010017842 Telomerase Proteins 0.000 description 1
• 108010012944 Tetragastrin Proteins 0.000 description 1
• 229940122388 Thrombin inhibitor Drugs 0.000 description 1
• 229940117028 Thrombin receptor agonist Drugs 0.000 description 1
• 108010078233 Thymalfasin Proteins 0.000 description 1
• 102400000160 Thymopentin Human genes 0.000 description 1
• 101800001703 Thymopentin Proteins 0.000 description 1
• 102400000800 Thymosin alpha-1 Human genes 0.000 description 1
• 240000002657 Thymus vulgaris Species 0.000 description 1
• 235000007303 Thymus vulgaris Nutrition 0.000 description 1
• 102000011923 Thyrotropin Human genes 0.000 description 1
• 108010061174 Thyrotropin Proteins 0.000 description 1
• 239000000627 Thyrotropin-Releasing Hormone Substances 0.000 description 1
• 102400000336 Thyrotropin-releasing hormone Human genes 0.000 description 1
• 101800004623 Thyrotropin-releasing hormone Proteins 0.000 description 1
• 108010048889 Thyroxine-Binding Proteins Proteins 0.000 description 1
• 102000009488 Thyroxine-Binding Proteins Human genes 0.000 description 1
• 108010009583 Transforming Growth Factors Proteins 0.000 description 1
• 102000009618 Transforming Growth Factors Human genes 0.000 description 1
• 206010052779 Transplant rejections Diseases 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• 108090000631 Trypsin Proteins 0.000 description 1
• 102000004142 Trypsin Human genes 0.000 description 1
• 229940122618 Trypsin inhibitor Drugs 0.000 description 1
• 101710162629 Trypsin inhibitor Proteins 0.000 description 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
• 108010084754 Tuftsin Proteins 0.000 description 1
• 102000001742 Tumor Suppressor Proteins Human genes 0.000 description 1
• 108010040002 Tumor Suppressor Proteins Proteins 0.000 description 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
• NOOMDULIORCDNF-IRXDYDNUSA-N Tyr-Gly-Phe Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O NOOMDULIORCDNF-IRXDYDNUSA-N 0.000 description 1
• IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 description 1
• 102400000757 Ubiquitin Human genes 0.000 description 1
• 108090000848 Ubiquitin Proteins 0.000 description 1
• 229910052770 Uranium Inorganic materials 0.000 description 1
• 206010046788 Uterine haemorrhage Diseases 0.000 description 1
• 206010057469 Vascular stenosis Diseases 0.000 description 1
• 206010047141 Vasodilatation Diseases 0.000 description 1
• 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 description 1
• 208000036142 Viral infection Diseases 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• 208000027418 Wounds and injury Diseases 0.000 description 1
• 244000273928 Zingiber officinale Species 0.000 description 1
• 235000006886 Zingiber officinale Nutrition 0.000 description 1
• JAWMENYCRQKKJY-UHFFFAOYSA-N [3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-ylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]methanone Chemical compound N1N=NC=2CN(CCC=21)CC1=NOC2(C1)CCN(CC2)C(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F JAWMENYCRQKKJY-UHFFFAOYSA-N 0.000 description 1
• 230000002350 accommodative effect Effects 0.000 description 1
• YFHNDHXQDJQEEE-UHFFFAOYSA-N acetic acid;hydrazine Chemical compound NN.CC(O)=O YFHNDHXQDJQEEE-UHFFFAOYSA-N 0.000 description 1
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
• 108010014878 acetyl-arginyl-phenylalanyl-tryptophyl-isoleucyl-asparaginyl-lysine Proteins 0.000 description 1
• OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
• 229960004373 acetylcholine Drugs 0.000 description 1
• 230000009858 acid secretion Effects 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 239000000488 activin Substances 0.000 description 1
• 125000005076 adamantyloxycarbonyl group Chemical group C12(CC3CC(CC(C1)C3)C2)OC(=O)* 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 208000009956 adenocarcinoma Diseases 0.000 description 1
• 239000003329 adenohypophysis hormone Substances 0.000 description 1
• LNQVTSROQXJCDD-UHFFFAOYSA-N adenosine monophosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)C(OP(O)(O)=O)C1O LNQVTSROQXJCDD-UHFFFAOYSA-N 0.000 description 1
• 210000001789 adipocyte Anatomy 0.000 description 1
• 210000000577 adipose tissue Anatomy 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 210000002556 adrenal cortex cell Anatomy 0.000 description 1
• 230000001780 adrenocortical effect Effects 0.000 description 1
• 230000003023 adrenocorticotropic effect Effects 0.000 description 1
• 238000005054 agglomeration Methods 0.000 description 1
• 230000002776 aggregation Effects 0.000 description 1
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
• 125000003158 alcohol group Chemical group 0.000 description 1
• 230000001476 alcoholic effect Effects 0.000 description 1
• 229960002478 aldosterone Drugs 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
• 229930013930 alkaloid Natural products 0.000 description 1
• 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 description 1
• 125000005205 alkoxycarbonyloxyalkyl group Chemical group 0.000 description 1
• 125000005036 alkoxyphenyl group Chemical group 0.000 description 1
• 150000003973 alkyl amines Chemical class 0.000 description 1
• 125000005907 alkyl ester group Chemical group 0.000 description 1
• 125000004414 alkyl thio group Chemical group 0.000 description 1
• 125000000304 alkynyl group Chemical group 0.000 description 1
• 108010055455 allatostatin Proteins 0.000 description 1
• 102000003801 alpha-2-Antiplasmin Human genes 0.000 description 1
• 108090000183 alpha-2-Antiplasmin Proteins 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 239000003263 anabolic agent Substances 0.000 description 1
• 229940124325 anabolic agent Drugs 0.000 description 1
• 230000001195 anabolic effect Effects 0.000 description 1
• 230000000202 analgesic effect Effects 0.000 description 1
• 229940035676 analgesics Drugs 0.000 description 1
• 239000004037 angiogenesis inhibitor Substances 0.000 description 1
• 229940121369 angiogenesis inhibitor Drugs 0.000 description 1
• 150000008064 anhydrides Chemical class 0.000 description 1
• 230000001539 anorectic effect Effects 0.000 description 1
• 208000022531 anorexia Diseases 0.000 description 1
• 239000000730 antalgic agent Substances 0.000 description 1
• 230000003288 anthiarrhythmic effect Effects 0.000 description 1
• PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
• 150000004056 anthraquinones Chemical class 0.000 description 1
• 230000001772 anti-angiogenic effect Effects 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 230000001093 anti-cancer Effects 0.000 description 1
• 229940121363 anti-inflammatory agent Drugs 0.000 description 1
• 230000003110 anti-inflammatory effect Effects 0.000 description 1
• 230000001475 anti-trypsic effect Effects 0.000 description 1
• 239000003146 anticoagulant agent Substances 0.000 description 1
• 229940127219 anticoagulant drug Drugs 0.000 description 1
• 229940041181 antineoplastic drug Drugs 0.000 description 1
• 239000003443 antiviral agent Substances 0.000 description 1
• 235000021407 appetite control Nutrition 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
• 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 description 1
• 125000005018 aryl alkenyl group Chemical group 0.000 description 1
• 125000005160 aryl oxy alkyl group Chemical group 0.000 description 1
• 108010063987 astressin Proteins 0.000 description 1
• HPYIIXJJVYSMCV-MGDXKYBTSA-N astressin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1C(N[C@@H](C)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@@H](CCCCNC(=O)CC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)=O)C(C)C)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CNC=N1 HPYIIXJJVYSMCV-MGDXKYBTSA-N 0.000 description 1
• 239000012298 atmosphere Substances 0.000 description 1
• 125000004429 atom Chemical group 0.000 description 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
• 230000001746 atrial effect Effects 0.000 description 1
• 210000002072 atrial myocyte Anatomy 0.000 description 1
• 230000009910 autonomic response Effects 0.000 description 1
• 150000001540 azides Chemical class 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 108010016341 bactenecin Proteins 0.000 description 1
• RHISNKCGUDDGEG-UHFFFAOYSA-N bactenecin Chemical compound CCC(C)C1NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)C(CCCN=C(N)N)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(N)CCCN=C(N)N)CSSCC(C(=O)NC(CCCN=C(N)N)C(O)=O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC1=O RHISNKCGUDDGEG-UHFFFAOYSA-N 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 229910052788 barium Inorganic materials 0.000 description 1
• 210000002469 basement membrane Anatomy 0.000 description 1
• 210000003651 basophil Anatomy 0.000 description 1
• 239000003659 bee venom Substances 0.000 description 1
• 230000003542 behavioural effect Effects 0.000 description 1
• 229940049706 benzodiazepine Drugs 0.000 description 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
• 230000003851 biochemical process Effects 0.000 description 1
• 230000000035 biogenic effect Effects 0.000 description 1
• 239000012472 biological sample Substances 0.000 description 1
• 229920001222 biopolymer Polymers 0.000 description 1
• 239000004305 biphenyl Substances 0.000 description 1
• 230000023555 blood coagulation Effects 0.000 description 1
• 238000009534 blood test Methods 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 210000002449 bone cell Anatomy 0.000 description 1
• 210000002798 bone marrow cell Anatomy 0.000 description 1
• 230000004097 bone metabolism Effects 0.000 description 1
• 230000003925 brain function Effects 0.000 description 1
• 239000011449 brick Substances 0.000 description 1
• 125000005998 bromoethyl group Chemical group 0.000 description 1
• 238000013276 bronchoscopy Methods 0.000 description 1
• 108010026970 bursopoietin Proteins 0.000 description 1
• 239000001273 butane Substances 0.000 description 1
• PMSGJXMYHUSZEI-UHFFFAOYSA-N butanedioic acid;pyrrolidine-2,5-dione Chemical compound O=C1CCC(=O)N1.OC(=O)CCC(O)=O PMSGJXMYHUSZEI-UHFFFAOYSA-N 0.000 description 1
• 125000004744 butyloxycarbonyl group Chemical group 0.000 description 1
• 229960005084 calcitriol Drugs 0.000 description 1
• 235000020964 calcitriol Nutrition 0.000 description 1
• 239000011612 calcitriol Substances 0.000 description 1
• 239000000480 calcium channel blocker Substances 0.000 description 1
• 230000004094 calcium homeostasis Effects 0.000 description 1
• 108010079785 calpain inhibitors Proteins 0.000 description 1
• 108010044208 calpastatin Proteins 0.000 description 1
• 201000003984 candidiasis Diseases 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 230000000747 cardiac effect Effects 0.000 description 1
• 230000009084 cardiovascular function Effects 0.000 description 1
• 210000000748 cardiovascular system Anatomy 0.000 description 1
• 238000010523 cascade reaction Methods 0.000 description 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 239000003054 catalyst Substances 0.000 description 1
• 150000003943 catecholamines Chemical class 0.000 description 1
• 230000034196 cell chemotaxis Effects 0.000 description 1
• 238000010609 cell counting kit-8 assay Methods 0.000 description 1
• 230000007969 cellular immunity Effects 0.000 description 1
• 230000007248 cellular mechanism Effects 0.000 description 1
• 230000036755 cellular response Effects 0.000 description 1
• 229940124587 cephalosporin Drugs 0.000 description 1
• 150000001780 cephalosporins Chemical class 0.000 description 1
• JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 description 1
• ZGOVYTPSWMLYOF-QEADGSHQSA-N chembl1790180 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CC=3C=CC=CC=3)C(=O)N[C@H](C(=O)N[C@H](CCC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)[C@H](C)O)=O)NC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZGOVYTPSWMLYOF-QEADGSHQSA-N 0.000 description 1
• XMLNCADGRIEXPK-KUMOIWDRSA-M chembl2146143 Chemical compound [Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C)C(=O)C(CO)C1=CC=CC=C1 XMLNCADGRIEXPK-KUMOIWDRSA-M 0.000 description 1
• AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
• 239000013043 chemical agent Substances 0.000 description 1
• 238000007385 chemical modification Methods 0.000 description 1
• 239000013626 chemical specie Substances 0.000 description 1
• 230000035606 childbirth Effects 0.000 description 1
• 229960003260 chlorhexidine Drugs 0.000 description 1
• 239000000460 chlorine Substances 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• 201000001352 cholecystitis Diseases 0.000 description 1
• 230000001713 cholinergic effect Effects 0.000 description 1
• 210000001612 chondrocyte Anatomy 0.000 description 1
• 210000003483 chromatin Anatomy 0.000 description 1
• 238000011210 chromatographic step Methods 0.000 description 1
• 229910052804 chromium Inorganic materials 0.000 description 1
• 239000011651 chromium Substances 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 239000003601 chymase inhibitor Substances 0.000 description 1
• 230000004087 circulation Effects 0.000 description 1
• 229950002162 cisconazole Drugs 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 230000015271 coagulation Effects 0.000 description 1
• 238000005345 coagulation Methods 0.000 description 1
• 108700032673 cocaine- and amphetamine-regulated transcript Proteins 0.000 description 1
• 230000003920 cognitive function Effects 0.000 description 1
• 108010049937 collagen type I trimeric cross-linked peptide Proteins 0.000 description 1
• 230000002301 combined effect Effects 0.000 description 1
• 238000010668 complexation reaction Methods 0.000 description 1
• 239000004020 conductor Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 229910052802 copper Inorganic materials 0.000 description 1
• 239000010949 copper Substances 0.000 description 1
• 238000012937 correction Methods 0.000 description 1
• OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 description 1
• 108010050742 corticotropin releasing hormone (9-41) Proteins 0.000 description 1
• DDRPLNQJNRBRNY-WYYADCIBSA-N cortistatin-14 Chemical compound C([C@H]1C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N1)NC(=O)[C@H]1NCCC1)C(=O)N[C@@H](CCCCN)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 DDRPLNQJNRBRNY-WYYADCIBSA-N 0.000 description 1
• 210000003792 cranial nerve Anatomy 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 239000003431 cross linking reagent Substances 0.000 description 1
• 229940095074 cyclic amp Drugs 0.000 description 1
• 125000004858 cycloalkoxyalkyl group Chemical group 0.000 description 1
• VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 description 1
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 230000009849 deactivation Effects 0.000 description 1
• 210000003785 decidua Anatomy 0.000 description 1
• 238000000354 decomposition reaction Methods 0.000 description 1
• 108010073977 decorsin Proteins 0.000 description 1
• 230000007547 defect Effects 0.000 description 1
• 239000008367 deionised water Substances 0.000 description 1
• 229910021641 deionized water Inorganic materials 0.000 description 1
• 108010053500 delicious peptide Proteins 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 238000001212 derivatisation Methods 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• 201000010064 diabetes insipidus Diseases 0.000 description 1
• 238000002405 diagnostic procedure Methods 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 150000004985 diamines Chemical class 0.000 description 1
• FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 description 1
• 235000021245 dietary protein Nutrition 0.000 description 1
• 108091007734 digestive enzymes Proteins 0.000 description 1
• 102000038379 digestive enzymes Human genes 0.000 description 1
• BGRWYRAHAFMIBJ-UHFFFAOYSA-N diisopropylcarbodiimide Natural products CC(C)NC(=O)NC(C)C BGRWYRAHAFMIBJ-UHFFFAOYSA-N 0.000 description 1
• 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
• WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 238000006073 displacement reaction Methods 0.000 description 1
• 125000002228 disulfide group Chemical group 0.000 description 1
• 150000002019 disulfides Chemical class 0.000 description 1
• 230000035619 diuresis Effects 0.000 description 1
• 230000001882 diuretic effect Effects 0.000 description 1
• 229960003638 dopamine Drugs 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 238000001647 drug administration Methods 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 208000000718 duodenal ulcer Diseases 0.000 description 1
• 108010093643 dynorphin A (2-12) Proteins 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 230000020595 eating behavior Effects 0.000 description 1
• 230000003804 effect on potassium Effects 0.000 description 1
• 238000000132 electrospray ionisation Methods 0.000 description 1
• 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
• 230000013020 embryo development Effects 0.000 description 1
• 210000003890 endocrine cell Anatomy 0.000 description 1
• 230000007368 endocrine function Effects 0.000 description 1
• 208000030172 endocrine system disease Diseases 0.000 description 1
• 239000006274 endogenous ligand Substances 0.000 description 1
• 230000002357 endometrial effect Effects 0.000 description 1
• 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
• 238000001839 endoscopy Methods 0.000 description 1
• MLFJHYIHIKEBTQ-IYRKOGFYSA-N endothelin 2 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=3C4=CC=CC=C4NC=3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CSSC1)C1=CNC=N1 MLFJHYIHIKEBTQ-IYRKOGFYSA-N 0.000 description 1
• ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N endothelin i Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CSSC[C@@H](C(N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-ZTNLKOGPSA-N 0.000 description 1
• 239000002158 endotoxin Substances 0.000 description 1
• 230000037149 energy metabolism Effects 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 210000004188 enterochromaffin-like cell Anatomy 0.000 description 1
• 239000000147 enterotoxin Substances 0.000 description 1
• 231100000655 enterotoxin Toxicity 0.000 description 1
• 230000002327 eosinophilic effect Effects 0.000 description 1
• KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 1
• 229960001123 epoprostenol Drugs 0.000 description 1
• UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical compound [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 description 1
• 230000032050 esterification Effects 0.000 description 1
• 238000005886 esterification reaction Methods 0.000 description 1
• 229940011871 estrogen Drugs 0.000 description 1
• 239000000262 estrogen Substances 0.000 description 1
• RIZMRRKBZQXFOY-UHFFFAOYSA-N ethion Chemical compound CCOP(=S)(OCC)SCSP(=S)(OCC)OCC RIZMRRKBZQXFOY-UHFFFAOYSA-N 0.000 description 1
• 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 230000029142 excretion Effects 0.000 description 1
• 229960001519 exenatide Drugs 0.000 description 1
• 210000002907 exocrine cell Anatomy 0.000 description 1
• 210000003499 exocrine gland Anatomy 0.000 description 1
• 210000003020 exocrine pancreas Anatomy 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 210000002219 extraembryonic membrane Anatomy 0.000 description 1
• 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 1
• 235000019197 fats Nutrition 0.000 description 1
• 230000008175 fetal development Effects 0.000 description 1
• 239000000208 fibrin degradation product Substances 0.000 description 1
• 230000019305 fibroblast migration Effects 0.000 description 1
• 230000004761 fibrosis Effects 0.000 description 1
• 229930003935 flavonoid Natural products 0.000 description 1
• 150000002215 flavonoids Chemical class 0.000 description 1
• 235000017173 flavonoids Nutrition 0.000 description 1
• RMBPEFMHABBEKP-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2C3=C[CH]C=CC3=CC2=C1 RMBPEFMHABBEKP-UHFFFAOYSA-N 0.000 description 1
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 1
• FATAVLOOLIRUNA-UHFFFAOYSA-N formylmethyl Chemical group [CH2]C=O FATAVLOOLIRUNA-UHFFFAOYSA-N 0.000 description 1
• 238000002309 gasification Methods 0.000 description 1
• 206010017758 gastric cancer Diseases 0.000 description 1
• 230000030136 gastric emptying Effects 0.000 description 1
• 201000005917 gastric ulcer Diseases 0.000 description 1
• 230000007661 gastrointestinal function Effects 0.000 description 1
• 230000005176 gastrointestinal motility Effects 0.000 description 1
• 239000010437 gem Substances 0.000 description 1
• 102000034356 gene-regulatory proteins Human genes 0.000 description 1
• 108091006104 gene-regulatory proteins Proteins 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 230000009395 genetic defect Effects 0.000 description 1
• 235000008397 ginger Nutrition 0.000 description 1
• 229950004143 glaspimod Drugs 0.000 description 1
• 230000004153 glucose metabolism Effects 0.000 description 1
• 229930182478 glucoside Natural products 0.000 description 1
• 150000008131 glucosides Chemical class 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• 230000002414 glycolytic effect Effects 0.000 description 1
• 229930182470 glycoside Natural products 0.000 description 1
• 150000002338 glycosides Chemical class 0.000 description 1
• YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• 239000003966 growth inhibitor Substances 0.000 description 1
• 150000002357 guanidines Chemical class 0.000 description 1
• 230000003394 haemopoietic effect Effects 0.000 description 1
• 230000023560 heart growth Effects 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 210000000087 hemolymph Anatomy 0.000 description 1
• 230000023597 hemostasis Effects 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 231100000283 hepatitis Toxicity 0.000 description 1
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 239000000833 heterodimer Substances 0.000 description 1
• 239000004312 hexamethylene tetramine Substances 0.000 description 1
• 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
• VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
• 231100000171 higher toxicity Toxicity 0.000 description 1
• 239000003667 hormone antagonist Substances 0.000 description 1
• 108091008039 hormone receptors Proteins 0.000 description 1
• 239000000704 hormone release inhibiting factor Substances 0.000 description 1
• 235000020256 human milk Nutrition 0.000 description 1
• 210000004251 human milk Anatomy 0.000 description 1
• 230000036571 hydration Effects 0.000 description 1
• 238000006703 hydration reaction Methods 0.000 description 1
• 238000006698 hydrazinolysis reaction Methods 0.000 description 1
• 238000005984 hydrogenation reaction Methods 0.000 description 1
• 230000003301 hydrolyzing effect Effects 0.000 description 1
• 230000002209 hydrophobic effect Effects 0.000 description 1
• NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
• 230000000148 hypercalcaemia Effects 0.000 description 1
• 208000030915 hypercalcemia disease Diseases 0.000 description 1
• 230000003345 hyperglycaemic effect Effects 0.000 description 1
• 239000000960 hypophysis hormone Substances 0.000 description 1
• 239000000601 hypothalamic hormone Substances 0.000 description 1
• 229940043650 hypothalamic hormone Drugs 0.000 description 1
• 230000000642 iatrogenic effect Effects 0.000 description 1
• 108010068927 iberiotoxin Proteins 0.000 description 1
• VDNVVLOBNHIMQA-UHFFFAOYSA-N iberiotoxin Chemical compound C1SSCC(C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C1NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CCSC)NC(=O)C(NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CCCNC(N)=N)NC(=O)C(CC(O)=O)NC(=O)C(C(C)C)NC(=O)CNC(=O)C(CC=1C=CC=CC=1)NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC1=O)CSSCC1NC(=O)C(C(C)C)NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CO)NC1=O)CSSCC1NC(=O)C(CC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(O)=O)NC(=O)C(C(C)O)NC(=O)C(NC(=O)C1NC(=O)CC1)CC1=CC=CC=C1 VDNVVLOBNHIMQA-UHFFFAOYSA-N 0.000 description 1
• 125000001841 imino group Chemical group [H]N=* 0.000 description 1
• 230000005965 immune activity Effects 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 230000036737 immune function Effects 0.000 description 1
• 230000008105 immune reaction Effects 0.000 description 1
• 230000003832 immune regulation Effects 0.000 description 1
• 208000026278 immune system disease Diseases 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 208000021267 infertility disease Diseases 0.000 description 1
• 210000004969 inflammatory cell Anatomy 0.000 description 1
• 229960003971 influenza vaccine Drugs 0.000 description 1
• 108010067471 inhibin A Proteins 0.000 description 1
• 108010067479 inhibin B Proteins 0.000 description 1
• 239000000201 insect hormone Substances 0.000 description 1
• 230000003914 insulin secretion Effects 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 208000001286 intracranial vasospasm Diseases 0.000 description 1
• 230000002601 intratumoral effect Effects 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 208000028867 ischemia Diseases 0.000 description 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
• 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
• 239000002949 juvenile hormone Substances 0.000 description 1
• 229930014550 juvenile hormone Natural products 0.000 description 1
• 150000003633 juvenile hormone derivatives Chemical class 0.000 description 1
• 229930191400 juvenile hormones Natural products 0.000 description 1
• 102000048260 kappa Opioid Receptors Human genes 0.000 description 1
• 108010082683 kemptide Proteins 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• 210000000244 kidney pelvis Anatomy 0.000 description 1
• 229940043355 kinase inhibitor Drugs 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 210000001756 lactotroph Anatomy 0.000 description 1
• 229910052747 lanthanoid Inorganic materials 0.000 description 1
• 150000002602 lanthanoids Chemical class 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 239000002523 lectin Substances 0.000 description 1
• URLZCHNOLZSCCA-UHFFFAOYSA-N leu-enkephalin Chemical compound C=1C=C(O)C=CC=1CC(N)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=CC=C1 URLZCHNOLZSCCA-UHFFFAOYSA-N 0.000 description 1
• NPNKBZWPJLBZHB-UHFFFAOYSA-N leucoxine Natural products COc1cc-2c(CC3N(C)CCc4cc5OCOc5c-2c34)c(O)c1OC NPNKBZWPJLBZHB-UHFFFAOYSA-N 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 201000002364 leukopenia Diseases 0.000 description 1
• 231100001022 leukopenia Toxicity 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 230000003212 lipotrophic effect Effects 0.000 description 1
• 238000004811 liquid chromatography Methods 0.000 description 1
• 230000036445 liquid secretion Effects 0.000 description 1
• 210000005229 liver cell Anatomy 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• 230000004807 localization Effects 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 231100000053 low toxicity Toxicity 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 108010091504 malantide Proteins 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 210000004962 mammalian cell Anatomy 0.000 description 1
• 210000001161 mammalian embryo Anatomy 0.000 description 1
• 238000007726 management method Methods 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 235000013310 margarine Nutrition 0.000 description 1
• 239000003264 margarine Substances 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 108010077372 mast cell degranulating peptide Proteins 0.000 description 1
• 235000012054 meals Nutrition 0.000 description 1
• 235000013372 meat Nutrition 0.000 description 1
• 239000002865 melanocortin Substances 0.000 description 1
• 210000002752 melanocyte Anatomy 0.000 description 1
• 229960003987 melatonin Drugs 0.000 description 1
• 230000006386 memory function Effects 0.000 description 1
• 230000009245 menopause Effects 0.000 description 1
• 230000029052 metamorphosis Effects 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 210000002617 middle hypothalamus Anatomy 0.000 description 1
• 230000003278 mimic effect Effects 0.000 description 1
• 230000009456 molecular mechanism Effects 0.000 description 1
• SLZIZIJTGAYEKK-CIJSCKBQSA-N molport-023-220-247 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CNC=N1 SLZIZIJTGAYEKK-CIJSCKBQSA-N 0.000 description 1
• YVIIHEKJCKCXOB-STYWVVQQSA-N molport-023-276-178 Chemical compound C([C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(N[C@@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)=O)CC(C)C)[C@@H](C)O)C(N)=O)C1=CNC=N1 YVIIHEKJCKCXOB-STYWVVQQSA-N 0.000 description 1
• 238000012544 monitoring process Methods 0.000 description 1
• 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 230000036651 mood Effects 0.000 description 1
• 230000037023 motor activity Effects 0.000 description 1
• 102000051367 mu Opioid Receptors Human genes 0.000 description 1
• BSOQXXWZTUDTEL-QAQREVAFSA-N muramyl dipeptide Chemical class OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-QAQREVAFSA-N 0.000 description 1
• 210000002464 muscle smooth vascular Anatomy 0.000 description 1
• 208000010125 myocardial infarction Diseases 0.000 description 1
• 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 1
• RIVIDPPYRINTTH-UHFFFAOYSA-N n-ethylpropan-2-amine Chemical compound CCNC(C)C RIVIDPPYRINTTH-UHFFFAOYSA-N 0.000 description 1
• 230000001452 natriuretic effect Effects 0.000 description 1
• 230000017074 necrotic cell death Effects 0.000 description 1
• 230000023533 negative regulation of action potential Effects 0.000 description 1
• 230000010807 negative regulation of binding Effects 0.000 description 1
• 230000011224 negative regulation of urine volume Effects 0.000 description 1
• 230000005709 nerve cell growth Effects 0.000 description 1
• 230000007830 nerve conduction Effects 0.000 description 1
• 210000000944 nerve tissue Anatomy 0.000 description 1
• 230000000955 neuroendocrine Effects 0.000 description 1
• 239000000712 neurohormone Substances 0.000 description 1
• 230000007658 neurological function Effects 0.000 description 1
• 230000009689 neuronal regeneration Effects 0.000 description 1
• 230000002981 neuropathic effect Effects 0.000 description 1
• 210000001719 neurosecretory cell Anatomy 0.000 description 1
• 239000002581 neurotoxin Substances 0.000 description 1
• 231100000618 neurotoxin Toxicity 0.000 description 1
• 206010029410 night sweats Diseases 0.000 description 1
• 230000036565 night sweats Effects 0.000 description 1
• 210000002445 nipple Anatomy 0.000 description 1
• 125000006501 nitrophenyl group Chemical group 0.000 description 1
• 230000003040 nociceptive effect Effects 0.000 description 1
• 238000010606 normalization Methods 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 description 1
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 229940127240 opiate Drugs 0.000 description 1
• 229960001027 opium Drugs 0.000 description 1
• 108060005714 orexin Proteins 0.000 description 1
• 210000004789 organ system Anatomy 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• 230000008520 organization Effects 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 230000027758 ovulation cycle Effects 0.000 description 1
• 230000004792 oxidative damage Effects 0.000 description 1
• 230000036542 oxidative stress Effects 0.000 description 1
• 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 description 1
• 150000002926 oxygen Chemical class 0.000 description 1
• RYZUEKXRBSXBRH-CTXORKPYSA-N pancreastatin Chemical compound C([C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C1=CN=CN1 RYZUEKXRBSXBRH-CTXORKPYSA-N 0.000 description 1
• 230000003076 paracrine Effects 0.000 description 1
• 244000045947 parasite Species 0.000 description 1
• 230000003071 parasitic effect Effects 0.000 description 1
• 230000000849 parathyroid Effects 0.000 description 1
• 210000003681 parotid gland Anatomy 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 230000001717 pathogenic effect Effects 0.000 description 1
• 230000009054 pathological process Effects 0.000 description 1
• 230000007170 pathology Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• 239000008188 pellet Substances 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
• 108010009779 peptide 32 Proteins 0.000 description 1
• 230000000737 periodic effect Effects 0.000 description 1
• 150000002989 phenols Chemical class 0.000 description 1
• 125000006678 phenoxycarbonyl group Chemical group 0.000 description 1
• HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
• 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 125000005496 phosphonium group Chemical group 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 230000010254 physiological adaptation Effects 0.000 description 1
• 230000001766 physiological effect Effects 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 210000005152 placental membrane Anatomy 0.000 description 1
• 108010024226 placental ribonuclease inhibitor Proteins 0.000 description 1
• 238000013439 planning Methods 0.000 description 1
• 239000002806 plasmin inhibitor Substances 0.000 description 1
• 231100000614 poison Toxicity 0.000 description 1
• 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
• 125000003367 polycyclic group Chemical group 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
• 239000001205 polyphosphate Substances 0.000 description 1
• 235000011176 polyphosphates Nutrition 0.000 description 1
• 150000007519 polyprotic acids Polymers 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 150000004804 polysaccharides Polymers 0.000 description 1
• 229920002223 polystyrene Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 230000012495 positive regulation of renal sodium excretion Effects 0.000 description 1
• 230000000291 postprandial effect Effects 0.000 description 1
• 230000001242 postsynaptic effect Effects 0.000 description 1
• BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 230000003334 potential effect Effects 0.000 description 1
• 229960000249 pregnenolone Drugs 0.000 description 1
• OZZAYJQNMKMUSD-DMISRAGPSA-N pregnenolone succinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 OZZAYJQNMKMUSD-DMISRAGPSA-N 0.000 description 1
• 230000003518 presynaptic effect Effects 0.000 description 1
• 239000002877 prolactin releasing hormone Substances 0.000 description 1
• 230000002062 proliferating effect Effects 0.000 description 1
• 230000013777 protein digestion Effects 0.000 description 1
• 239000003909 protein kinase inhibitor Substances 0.000 description 1
• 230000009822 protein phosphorylation Effects 0.000 description 1
• 239000012460 protein solution Substances 0.000 description 1
• 230000002797 proteolythic effect Effects 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 description 1
• 201000003004 ptosis Diseases 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 150000004053 quinones Chemical class 0.000 description 1
• 230000005855 radiation Effects 0.000 description 1
• 239000002516 radical scavenger Substances 0.000 description 1
• 150000003254 radicals Chemical class 0.000 description 1
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 229940044601 receptor agonist Drugs 0.000 description 1
• 239000000018 receptor agonist Substances 0.000 description 1
• 229940044551 receptor antagonist Drugs 0.000 description 1
• 239000002464 receptor antagonist Substances 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000008929 regeneration Effects 0.000 description 1
• 238000011069 regeneration method Methods 0.000 description 1
• 230000026267 regulation of growth Effects 0.000 description 1
• 108091006091 regulatory enzymes Proteins 0.000 description 1
• 230000009711 regulatory function Effects 0.000 description 1
• 108010004459 relacin Proteins 0.000 description 1
• 230000008327 renal blood flow Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 238000009256 replacement therapy Methods 0.000 description 1
• 230000000241 respiratory effect Effects 0.000 description 1
• 230000029058 respiratory gaseous exchange Effects 0.000 description 1
• 210000002345 respiratory system Anatomy 0.000 description 1
• 230000026416 response to pain Effects 0.000 description 1
• 210000003660 reticulum Anatomy 0.000 description 1
• 230000002441 reversible effect Effects 0.000 description 1
• 206010039073 rheumatoid arthritis Diseases 0.000 description 1
• 108010091078 rigin Proteins 0.000 description 1
• 239000011435 rock Substances 0.000 description 1
• 210000004358 rod cell outer segment Anatomy 0.000 description 1
• 238000005096 rolling process Methods 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 238000005070 sampling Methods 0.000 description 1
• 235000019627 satiety Nutrition 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 239000002795 scorpion venom Substances 0.000 description 1
• 150000003335 secondary amines Chemical class 0.000 description 1
• 229960002101 secretin Drugs 0.000 description 1
• OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 1
• 230000001235 sensitizing effect Effects 0.000 description 1
• 230000009329 sexual behaviour Effects 0.000 description 1
• 230000001568 sexual effect Effects 0.000 description 1
• 230000035938 sexual maturation Effects 0.000 description 1
• 239000009671 shengli Substances 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 230000008054 signal transmission Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
• 229960002930 sirolimus Drugs 0.000 description 1
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
• 210000002363 skeletal muscle cell Anatomy 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 230000008665 sleep physiology Effects 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 150000003384 small molecules Chemical class 0.000 description 1
• 239000003998 snake venom Substances 0.000 description 1
• 238000002791 soaking Methods 0.000 description 1
• 238000000638 solvent extraction Methods 0.000 description 1
• 210000001082 somatic cell Anatomy 0.000 description 1
• 210000002325 somatostatin-secreting cell Anatomy 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• 210000000278 spinal cord Anatomy 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 102000005963 steroid binding proteins Human genes 0.000 description 1
• 108020003178 steroid binding proteins Proteins 0.000 description 1
• 125000002328 sterol group Chemical group 0.000 description 1
• 201000011549 stomach cancer Diseases 0.000 description 1
• 239000010902 straw Substances 0.000 description 1
• 125000005504 styryl group Chemical group 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 125000003107 substituted aryl group Chemical group 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• GECHUMIMRBOMGK-UHFFFAOYSA-N sulfapyridine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CC=CC=N1 GECHUMIMRBOMGK-UHFFFAOYSA-N 0.000 description 1
• 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 230000000153 supplemental effect Effects 0.000 description 1
• 230000009469 supplementation Effects 0.000 description 1
• 230000008093 supporting effect Effects 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 230000005062 synaptic transmission Effects 0.000 description 1
• 230000002195 synergetic effect Effects 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1
• 230000001839 systemic circulation Effects 0.000 description 1
• 229940037128 systemic glucocorticoids Drugs 0.000 description 1
• 208000037905 systemic hypertension Diseases 0.000 description 1
• HOWHQWFXSLOJEF-MGZLOUMQSA-N systemin Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)OC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2N(CCC2)C(=O)[C@H]2N(CCC2)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)CCC1 HOWHQWFXSLOJEF-MGZLOUMQSA-N 0.000 description 1
• 108010050014 systemin Proteins 0.000 description 1
• 108060008037 tachykinin Proteins 0.000 description 1
• 229920002258 tannic acid Polymers 0.000 description 1
• LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
• 229940033123 tannic acid Drugs 0.000 description 1
• 235000015523 tannic acid Nutrition 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• RGYLYUZOGHTBRF-BIHRQFPBSA-N tetragastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)CCSC)C(N)=O)C1=CC=CC=C1 RGYLYUZOGHTBRF-BIHRQFPBSA-N 0.000 description 1
• 150000003568 thioethers Chemical class 0.000 description 1
• 239000003868 thrombin inhibitor Substances 0.000 description 1
• NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
• 229960004231 thymalfasin Drugs 0.000 description 1
• 230000002992 thymic effect Effects 0.000 description 1
• 229940104230 thymidine Drugs 0.000 description 1
• 229960004517 thymopentin Drugs 0.000 description 1
• 239000001585 thymus vulgaris Substances 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
• 229940034208 thyroxine Drugs 0.000 description 1
• XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
• 230000008467 tissue growth Effects 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 239000003440 toxic substance Substances 0.000 description 1
• 238000012549 training Methods 0.000 description 1
• 230000002463 transducing effect Effects 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 238000005809 transesterification reaction Methods 0.000 description 1
• 230000001131 transforming effect Effects 0.000 description 1
• 230000009261 transgenic effect Effects 0.000 description 1
• 230000007704 transition Effects 0.000 description 1
• 230000014616 translation Effects 0.000 description 1
• OXHYRVSBKWIFES-WWSDOYNLSA-N trap-14 peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=CC=C1 OXHYRVSBKWIFES-WWSDOYNLSA-N 0.000 description 1
• 230000008733 trauma Effects 0.000 description 1
• 125000005270 trialkylamine group Chemical group 0.000 description 1
• 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 1
• 230000001960 triggered effect Effects 0.000 description 1
• 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
• 239000012588 trypsin Substances 0.000 description 1
• IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 description 1
• 229940035670 tuftsin Drugs 0.000 description 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
• 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
• 229960003732 tyramine Drugs 0.000 description 1
• 210000002438 upper gastrointestinal tract Anatomy 0.000 description 1
• 208000009852 uremia Diseases 0.000 description 1
• 210000001635 urinary tract Anatomy 0.000 description 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
• 210000001215 vagina Anatomy 0.000 description 1
• 108010058394 valyl-prolyl-aspartyl-prolyl-arginine Proteins 0.000 description 1
• 210000005167 vascular cell Anatomy 0.000 description 1
• 210000005166 vasculature Anatomy 0.000 description 1
• 230000003639 vasoconstrictive effect Effects 0.000 description 1
• 239000005526 vasoconstrictor agent Substances 0.000 description 1
• 229940124549 vasodilator Drugs 0.000 description 1
• 239000003071 vasodilator agent Substances 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 230000001720 vestibular Effects 0.000 description 1
• 230000035899 viability Effects 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 230000029812 viral genome replication Effects 0.000 description 1
• 230000009385 viral infection Effects 0.000 description 1
• 230000000007 visual effect Effects 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 230000001755 vocal effect Effects 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 239000002578 wasp venom Substances 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 239000002023 wood Substances 0.000 description 1
• 230000029663 wound healing Effects 0.000 description 1
• 229940075420 xanthine Drugs 0.000 description 1
• 239000002676 xenobiotic agent Substances 0.000 description 1
• 229910052727 yttrium Inorganic materials 0.000 description 1
• VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
• MMSLSKDMIZOHRX-WYDAWZGFSA-N α-helical crf(9-41) Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(N)=O MMSLSKDMIZOHRX-WYDAWZGFSA-N 0.000 description 1
• 108020001588 κ-opioid receptors Proteins 0.000 description 1
• 108020001612 μ-opioid receptors Proteins 0.000 description 1