ES2262353T3 - Procedimientos y equipos para el tratamiento de la candidiasis vulvovaginal con nitrato de miconazol. - Google Patents
Procedimientos y equipos para el tratamiento de la candidiasis vulvovaginal con nitrato de miconazol.Info
- Publication number
- ES2262353T3 ES2262353T3 ES99963905T ES99963905T ES2262353T3 ES 2262353 T3 ES2262353 T3 ES 2262353T3 ES 99963905 T ES99963905 T ES 99963905T ES 99963905 T ES99963905 T ES 99963905T ES 2262353 T3 ES2262353 T3 ES 2262353T3
- Authority
- ES
- Spain
- Prior art keywords
- miconazole
- nitrate
- miconazole nitrate
- cream
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 7
- 238000011282 treatment Methods 0.000 title claims description 34
- 229960005040 miconazole nitrate Drugs 0.000 claims abstract description 75
- 210000003905 vulva Anatomy 0.000 claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 claims description 54
- 239000006071 cream Substances 0.000 claims description 33
- 229960002509 miconazole Drugs 0.000 claims description 21
- 229910002651 NO3 Inorganic materials 0.000 claims description 16
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 16
- 229940000973 monistat Drugs 0.000 description 29
- 229940044959 vaginal cream Drugs 0.000 description 13
- 239000000522 vaginal cream Substances 0.000 description 13
- 230000002906 microbiologic effect Effects 0.000 description 12
- 208000024891 symptom Diseases 0.000 description 10
- 230000001225 therapeutic effect Effects 0.000 description 10
- 239000003981 vehicle Substances 0.000 description 8
- 241000222122 Candida albicans Species 0.000 description 6
- 206010007134 Candida infections Diseases 0.000 description 5
- 201000003984 candidiasis Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 102000002322 Egg Proteins Human genes 0.000 description 4
- 108010000912 Egg Proteins Proteins 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229940127234 oral contraceptive Drugs 0.000 description 4
- 239000003539 oral contraceptive agent Substances 0.000 description 4
- 210000004681 ovum Anatomy 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 239000006216 vaginal suppository Substances 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US197019 | 1998-11-20 | ||
| US09/197,019 US6153635A (en) | 1998-11-20 | 1998-11-20 | Methods and kits for treating vulvovaginal candidiasis with miconazole nitrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2262353T3 true ES2262353T3 (es) | 2006-11-16 |
Family
ID=22727682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99963905T Expired - Lifetime ES2262353T3 (es) | 1998-11-20 | 1999-11-15 | Procedimientos y equipos para el tratamiento de la candidiasis vulvovaginal con nitrato de miconazol. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6153635A (https=) |
| EP (1) | EP1051162B1 (https=) |
| JP (1) | JP2002530327A (https=) |
| KR (1) | KR100701490B1 (https=) |
| CN (1) | CN1332663C (https=) |
| AR (1) | AR021863A1 (https=) |
| AU (1) | AU777508B2 (https=) |
| BR (1) | BR9907150A (https=) |
| CA (1) | CA2318125C (https=) |
| DE (1) | DE69930725T2 (https=) |
| ES (1) | ES2262353T3 (https=) |
| TW (1) | TWI229599B (https=) |
| WO (1) | WO2000030626A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA010155B1 (ru) * | 2002-12-18 | 2008-06-30 | Феррер Интернасионал, С.А. | Вагинальная мукоадгезивная композиция на основе нитрата сертаконазола, фармацевтический набор на основе композиции, фармацевтическая дозированная форма для лечения вульвовагинального кандидоза и способ его лечения |
| EP1500394A1 (en) * | 2003-07-22 | 2005-01-26 | Polichem S.A. | Pharmaceutical compositions comprising ascorbic acid or the treatment of fungal superinfections and fungal recurrences |
| EP1667632A4 (en) * | 2003-09-18 | 2009-07-01 | Childrens Medical Center | TREATMENT OF HEAVY DISTAL COLITIS |
| US20070065504A1 (en) * | 2004-03-23 | 2007-03-22 | Lin Shun Y | Products and methods for treating vaginal infections |
| US20050214364A1 (en) * | 2004-03-23 | 2005-09-29 | Hutman Herbert W | Products and methods for treating vaginal infections |
| US8057433B2 (en) | 2004-07-08 | 2011-11-15 | Drugtech Corporation | Delivery system |
| US20090156987A1 (en) * | 2007-12-14 | 2009-06-18 | Mclean Barbara Wanamaker | Apparatus and method of delivery of substances into target tissue |
| WO2018013625A1 (en) * | 2016-07-13 | 2018-01-18 | Concert Pharmaceuticals, Inc. | Deuterated miconazole |
| CN118946343A (zh) * | 2022-02-17 | 2024-11-12 | 泽威恩制药有限责任公司 | 包含咪康唑和卢立康唑或其盐的阴道药物组合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8830405D0 (en) * | 1988-12-30 | 1989-03-01 | Embil Koral | Pharmaceutical formulation |
-
1998
- 1998-11-20 US US09/197,019 patent/US6153635A/en not_active Expired - Fee Related
-
1999
- 1999-11-15 KR KR1020007007770A patent/KR100701490B1/ko not_active Expired - Fee Related
- 1999-11-15 DE DE69930725T patent/DE69930725T2/de not_active Expired - Fee Related
- 1999-11-15 WO PCT/US1999/027091 patent/WO2000030626A2/en not_active Ceased
- 1999-11-15 AU AU20248/00A patent/AU777508B2/en not_active Ceased
- 1999-11-15 JP JP2000583509A patent/JP2002530327A/ja active Pending
- 1999-11-15 BR BR9907150-9A patent/BR9907150A/pt not_active Application Discontinuation
- 1999-11-15 ES ES99963905T patent/ES2262353T3/es not_active Expired - Lifetime
- 1999-11-15 EP EP99963905A patent/EP1051162B1/en not_active Expired - Lifetime
- 1999-11-15 CN CNB998021989A patent/CN1332663C/zh not_active Expired - Fee Related
- 1999-11-15 CA CA002318125A patent/CA2318125C/en not_active Expired - Fee Related
- 1999-11-19 AR ARP990105925A patent/AR021863A1/es unknown
- 1999-12-09 TW TW088120198A patent/TWI229599B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR021863A1 (es) | 2002-08-07 |
| CA2318125C (en) | 2005-03-08 |
| WO2000030626A2 (en) | 2000-06-02 |
| EP1051162A1 (en) | 2000-11-15 |
| KR100701490B1 (ko) | 2007-04-02 |
| CN1288379A (zh) | 2001-03-21 |
| KR20010034150A (ko) | 2001-04-25 |
| EP1051162B1 (en) | 2006-04-05 |
| DE69930725T2 (de) | 2007-04-12 |
| AU2024800A (en) | 2000-06-13 |
| TWI229599B (en) | 2005-03-21 |
| CN1332663C (zh) | 2007-08-22 |
| HK1036930A1 (zh) | 2002-01-25 |
| WO2000030626A3 (en) | 2000-11-23 |
| DE69930725D1 (de) | 2006-05-18 |
| JP2002530327A (ja) | 2002-09-17 |
| BR9907150A (pt) | 2000-10-24 |
| US6153635A (en) | 2000-11-28 |
| CA2318125A1 (en) | 2000-06-02 |
| AU777508B2 (en) | 2004-10-21 |
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