TWI229599B - Kits for treating vulvovaginal candidiasis with miconazole nitrate - Google Patents
Kits for treating vulvovaginal candidiasis with miconazole nitrate Download PDFInfo
- Publication number
- TWI229599B TWI229599B TW088120198A TW88120198A TWI229599B TW I229599 B TWI229599 B TW I229599B TW 088120198 A TW088120198 A TW 088120198A TW 88120198 A TW88120198 A TW 88120198A TW I229599 B TWI229599 B TW I229599B
- Authority
- TW
- Taiwan
- Prior art keywords
- nitrate
- cream
- group
- acceptable carrier
- patent application
- Prior art date
Links
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 title claims abstract description 26
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 title abstract description 6
- 229960005040 miconazole nitrate Drugs 0.000 title abstract description 6
- 239000003937 drug carrier Substances 0.000 claims abstract description 13
- 210000003905 vulva Anatomy 0.000 claims abstract description 12
- 229910002651 NO3 Inorganic materials 0.000 claims description 33
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 33
- 239000006071 cream Substances 0.000 claims description 29
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 11
- 229960001259 diclofenac Drugs 0.000 claims description 10
- NSYCNXOFRPQHGG-UHFFFAOYSA-N 1h-benzimidazole;nitric acid Chemical compound O[N+]([O-])=O.C1=CC=C2NC=NC2=C1 NSYCNXOFRPQHGG-UHFFFAOYSA-N 0.000 claims description 9
- 230000002079 cooperative effect Effects 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000007789 gas Substances 0.000 claims 3
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-M benzenecarboximidate Chemical compound [NH-]C(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-M 0.000 claims 1
- 239000012159 carrier gas Substances 0.000 claims 1
- CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 29
- 238000000034 method Methods 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 description 20
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 19
- 229940000973 monistat Drugs 0.000 description 18
- 210000001215 vagina Anatomy 0.000 description 15
- 229940044959 vaginal cream Drugs 0.000 description 12
- 239000000522 vaginal cream Substances 0.000 description 12
- -1 1200 mg Chemical compound 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 5
- 229940127234 oral contraceptive Drugs 0.000 description 4
- 239000003539 oral contraceptive agent Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 230000002906 microbiologic effect Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 2
- 125000006286 dichlorobenzyl group Chemical group 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 150000002823 nitrates Chemical class 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 2
- 229960001860 salicylate Drugs 0.000 description 2
- 229940120293 vaginal suppository Drugs 0.000 description 2
- 239000006216 vaginal suppository Substances 0.000 description 2
- DSPHFASHOJAOKN-UHFFFAOYSA-N 1-[(7-oxobenzo[a]phenalen-2-yl)amino]anthracene-9,10-dione Chemical compound C1=CC2=CC(NC3=C4C(=O)C5=CC=CC=C5C(C4=CC=C3)=O)=CC(C=3C(=CC=CC=3)C3=O)=C2C3=C1 DSPHFASHOJAOKN-UHFFFAOYSA-N 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- CYBAWVCMEUZAGR-UHFFFAOYSA-N N1N=CC=CC2=C1C=CC=C2.[N+](=O)(O)[O-] Chemical compound N1N=CC=CC2=C1C=CC=C2.[N+](=O)(O)[O-] CYBAWVCMEUZAGR-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012871 anti-fungal composition Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/197,019 US6153635A (en) | 1998-11-20 | 1998-11-20 | Methods and kits for treating vulvovaginal candidiasis with miconazole nitrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI229599B true TWI229599B (en) | 2005-03-21 |
Family
ID=22727682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW088120198A TWI229599B (en) | 1998-11-20 | 1999-12-09 | Kits for treating vulvovaginal candidiasis with miconazole nitrate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6153635A (https=) |
| EP (1) | EP1051162B1 (https=) |
| JP (1) | JP2002530327A (https=) |
| KR (1) | KR100701490B1 (https=) |
| CN (1) | CN1332663C (https=) |
| AR (1) | AR021863A1 (https=) |
| AU (1) | AU777508B2 (https=) |
| BR (1) | BR9907150A (https=) |
| CA (1) | CA2318125C (https=) |
| DE (1) | DE69930725T2 (https=) |
| ES (1) | ES2262353T3 (https=) |
| TW (1) | TWI229599B (https=) |
| WO (1) | WO2000030626A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE400270T1 (de) * | 2002-12-18 | 2008-07-15 | Ferrer Int | Pharmazeutische zusammensetzungen mit sertaconazol für vaginale verwendung |
| EP1500394A1 (en) * | 2003-07-22 | 2005-01-26 | Polichem S.A. | Pharmaceutical compositions comprising ascorbic acid or the treatment of fungal superinfections and fungal recurrences |
| CA2538991A1 (en) | 2003-09-18 | 2005-03-31 | Children's Medical Center Corporation | Treatment of severe distal colitis |
| US20070065504A1 (en) * | 2004-03-23 | 2007-03-22 | Lin Shun Y | Products and methods for treating vaginal infections |
| US20050214364A1 (en) * | 2004-03-23 | 2005-09-29 | Hutman Herbert W | Products and methods for treating vaginal infections |
| US8057433B2 (en) | 2004-07-08 | 2011-11-15 | Drugtech Corporation | Delivery system |
| US20090156987A1 (en) * | 2007-12-14 | 2009-06-18 | Mclean Barbara Wanamaker | Apparatus and method of delivery of substances into target tissue |
| WO2018013625A1 (en) * | 2016-07-13 | 2018-01-18 | Concert Pharmaceuticals, Inc. | Deuterated miconazole |
| JP2025507426A (ja) * | 2022-02-17 | 2025-03-18 | ゼンビジョン ファルマ エルエルピー | ミコナゾール及びルリコナゾール又はそれらの塩を含む膣用医薬組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8830405D0 (en) * | 1988-12-30 | 1989-03-01 | Embil Koral | Pharmaceutical formulation |
-
1998
- 1998-11-20 US US09/197,019 patent/US6153635A/en not_active Expired - Fee Related
-
1999
- 1999-11-15 CN CNB998021989A patent/CN1332663C/zh not_active Expired - Fee Related
- 1999-11-15 AU AU20248/00A patent/AU777508B2/en not_active Ceased
- 1999-11-15 JP JP2000583509A patent/JP2002530327A/ja active Pending
- 1999-11-15 EP EP99963905A patent/EP1051162B1/en not_active Expired - Lifetime
- 1999-11-15 DE DE69930725T patent/DE69930725T2/de not_active Expired - Fee Related
- 1999-11-15 CA CA002318125A patent/CA2318125C/en not_active Expired - Fee Related
- 1999-11-15 KR KR1020007007770A patent/KR100701490B1/ko not_active Expired - Fee Related
- 1999-11-15 WO PCT/US1999/027091 patent/WO2000030626A2/en not_active Ceased
- 1999-11-15 BR BR9907150-9A patent/BR9907150A/pt not_active Application Discontinuation
- 1999-11-15 ES ES99963905T patent/ES2262353T3/es not_active Expired - Lifetime
- 1999-11-19 AR ARP990105925A patent/AR021863A1/es unknown
- 1999-12-09 TW TW088120198A patent/TWI229599B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010034150A (ko) | 2001-04-25 |
| ES2262353T3 (es) | 2006-11-16 |
| EP1051162A1 (en) | 2000-11-15 |
| WO2000030626A2 (en) | 2000-06-02 |
| AU2024800A (en) | 2000-06-13 |
| CA2318125A1 (en) | 2000-06-02 |
| WO2000030626A3 (en) | 2000-11-23 |
| CN1332663C (zh) | 2007-08-22 |
| KR100701490B1 (ko) | 2007-04-02 |
| EP1051162B1 (en) | 2006-04-05 |
| CN1288379A (zh) | 2001-03-21 |
| CA2318125C (en) | 2005-03-08 |
| AU777508B2 (en) | 2004-10-21 |
| US6153635A (en) | 2000-11-28 |
| DE69930725D1 (de) | 2006-05-18 |
| DE69930725T2 (de) | 2007-04-12 |
| BR9907150A (pt) | 2000-10-24 |
| AR021863A1 (es) | 2002-08-07 |
| HK1036930A1 (zh) | 2002-01-25 |
| JP2002530327A (ja) | 2002-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |